Immunogenic Tumor Cell Death for Optimal Anticancer Therapy: The Calreticulin Exposure Pathway

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Clinical Cancer Research

• Publication date

  2010-04-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1078-0432.CCR-09-2891PMID 20421432
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Relationship between HLA class I antigen processing machinery component expression and the clinicopathologic characteristics of bladder carcinomas

  2010cited by this paper
• Immune infiltration in human tumors: a prognostic factor that should not be ignored

  2010cited by this paper
• Decoding cell death signals in inflammation and immunity.

  2010cited by this paper
• Immunogenic death of colon cancer cells treated with oxaliplatin

  2010cited by this paper
• Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer.

  2010cited by this paper
• Calreticulin: non‐endoplasmic reticulum functions in physiology and disease

  2010cited by this paper
• Immunity, inflammation, and cancer.

  2010cited by this paper
• Immunogenic chemotherapy with cyclophosphamide and doxorubicin against established murine carcinoma

  2010cited by this paper
• The Structure of Calreticulin C-terminal Domain Is Modulated by Physiological Variations of Calcium Concentration*

  2009cited by this paper
• Mitoxantrone-Mediated Apoptotic B16-F1 Cells Induce Specific Anti-tumor Immune Response

  2009cited by this paper
• Radiation induces an antitumour immune response to mouse melanoma

  2009cited by this paper
• Mechanisms of pre‐apoptotic calreticulin exposure in immunogenic cell death

  2009cited by this paper
• Disruption of the PP1/GADD34 complex induces calreticulin exposure

  2009cited by this paper
• Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

  2009cited by this paper
• Viral subversion of immunogenic cell death

  2009influential reference
• iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cells

  2009cited by this paper
• Phylogenetic conservation of the preapoptotic calreticulin exposure pathway from yeast to mammals

  2009influential reference
• Immunogenic and tolerogenic cell death

  2009cited by this paper
• Reprogramming mRNA translation during stress.

  2008cited by this paper
• The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death

  2008cited by this paper
• Immunological aspects of cancer chemotherapy

  2008cited by this paper
• Reduction of endoplasmic reticulum Ca2+ levels favors plasma membrane surface exposure of calreticulin

  2008cited by this paper
• The anticancer immune response: indispensable for therapeutic success?

  2008cited by this paper
• Bap31 Is a Novel Target of the Human Papillomavirus E5 Protein

  2008influential reference
• Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals.

  2008cited by this paper
• Calreticulin exposure dictates the immunogenicity of cancer cell death

  2007cited by this paper
• Calreticulin exposure is required for the immunogenicity of γ-irradiation and UVC light-induced apoptosis

  2007cited by this paper
• Ecto‐calreticulin in immunogenic chemotherapy

  2007cited by this paper
• Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

  2007cited by this paper
• After shrinkage apoptotic cells expose internal membrane-derived epitopes on their plasma membranes

  2007cited by this paper
• Expression and prognostic significance of prothymosin-alpha and ERp57 in human gastric cancer.

  2007cited by this paper
• Expression and prognostic significance of prothymosin-α and ERp57 in human gastric cancer

  2007cited by this paper
• Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity.

  2006cited by this paper
• Hepatitis C Virus Core Protein Inhibits Tumor Necrosis Factor Alpha-Mediated Apoptosis by a Protective Effect Involving Cellular FLICE Inhibitory Protein

  2006cited by this paper
• Cleavage of endoplasmic reticulum proteins in hepatocellular carcinoma: Detection of generated fragments in patient sera.

  2006cited by this paper
• Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1α

  2006cited by this paper
• Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

  2005cited by this paper
• Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte.

  2005cited by this paper
• Protein Synthesis and Endoplasmic Reticulum Stress Can Be Modulated by the Hepatitis C Virus Envelope Protein E2 through the Eukaryotic Initiation Factor 2α Kinase PERK

  2003cited by this paper
• Scavenger receptor‐A mediates gp96/GRP94 and calreticulin internalization by antigen‐presenting cells

  2003cited by this paper
• Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

  2003cited by this paper
• Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK.

  2003cited by this paper
• Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway

  2001cited by this paper
• Translational control is required for the unfolded protein response and in vivo glucose homeostasis.

  2001cited by this paper
• Immunological Aspects of Cancer Chemotherapy

  1980cited by this paper

• Penpulimab combined with rituximab, high-dose methotrexate, and cytarabine (Pen-RMA) in newly diagnosed primary central nervous system lymphoma (PCNSL): a phase 2 trial

  2026cites this paper
• Markers of immune activation and immunotherapy responsiveness are increased in 3D Pancreatic cancer organoids when primed with photodynamic- and chemo-therapy.

