Changing RANKL/OPG mRNA expression in differentiating murine primary osteoblasts.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Endocrinology

• Publication date

  2001-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1677/JOE.0.1700451PMID 11479141
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of osteoblasts in hormonal control of bone resorption—A hypothesis

  2006cited by this paper
• Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget's disease of bone.

  2000cited by this paper
• Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene.

  2000cited by this paper
• Species-divergent regulation of human and mouse osteocalcin genes by calciotropic hormones.

  2000cited by this paper
• Low calcium environment effects osteoprotegerin ligand/osteoclast differentiation factor.

  2000cited by this paper
• Increased formation and decreased resorption of bone in mice with elevated vitamin D receptor in mature cells of the osteoblastic lineage

  2000cited by this paper
• Osteoblast maturation suppressed osteoclastogenesis in coculture with bone marrow cells.

  2000influential reference
• Reciprocal gene expression of osteoclastogenesis inhibitory factor and osteoclast differentiation factor regulates osteoclast formation.

  1999influential reference
• Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.

  1999cited by this paper
• Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families.

  1999cited by this paper
• 1,25 Dihydroxyvitamin-D3 Attenuates the Confluence-Dependent Differences in the Osteoblast Characteristic Proteins Alkaline Phosphatase, Procollagen I Peptide, and Osteocalcin

  1999cited by this paper
• The Ligand for Osteoprotegerin (OPGL) Directly Activates Mature Osteoclasts

  1999cited by this paper
• Effect of extracellular calcium concentrations on osteoclast differentiation in vitro.

  1999cited by this paper
• A novel molecular mechanism modulating osteoclast differentiation and function.

  1999cited by this paper
• Stimulation of Osteoprotegerin Ligand and Inhibition of Osteoprotegerin Production by Glucocorticoids in Human Osteoblastic Lineage Cells: Potential Paracrine Mechanisms of Glucocorticoid-Induced Osteoporosis1.

  1999cited by this paper
• Breast cancer cells interact with osteoblasts to support osteoclast formation.

  1999cited by this paper
• osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.

  1998cited by this paper
• Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro.

  1998influential reference
• Estrogen enhances differentiation of osteoblasts in mouse bone marrow culture.

  1998cited by this paper
• Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

  1998cited by this paper
• Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures.

  1998cited by this paper
• Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL.

  1998cited by this paper
• Transforming growth factor-beta1 increases mRNA levels of osteoclastogenesis inhibitory factor in osteoblastic/stromal cells and inhibits the survival of murine osteoclast-like cells.

  1998cited by this paper
• Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin.

  1998cited by this paper
• Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells.

  1998influential reference
• Transforming Growth Factor-β1 Increases mRNA Levels of Osteoclastogenesis Inhibitory Factor in Osteoblastic/Stromal Cells and Inhibits the Survival of Murine Osteoclast-like Cells

  1998cited by this paper
• Analysis of Osteocalcin Expression in Transgenic Mice Reveals a Species Difference in Vitamin D Regulation of Mouse and Human Osteocalcin Genes

  1997cited by this paper
• Species-specific glucocorticoid and 1,25-dihydroxyvitamin D responsiveness in mouse MC3T3-E1 osteoblasts: dexamethasone inhibits osteoblast differentiation and vitamin D down-regulates osteocalcin gene expression.

  1997influential reference
• A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

  1997cited by this paper
• 1,25-Dihydroxyvitamin D3 Inhibits Osteocalcin Expression in Mouse through an Indirect Mechanism*

  1997cited by this paper
• Role of 1 alpha,25-dihydroxyvitamin D3 in osteoclast differentiation and function.

  1997cited by this paper
• Human and murine osteocalcin gene expression: conserved tissue restricted expression and divergent responses to 1,25-dihydroxyvitamin D3 in vivo.

  1997cited by this paper
• TRANCE Is a Novel Ligand of the Tumor Necrosis Factor Receptor Family That Activates c-Jun N-terminal Kinase in T Cells*

  1997cited by this paper
• Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

  1997cited by this paper
• Subcloning of three osteoblastic cell lines with distinct differentiation phenotypes from the mouse osteoblastic cell line KS-4.

  1996cited by this paper
• Increased bone formation in osteocalcin-deficient mice

  1996cited by this paper
• Development and characterization of a conditionally immortalized human fetal osteoblastic cell line

  1995cited by this paper
• The role of 1,25-dihydroxycholecalciferol and prostaglandin E2 in the regulation of human osteoclastic bone resorption in vitro.

