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The NLRP3 inflammasome is critically involved in the development of bronchopulmonary dysplasia

J. Liao,V. Kapadia,L. Brown,N. Cheong,C. Longoria,Dan Mija,M. Ramgopal,J. Mirpuri,D. Mccurnin,R. Savani

Published 2015 in Nature Communications

ABSTRACT

The pathogenesis of bronchopulmonary dysplasia (BPD), a devastating lung disease in preterm infants, includes inflammation, the mechanisms of which are not fully characterized. Here we report that the activation of the NLRP3 inflammasome is associated with the development of BPD. Hyperoxia-exposed neonatal mice have increased caspase-1 activation, IL1β and inflammation, and decreased alveolarization. Nlrp3−/− mice have no caspase-1 activity, no IL1β, no inflammatory response and undergo normal alveolarization. Treatment of hyperoxia-exposed mice with either IL1 receptor antagonist to block IL1β or glyburide to block the Nlrp3 inflammasome results in decreased inflammation and increased alveolarization. Ventilated preterm baboons show activation of the NLRP3 inflammasome with increased IL1β:IL1ra ratio. The IL1β:IL1ra ratio in tracheal aspirates from preterm infants with respiratory failure is predictive of the development of BPD. We conclude that early activation of the NLRP3 inflammasome is a key mechanism in the development of BPD, and represents a novel therapeutic target for BPD. Bronchopulmonary dysplasia (BPD) is a severe pulmonary complication seen in preterm infants, the molecular mechanisms of which are not clear. Here the authors establish a link between NLRP3 inflammasome activation, leading to production of pro-inflammatory cytokine IL1β, and the development of BPD.

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