Targeted-simultaneous expression of Gas1 and p53 using a bicistronic adenoviral vector in gliomas

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Cancer Gene Therapy

• Publication date

  2007-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.cgt.7701076PMID 17599090
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Restoration of p53 function leads to tumour regression in vivo

  2007cited by this paper
• Synergistic tumor suppression by coexpression of FUS1 and p53 is associated with down-regulation of murine double minute-2 and activation of the apoptotic protease-activating factor 1-dependent apoptotic pathway in human non-small cell lung cancer cells.

  2007cited by this paper
• Recombinant baculovirus containing the diphtheria toxin A gene for malignant glioma therapy.

  2006cited by this paper
• Modeling the therapeutic efficacy of p53 restoration in tumors.

  2006cited by this paper
• Clinical trials of gene therapy, virotherapy, and immunotherapy for malignant gliomas

  2006cited by this paper
• Glial cell-derived neurotrophic factor (GDNF) promotes low-grade Hs683 glioma cell migration through JNK, ERK-1/2 and p38 MAPK signaling pathways.

  2006cited by this paper
• Gas1 Is Related to the Glial Cell-derived Neurotrophic Factor Family Receptors α and Regulates Ret Signaling*

  2006cited by this paper
• Genetic strategies for brain tumor therapy

  2006cited by this paper
• Is GAS1 a co-receptor for the GDNF family of ligands?

  2006cited by this paper
• Growth factor regulation of autophagy and cell survival in the absence of apoptosis.

  2005cited by this paper
• Negative effects of wild-type p53 and s-Myc on cellular growth and tumorigenicity of glioma cells

  2005cited by this paper
• Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB.

  2004cited by this paper
• Autophagy in Health and Disease: A Double-Edged Sword

  2004cited by this paper
• Glioma-Specific and Cell Cycle-Regulated Herpes Simplex Virus Type 1 Amplicon Viral Vector

  2004cited by this paper
• Hedgehog--Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer.

  2004cited by this paper
• Apoptosis and dependence receptors: a molecular basis for cellular addiction.

  2004cited by this paper
• Getting at the root and stem of brain tumors.

  2004cited by this paper
• Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

  2004cited by this paper
• Stabilization of p53 Is a Novel Mechanism for Proapoptotic Function of NF-κB*

  2004cited by this paper
• Delivery of GDNF by an E1,E3/E4 deleted adenoviral vector and driven by a GFAP promoter prevents dopaminergic neuron degeneration in a rat model of Parkinson's disease

  2004cited by this paper
• Glial-specific retrovirally mediated gas1 gene expression induces glioma cell apoptosis and inhibits tumor growth in vivo.

  2004cited by this paper
• Transcriptionally mediated gene targeting of gas1 to glioma cells elicits growth arrest and apoptosis

  2003cited by this paper
• Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical results.

  2003cited by this paper
• Gene therapy targeting in the central nervous system.

  2003cited by this paper
• GDNF-deprived sympathetic neurons die via a novel nonmitochondrial pathway

  2003cited by this paper
• Induction of autophagic cell death in malignant glioma cells by arsenic trioxide.

  2003cited by this paper
• The dual role of dexamethasone on anti-inflammation and outflow resistance demonstrated in cultured human trabecular meshwork cells.

  2003cited by this paper
• Enhanced tumor suppression by a p14ARF/p53 bicistronic adenovirus through increased p53 protein translation and stability.

  2003cited by this paper
• Immune enhancement of nitroreductase‐induced cytotoxicity: Studies using a bicistronic adenovirus vector

  2003cited by this paper
• hTERT promoter induces tumor-specific Bax gene expression and cell killing in syngenic mouse tumor model and prevents systemic toxicity

  2002cited by this paper
• Suppression of glioma invasion and growth by adenovirus-mediated delivery of a bicistronic construct containing antisense uPAR and sense p16 gene sequences

  2002cited by this paper
• A novel single tetracycline-regulative adenoviral vector for tumor-specific Bax gene expression and cell killing in vitro and in vivo

  2002cited by this paper
• Gas1 is induced during and participates in excitotoxic neuronal death.