  1995cited by this paper
• The effects of dexamethasone and 1,25-dihydroxyvitamin D3 on osteogenic differentiation of human marrow stromal cells in vitro.

  1994cited by this paper
• Mechanisms by which cells of the osteoblast lineage control osteoclast formation and activity

  1994influential reference
• Characterization of the 1,25-(OH)2D3-induced inhibition of bone nodule formation in long-term cultures of fetal rat calvaria cells.

  1993cited by this paper
• Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype.

  1993cited by this paper
• Fluorimetric DNA assay for cell growth estimation.

  1992cited by this paper
• Development and validation of a radioimmunoassay for mouse osteocalcin: paradoxical response in the Hyp mouse.

  1992cited by this paper
• Stimulation by 1,25-dihydroxyvitamin D3 of in vitro mineralization induced by osteoblast-like MC3T3-E1 cells.

  1991cited by this paper
• Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix

  1990influential reference
• Culture and behavior of osteoblastic cells isolated from normal trabecular bone surfaces

  1989cited by this paper
• The effects of parathyroid hormone or 1,25-dihydroxyvitamin D3 on monocyte-osteoclast fusion

  1988cited by this paper
• Characterization of a human osteoblastic osteosarcoma cell line (SAOS‐2) with high bone alkaline phosphatase activity

  1987cited by this paper
• Human bone cells in vitro.

  1985cited by this paper
• Characterization of human bone cells in culture

  1985cited by this paper
• Effect of 1,25-dihydroxyvitamin D3 on alkaline phosphatase activity and collagen synthesis in osteoblastic cells, clone MC3T3-E1.

  1984cited by this paper
• Effect of 1,25-dihydroxyvitamin D3 on alkaline phosphatase activity and collagen synthesis in osteoblastic cells, clone MC3T3-El1

  1984cited by this paper
• Fluorometric quantification of DNA in cells and tissue.

  1983cited by this paper
• Target cells in bone for parathormone and calcitonin are different: enrichment for each cell type by sequential digestion of mouse calvaria and selective adhesion to polymeric surfaces.

  1975cited by this paper
• The quantitative histochemistry of brain. II. Enzyme measurements.

  1954cited by this paper
• Received

  1868cited by this paper
• Printed in U.S.A. Copyright © 1999 by The Endocrine Society Parathyroid Hormone Stimulates TRANCE and Inhibits Osteoprotegerin Messenger Ribonucleic Acid Expression in Murine Bone Marrow Cultures: Correlation with

  year unknowncited by this paper
• Printed in U.S.A. Copyright © 1999 by The Endocrine Society Breast Cancer Cells Interact with Osteoblasts to Support

  year unknowncited by this paper

• Bisphosphonates and Periodontal Health: A Systematic Review in Postmenopausal Women

  2025cites this paper
• Bone Marrow Adipoq-lineage Progenitors: an Emerging Osteoclast Niche Cell Population

  2025cites this paper
• Electrospun Poly(L-lactide-co-ε-caprolactone) Nanofibers with Hydroxyapatite Nanoparticles Mimic Cellular Interplay in Bone Regeneration

  2025cites this paper
• Mapping RANKL- and OPG-expressing cells in bone tissue: the bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect

  2024cites this paper
• Osteogenic differentiation of periodontal ligament fibroblasts inhibits osteoclast formation.

  2024cites this paper
• Dihydromyricetin-loaded oxidized polysaccharide/L-arginine chitosan adhesive hydrogel promotes bone regeneration by regulating PI3K/AKT signaling pathway and MAPK signaling pathway.

  2024cites this paper
• The role of the Piezo1 channel in osteoblasts under cyclic stretching: A study on osteogenic and osteoclast factors.

  2024cites this paper
• p57Kip2 is an essential regulator of vitamin D receptor-dependent mechanisms

  2023cites this paper
• Cytokines: The links between bone and the immune system.

