Signals mediating nuclear targeting and their regulation: Application in drug delivery

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Medicinal research reviews (Print)

• Publication date

  1998-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/(SICI)1098-1128(199807)18:4<189::AID-MED1>3.0.CO;2-RPMID 9664290
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Photodynamic therapy.

  2022cited by this paper
• The HIV-1 Tat Nuclear Localization Sequence Confers Novel Nuclear Import Properties*

  1998cited by this paper
• Nucleocytoplasmic Recycling of the Nuclear Localization Signal Receptor α Subunit In Vivo Is Dependent on a Nuclear Export Signal, Energy, and RCC1

  1997cited by this paper
• Exportin 1 (Crm1p) is an essential nuclear export factor.

  1997cited by this paper
• The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export.

  1997cited by this paper
• Nucleocytoplasmic transport: signals, mechanisms and regulation

  1997cited by this paper
• Karyopherin beta2 mediates nuclear import of a mRNA binding protein.

  1997cited by this paper
• Nuclear localization signal peptides for the import of plasmid DNA in gene therapy (review).

  1997cited by this paper
• Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.

  1997cited by this paper
• Regulation of gene expression by cyclic GMP-dependent protein kinase requires nuclear translocation of the kinase: identification of a nuclear localization signal

  1997cited by this paper
• Regulated nuclear translocation of the Mig1 glucose repressor.

  1997cited by this paper
• Nuclear entry, oligomerization, and DNA binding of the Drosophila heat shock transcription factor are regulated by a unique nuclear localization sequence.

  1997cited by this paper
• Nuclear translocation of mitogen-activated protein kinase kinase (MEK1) in response to mitogenic stimulation.

  1997cited by this paper
• The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

  1997cited by this paper
• Evidence for a role of CRM1 in signal-mediated nuclear protein export.

  1997cited by this paper
• Kinetic Characterization of the Human Retinoblastoma Protein Bipartite Nuclear Localization Sequence (NLS) in Vivo andin Vitro

  1997cited by this paper
• The cytokine interleukin‐5 (IL‐5) effects cotransport of its receptor subunits to the nucleus in vitro

  1997cited by this paper
• Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

  1997cited by this paper
• Nuclear localization of cyclin B1 mediates its biological activity and is regulated by phosphorylation.

  1997cited by this paper
• Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-beta.

  1997cited by this paper
• Nuclear import of DNA in digitonin-permeabilized cells.

  1997cited by this paper
• Association of the T-cell Protein Tyrosine Phosphatase with Nuclear Import Factor p97*

  1997cited by this paper
• Multisite Phosphorylation and the Nuclear Localization of Phosphatase Inhibitor 2-Green Fluorescent Protein Fusion Protein during S Phase of the Cell Growth Cycle*

  1997cited by this paper
• Regulation of yAP‐1 nuclear localization in response to oxidative stress

  1997cited by this paper
• Cloning and characterization of human karyopherin β3

  1997cited by this paper
• A Novel Mechanism of JNK1 Activation

  1997cited by this paper
• Nuclear import of U snRNPs requires importin β

  1997cited by this paper
• A functional bipartite nuclear localisation signal in the cytokine interleukin‐5

  1997cited by this paper
• The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein

  1997cited by this paper
• Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor.

  1997cited by this paper
• SV40 Large Tumor Antigen Nuclear Import Is Regulated by the Double-stranded DNA-dependent Protein Kinase Site (Serine 120) Flanking the Nuclear Localization Sequence*

  1997cited by this paper
• The Protein Kinase CK2 Site (Ser111/112) Enhances Recognition of the Simian Virus 40 Large T-antigen Nuclear Localization Sequence by Importin*

  1997cited by this paper
• Nuclear Targeting of Chlorin e6 Enhances Its Photosensitizing Activity*

  1997cited by this paper
• The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

  1997cited by this paper
• Nuclear import of U snRNPs requires importin beta.

  1997cited by this paper
• Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta.

  1997cited by this paper
• Gene Transfer Using a Novel Fusion Protein, GAL4/Invasin

  1997cited by this paper
• A Nuclear Localization Signal of Human Aryl Hydrocarbon Receptor Nuclear Translocator/Hypoxia-inducible Factor 1β Is a Novel Bipartite Type Recognized by the Two Components of Nuclear Pore-targeting Complex*

  1997cited by this paper
• Nuclear localization of basonuclin in human keratinocytes and the role of phosphorylation.

