Detecting Blood Flow Response to Stimulation of the Human Eye

Retinal blood supply is tightly regulated under a variety of hemodynamic considerations in order to satisfy a high metabolic need and maintain both vessel structure and function. Simulation of the human eye can induce hemodynamics alterations, and attempt to assess the vascular reactivity response has been well documented in the scientific literature. Advancements in noninvasive imaging technologies have led to the characterization of magnitude and time course in retinal blood flow response to stimuli. This allowed for a better understanding of the mechanism in which blood flow is regulated, as well as identifying functional impairments in the diseased eye. Clinically, the ability to detect retinal blood flow reactivity during stimulation of the eye offers potential for the detection, differentiation, and diagnosis of diseases.

• Publication year

  2015

• Venue

  BioMed Research International

• Publication date

  2015-10-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2015/121973PMID 26504775PMCID 4609341
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Optical coherence angiography

  2016cited by this paper
• Optical Coherence Tomography Angiography Signs of Vascular Abnormalization With Antiangiogenic Therapy for Choroidal Neovascularization.

  2015cited by this paper
• En face Doppler total retinal blood flow measurement with 70 kHz spectral optical coherence tomography

  2015cited by this paper
• Optical Coherence Tomography Angiography of Peripapillary Retinal Blood Flow Response to Hyperoxia.

  2015cited by this paper
• A Promising Future for Optical Coherence Tomography Angiography.

  2015cited by this paper
• Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye

  2015cited by this paper
• Spectral-domain optical coherence tomography angiography of choroidal neovascularization.

  2015cited by this paper
• Optimization of the split-spectrum amplitude-decorrelation angiography algorithm on a spectral optical coherence tomography system.

  2015cited by this paper
• Inner ocular blood flow responses to an acute decrease in blood pressure in resting humans

  2015cited by this paper
• En face OCT angiography demonstrates flow in early type 3 neovascularization (retinal angiomatous proliferation)

  2015cited by this paper
• En face enhanced-depth swept-source optical coherence tomography features of chronic central serous chorioretinopathy.

  2014cited by this paper
• Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration.

  2014cited by this paper
• Swept-source OCT angiography of the retinal vasculature using intensity differentiation-based optical microangiography algorithms.

  2014cited by this paper
• Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis

  2014cited by this paper
• Parafoveal Retinal Vascular Response to Pattern Visual Stimulation Assessed with OCT Angiography

  2013cited by this paper
• Logarithmic intensity and speckle-based motion contrast methods for human retinal vasculature visualization using swept source optical coherence tomography

  2012cited by this paper
• A comparison of Doppler optical coherence tomography methods

  2012cited by this paper
• Laser Doppler Techniques for Ocular Blood Velocity and Flow

  2012cited by this paper
• In vivo human choroidal vascular pattern visualization using high-speed swept-source optical coherence tomography at 1060 nm.

  2012cited by this paper
• Response of Retinal Blood Flow to Systemic Hyperoxia as Measured with Dual-Beam Bidirectional Doppler Fourier-Domain Optical Coherence Tomography

  2012cited by this paper
• Split-spectrum amplitude-decorrelation angiography with optical coherence tomography

  2012cited by this paper
• Optical microangiography provides an ability to monitor responses of cerebral microcirculation to hypoxia and hyperoxia in mice.

  2011cited by this paper
• Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT

  2011cited by this paper
• In vivo imaging of the microcirculation of the volar forearm using correlation mapping optical coherence tomography (cmOCT)

  2011cited by this paper
• Flicker-induced changes in retinal blood flow assessed by Doppler optical coherence tomography

  2011cited by this paper
• Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans

  2010cited by this paper
• Ocular blood flow assessment using continuous laser Doppler flowmetry

  2010influential reference
• Ultra-high-speed volumetric tomography of human retinal blood flow.

  2009cited by this paper
• Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique.

  2009cited by this paper
• Retinal mean transit time determined with an impulse-response analysis from video fluorescein angiograms.

  2009cited by this paper
• Speckle variance detection of microvasculature using swept-source optical coherence tomography.

  2008cited by this paper
• Regulation of retinal blood flow in health and disease.

  2008cited by this paper
• In vivo high-contrast imaging of deep posterior eye by 1-microm swept source optical coherence tomography and scattering optical coherence angiography.

  2007cited by this paper
• Increased blood pressure induces a diameter response of retinal arterioles that increases with decreasing arteriolar diameter.

  2007cited by this paper
• Three dimensional optical angiography.

  2007cited by this paper
• Optical coherence angiography.

  2006cited by this paper
• Relationship between the parameters of retinal circulation measured by laser Doppler velocimetry and a marker of early systemic atherosclerosis.