  2002cited by this paper
• Growth, hedgehog and the price of GAS.

  2002cited by this paper
• Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite

  2001cited by this paper
• Glial Cell Line-derived Neurotrophic Factor-stimulated Phosphatidylinositol 3-Kinase and Akt Activities Exert Opposing Effects on the ERK Pathway

  2001cited by this paper
• Malignant glioma: genetics and biology of a grave matter.

  2001cited by this paper
• Biochemical and histochemical analysis of 71 kDa dystrophin isoform (Dp71f) in rat brain.

  2001cited by this paper
• Functions of the growth arrest specific 1 gene in the development of the mouse embryo.

  2001cited by this paper
• A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles.

  2001cited by this paper
• Glial cell line-derived neurotrophic factor (GDNF) is a proliferation factor for rat C6 glioma cells: evidence from antisense experiments.

  2000cited by this paper
• Brain tumors in Mexico: characteristics and prognosis of glioblastoma.

  2000cited by this paper
• The RET proto‐oncogene induces apoptosis: a novel mechanism for Hirschsprung disease

  2000cited by this paper
• Role of NF-κB in p53-mediated programmed cell death

  2000cited by this paper
• The growth suppressing gas1 product is a GPI‐linked protein

  2000cited by this paper
• Glial cell line-derived neurotrophic factor (GDNF) and its receptor (GFR-α1) are strongly expressed in human gliomas

  2000cited by this paper
• Inhibition of glioma cells in vitro and in vivo using a recombinant adenoviral vector containing an astrocyte-specific promoter

  2000cited by this paper
• Glial Fibrillary Acidic Protein: GFAP-Thirty-One Years (1969–2000)

  2000cited by this paper
• Role of NF-kappaB in p53-mediated programmed cell death.

  2000cited by this paper
• Induction of NF-kappaB by the Akt/PKB kinase.

  1999cited by this paper
• Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity.

  1999cited by this paper
• Induction of NF-κB by the Akt/PKB kinase

  1999cited by this paper
• Internal ribosome entry sites (IRESs): reality and use

  1999cited by this paper
• The optimal use of IRES (internal ribosome entry site) in expression vectors.

  1999cited by this paper
• Glutamate‐modulated production of GABA in immortalized astrocytes transduced by a glutamic acid decarboxylase‐expressing retrovirus

  1998cited by this paper
• Selective killing of glioma cell lines using an astrocyte-specific expression of the herpes simplex virus-thymidine kinase gene.

  1998cited by this paper
• Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice.

  1998cited by this paper
• Astrocyte-specific expression of tyrosine hydroxylase after intracerebral gene transfer induces behavioral recovery in experimental Parkinsonism

  1998cited by this paper
• A simplified system for generating recombinant adenoviruses.

  1998cited by this paper
• Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase.

  1997cited by this paper
• A proline-rich motif in p53 is required for transactivation-independent growth arrest as induced by Gas1.

  1997cited by this paper
• 霊長類パｰキンソン病モデルにおける Glial Cell Line-Derived Neurotrophic Factor (GDNF) とレボドｰパの相互作用について

  1997cited by this paper
• Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis.

  1996cited by this paper
• p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

  1996cited by this paper
• Ontogeny and distribution of glial cell line-derived neurotrophic factor (GDNF) mRNA in rat.

  1995cited by this paper
• Gas1-induced growth suppression requires a transactivation-independent p53 function

  1995cited by this paper
• Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells.

  1995cited by this paper
• The growth arrest-specific gene, gas1, is involved in growth suppression.

  1992cited by this paper
• The encephalomyocarditis virus internal ribosome entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and in embryos

  1991cited by this paper
• Suppression of human colorectal carcinoma cell growth by wild-type p53.

  1990cited by this paper

• The systemic administration of neural stem cells expressing an inducible and soluble form of growth arrest specific 1 inhibits mammary gland tumor growth and the formation of metastases.