  1997cited by this paper
• Dominant‐negative mutants of importin‐β block multiple pathways of import and export through the nuclear pore complex

  1997cited by this paper
• Importin [alpha] from Arabidopsis thaliana Is a Nuclear Import Receptor That Recognizes Three Classes of Import Signals

  1997cited by this paper
• CRM1 is an export receptor for leucine-rich nuclear export signals.

  1997cited by this paper
• Cloning and characterization of human karyopherin beta3.

  1997cited by this paper
• Gene therapy of prostate cancer: p53, suicidal genes, and other targets.

  1997cited by this paper
• Nuclear export of the E1B 55‐kDa and E4 34‐kDa adenoviral oncoproteins mediated by a rev‐like signal sequence

  1997cited by this paper
• Nuclear import in permeabilized protoplasts from higher plants has unique features.

  1996cited by this paper
• Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities.

  1996cited by this paper
• A Consensus cAMP-dependent Protein Kinase (PK-A) Site in Place of the CcN Motif Casein Kinase II Site of Simian Virus 40 Large T-antigen Confers PK-A-mediated Regulation of Nuclear Import (*)

  1996cited by this paper
• Target Cell-specific DNA Transfer Mediated by a Chimeric Multidomain Protein

  1996cited by this paper
• The human T-cell leukemia virus type 1 posttranscriptional trans-activator Rex contains a nuclear export signal

  1996cited by this paper
• Cytoplasmic Localization of Mitogen-activated Protein Kinase Kinase Directed by Its NH2-terminal, Leucine-rich Short Amino Acid Sequence, Which Acts as a Nuclear Export Signal*

  1996cited by this paper
• A novel receptor-mediated nuclear protein import pathway.

  1996cited by this paper
• Targeting DNA to Cells with Basic Fibroblast Growth Factor (FGF2)*

  1996cited by this paper
• Toward the molecular dissection of protein import into nuclei.

  1996cited by this paper
• Comparative mutagenesis of nuclear localization signals reveals the importance of neutral and acidic amino acids.

  1996cited by this paper
• Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev.

  1996cited by this paper
• Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

  1996cited by this paper
• Transportin: nuclear transport receptor of a novel nuclear protein import pathway.

  1996cited by this paper
• Kap104p: A Karyopherin Involved in the Nuclear Transport of Messenger RNA Binding Proteins

  1996cited by this paper
• Calmodulin activates nuclear protein import: a link between signal transduction and nuclear transport.

  1996cited by this paper
• Regulated nuclear import of the Drosophila rel protein dorsal: structure-function analysis

  1996cited by this paper
• A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus

  1996cited by this paper
• An RNA-export mediator with an essential nuclear export signal

  1996cited by this paper
• Noninfectious gene transfer and expression systems for cancer gene therapy.

  1996cited by this paper
• Dephosphorylation of Serine 3 Regulates Nuclear Translocation of Cofilin*

  1996cited by this paper
• Gene Transfer into Mammalian Cells Using Histone-Condensed Plasmid DNA

  1996cited by this paper
• Identification of different roles for RanGDP and RanGTP in nuclear protein import.

  1996cited by this paper
• Oxidation of Sulfhydryl Groups of Ribonuclease Inhibitor in Epithelial Cells Is Sufficient for Its Intracellular Degradation*

  1996cited by this paper
• Condensation of plasmid DNA with polylysine improves liposome-mediated gene transfer into established and primary muscle cells.

  1996cited by this paper
• Regulation of protein transport to the nucleus: central role of phosphorylation.

  1996cited by this paper
• IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines

  1995cited by this paper
• Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins.

  1995cited by this paper
• The Essential Yeast Nucleoporin NUP159 Is Located on the Cytoplasmic Side of the Nuclear Pore Complex and Serves in Karyopherin-mediated Binding of Transport Substrate (*)

  1995cited by this paper
• Cyclin-dependent Kinase Site-regulated Signal-dependent Nuclear Localization of the SWI5 Yeast Transcription Factor in Mammalian Cells (*)

  1995cited by this paper
• Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes.

  1995cited by this paper
• Signal sequences that target nuclear import and nuclear export of pre-mRNA-binding proteins.

