Inhibitors of monoamine oxidase. Influence of methyl substitution on the inhibitory activity of beta-carbolines.

No abstract is available for this paper.

• Publication year

  1968

• Venue

  Journal of Pharmacy and Science

• Publication date

  1968-02-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/JPS.2600570205PMID 5641670
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structure-action relationship of β-carbolines as monoamine oxidase inhibitors

  1966cited by this paper
• Structure-action relationship of beta-carbolines as monoamine oxidase inhibitors.

  1966cited by this paper
• Analogs of tetrahydrofolic acid. XXVII. Hydrophobic bonding to dihydrofolic reductase by 2-amino-4,6-disubstituted-5-alkylpyrimidines and 1-alkyl-4,6-diamino-1,2-dihydro-s-triazines.

  1965cited by this paper
• THE SYNTHESIS AND PRELIMINARY PHARMACOLOGY OF SOME 9H-PYRIDO(3,4-B)INDOLES (BETA-CARBOLINES) AND TRYPTAMINES RELATED TO SEROTONIN AND MELATONIN.

  1964cited by this paper
• Synthetic experiments in the group of hypotensive alkaloids. XXI.Chemistry of 1,2,3,4- tetrahydronorharmane-1-carboxylic acid and derivatives.

  1961cited by this paper
• The Chemistry of Hortiamine and 6-Methoxyrhetsinine1

  1961cited by this paper
• ELECTRON TRANSFER FROM THE INDOLE NUCLEUS TO THE PYRIDINE COENZYMES

  1959cited by this paper

• Monoamine Oxidase Inhibitors Present in Tobacco Modulate Dopamine Balance Via the Dopamine Transporter

  2025cites this paper
• Synthetic pathways to create asymmetric center at C1 position of 1-substituted-tetrahydro-β-carbolines – a review

  2024cites this paper
• Review of β‐carboline and its derivatives as selective MAO‐A inhibitors

  2023cites this paper
• Harmane Potentiates Nicotine Reinforcement Through MAO-A Inhibition at the Dose Related to Cigarette Smoking

  2022cites this paper
• Applications of Pictet–Spengler reaction in the total synthesis of alkaloids

  2021cites this paper
• Application of the Asymmetric Pictet–Spengler Reaction in the Total Synthesis of Natural Products and Relevant Biologically Active Compounds

  2018cites this paper
• Privileged structures: efficient chemical "navigators" toward unexplored biologically relevant chemical spaces.

  2014cites this paper
• Design, synthesis and anticancer evaluation of tetrahydro-β-carboline-hydantoin hybrids.

  2014cites this paper
• The uptake of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline and its effect on 5-hydroxytryptamine uptake and release in blood platelets.

  2009cites this paper
• Tetrahydro-β-carbolines and Corresponding Tryptamines: In Vitro Inhibition of Serotonin, Dopamine and Noradrenaline Uptake in Rat Brain Synaptosomes

  2009cites this paper
• Variety of natural products derived from tryptophan and stereoselective synthesis of tetrahydro-β-carboline derivatives of pharmacological importance

  2007cites this paper
• Preparation of pilot library with tetrahydro-β-carboline alkaloid core skeleton using tandem intramolecular Pictet–Spengler cyclization

  2006cites this paper
• 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors.

  2006cites this paper
• Synthesis of C‐14‐labeled novel IKK inhibitor: 2‐[14C]‐N‐(6‐chloro‐9H‐pyrido [3,4‐b]indol‐8‐yl)‐3‐pyridinecarboxamide

  2005cites this paper
• A diversity oriented four-component approach to tetrahydro-beta-carbolines initiated by Sonogashira coupling.

  2005cites this paper
• β-Carbolines as selective monoamine oxidase inhibitors:In vivo implications

  2005cites this paper
• Catalytic N-sulfonyliminium ion-mediated cyclizations to alpha-vinyl-substituted isoquinolines and beta-carbolines and applications in metathesis.

  2005cites this paper
• Diastereodivergent synthesis of 2,5-diketopiperazine derivatives of β-carboline and isoquinoline from L-amino acids

  2005cites this paper
• Biological activities of some 5-substituted N,N-dimethyltryptamines, α-methyltryptamines, and gramines

  2004cites this paper
• Identification of harman in the rat arcuate nucleus

  2004cites this paper
• Photophysical properties of methyl beta-carboline-3-carboxylate mediated by hydrogen-bonded complexes--a comparative study in different solvents.

  2003cites this paper
• Structural, chemical topological, electrotopological and electronic structure hypotheses.