  2023cites this paper
• The Emerging Role of Interleukin-(IL)-11/IL-11R in Bone Metabolism and Homeostasis: From Cytokine to Osteokine

  2023cites this paper
• Hypoxia Preconditioned Serum (HPS) Promotes Osteoblast Proliferation, Migration and Matrix Deposition

  2022cites this paper
• Mechanical force regulates root resorption in rats through RANKL and OPG

  2022cites this paper
• Inhibition of Cdk5 Ameliorates Skeletal Bone Loss in Glucocorticoid-Treated Mice

  2022cites this paper
• Osteoblasts and osteoclasts: an important switch of tumour cell dormancy during bone metastasis

  2022cites this paper
• Signaling Pathway and Transcriptional Regulation in Osteoblasts during Bone Healing: Direct Involvement of Hydroxyapatite as a Biomaterial

  2021cites this paper
• Telmisartan impairs the in vitro osteogenic differentiation of mesenchymal stromal cells from spontaneously hypertensive male rats.

  2021cites this paper
• Toward a Mathematical Modeling of Diseases’ Impact on Bone Remodeling: Technical Review

  2020cites this paper
• Tankyrase inhibitor XAV-939 enhances osteoblastogenesis and mineralization of human skeletal (mesenchymal) stem cells

  2020cites this paper
• Carboxy-Terminal Cementum Protein 1-Derived Peptide 4 (cemp1-p4) Promotes Mineralization through wnt/β-catenin Signaling in Human Oral Mucosa Stem Cells

  2020cites this paper
• Osteoblasts derived from mouse mandible enhance tumor growth of prostate cancer more than osteoblasts derived from long bone

  2020influential citation
• Long-Term Exposure to Low-Dose Lead Induced Deterioration in Bone Microstructure of Male Mice

  2019cites this paper
• Clinical Factors and Cellular Responses of In Situ Human Alveolar Bone-Derived Mesenchymal Stromal Cells Associated With Early Periimplant Marginal Bone Loss: A Prospective Cohort Pilot Study.

  2019cites this paper
• CCAAT/enhancer-binding protein beta (C/EBPβ) is an important mediator of 1,25 dihydroxyvitamin D3 (1,25D3)-induced receptor activator of nuclear factor kappa-B ligand (RANKL) expression in osteoblasts

  2019cites this paper
• Understanding the Bone in Cancer Metastasis

  2018influential citation
• The immunopathogenic and immunomodulatory effects of interleukin-12 in periodontal disease.

  2018cites this paper
• Synthetic cementum protein 1–derived peptide regulates mineralization in vitro and promotes bone regeneration in vivo

  2018cites this paper
• Molecular mechanisms, current management and next generation therapy in myeloma bone disease

  2018cites this paper
• Baicalein enhances the osteogenic differentiation of human periodontal ligament cells by activating the Wnt/β-catenin signaling pathway.

  2017cites this paper
• KitW-sh Mutation Prevents Cancellous Bone Loss during Calcium Deprivation

  2017influential citation
• Fatty Acids on Osteoclastogenesis

  2017cites this paper
• Liraglutide, a glucagon‐like peptide‐1 receptor agonist, facilitates osteogenic proliferation and differentiation in MC3T3‐E1 cells through phosphoinositide 3‐kinase (PI3K)/protein kinase B (AKT), extracellular signal‐related kinase (ERK)1/2, and cAMP/protein kinase A (PKA) signaling pathways involv

  2017cites this paper
• Effects of flavonoids incorporated biological macromolecules based scaffolds in bone tissue engineering.

  2017cites this paper
• Multiple myeloma bone disease: from mechanisms to next generation therapy

  2017cites this paper
• Interleukin‐12 Induces Receptor Activator of Nuclear Factor‐Kappa B Ligand Expression by Human Periodontal Ligament Cells

  2017cites this paper
• Assessment of bone metabolism and biomechanical properties of the femur, following treatment with anastrozole and letrozole in an experimental model of menopause

  2017cites this paper
• Use of ethanol extracts of Terminalia chebula to prevent periodontal disease induced by dental plaque bacteria

  2017cites this paper
• New metabolites from the biotransformation of ginsenoside Rb1 by Paecilomyces bainier sp.229 and activities in inducing osteogenic differentiation by Wnt/β-catenin signaling activation

  2017cites this paper
• Combination breast cancer chemotherapy with doxorubicin and cyclophosphamide damages bone and bone marrow in a female rat model

  2017cites this paper
• Proteomic approaches to study osteoclast biology

  2016cites this paper
• Differential osteogenicity of multiple donor-derived human mesenchymal stem cells and osteoblasts in monolayer, scaffold-based 3D culture and in vivo

  2016cites this paper
• Apolipoprotein D deficiency is associated to high bone turnover, low bone mass and impaired osteoblastic function in aged female mice

  2016cites this paper
• Novel Approaches in the Treatment of Virus- Induced Inflammatory Disease

  2016cites this paper
• Downregulation of RANKL and RANKL/osteoprotegerin ratio in human periodontal ligament cells during their osteogenic differentiation.

