Changes in excitability of human motor axons underlying post‐ischaemic fasciculations: evidence for two stable states.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Journal of Physiology

• Publication date

  1991-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1113/jphysiol.1991.sp018766PMID 1667800PMCID PMC1180213
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Changes in excitability and accommodation of human motor axons following brief periods of ischaemia.

  1991cited by this paper
• Is resistance to ischaemia of motor axons in diabetic subjects due to membrane depolarization?

  1990cited by this paper
• Ion channel expression by white matter glia: the O-2A glial progenitor cell.

  1990cited by this paper
• Depolarization changes the mechanism of accommodation in rat and human motor axons.

  1989cited by this paper
• Heterogeneous distribution of fast and slow potassium channels in myelinated rat nerve fibres.

  1989cited by this paper
• Sodium channels in single demyelinated mammalian axons.

  1989cited by this paper
• Changes in excitability of human cutaneous afferents following prolonged high-frequency stimulation.

  1989cited by this paper
• Evidence for two types of potassium channel in human motor axons in vivo.

  1988cited by this paper
• Ion channel expression by white matter glia: I. Type 2 astrocytes and oligodendrocytes

  1988cited by this paper
• Sodium and potassium currents in acutely demyelinated internodes of rabbit sciatic nerves.

  1987cited by this paper
• Na currents and action potentials in rat myelinated nerve fibres at 20 and 37 degrees C.

  1987cited by this paper
• Function and distribution of three types of rectifying channel in rat spinal root myelinated axons.

  1987cited by this paper
• Properties of potassium and sodium channels in frog internode.

  1986cited by this paper
• Localization of sodium/potassium adenosine triphosphatase in multiple cell types of the murine nervous system with antibodies raised against the enzyme from kidney

  1985cited by this paper
• Activity‐dependent excitability changes in normal and demyelinated rat spinal root axons.

  1985cited by this paper
• Abnormal Nerves and Muscles as Impulse Generators

  1984cited by this paper
• A voltage‐clamp analysis of inward (anomalous) rectification in mouse spinal sensory ganglion neurones.

  1983cited by this paper
• Intracellular recording from vertebrate myelinated axons: mechanism of the depolarizing afterpotential

  1982cited by this paper
• Voltage-clamp analysis of muscarinic excitation in hippocampal neurons.

  1982cited by this paper
• Evidence for the existence of three types of potassium channels in the frog Ranvier node membrane.

  1981cited by this paper
• Inward rectification in frog skeletal muscle fibres and its dependence on membrane potential and external potassium.

  1981cited by this paper
• Paraesthesiae from ectopic impulse generation in human sensory nerves.

  1980cited by this paper
• Ultra-slow inactivation of the ionic currents through the membrane of myelinated nerve.

  1976cited by this paper
• Computation of impulse conduction in myelinated fibers; theoretical basis of the velocity-diameter relation.

  1968cited by this paper
• IS THE RESTING POTENTIAL OF RANVIER NODES A POTASSIUM POTENTIAL? *

  1959cited by this paper
• Demonstration of two stable states of the nerve membrane in potassium‐rich media

  1959cited by this paper
• An Anodal Threshold Phenomenon in the Squid Giant Axon

  1958cited by this paper
• Anoxic depolarization of mammalian nerve fibres.

  1953cited by this paper
• REPETITIVE DISCHARGES IN HUMAN MOTOR NERVE FIBRES DURING THE POST-ISCHAEMIC STATE

  1951cited by this paper
• A study of post-ischaemic paraesthesiae.

  1949cited by this paper
• Injury activity and trigger zones in human nerves.

  1946cited by this paper

• A nociceptor excitability test for identifying alterations of the Nav1.7 channels in humans

  2025cites this paper
• Peripheral nerve excitability abnormalities in Neuronal Intranuclear Inclusion Disease: Assessment with histopathological analysis.

  2024cites this paper
• Impact of glucagon-like peptide-1 receptor agonists on axonal function in diabetic peripheral neuropathy.

  2024cites this paper
• Application of near infra-red laser light increases current threshold in optic nerve consistent with increased Na+-dependent transport

  2024cites this paper
• Altered flexor carpi radialis motor axon excitability properties after cerebrovascular stroke

  2023cites this paper
• Differences in nerve excitability properties across upper limb sensory and motor axons.

  2021cites this paper
• Changing the firing threshold for normal optic nerve axons by the application of infra-red laser light

  2021cites this paper
• Effects of Different Tissue Flossing Applications on Range of Motion, Maximum Voluntary Contraction, and H-Reflex in Young Martial Arts Fighters

  2021cites this paper
• A Multiscale Approach to Axon and Nerve Stimulation Modeling: A Review

  2021cites this paper
• Myelin protein zero gene dose dependent axonal ion-channel dysfunction in a family with Charcot-Marie-Tooth disease.

  2020cites this paper
• Altered nerve excitability properties after stroke are potentially associated with reduced neuromuscular activation.

  2020cites this paper
• Modified ischaemic nerve block of the forearm: use for the induction of cortical plasticity in distal hand muscles

  2019cites this paper
• Conduction block in immune‐mediated neuropathy: paranodopathy versus axonopathy

  2019cites this paper
• From Perception Threshold to Ion Channels-A Computational Study.