  2020cites this paper
• microRNA-mediated GAS1 downregulation promotes the proliferation of synovial fibroblasts by PI3K-Akt signaling in osteoarthritis

  2019cites this paper
• Annexin A1, Annexin A2, and Dyrk 1B are upregulated during GAS1‐induced cell cycle arrest

  2018cites this paper
• GAS1 is present in the cerebrospinal fluid and is expressed in the choroid plexus of the adult rat

  2016cites this paper
• Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models

  2016cites this paper
• Gas1 is present in germinal niches of developing dentate gyrus and cortex

  2016cites this paper
• Growth Arrest Specific-1 (GAS1) Is a C/EBP Target Gene That Functions in Ovulation and Corpus Luteum Formation in Mice

  2016cites this paper
• Brain tumor cell invasion and metastasis : anatomical , biological and clinical considerations Effects of Gas 1 on gliomas : a review on current preclinical studies

  2016influential citation
• Effects of Gas1 on gliomas: a review on current preclinical studies

  2016cites this paper
• The Internalization of Neurotensin by the Low-Affinity Neurotensin Receptors (NTSR2 and vNTSR2) Activates ERK 1/2 in Glioma Cells and Allows Neurotensin-Polyplex Transfection of tGAS1

  2015cites this paper
• Growth Arrest Specific 1 (Gas1) Gene Overexpression in Liver Reduces the In Vivo Progression of Murine Hepatocellular Carcinoma and Partially Restores Gene Expression Levels

  2015cites this paper
• Gas1 is a pleiotropic regulator of cellular functions: from embryonic development to molecular actions in cancer gene therapy.

  2014cites this paper
• Neural stem cells producing an inducible and soluble form of Gas1 target and inhibit intracranial glioma growth.

  2014cites this paper
• A soluble form of GAS1 inhibits tumor growth and angiogenesis in a triple negative breast cancer model.

  2014cites this paper
• Growth Arrest Specific 1 (GAS1) Is Abundantly Expressed in the Adult Mouse Central Nervous System

  2013cites this paper
• Mouse Central Nervous System

  2013cites this paper
• GAS1 induces cell death through an intrinsic apoptotic pathway

  2012cites this paper
• Behavioral improvement in MPTP-treated nonhuman primates in the HALLWAY task after transfer of TH cDNA to host astrocytes.

  2012cites this paper
• Lentiviral transfer of an inducible transgene expressing a soluble form of Gas1 causes glioma cell arrest, apoptosis and inhibits tumor growth

  2011cites this paper
• Adenoviral Astrocyte-Specific Expression of BDNF in the Striata of Mice Transgenic for Huntington’s Disease Delays the Onset of the Motor Phenotype

  2011cites this paper
• Molecular Mechanisms of Action of Gas1 and its Possible Therapeutic Applications

  2011cites this paper
• Epigenetic Transcriptional Regulation of the Growth Arrest-Specific gene 1 (Gas1) in Hepatic Cell Proliferation at Mononucleosomal Resolution

  2011cites this paper
• [Development of gene therapy in major brain diseases].

  2010cites this paper
• Recent advances in the manipulation of murine gene expression and its utility for the study of human neurological disease.

  2010cites this paper
• Effect of dietary folate restriction on colon carcinogenesis in DNA polymerase beta haploinsufficient mice

  2010cites this paper
• Viruses, gene therapy and stem cells for the treatment of human glioma

  2009cites this paper
• FOS Proliferating Network Construction in Early Colorectal Cancer (CRC) Based on Integrative Significant Function Cluster and Inferring Analysis

  2009cites this paper
• Gas1 inhibits cell proliferation and induces apoptosis of human primary gliomas in the absence of Shh

  2009cites this paper
• Gas1 reduces Ret tyrosine 1062 phosphorylation and alters GDNF‐mediated intracellular signaling

  2008influential citation
• Valproic acid induces polarization, neuronal-like differentiation of a subpopulation of C6 glioma cells and selectively regulates transgene expression.

  2008cites this paper