F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling

Heath E Johnson,S. King,Sreeja B. Asokan,Jeremy D. Rotty,J. Bear,J. Haugh

Published 2015 in Journal of Cell Biology

ABSTRACT

During cell migration, F-actin bundles/filopodia serve as templates for formation and orientation of lamellipodia and prime their stabilization by adhesion-based PI3K signaling.

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