Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma

SummaryImmunohistochemical, cytochemical and ultrastructural data showing vivid angiogenesis and numerous mast cells (MCs) in the bone marrow of 24 patients with active multiple myeloma (MM) compared with 34 patients with non-active MM and 22 patients with monoclonal gammopathy of undetermined significance (MGUS) led us to hypothesize that angiogenesis parallels progression of MM, and that MCs participate in its induction via angiogenic factors in their secretory granules.

• Publication year

  1999

• Venue

  British Journal of Cancer

• Publication date

  1999-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.bjc.6690070PMID 10027312PMCID 2362443
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1996influential reference
• Clinical applications of research on angiogenesis

  1996cited by this paper
• Interleukin‐8 and de novo mammalian angiogenesis

  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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