  2005cited by this paper
• Evaluation of micrometric and microdensitometric methods for measuring the width of retinal vessel images on fundus photographs

  2005cited by this paper
• Comparison of the autoregulatory mechanisms between middle cerebral artery and ophthalmic artery after thigh cuff deflation in healthy subjects.

  2005cited by this paper
• Systemic hyperoxia and retinal vasomotor responses.

  2005cited by this paper
• Video fluorescein angiography: Method and clinical application

  2005cited by this paper
• Color Doppler imaging in ocular hypertension and open-angle glaucoma

  2004cited by this paper
• Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation.

  2004cited by this paper
• Reduced response of retinal vessel diameters to flicker stimulation in patients with diabetes

  2004cited by this paper
• Retinal circulation times in quantitative fluorescein angiography

  2004cited by this paper
• Flicker-evoked response measured at the optic disc rim is reduced in ocular hypertension and early glaucoma.

  2004cited by this paper
• Retinal vessel reaction in response to chromatic flickering light

  2004influential reference
• Evaluation of optic nerve head and peripapillary retinal blood flow in glaucoma patients, ocular hypertensives, and normal subjects.

  2003cited by this paper
• Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography.

  2003cited by this paper
• Hyperglycemia affects flicker-induced vasodilation in the retina of healthy subjects.

  2003cited by this paper
• Performance of fourier domain vs. time domain optical coherence tomography.

  2003cited by this paper
• In vivo imaging of human retinal flow dynamics by color Doppler optical coherence tomography.

  2003cited by this paper
• Influence of flicker frequency on flicker-induced changes of retinal vessel diameter.

  2002cited by this paper
• Influence of diffuse luminance flicker on choroidal and optic nerve head blood flow

  2002cited by this paper
• FLICKERING LIGHT INCREASES RETINAL BLOOD FLOW

  2002cited by this paper
• Retinal artery response to acute systemic blood pressure increase during cold pressor test in humans.

  2002cited by this paper
• RI in central retinal artery as assessed by CDI does not correspond to retinal vascular resistance.

  2001cited by this paper
• Flicker-evoked responses of human optic nerve head blood flow: luminance versus chromatic modulation.

  2001cited by this paper
• Imaging and velocimetry of the human retinal circulation with color Doppler optical coherence tomography.

  2000cited by this paper
• Evaluation of the Zeiss retinal vessel analyser

  2000cited by this paper
• Relationship between ocular perfusion pressure and retrobulbar blood flow in patients with glaucoma with progressive damage.

  2000cited by this paper
• Retinal blood flow changes in diabetic retinopathy measured with the Heidelberg scanning laser Doppler flowmeter

  2000cited by this paper
• Modulation of Heidelberg Retinal Flowmeter parameter flow at the papilla of healthy subjects: effect of carbogen, oxygen, high intraocular pressure, and beta-blockers.

  1999cited by this paper
• Glaucoma patients demonstrate faulty autoregulation of ocular blood flow during posture change

  1999cited by this paper
• Noninvasive measurement of the Bayliss effect in retinal autoregulation

  1999cited by this paper
• Laser Doppler flowmetry and optic nerve head blood flow.

  1999cited by this paper
• Color Doppler imaging of the eye and orbit.

  1998cited by this paper
• Optical coherence tomography.

  1998cited by this paper
• Assessment of human ocular hemodynamics.

  1998influential reference
• In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography.

  1997cited by this paper
• Retinal vessel dilatation and elongation precedes diabetic macular oedema

  1997cited by this paper
• Clinical findings and hemodynamic changes associated with severe occlusive carotid artery disease.

  1997cited by this paper
• Diffuse luminance flicker increases retinal vessel diameter in humans.

  1997cited by this paper
• Autoregulation of human optic nerve head blood flow in response to acute changes in ocular perfusion pressure

  1997cited by this paper
• Effect of breathing 100% oxygen on retinal and optic nerve head capillary blood flow in smokers and non-smokers

  1997cited by this paper
• A hemodynamic model of the pathogenesis of age-related macular degeneration.

  1997cited by this paper
• Laser Doppler flowmetry measurement of changes in human optic nerve head blood flow in response to blood gas perturbations.

  1996cited by this paper
• Principle, Validity, and Reliability of Scanning Laser Doppler Flowmetry

  1996cited by this paper
• Hyperoxia improves contrast sensitivity in early diabetic retinopathy.

  1996cited by this paper
• Autoregulation in the human retinal circulation: assessment using isometric exercise, laser Doppler velocimetry, and computer-assisted image analysis.