  2003cites this paper
• Comparative study on separation of diastereomers by HPLC

  2003cites this paper
• Elevation of blood &bgr;-carboline alkaloids in essential tremor

  2002cites this paper
• Elevation of blood β-carboline alkaloids in essential tremor

  2002cites this paper
• Molecular and Cellular Events Regulating Dopamine Neuron Survival

  2002cites this paper
• Synthesis and isolation of nitro-bT-carbolines obtained by nitration of commercial β-carboline alkaloids

  2001cites this paper
• Long-lived emission at room temperature of harmane dispersed in poly (acrylic acid)-poly (vinyl alcohol) polymer network

  1999cites this paper
• Steady-state and time-resolved study of the proton-transfer fluorescence of harmine and 2-methyl-harmine in organic solvents

  1999cites this paper
• Low temperature synthesis of no-carrier-added [11C]formaldehyde with metal hydrides and preparation of [1-11C]1,2,3,4-Tetrahydro-β-Carboline Derivatives

  1998cites this paper
• Inhibition of monoamine oxidase A by beta-carboline derivatives.

  1997cites this paper
• Photochemical behaviour of β-carbolines. Part4.1 Acid–base equilibria in the ground andexcited states in organic media

  1997cites this paper
• [Mechanistic study of monoamine oxidase: significance for MAO A and MAO B in situ].

  1997cites this paper
• Ground and excited state interactions between tetrahydroharmane and pyridine

  1996cites this paper
• Genotoxic potential of beta-carbolines: a review.

  1995cites this paper
• Genotoxic potential of beta-carbolines: a review.

  1995cites this paper
• A reversible monoamine oxidase inhibitor, Toloxatone: comparison of its physicochemical properties with those of other inhibitors including Brofaromine, Harmine, R40519 and Moclobemide

  1995cites this paper
• Structural studies of condensation products of biogenic amines as inhibitors of tryptophan hydroxylase.

  1994cites this paper
• Potential bioactivated neurotoxicants, N-methylated beta-carbolinium ions, are present in human brain.

  1993cites this paper
• Chapter 2 Mammalian Alkaloids II

  1993cites this paper
• Gas chromatographic-mass spectrometric screening procedure for the identification of formaldehyde-derived tetrahydro-beta-carbolines in human urine.

  1993cites this paper
• Photochemical reaction of harmaline. Part 1. Electronic spectra

  1992cites this paper
• Novel S‐Adenosylmethionine‐Dependent Indole‐N‐Methylation of β‐Carbolines in Brain Particulate Fractions

  1992cites this paper
• Mono‐N‐Methylation of 1,2,3,4‐Tetrahydro‐β‐Carbolines in Brain Cytosol: Absence of Indole Methylation

  1992cites this paper
• The fischer indole synthesis of 8-methyl-5-substituted-1-oxo-β-carbolines: A remarkable high yield of a [1,2]-methyl migration.

  1991cites this paper
• AM1 Study of a β-carboline set. Part II: pyrrole-N deprotonated species

  1990cites this paper
• Bacterial mutagenicity of heterocyclic amines found in heat-processed food.

  1989cites this paper
• Bacterial mutagenicity of heterocyclic amines found in heat-processed food

  1989cites this paper
• Isolation, Structure, and Properties of the β‐Carboline Formed from 5‐Hydroxytryptamine by the Superoxide Anion‐Generating System

  1988cites this paper
• A thiazole and two β-carboline constitutents fromPanax ginseng

  1988cites this paper
• Quantum yield and fluorescence lifetime measurements of neutral and cationic species for six β-carboline derivatives

  1988cites this paper
• Tricyclic and Monoamine Oxidase Inhibitor Antidepressants: Structure-Activity Relationships

  1987cites this paper
• Effect of 1-methyl-tetrahydro-beta-carboline on voluntary alcohol intake in rats: lack of increase with fixed alcohol concentrations.

  1986cites this paper
• Spectroscopic study of intermolecular complexes between FAD and some β-carboline derivatives

  1986cites this paper
• Tetrahydro-beta-carbolines in human urine and rat brain--no evidence of formation by alcohol drinking.

  1986cites this paper
• 6-Hydroxymethtryptoline is naturally occurring in mammalian urine: identification by combined chiral capillary gas chromatography and high resolution mass spectrometry.

  1986cites this paper
• Ethanol increases single unit activity in the inferior olivary nucleus.

  1986cites this paper
• Analysis of β-carbolines by reversed-phase ion-pair partition chromatography with fluorometric detection

  1985cites this paper
• Combined inhibition of serotonin uptake and oxidative deamination attenuates audiogenic seizures in DBA/2J mice.

  1985cites this paper
• 6-methoxy-tetrahydro-beta-carboline (pinoline): effects on plasma renin activity and aldosterone, TSH, LH and beta-endorphin levels in rats.

  1984cites this paper
• LIGHT MICROSCOPIC AUTORADIOGRAPHY OF RAT RETINAE AFTER INTRAVITREAL INJECTION OF [3H]6‐METHOXY‐TETRAHYDRO‐β‐CARBOLINE

  1984cites this paper
• Biochemistry and pharmacology of tryptamines and beta-carbolines. A minireview.