  2026cites this paper
• Manipulation of tumor microenvironment by induction of immunogenic cell death and immune check point inhibitors for enhancing the efficacy of cancer treatments.

  2026cites this paper
• Ambivalent Copper: Mechanistically Distinct Immune Effects Driving Innovation in Cancer Nanomedicine

  2026cites this paper
• Impaired autophagy by cepharanthine induces immunogenic cell death and enhances anti-PD-1 response in MSS-type colorectal cancer

  2025cites this paper
• PD-L1 targeted antibody-polymer-Epirubicin conjugate prolongs survival in a preclinical murine model of advanced ovarian cancer.

  2025cites this paper
• Endoplasmic Reticulum-Targeting Iridium(III) Complexes Induce Pyroptosis and Enhance Immunogenic Cell Death in MDA-MB-231 Cells.

  2025cites this paper
• Metal-based immunogenic cell death inducers for cancer immunotherapy

  2025cites this paper
• Chemotherapy-induced immunogenic cell death in combination with ICIs: a brief review of mechanisms, clinical insights, and therapeutic implications

  2025cites this paper
• Metronomic Chemotherapy in Breast Cancer: Unleashing the Potential of Combination Regimens

  2025cites this paper
• Investigation of the in vitro anticancer potential of bis(imino)acenaphthene–N-heterocyclic carbene transition metal complexes revealed TrxR inhibition and triggering of immunogenic cell death (ICD) for allyl palladates

  2025cites this paper
• Development of an alkaliptosis-related lncRNA risk model and immunotherapy target analysis in lung adenocarcinoma

  2025cites this paper
• Brachytherapy: Perspectives for combined treatments with immunotherapy

  2025cites this paper
• NIR-activated endoplasmic reticulum stress amplifier to regulate phagocytosis for macrophage-mediated cancer immunotherapy

  2025cites this paper
• Tumor vascular disruption and cGAS–STING activation by gambogic amide-loaded nanomicelles for multiple synergistic treatment of triple-negative breast cancer

  2025cites this paper
• Copper-Based Biomaterials for Anti-Tumor Therapy: Recent Advances and Perspectives.

  2025cites this paper
• Thrombospondin-1 induces immunogenic cell death in human mucoepidermoid carcinoma MC-3 cells via the PERK/eIF2α signaling pathway: potential implications for tumor immunotherapy

  2025cites this paper
• Functionalized Trichinella spiralis anti-tumor protein with polydopamine for hepatocellular carcinoma phototherapy and immunotherapy.

  2025cites this paper
• Investigating the potential role of miR-451a as a tumor suppressor in immunogenic cell death induction and dendritic cell maturation in colorectal cancer cell lines

  2025cites this paper
• Generation of a Synthetic Single Domain Antibody Library for Radiopharmaceutical Ligand Discovery

  2025cites this paper
• Harnessing prazosin for tumors: Liposome hybrid nanovesicles activate tumor immunotherapy via autophagy inhibition.

  2025cites this paper
• Apoptosis-inducing activity of a steroidal glycoside from Allium chinense G. Don. bulbs in human small-cell lung cancer cells via mitochondrial dysfunction and ER stress

  2025cites this paper
• Phagocytosis‐Activating Nanocomplex Orchestrates Macrophage‐Mediated Cancer Immunotherapy

  2025cites this paper
• Construction of an Immunogenic Cell Death-Related Gene Signature and Genetic Subtypes for Predicting Prognosis, Immune Microenvironments, and Drug Sensitivity in Hepatocellular Carcinoma

  2024cites this paper
• Immunogenic Bifunctional Nanoparticle Suppresses Programmed Cell Death-Ligand 1 in Cancer and Dendritic Cells to Enhance Adaptive Immunity and Chemo-Immunotherapy.

  2024cites this paper
• Integration of Single-Cell RNA Sequencing and Bulk RNA Sequencing to Identify an Immunogenic Cell Death-Related 5-Gene Prognostic Signature in Hepatocellular Carcinoma

  2024cites this paper
• STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition

  2024cites this paper
• Paradoxical cell targeting of calreticulin-empowered, protein-only nanoparticles.

  2024cites this paper
• Synergizing autophagic cell death and oxaliplatin-induced immunogenic death by a self-delivery micelle for enhanced tumor immunotherapy.

  2024cites this paper
• A new era of cancer phototherapy: mechanisms and applications.

  2024cites this paper
• Reactive oxygen species of tumor microenvironment: Harnessing for immunogenic cell death.

  2024cites this paper
• Mitochondria- and endoplasmic reticulum-localizing iridium(III) complexes induce immunogenic cell death of 143B cells.