  1995cited by this paper
• Nuclear localization of the testis determining gene product SRY

  1995cited by this paper
• The cell cycle-dependent nuclear import of v-Jun is regulated by phosphorylation of a serine adjacent to the nuclear localization signal

  1995cited by this paper
• Active oxygen generated in the process of carcinogen metabolism can induce oxidative damage in nuclei.

  1995cited by this paper
• Rhinovirus-mediated endosomal release of transfection complexes

  1995cited by this paper
• Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.

  1995cited by this paper
• A family of Ran binding proteins that includes nucleoporins.

  1995cited by this paper
• Improved Cationic Lipid Formulations for In Vivo Gene Therapy

  1995cited by this paper
• Insulin-mediated intracellular targeting enhances the photodynamic activity of chlorin e6.

  1995cited by this paper
• Depletion of calcium from the lumen of endoplasmic reticulum reversibly inhibits passive diffusion and signal-mediated transport into the nucleus

  1995cited by this paper
• The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex.

  1995cited by this paper
• Nup358, a Cytoplasmically Exposed Nucleoporin with Peptide Repeats, Ran-GTP Binding Sites, Zinc Fingers, a Cyclophilin A Homologous Domain, and a Leucine-rich Region (*)

  1995cited by this paper
• Two nuclear localization signals present in the basic-helix 1 domains of MyoD promote its active nuclear translocation and can function independently.

  1995cited by this paper
• Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins.

  1995cited by this paper
• Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid (*)

  1995cited by this paper
• Gene delivery and expression mediated by an integrin-binding peptide.

  1995cited by this paper
• Identification of a Yeast Karyopherin Heterodimer That Targets Import Substrate to Mammalian Nuclear Pore Complexes (*)

  1995cited by this paper
• The N‐terminal domain of human DNA ligase I contains the nuclear localization signal and directs the enzyme to sites of DNA replication.

  1995cited by this paper
• Cationic liposome-mediated gene transfer.

  1995cited by this paper
• [Porfimer sodium (Photofrin-II)].

  1995cited by this paper
• Distinct functions for the two importin subunits in nuclear protein import

  1995cited by this paper
• Identification of a signal for rapid export of proteins from the nucleus.

  1995cited by this paper
• Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62

  1995cited by this paper
• Co‐activation of RanGTPase and inhibition of GTP dissociation by Ran‐GTP binding protein RanBP1.

  1995cited by this paper
• Nucleoplasmin associates with and is phosphorylated by casein kinase II.

  1995cited by this paper

• Polymeric nanocarriers for therapeutic gene delivery

  2025cites this paper
• Aggressive Impacts Affecting the Biodegradable Ultrathin Fibers Based on Poly(3-Hydroxybutyrate), Polylactide and Their Blends: Water Sorption, Hydrolysis and Ozonolysis

  2021cites this paper
• Application of nano-based systems for drug delivery and targeting: a review

  2020cites this paper
• Nanotechnology and Immunoengineering: How nanotechnology can boost CAR-T therapy.

  2020cites this paper
• Peptide‐Based Multifunctional Nanomaterials for Tumor Imaging and Therapy

  2018cites this paper
• Organelle-targeting metal complexes: From molecular design to bio-applications

  2017cites this paper
• Future of nanotherapeutics: Targeting the cellular sub-organelles.

  2016cites this paper
• Journey to the Center of the Cell: Current Nanocarrier Design Strategies Targeting Biopharmaceuticals to the Cytoplasm and Nucleus.

  2016cites this paper
• Factors influencing the nuclear targeting ability of nuclear localization signals

  2016cites this paper
• LocSigDB: a database of protein localization signals

  2015cites this paper
• Dengue NS5 Global Consensus Sequence Development to Find Conserved Region for Antiviral Drug Development

  2015cites this paper
• Renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy

  2013cites this paper
• Targeted Drug Delivery to the Nucleus and its Potential Role in Cancer Chemotherapy

  2013cites this paper
• Sequence and Effects of Glucocorticoid Receptor Nuclear Retention; An Aid to Understanding Nuclear Retention in Other Proteins?

  2011cites this paper
• The small nuclear ribonucleoprotein U1A interacts with NS5 from yellow fever virus

  2011cites this paper
• The Red clover necrotic mosaic virus capsid as a multifunctional cell targeting plant viral nanoparticle.