  2016cites this paper
• Studies on the Relationship between Dietary Calcium and Bone Mineral Homeostasis in Post-menopausal Women

  2016cites this paper
• Modulation of osteoblast behavior on TiNxOy coatings by altering the N/O stoichiometry while maintaining a high thrombogenic potential

  2016cites this paper
• Evidence for altered osteoclastogenesis in splenocyte cultures from Cyp27b1 knockout mice.

  2016cites this paper
• The Effect of Golden Sea cucumber (Stichopus hermanii) and Hyperbaric Oxygen Therapy to The Expression of Osteoprotegerin in Diabetes Mellitus Induce by Porphyromonas gingivalis Bacteria

  2016influential citation
• Disruption of c-Kit Signaling in KitW-sh/W-sh Growing Mice Increases Bone Turnover

  2016cites this paper
• Runx2 Controls Bone Resorption through the Down-Regulation of the Wnt Pathway in Osteoblasts.

  2016cites this paper
• Regulation of Osteoblast Migration Involving Receptor Activator of Nuclear Factor‐kappa B (RANK) Signaling

  2015cites this paper
• MAGED1 is a negative regulator of bone remodeling in mice.

  2015cites this paper
• Effects of enamel matrix derivative and transforming growth factor-β1 on connective tissue growth factor in human periodontal ligament fibroblasts.

  2015cites this paper
• Analysis of skeleton in a mouse model of Rett syndrome

  2015cites this paper
• Effects of 1α,25-(OH)2D3 on the formation and activity of osteoclasts in RAW264.7 cells.

  2015cites this paper
• evaluation of the protective effects of curcuminoid (curcumin and bisdemethoxycurcumin)-loaded liposomes against bone turnover in a cell-based model of osteoarthritis

  2015cites this paper
• 1α,25-dihydroxyvitamin D3 stimulates human SOST gene expression and sclerostin secretion.

  2015cites this paper
• Mouse ENU mutagenesis and molecular genetics approach to identify novel regulating bone homeostasis

  2015cites this paper
• Effect of Bisphosphonates on the Levels of Rankl and Opg in Gingival Crevicular Fluid of Patients With Periodontal Disease and Post-menopausal Osteoporosis.

  2015cites this paper
• ICRP Publication 131: Stem Cell Biology with Respect to Carcinogenesis Aspects of Radiological Protection

  2015cites this paper
• Osteocyte specific responses to soluble and mechanical stimuli in a stem cell derived culture model

  2015cites this paper
• Oxidized Titanium Implants Enhance Osseointegration via Mechanisms Involving RANK/RANKL/OPG Regulation.

  2015cites this paper
• Evaluation of the protective effects of curcuminoid (curcumin and bisdemethoxycurcumin)-loaded liposomes against bone turnover in a cell-based model of osteoarthritis

  2015cites this paper
• evaluation of the protective effects of curcuminoid (curcumin and bisdemethoxycurcumin)-loaded liposomes against bone turnover in a cell-based model of osteoarthritis

  2015cites this paper
• Mathematical modelling of basic multicellular units: The functional units of bone remodeling

  2015cites this paper
• Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio.

  2015cites this paper
• Sulfated Glycosaminoglycans Support Osteoblast Functions and Concurrently Suppress Osteoclasts

  2014cites this paper
• Immunomodulatory effects of vitamin D in peripheral blood monocyte-derived macrophages from patients with rheumatoid arthritis

  2014cites this paper
• Functions of Novel Ligand-independent Flt3 Alleles and RANKL in Promoting Dissemination of Murine B-Cell Leukemias to the Central Nervous System

  2014cites this paper
• Alendronate in Vitro Differences in Otosclerotic and Normal Human Stapedial Osteoblast Properties Are Normalized

  2014cites this paper
• Differences in Otosclerotic and Normal Human Stapedial Osteoblast Properties Are Normalized by Alendronate in Vitro

  2014cites this paper
• Genistein supplementation increases bone turnover but does not prevent alcohol-induced bone loss in male mice

  2014cites this paper
• The impact of bone marrow adipocytes on osteoblast and osteoclast differentiation

  2014cites this paper
• Regulation of cortical and trabecular bone mass by communication between osteoblasts, osteocytes and osteoclasts.