  2024cites this paper
• Progress in nanomedicine for sonodynamic immunotherapy of tumors

  2024cites this paper
• Development of an Intracellular Nitric Oxide-Donating Cell-Penetrating Polypeptide as an Immunogenic Cell Death Inducer.

  2024cites this paper
• Shikonin improves the effectiveness of PD-1 blockade in colorectal cancer by enhancing immunogenicity via Hsp70 upregulation

  2024cites this paper
• Global research progress of nanomedicine and colorectal cancer: a bibliometrics and visualization analysis

  2024cites this paper
• Ferroptosis and HMGB2 induced calreticulin translocation required for immunogenic cell death are controlled by the nuclear exporter XPO1

  2024cites this paper
• Impact on CD4+ CD25High-CD127low regulatory T (Treg) cells of neoadjuvant therapy for rectal cancer patients

  2024cites this paper
• HMGB2-induced calreticulin translocation required for immunogenic cell death and ferroptosis of cancer cells are controlled by the nuclear exporter XPO1

  2024cites this paper
• Immunogenic cell death-based oncolytic virus therapy: a sharp sword of tumor immunotherapy.

  2024cites this paper
• Progress in Research on Immunogenic Cell Death and Its Application in Hepatocellular Carcinoma Therapy

  2024cites this paper
• A phase II study of neoadjuvant atezolizumab and nab-paclitaxel in patients with anthracycline-resistant early-stage triple-negative breast cancer

  2023cites this paper
• Quantitative image analysis of intracellular protein translocation in 3-dimensional tissues for pharmacodynamic studies of immunogenic cell death.

  2023cites this paper
• Nanotechnology-based photo-immunotherapy: a new hope for inhibition of melanoma growth and metastasis

  2023cites this paper
• Pharmacological tumor PDL1 depletion with chlorambucil treats ovarian cancer and melanoma: improves antitumor immunity and renders anti-PDL1-resistant tumors anti-PDL1-sensitive through NK cell effects

  2023cites this paper
• Engineered tumor-specific T cells using immunostimulatory photothermal nanoparticles

  2023cites this paper
• Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103.

  2023cites this paper
• Radiopharmaceuticals heat anti-tumor immunity

  2023cites this paper
• NIR-responsive hollow germanium nanospheres mediate photothermal/photodynamic therapy and restrain immunosuppression to cooperatively eradicate primary and metastatic tumors

  2023cites this paper
• Calreticulin Expression Controls Cellular Redox, Stemness, and Radiosensitivity to Function as a Novel Adjuvant for Radiotherapy in Neuroblastoma

  2023cites this paper
• Immunogenic cell stress and death in the treatment of cancer.

  2023cites this paper
• A Journey of Challenges and Victories: A Bibliometric Worldview of Nanomedicine since the 21st Century

  2023cites this paper
• Supramolecular immunotherapy on diversiform immune cells.

  2023cites this paper
• Dendritic cells as shepherds of T cell immunity in cancer.

  2023cites this paper
• Redox regulation and its emerging roles in cancer treatment

  2023cites this paper
• Synthesis of novel zinc porphyrins with bioisosteric replacement of Sorafenib: Efficient theranostic agents for anti-cancer application.

  2023cites this paper
• Gold Nanoparticles: Construction for Drug Delivery and Application in Cancer Immunotherapy

  2023cites this paper
• Platinum(IV) Derivatives of [Pt(1S,2S-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)] with Diclofenac Ligands in the Axial Positions: A New Class of Potent Multi-action Agents Exhibiting Selectivity to Cancer Cells

  2023cites this paper
• Nanotechnology-enabled immunogenic cell death for improved cancer immunotherapy.

  2023cites this paper
• Carbonic anhydrase IX inhibitor S4 triggers release of DAMPs related to immunogenic cell death in glioma cells via endoplasmic reticulum stress pathway

  2023cites this paper
• Stromal and tumor immune microenvironment reprogramming through multifunctional cisplatin-based liposomes boosts the efficacy of anti-PD-1 immunotherapy in pancreatic cancer.

  2023cites this paper
• High Intensity Aerobic exercise training and Immune cell Mobilization in patients with lung cancer (HI AIM)—a randomized controlled trial

  2022cites this paper
• Cu-Chelated polydopamine nanoparticles as a photothermal medium and "immunogenic cell death" inducer for combined tumor therapy.

  2022cites this paper
• Cell-Based Drug Delivery Systems Participate in the Cancer Immunity Cycle for Improved Cancer Immunotherapy.