  2011cites this paper
• Non-viral nucleic acid delivery: key challenges and future directions.

  2011cites this paper
• Formulations and Delivery Limitations of Nucleic-Acid-Based Therapies

  2010cites this paper
• Biodegradable branched polycationic polymers as non-viral gene delivery vectors for bone tissue engineering

  2010cites this paper
• Study of bioactivity of complexed DNA in biodegradable polymer films

  2010cites this paper
• Advancing nonviral gene delivery: lipid- and surfactant-based nanoparticle design strategies.

  2010cites this paper
• Enhanced Cellular Uptake and Cytotoxicity Studies of Organometallic Bioconjugates of the NLS Peptide in Hep G2 Cells

  2009cites this paper
• Quantification of Nuclear Protein Transport using Induced Heterodimerization

  2009cites this paper
• Nuclear drug delivery to target tumour cells.

  2009cites this paper
• Caspase-mediated cleavage of importin-alpha increases its affinity for MCM and downregulates DNA synthesis by interrupting the binding of MCM to chromatin.

  2008cites this paper
• Characterisation of a dominant negative androgen receptor in prostate cancer cells.

  2008cites this paper
• Gene delivery to the lung

  2008cites this paper
• Targeted delivery to the nucleus.

  2007cites this paper
• Rad52 and Rad59 exhibit both overlapping and distinct functions.

  2007cites this paper
• Nucleocytoplasmic transport of DNA: enhancing non-viral gene transfer.

  2007cites this paper
• Signal Sequences for Targeting of Gene Therapy Products to Subcellular Compartments: The Role Of CRM1 in Nucleocytoplasmic Shuttling of the Protein Switch

  2007cites this paper
• The Nuclear Pore Complex: The Gateway to Successful Nonviral Gene Delivery

  2006influential citation
• Cationic liposome–DNA complexes: from liquid crystal science to gene delivery applications

  2006cites this paper
• Geldanamycin, an inhibitor of Hsp90, Blocks cytoplasmic retention of progesterone receptors and glucocorticoid receptors via their respective ligand binding domains

  2006cites this paper
• The C-terminal tail of protein kinase D2 and protein kinase D3 regulates their intracellular distribution.

  2006cites this paper
• Controlling Protein Compartmentalization to Overcome Disease

  2006cites this paper
• Biological and Cellular Barriers Limiting the Clinical Application of Nonviral Gene Delivery Systems

  2006cites this paper
• Central role of the respiratory syncytial virus matrix protein in infection.

  2006cites this paper
• DNA-Pharmaceuticals: Formulation and Delivery in Gene Therapy, DNA Vaccination and Immunotherapy

  2006cites this paper
• Effect of different nuclear localization sequences on the immune responses induced by a MIDGE vector encoding bovine herpesvirus-1 glycoprotein D.

  2006cites this paper
• Lipoplex structures and their distinct cellular pathways.

  2005cites this paper
• Bioplex technology: novel synthetic gene delivery pharmaceutical based on peptides anchored to nucleic acids.

  2005cites this paper
• Nuclear Protein Import

  2005cites this paper
• A cobaltocenium-peptide bioconjugate shows enhanced cellular uptake and directed nuclear delivery.

  2005cites this paper
• Nuclear Targeting and Cell Cycle Regulatory Function of Human BARD1*

  2005cites this paper
• Effect of initial subcellular localization of progesterone receptor on import kinetics and transcriptional activity.

  2005cites this paper
• Nuclear-Cytoplasmic Shuttling of the Oncogenic Mouse UNP/USP4 Deubiquitylating Enzyme*

  2005cites this paper
• Cationic lipid–DNA complexes for non-viral gene therapy: relating supramolecular structures to cellular pathways

  2005influential citation
• Ein Peptid-Cobaltocenium-Biokonjugat mit verbesserter Aufnahme in Zellen und Anreicherung im Zellkern

  2005cites this paper
• Nuclear Import and Export in Plants and Animals

  2005cites this paper
• [Approaches to the targeted intracellular delivery of photosensitizers in order to enhance their efficacy and cell specificity].

  2004cites this paper
• Bidirectional on/off switch for controlled targeting of proteins to subcellular compartments.