  2019cites this paper
• Electrodiagnostic Nerve Tests: Understanding Healthy Peripheral Nerves

  2019influential citation
• Altered peripheral nerve structure and function in latent autoimmune diabetes in adults

  2019cites this paper
• Physiology of Myelinated Nerve Conduction and Pathophysiology of Demyelination.

  2019cites this paper
• Relative contributions of diabetes and chronic kidney disease to neuropathy development in diabetic nephropathy patients.

  2019cites this paper
• Myelinated axon physiology and regulation of neural circuit function

  2019cites this paper
• Simulation of impedance changes with a FEM model of a myelinated nerve fibre

  2019cites this paper
• Excitability tests using high-density surface-EMG: A novel approach to studying single motor units.

  2018cites this paper
• Ih contributes to increased motoneuron excitability in restless legs syndrome

  2018cites this paper
• Anti-MAG neuropathy: Role of IgM antibodies, the paranodal junction and juxtaparanodal potassium channels.

  2018cites this paper
• A model of motor and sensory axon activation in the median nerve using surface electrical stimulation

  2018cites this paper
• Neurofascin‐155 IGG4 Neuropathy: Pathophysiological Insights, Spectrum of Clinical Severity and Response To treatment

  2018cites this paper
• Perspectives on the modeling of the neuromusculoskeletal system to investigate the influence of neurodegenerative diseases on sensorimotor control

  2018cites this paper
• Diuretic‐sensitive electroneutral Na+ movement and temperature effects on central axons

  2017cites this paper
• F-wave of single firing motor units: correct or misleading criterion of motoneuron excitability in humans?

  2017cites this paper
• Temperature effects on accommodative processes in simulated amyotrophic lateral sclerosis in the physiological range.

  2017cites this paper
• Burning pain: axonal dysfunction in erythromelalgia

  2017cites this paper
• KCC3 deficiency-induced disruption of paranodal loops and impairment of axonal excitability in the peripheral nervous system.

  2016cites this paper
• Progression of motor axon dysfunction and ectopic Nav1.8 expression in a mouse model of Charcot-Marie-Tooth disease 1B.

  2016cites this paper
• Critical illness polyneuropathy in ICU patients is related to reduced motor nerve excitability caused by reduced sodium permeability

  2016cites this paper
• Persistent alterations in active and passive electrical membrane properties of regenerated nerve fibers of man and mice

  2016influential citation
• Relative sparing of the second lumbrical muscle in carpal tunnel syndrome is not associated with regional differences in axonal membrane potential.

  2016cites this paper
• In vivo evidence of reduced nodal and paranodal conductances in type 1 diabetes.

  2016cites this paper
• Accommodation to hyperpolarization of human axons assessed in the frequency domain.

  2016cites this paper
• Pathophysiology of motor dysfunction in a childhood motor neuron disease caused by mutations in the riboflavin transporter.

  2016influential citation
• Aging-associated changes in motor axon voltage-gated Na(+) channel function in mice.

  2016cites this paper
• Design of a wearable device for conditional neuromodulation of the pudendal nerve

  2016cites this paper
• Two state model for a constant disease hazard in paratuberculosis (and other bovine diseases)

  2015cites this paper
• Axonal ion channel dysfunction in c9orf72 familial amyotrophic lateral sclerosis.

  2015cites this paper
• Vertigo and nystagmus in orthostatic hypotension

  2015cites this paper
• The Temporal Profiles of Changes in Nerve Excitability Indices in Familial Amyloid Polyneuropathy

  2015cites this paper
• Increased HCN channel driven inward rectification in benign cramp fasciculation syndrome.

  2015cites this paper
• Electrotonic potentials in simulated chronic inflammatory demyelinating polyneuropathy at 20°C-42°C.

  2015cites this paper
• Award ( FRA ) Cover Sheet Title Mathematical models to predict nerve activation to develop a treatment for phantom limb pain

  2015cites this paper
• Neuropathy in childhood mitochondrial disease, including riboflavin transporter deficiency: phenotype, neurophysiology and disease-modifying therapy in a recently described treatable disorder

  2015cites this paper
• Physiological Dynamics in Demyelinating Diseases: Unraveling Complex Relationships through Computer Modeling

  2015cites this paper
• Excitability properties of motor axons in adults with cerebral palsy

  2015cites this paper
• Through Branch Point in Myelinated Nerves Computer Model for Action Potential Propagation

  2015cites this paper
• Effects of temperature on simulated electrotonic potentials and their current kinetics of human motor axons at 20°C-42°C.

  2014influential citation
• Excitability properties of single human motor axons: are all axons identical?

  2014cites this paper
• The Role Of The Periaxonal Space In Sustained Impulse Conduction

  2014cites this paper
• Evidence for a causal relationship between hyperkalaemia and axonal dysfunction in end-stage kidney disease.

  2014cites this paper
• Axonal excitability in X-linked dominant Charcot Marie Tooth disease.