  1996cited by this paper
• Regional retinal blood flow and vascular autoregulation

  1996cited by this paper
• Characterization of fluid flow velocity by optical Doppler tomography.

  1995cited by this paper
• Color Doppler imaging: a new technique to assess orbital blood flow in patients with diabetic retinopathy.

  1995cited by this paper
• Role of Blood Flow and Impaired Autoregulation in the Pathogenesis of Diabetic Retinopathy

  1995cited by this paper
• The effect of experimental hypertension on retinal vascular autoregulation in humans: a mechanism for the progression of diabetic retinopathy

  1995cited by this paper
• Effect of flicker on macular blood flow assessed by the blue field simulation technique.

  1994cited by this paper
• Measurement of retinal hemodynamics with scanning laser ophthalmoscopy: reference values and variation.

  1994cited by this paper
• Retinal circulatory abnormalities in type 1 diabetes.

  1994cited by this paper
• Physiological perturbation of ocular and cerebral blood flow as measured by scanning laser ophthalmoscopy and color Doppler imaging.

  1994cited by this paper
• Local choroidal blood flow in the cat by laser Doppler flowmetry.

  1994cited by this paper
• Blood velocity in the ophthalmic artery determined by color Doppler imaging in normal subjects and diabetics.

  1993cited by this paper
• In vivo retinal imaging by optical coherence tomography.

  1993cited by this paper
• Effects of oxygen and carbon dioxide on human retinal circulation.

  1993cited by this paper
• Retinal hemodynamic effects of carbon dioxide, hyperoxia, and mild hypoxia.

  1992cited by this paper
• Laser Doppler flowmetry in the optic nerve.

  1992cited by this paper
• Retinal blood flow in diabetic retinopathy.

  1992cited by this paper
• Optical Coherence Tomography

  1991cited by this paper
• Flicker evoked increase in optic nerve head blood flow in anesthetized cats.

  1991cited by this paper
• Laser Doppler velocimetry stabilized in one dimension

  1991influential reference
• Oxygen in mammalian tissue: methods of measurement and affinities of various reactions.

  1991cited by this paper

• Wavefront coding for retinal imaging

  2025cites this paper
• Ozone-induced retinal vascular reactivity as assessed by optical coherence tomography angiography.

  2022cites this paper
• Functional optical coherence tomography at altitude: retinal microvascular perfusion and retinal thickness at 3,800 meters

  2022influential citation
• A comprehensive update on the use of optical coherence tomography angiography in glaucoma

  2022cites this paper
• Computational investigation of blood cell transport in retinal microaneurysms

  2022cites this paper
• Retinal Neurovascular Changes in Patients With Ischemic Stroke Investigated by Optical Coherence Tomography Angiography

  2022cites this paper
• Retinal Vascular Response to Hyperoxia in Patients with Diabetes Mellitus without Diabetic Retinopathy

  2021cites this paper
• Change in the Foveal Avascular Zone and Macular Capillary Network Density after Hyperbaric Oxygen Therapy in Healthy Retina

  2021cites this paper
• Wavefront coding with Jacobi-Fourier phase masks for retinal imaging.

  2020cites this paper
• Systematic review on retinal microvasculature, physical activity, sedentary behaviour and adiposity in children and adolescents

  2020cites this paper
• Predictive modelling of thrombus formation in diabetic retinal microaneurysms

  2020cites this paper
• Automatic measurement of global retinal circulation in fluorescein angiography

  2018cites this paper
• Imaging modalities for assessing ocular hemodynamics

  2018cites this paper
• Effects of high-intensity interval training on optic nerve head and macular perfusion using optical coherence tomography angiography in healthy adults.

  2018cites this paper
• Correlation of Visually Evoked Functional and Blood Flow Changes in the Rat Retina Measured With a Combined OCT+ERG System.

  2017cites this paper
• Evaluating ocular blood flow

  2017influential citation
• Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications

  2017cites this paper
• Optical coherence tomography angiography: Technical principles and clinical applications in ophthalmology

  2017cites this paper
• OCT Angiography Changes in the 3 Parafoveal Retinal Plexuses in Response to Hyperoxia.

  2017cites this paper
• Optical coherence tomography angiography changes in the three parafoveal retinal plexuses in response to hyperoxia

  2017cites this paper
• Assessing total retinal blood flow in diabetic retinopathy using multiplane en face Doppler optical coherence tomography

  2016cites this paper
• Retinal Blood Flow Response to Hyperoxia Measured With En Face Doppler Optical Coherence Tomography

  2016cites this paper
• Optical coherence tomography angiography of stimulus evoked hemodynamic responses in individual retinal layers.

  2016cites this paper