A semi‐empirical mathematical model useful for describing the relationship between carbon dioxide, pH, lactate and base in a bicarbonate‐buffered cell‐culture process

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Biotechnology and applied biochemistry

• Publication date

  2007-08-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1042/BA20070001PMID 17362203
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of Elevated pCO2 and Osmolality on Growth of CHO Cells and Production of Antibody‐Fusion Protein B1: A Case Study

  2008cited by this paper
• Monitoring Chinese hamster ovary cell culture by the analysis of glucose and lactate metabolism.

  2005cited by this paper
• Impact of dynamic online fed-batch strategies on metabolism, productivity and N-glycosylation quality in CHO cell cultures.

  2005cited by this paper
• CO2 in large-scale and high-density CHO cell perfusion culture

  2004cited by this paper
• Large scale production of recombinant mouse and rat growth hormone by fed-batch GS-NSO cell cultures

  2004cited by this paper
• Engineering challenges in high density cell culture systems

  2004cited by this paper
• pH, pCO2, and Temperature Effect on R‐Adenovirus Production

  2003cited by this paper
• Strategies for Improved dCO2 Removal in Large‐Scale Fed‐Batch Cultures

  2003cited by this paper
• Effects of buffering conditions and culture pH on production rates and glycosylation of clinical phase I anti-melanoma mouse IgG3 monoclonal antibody R24.

  2003cited by this paper
• Effects of osmoprotectant compounds on NCAM polysialylation under hyperosmotic stress and elevated pCO(2).

  2002cited by this paper
• Selected amino acids protect hybridoma and CHO cells from elevated carbon dioxide and osmolality.

  2002cited by this paper
• The response of GS-NS0 myeloma cells to single and multiple pH perturbations.

  2002cited by this paper
• Hyperosmotic Stress and Elevated pCO2 Alter Monoclonal Antibody Charge Distribution and Monosaccharide Content

  2002cited by this paper
• Characterization of hybridoma cell responses to elevated pCO(2) and osmolality: intracellular pH, cell size, apoptosis, and metabolism.

  2002cited by this paper
• The response of GS-NS0 myeloma cells to pH shifts and pH perturbations.

  2001cited by this paper
• Engineering of a mammalian cell line for reduction of lactate formation and high monoclonal antibody production.

  2001cited by this paper
• Effects of ammonia and lactate on growth, metabolism, and productivity of BHK cells.

  2000cited by this paper
• Considerations for osmolality measurement under elevated pCO(2): comparison of vapor pressure and freezing point osmometry.

  2000cited by this paper
• A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: Effect of nutrient concentration, dilution rate, and pH

  2000cited by this paper
• A high-yielding, generic fed-batch cell culture process for production of recombinant antibodies.

  2000cited by this paper
• Measurement and Control of Dissolved Carbon Dioxide in Mammalian Cell Culture Processes Using an in Situ Fiber Optic Chemical Sensor

  2000cited by this paper
• Improvement of the primary metabolism of cell cultures by introducing a new cytoplasmic pyruvate carboxylase reaction.

  1999cited by this paper
• Bicarbonate concentration and osmolality are key determinants in the inhibition of CHO cell polysialylation under elevated pCO(2) or pH.

  1999cited by this paper
• Effects of CO2 and osmolality on hybridoma cells: growth, metabolism and monoclonal antibody production

  1998cited by this paper
• Glycosylation of CHO‐Derived Recombinant tPA Produced under Elevated pCO2

  1997cited by this paper
• Effects of Ammonium and Lactate on Growth and Metabolism of a Recombinant Chinese Hamster Ovary Cell Culture

  1997cited by this paper
• Effects of elevated pCO(2) and/or osmolality on the growth and recombinant tPA production of CHO cells.

  1996cited by this paper
• High viable cell concentration fed‐batch cultures of hybridoma cells through on‐line nutrient feeding

  1995cited by this paper
• Growth characteristics in fed‐batch culture of hybridoma cells with control of glucose and glutamine concentrations

  1994cited by this paper
• Catabolic control of hybridoma cells by glucose and glutamine limited fed batch cultures

  1994cited by this paper
• On‐line characterization of a hybridoma cell culture process

  1994cited by this paper
• Culture pH Affects Expression Rates and Glycosylation of Recombinant Mouse Placental Lactogen Proteins by Chinese Hamster Ovary (CHO) Cells

  1993cited by this paper
• Effects of lactate concentration on hybridoma culture in lactate‐controlled fed‐batch operation

  1992cited by this paper
• Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production

  1992cited by this paper
• Animal cell bioreactors.

  1991cited by this paper
• Growth, Metabolic, and Antibody Production Kinetics of Hybridoma Cell Culture: 2. Effects of Serum Concentration, Dissolved Oxygen Concentration, and Medium pH in a Batch Reactor

  1991cited by this paper
• Bioreactor control and optimization.

  1991cited by this paper
• Growth inhibition in animal cell culture

  1991cited by this paper
• Reduction of waste product excretion via nutrient control: Possible strategies for maximizing product and cell yields on serum in cultures of mammalian cells

  1986cited by this paper

• Low CO2 partial pressure steers CHO cells into a defective metabolic state

  2023cites this paper
• Decision letter for "A semi‐empirical mathematical model to specify the pH of bicarbonate‐buffered cell culture medium formulations"

  2021cites this paper
• Double substrate limitation model for the bio-based production of succinic acid from glycerol

  2020cites this paper
• Investigation of cell line specific responses to pH inhomogeneity and consequences for process design

  2020cites this paper
• Development, characterization, and application of a 2‐Compartment system to investigate the impact of pH inhomogeneities in large‐scale CHO‐based processes

  2020cites this paper
• Biotechnology and Bioengineering

  2019cites this paper
• Monitoring pH, temperature and humidity in long-term stem cell culture in CO2 incubator

  2017cites this paper
• Modeling, estimation, and control of glycosylation in monoclonal antibodies produced in CHO cells

  2016cites this paper
• High-density mammalian cell cultures in stirred-tank bioreactor without external pH control.

  2016cites this paper
• Development of a mathematical model for animal cell culture without pH control and its application for evaluation of clone screening outcomes in shake flask culture

  2015cites this paper
• Cell culture process operations for recombinant protein production.

  2014cites this paper
• On metabolic shift to lactate consumption in fed-batch culture of mammalian cells.

  2012cites this paper
• First principles, unstructured, dynamic model for regulating CO2 and pH in bicarbonate buffered perfusion bioreactor

  2012cites this paper
• Development of an in vitro model of myotube ischemia

  2011cites this paper
• Bioreactors, Cell Culture, Commercial Production

  2010cites this paper