  1984cites this paper
• Effects of 6‐methoxytetrahydro‐β‐carboline on 5‐hydroxytryptamine binding in rat brain

  1984cites this paper
• Tetrahydro-β-carbolines: Effect on alcohol intake in rats

  1983cites this paper
• Effects of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline and yohimbine on hypothalamic monoamine status and pituitary hormone release in the rat.

  1983cites this paper
• Tetrahydro-beta-carbolines: effect on alcohol intake in rats.

  1983cites this paper
• Acidity constants of β-carbolines in the ground and excited singlet states

  1983cites this paper
• Monoamine oxidase activity in bovine retina: Subcelluar distribution and drug sensitivities

  1981cites this paper
• Identification and quantification of 1,2,3,4-tetrahydro-β-carboline, 2-methyl-1,2,3,4-tetrahydro-β-carboline, and 6-methoxy-1,2,3,4-tetrahydro-β-carboline as in vivo constituents of rat brain and adrenal gland

  1981cites this paper
• [Role of the serotoninergic structures of the brain in alcoholism].

  1981cites this paper
• Identification and quantification of 1,2,3,4-tetrahydro-beta-carboline, 2-methyl-1,2,3,4-tetrahydro-beta-carboline, and 6-methoxy-1,2,3,4-tetrahydro-beta-carboline as in vivo constituents of rat brain and adrenal gland.

  1981cites this paper
• Actions of amine-aldehyde condensation products

  1981cites this paper
• beta-Carbolines, psychoactive compounds in the mammalian body. Part II: Effects.

  1981cites this paper
• Beta-carbolines, psychoactive compounds in the mammalian body. Part I: Occurrence, origin and metabolism.

  1981cites this paper
• 6-Methoxy-1,2,3,4-tetrahydro-beta-carboline: a specific monoamine oxidase-A inhibitor in CF-1 mouse brain.

  1980cites this paper
• Inhibition by norharman of metabolism of benzo[a]pyrene by the microsomal mixed function oxidase of rat liver.

  1980cites this paper
• Biogenic amine-aldehyde condensation products: tetrahydroisoquinolines and tryptolines (beta-carbolines).

  1980cites this paper
• Brain serotonin and 5-hydroxyindoleacetic acid concentrations and serotonin synthesis following tetrahydro-β-carboline administration in mice

  1980influential citation
• Effects of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeO-THbetaC) on audiogenic seizures in DBA/2J mice.

  1980cites this paper
• Hyperformaldehydism: a unifying hypothesis for the major biochemical theories of schizophrenia.

  1980cites this paper
• Effects of 6-methoxy-1,2,3,4-tetrahydro-β-carboline (6-MeO-THβC) on audiogenic seizures in DBA/2J mice ☆

  1980cites this paper
• Neurobiology of tetrahydro-beta-carbolines.

  1980cites this paper
• Neurobiology of tetrahydro-β-carbolines

  1980cites this paper
• Tetrahydro-beta-carbolines elevate plasma prolactin in male rats.

  1980cites this paper
• Effect of some β-carbolines on phenylethylamine and apomorphine stereotypies in rats

  1980cites this paper
• Tetrahydro-beta-carbolines and corresponding tryptamines: In vitro inhibition of serotonin, dopamine and noradrenaline uptake in rat brain synaptosomes.

  1980cites this paper
• Gas chromatographic/mass spectrometric evidence for the identification of 1,2,3,4-tetrahydro-beta-carboline as an in vivo constituent of rat brain.

  1979cites this paper
• Monoamine oxidase inhibition by beta-carbolines: a quantum chemical approach.

  1979cites this paper
• Interrelationship between Ethanol Consumption and Circadian Rhythm

  1979cites this paper
• Monoamine Oxidase Inhibition by β-Carbolines: A Quantum Chemical Approach

  1979cites this paper
• Serotonergic stimulation of pituitary-adrenal activity in the mouse.

  1978cites this paper
• Major pharmacological effects of 6-methoxytetrahydro-beta-carboline, a drug elevating the tissue 5-hydroxytryptamine level.

  1978cites this paper
• Conditions for the formation of cyclic compounds between pyridoxal phosphate and 5-hydroxytryptamine or 5-hydroxytryptophan

  1978cites this paper
• Pharmacological and biochemical properties of isomeric yohimbine alkaloids.

  1978cites this paper
• Effect of 6-methoxy-tetrahydro-beta-carboline on serum prolactin levels of male rats.

  1978cites this paper
• Inhibition by beta-carbolines of monoamine uptake into a synaptosomal preparation: structure-activity relationships.

  1977cites this paper
• Monoamine oxidase inhibition in brain and liver produced by beta-carbolines: structure-activity relationships and substrate specificity.

  1977cites this paper
• Alteration of ethanol preference in hamsters: effects of photoperiod and 5-hydroxytryptophan.

  1977cites this paper
• Inhibition by β-carbolines of monoamine uptake into a synaptosomal preparation: Structure-activity relationships

  1977cites this paper
• Tetrahydro-beta-carbolines: specific inhibitors of type A monoamine oxidase in rat brain.

  1977cites this paper