  2004cites this paper
• Bidirectional on / off switch for controlled targeting of proteins to subcellular compartments

  2004cites this paper
• Characterization of nuclear localization and export signals of the major tegument protein VP8 of bovine herpesvirus-1.

  2004cites this paper
• Mitochondrial and nuclear localization of kanadaptin.

  2003cites this paper
• Induction of immune responses by DNA vaccines in large animals.

  2003cites this paper
• Parathyroid hormone-related protein (PTHrP): a nucleocytoplasmic shuttling protein with distinct paracrine and intracrine roles.

  2003cites this paper
• BACH1 517C→T transition impairs protein translocation to nucleus: A role in breast cancer susceptibility?

  2003cites this paper
• BIOLOGICAL ACTIVITY AND THERAPEUTIC APPLICATIONS OF INTRACELLULAR INTERFERON GAMMA AND INTERFERON GAMMA MIMETIC PEPTIDES

  2003influential citation
• Handbook of pharmaceutical biotechnology

  2003cites this paper
• Gene Delivery to the Lung

  2003cites this paper
• BIOLOGICAL ACTIVITY AND THERAPEUTIC APPLICATIONS OF INTRACELLULAR INTERFERON GAMMA AND INTERFERON GAMMA MIMETIC PEPTIDES

  2003cites this paper
• MALIGNANT MESOTHELIOMA an experimental study with emphasis on proteoglycans in mesothelial cell growth and differentiation

  2002cites this paper
• Peptides Containing Cyclin/Cdk-Nuclear Localization Signal Motifs Derived from Viral Initiator Proteins Bind to DNA When Unphosphorylated

  2002cites this paper
• Utilization of synthetic peptides containing nuclear localization signals for nonviral gene transfer systems

  2002cites this paper
• The Interdomain Region of Dengue NS5 Protein Interacts with NS3 and Host Proteins

  2002cites this paper
• Two nuclear localization signals required for the nuclear localization of rice ribosomal protein S4

  2002cites this paper
• The Interdomain Region of Dengue NS5 Protein That Binds to the Viral Helicase NS3 Contains Independently Functional Importin β1 and Importin α/β-Recognized Nuclear Localization Signals*

  2002cites this paper
• LEI / L-DNase II : les implications structurales d’un détournement de fonction

  2002cites this paper
• Immunoreactivity to cell surface syndecans in cytoplasm and nucleus: tubulin-dependent rearrangements.

  2002cites this paper
• Roles of cytoskeletal and junctional plaque proteins in nuclear signaling.

  2001cites this paper
• Characterisation of inter- and intra-molecular interactions of the dengue virus RNA dependent RNA polymerase as potential drug targets.

  2001cites this paper
• Identification of Factors Interacting with hMSH2 and hMLH1 in the Fetal Liver and Investigations of how Mitochondrial Dysfunction Creates a Mutator Phenotype

  2001cites this paper
• Materials for Non-Viral Gene Delivery

  2001cites this paper
• A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-beta and the viral helicase, NS3.

  2001influential citation
• Gene therapy: optimising DNA delivery to the nucleus.

  2001cites this paper
• The development of synthetic gene delivery systems

  2001cites this paper
• Dynamics of intracellular movement and nucleocytoplasmic recycling of the ligand-activated androgen receptor in living cells.

  2000cites this paper
• Targeted intracellular delivery of photosensitizers to enhance photodynamic efficiency

  2000cites this paper
• Nuclear targeting signal recognition: a key control point in nuclear transport?

  2000cites this paper
• Targeted intracellular delivery of photosensitizers.

  2000cites this paper
• Nuclear and nucleolar localization of parathyroid hormone‐related protein

  2000cites this paper
• Importin β Recognizes Parathyroid Hormone-related Protein with High Affinity and Mediates Its Nuclear Import in the Absence of Importin α*

  1999cites this paper
• Regulation of nuclear localization: a key to a door.

  1999cites this paper
• REGULATION OF NUCLEAR LOCALIZATION

  1999cites this paper
• An engineered site for protein kinase C flanking the SV40 large T‐antigen NLS confers phorbol ester‐inducible nuclear import

  1998cites this paper
• Negative charge at the protein kinase CK2 site enhances recognition of the SV40 large T‐antigen NLS by importin: effect of conformation

  1998cites this paper