  2014cites this paper
• Immunomodulatory effects of vitamin D in peripheral blood monocyte-derived macrophages from patients with rheumatoid arthritis

  2014cites this paper
• Periostin and receptor activator of nuclear factor κ‐B ligand expression in allergic fungal rhinosinusitis

  2014cites this paper
• Ethyl-3,4-Dihydroxybenzoate with a Dual Function of Induction of Osteogenic Differentiation and Inhibition of Osteoclast Differentiation for Bone Tissue Engineering

  2014cites this paper
• The Osteocyte as an Orchestrator of Bone Remodeling: An Engineer’s Perspective

  2014influential citation
• Kruppel-like factor 4 attenuates osteoblast formation, function, and cross talk with osteoclasts

  2014cites this paper
• Galnon, a galanin receptor agonist, improves intrinsic cortical bone tissue properties but exacerbates bone loss in an ovariectomised rat model.

  2014cites this paper
• Identification of a Subpopulation of Marrow MSC-Derived Medullary Adipocytes That Express Osteoclast-Regulating Molecules: Marrow Adipocytes Express Osteoclast Mediators

  2014cites this paper
• Anti-osteoporotic Effects of Unripe Fructus of Rubus coreanus Miquel in Osteoblastic and Osteoclastic Cells

  2014influential citation
• Regulation of matrix metalloproteinase-9 protein expression by 1α,25-(OH)2D3 during osteoclast differentiation

  2014cites this paper
• RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization

  2014cites this paper
• Essential roles of Pdia3/PLAA receptor complex and CaMKII IN 1α,25(OH)₂D₃ and Wnt5a calcium-dependent signaling pathways in osteoblasts and chondrocytes

  2014cites this paper
• Osteogenic differentiation of adipose‐derived stem cells promoted by quercetin

  2014cites this paper
• 1,25-Dihydroxyvitamin D3 prevents bone loss of the secondary spongiosa in arthritic rats by an increase of bone formation and mineralization and inhibition of bone resorption

  2014cites this paper
• Bone refilling in cortical basic multicellular units: insights into tetracycline double labelling from a computational model

  2013influential citation
• Alginate/silica composite hydrogel as a potential morphogenetically active scaffold for three-dimensional tissue engineering

  2013cites this paper
• Production, characterisation, and cytocompatibility of porous titanium-based particulate scaffolds

  2013cites this paper
• UV-irradiated 7-dehydrocholesterol coating on polystyrene surfaces is converted to active vitamin D by osteoblastic MC3T3-E1 cells

  2013cites this paper
• Chitosan and chitosan derivatives in tissue engineering and stem cell biology

  2013cites this paper
• Endotoxins affect bioactivity of chitosan derivatives in cultures of bone marrow-derived human mesenchymal stem cells.

  2013cites this paper
• Histone Deacetylase Inhibitors Trichostatin A (tsa) And Sulforaphane (sfn) Modulate Vitamin D Responsive Cyp24 Gene Expression in 3t3-l1 Preadipocytes

  2013cites this paper
• Inorganic polymers: morphogenic inorganic biopolymers for rapid prototyping chain.

  2013cites this paper
• Adenovirus-mediated siRNA targeting TNF-α and overexpression of bone morphogenetic protein-2 promotes early osteoblast differentiation on a cell model of Ti particle-induced inflammatory response in vitro

  2013cites this paper
• Effect of compressive force on human osteoblast-like cells and bone remodelling: an in vitro study.

  2013cites this paper
• Adenovirus-mediated small interfering RNA targeting tumor necrosis factor-α inhibits titanium particle-induced osteoclastogenesis and bone resorption.

  2013cites this paper
• Glass-Ceramics for Non-Metallic Dental Implant Applications

  2013cites this paper
• Death receptor 3 : a regulator of bone turnover and new target for therapy for osteoporosis?

  2013cites this paper
• The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis.

  2012cites this paper