  2014cites this paper
• Potassium and the Excitability Properties of Normal Human Motor Axons In Vivo

  2014cites this paper
• Transient impairment of the axolemma following regional anaesthesia by lidocaine in humans

  2014influential citation
• Excitability and the safety margin in human axons during hyperthermia

  2013cites this paper
• Pathophysiology of immune‐mediated demyelinating neuropathies—Part II: Neurology

  2013cites this paper
• Influence of Afterpotentials on the Recovery Cycle Modeling the Excitability of Mammalian Nerve Fibers

  2013cites this paper
• Effects of Hemodiafiltration and High Flux Hemodialysis on Nerve Excitability in End-Stage Kidney Disease

  2013cites this paper
• The influence of pressure stimulus intensity on pain perception and neuromuscular performance in healthy males

  2013cites this paper
• Why Are Sensory Axons More Vulnerable for Ischemia than Motor Axons?

  2013cites this paper
• Axonal excitability in disorders of the peripheral and central nervous system

  2013influential citation
• Activation of axonal Kv7 channels in human peripheral nerve by flupirtine but not placebo - therapeutic potential for peripheral neuropathies: results of a randomised controlled trial

  2013cites this paper
• Evolution of peripheral nerve function in humans: novel insights from motor nerve excitability

  2013cites this paper
• Different mechanisms underlying changes in excitability of peripheral nerve sensory and motor axons in multiple sclerosis

  2013cites this paper
• Pathophysiology of HNPP explored using axonal excitability

  2013cites this paper
• Peripheral motor axons of SOD1(G127X) mutant mice are susceptible to activity-dependent degeneration.

  2013cites this paper
• Assessing the neurotoxic effects of palytoxin and ouabain, both Na⁺/K⁺-ATPase inhibitors, on the myelinated sciatic nerve fibres of the mouse: an ex vivo electrophysiological study.

  2012cites this paper
• The voltage dependence of Ih in human myelinated axons

  2012cites this paper
• Mechanisms defining the action potential abnormalities in simulated amyotrophic lateral sclerosis.

  2012cites this paper
• Mechanisms defining the electrotonic potential abnormalities in simulated amyotrophic lateral sclerosis.

  2012cites this paper
• Excitation block in a nerve fibre model owing to potassium-dependent changes in myelin resistance

  2011cites this paper
• Origin of isolated vertigo in rotational vertebral artery syndrome

  2011cites this paper
• Explaining pathological changes in axonal excitability through dynamical analysis of conductance-based models

  2011cites this paper
• Hyperexcitability of the facial nerve in tuberculous meningitis.

  2011cites this paper
• Nerve compression, membrane excitability, and symptoms of carpal tunnel syndrome

  2011cites this paper
• Dysfunction of axonal membrane conductances in adolescents and young adults with spinal muscular atrophy

  2011cites this paper
• EQUIVALENT CIRCUIT IMPLEMENTATION OF DEMYELINATED HUMAN NEURON IN SPICE

  2011cites this paper
• Mechanisms of cramp contractions: peripheral or central generation?

  2011cites this paper
• A model of mouse motor nerve excitability and the effects of polarizing currents

  2011cites this paper
• Activity-Related Structural Changes in the Myelinated Nerve Fiber in Biosimulation in Biomedical Research. Health Care and Drug Development

  2011cites this paper
• Properties of low‐threshold motor axons in the human median nerve

  2010cites this paper
• Axonal excitability in viral polyneuropathy and nucleoside neuropathy in HIV patients

  2010cites this paper
• Entrapment neuropathy and beyond

  2010cites this paper
• Effect of Goreisan in Refractory Neuralgia after Hansen's Disease

  2010cites this paper
• Changes in skin blood flow and current perception threshold during pain ⁄ numbness sensation evoked by ischemia-reperfusion in human subjects

  2010cites this paper
• ORIGINAL ime and frequency domain analysis of surface yoelectric signals during electrically-elicited ramps nalyse temporelle et fréquentielle de l ’ activité lectromyographique de surface pendant la crampe usculaire obtenue par stimulation électrique

  2009cites this paper
• Clinical neurophysiology of the episodic ataxias: insights into ion channel dysfunction in vivo.

  2009cites this paper
• Optimized design of neural interfaces for femoral nerve clinical neuroprostheses: Anatomically-based modeling and intraoperative evaluation

  2009cites this paper
• Time and frequency domain analysis of surface myoelectric signals during electrically-elicited cramps.

  2009cites this paper
• Axonal ion channels from bench to bedside: a translational neuroscience perspective.

  2009cites this paper
• Local antinociception induced by endothelin-1 in the hairy skin of the rat's back.

  2009cites this paper
• Ischaemic sensitivity of axons in carpal tunnel syndrome

  2009influential citation
• Threshold behaviour of human axons explored using subthreshold perturbations to membrane potential

  2009influential citation
• The Effect of Blood Flow on H-Reflex and Motor Responses in Adults With Type 2 Diabetes

  2009cites this paper
• Effects of experimental focal compression on excitability of human median motor axons.

  2009cites this paper
• Nerve function and dysfunction in acute intermittent porphyria.

  2008cites this paper