  2022cites this paper
• Oxidative Stress in Cancer Immunotherapy: Molecular Mechanisms and Potential Applications

  2022cites this paper
• Targeting Bone Tumor and Subcellular Endoplasmic Reticulum via Near Infrared II Fluorescent Polymer for Photodynamic‐Immunotherapy to Break the Step‐Reduction Delivery Dilemma

  2022cites this paper
• Distinct roles in phagocytosis of the early and late increases of cell surface calreticulin induced by oxaliplatin

  2022cites this paper
• Cancer-targeted photoimmunotherapy induces antitumor immunity and can be augmented by anti-PD-1 therapy for durable anticancer responses in an immunologically active murine tumor model

  2022cites this paper
• Excipient-free prodrug-based three-in-one nanoparticles co-deliver diversified agents to amplify tumor therapy

  2022cites this paper
• Revisiting the Anti-Cancer Toxicity of Clinically Approved Platinating Derivatives

  2022cites this paper
• Effective combination of liposome-targeted chemotherapy and PD-L1 blockade of murine colon cancer.

  2022cites this paper
• Boosting cancer immunotherapy by biomineralized nanovaccine with ferroptosis-inducing and photothermal properties.

  2022cites this paper
• 5-ALA mediated photodynamic therapy with combined treatment improves anti-tumor efficacy of immunotherapy through boosting immunogenic cell death.

  2022cites this paper
• Research progress in inducing immunogenic cell death of tumor cells

  2022cites this paper
• Nanoparticles for Chemoimmunotherapy Against Triple-Negative Breast Cancer

  2022cites this paper
• Nanoparticle Enhancement of Natural Killer (NK) Cell-Based Immunotherapy

  2022cites this paper
• Targeted delivery of liposomal chemoimmunotherapy for cancer treatment

  2022cites this paper
• Immunostimulatory oncolytic activity of coxsackievirus A11 in human malignant pleural mesothelioma

  2022cites this paper
• Haemaphysalis longicornis calreticulin is not an effective molecular tool for tick bite diagnosis and disruption of tick infestations.

  2022cites this paper
• [Immuno-radiotherapy: A review of the rationale, recent clinical developments and future prospects].

  2022cites this paper
• The New Microtubule-Targeting Agent SIX2G Induces Immunogenic Cell Death in Multiple Myeloma

  2022influential citation
• Two-Stage SN38 Release from a Core–Shell Nanoparticle Enhances Tumor Deposition and Antitumor Efficacy for Synergistic Combination with Immune Checkpoint Blockade

  2022cites this paper
• Sphingosine Kinase Inhibition Enhances Dimerization of Calreticulin at the Cell Surface in Mitoxantrone-Induced Immunogenic Cell Death

  2021cites this paper
• Pembrolizumab with Capox Bevacizumab in patients with microsatellite stable metastatic colorectal cancer and a high immune infiltrate: The FFCD 1703-POCHI trial.

  2021cites this paper
• Sialic acid conjugate-modified liposomal platform modulates immunosuppressive tumor microenvironment in multiple ways for improved immune checkpoint blockade therapy.

  2021cites this paper
• Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

  2021cites this paper
• Immune Stimulating Antibody-Photosensitizer Conjugates via Fc-Mediated Dendritic Cell Phagocytosis and Phototriggered Immunogenic Cell Death for KRAS-Mutated Pancreatic Cancer Treatment.

  2021cites this paper
• Targeting Stress-Response Pathways and Therapeutic Resistance in Head and Neck Cancer

  2021cites this paper
• Nanotechnology-Enabled Chemodynamic & Immunotherapy.

  2021cites this paper
• Endoplasmic reticulum stress, cell death and tumor: Association between endoplasmic reticulum stress and the apoptosis pathway in tumors

  2021influential citation
• Cisplatin nanoparticles boost abscopal effect of radiation plus anti-PD1 therapy.

  2021cites this paper
• Melanization as unfavorable factor in amelanotic melanoma cell biology

  2021cites this paper
• Immunochemo combination therapy in cancer treatment

  2021cites this paper
• Role of nano-sensitizers in radiation therapy of metastatic tumors.

  2021cites this paper
• Engineering Calreticulin-Targeting Monobodies to Detect Immunogenic Cell Death in Cancer Chemotherapy

  2021cites this paper
• Belantamab Mafodotin (GSK2857916) Drives Immunogenic Cell Death and Immune-mediated Antitumor Responses In Vivo

  2021cites this paper
• A combinational chemo-immune therapy using an enzyme-sensitive nanoplatform for dual-drug delivery to specific sites by cascade targeting

  2021cites this paper
• A photoactivated Ir(iii) complex targets cancer stem cells and induces secretion of damage-associated molecular patterns in melanoma cells characteristic of immunogenic cell death

  2021cites this paper
• Locally advanced gastroesophageal junction cancer with pathological complete response to neoadjuvant therapy: a case report and literature review

  2021cites this paper
• The gold complex auranofin: new perspectives for cancer therapy

  2021cites this paper