Intra-VTA baclofen attenuates cocaine self-administration on a progressive ratio schedule of reinforcement.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Pharmacology, Biochemistry and Behavior

• Publication date

  2000-08-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/S0091-3057(00)00286-0PMID 10973526
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Differential effects of chronic antidepressants in behavioural tests of β-adrenergic and GABAB receptor function

  2005cited by this paper
• A concurrently available nondrug reinforcer prevents the acquisition or decreases the maintenance of cocaine-reinforced behavior

  2004cited by this paper
• Food deprivation and stimulant self-administration in rats: differences between cocaine and d-amphetamine

  2004cited by this paper
• Effect of baclofen on cocaine self-administration in rats reinforced under fixed-ratio 1 and progressive-ratio schedules

  2000cited by this paper
• The irreversible gamma-aminobutyric acid (GABA) transaminase inhibitor gamma-vinyl-GABA blocks cocaine self-administration in rats.

  1999cited by this paper
• Localization of brain reinforcement mechanisms: intracranial self-administration and intracranial place-conditioning studies.

  1999cited by this paper
• The GABA(B) agonist CGP 44532 decreases cocaine self-administration in rats: demonstration using a progressive ratio and a discrete trials procedure.

  1999cited by this paper
• Effects of baclofen on maintenance and reinstatement of intravenous cocaine self-administration in rats

  1999cited by this paper
• Baclofen inhibits heroin self-administration behavior and mesolimbic dopamine release.

  1999cited by this paper
• Effects of pharmacologic increases in brain GABA levels on cocaine‐induced changes in extracellular dopamine

  1998cited by this paper
• Baclofen as a Cocaine Anti-Craving Medication: A Preliminary Clinical Study

  1998cited by this paper
• Electrophysiological Characterization of GABAergic Neurons in the Ventral Tegmental Area

  1998cited by this paper
• The pharmacology of mesocortical dopamine neurons: a dual-probe microdialysis study in the ventral tegmental area and prefrontal cortex of the rat brain.

  1998cited by this paper
• The role of afferents to the ventral tegmental area in the handling stress-induced increase in the release of dopamine in the medial prefrontal cortex: a dual-probe microdialysis study in the rat brain.

  1998cited by this paper
• Neuropharmacological mechanisms of drug reward: beyond dopamine in the nucleus accumbens.

  1998cited by this paper
• The GABAB agonist baclofen modifies cocaine self-administration in rats.

  1998cited by this paper
• GABA in the Nucleus Accumbens Shell Participates in the Central Regulation of Feeding Behavior

  1997cited by this paper
• Baclofen suppression of cocaine self-administration: demonstration using a discrete trials procedure

  1997cited by this paper
• GABAergic attenuation of cocaine‐induced dopamine release and locomotor activity

  1997cited by this paper
• Eating‐Induced Dopamine Release from Mesolimbic Neurons Is Mediated by NMDA Receptors in the Ventral Tegmental Area: A Dual‐Probe Microdialysis Study

  1997cited by this paper
• Activation of ventral tegmental GABAB receptors inhibits morphine-induced place preference in rats.

  1996cited by this paper
• Baclofen Attenuates the Reinforcing Effects of Cocaine in Rats

  1996cited by this paper
• Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy.

  1996cited by this paper
• Synaptic regulation of mesocorticolimbic dopamine neurons.

  1996cited by this paper
• The pharmacology of mesolimbic dopamine neurons: a dual-probe microdialysis study in the ventral tegmental area and nucleus accumbens of the rat brain

  1996cited by this paper
• Food deprivation affects extinction and reinstatement of responding in rats

  1995cited by this paper
• The effects of ventral tegmental administration of GABAA, GABAB and NMDA receptor agonists on medial forebrain bundle self-stimulation.

  1995cited by this paper
• GABA-containing neurons in the ventral tegmental area project to the nucleus accumbens in rat brain.

  1995cited by this paper
• Influence of an alternative reinforcer on human cocaine self-administration.

  1994cited by this paper
• Opposite changes in the mesolimbic dopamine metabolism in the nerve terminal and cell body sites induced by locally infused baclofen in the rat.

  1994cited by this paper
• Neurotransmitter regulation of dopamine neurons in the ventral tegmental area.

  1993cited by this paper
• Autoradiographic localization of gamma-aminobutyric acidA receptors within the ventral tegmental area.

  1992cited by this paper
• Regulation of somatodendritic dopamine release in the ventral tegmental area by opioids and GABA: an in vivo microdialysis study

  1992cited by this paper
• Modulation of A10 dopamine neurons by gamma-aminobutyric acid agonists.

  1990cited by this paper
• Food deprivation and acquisition of intravenous cocaine self-administration in rats: effect of naltrexone and haloperidol.

  1989cited by this paper
• Drug Self-Administration

  1989cited by this paper
• Stereospecific actions of baclofen on sociosexual behavior, locomotor activity and motor execution

  1989cited by this paper
• Cellular and molecular mechanisms of drug dependence.

  1988cited by this paper
• Glutamate decarboxylase immunoreactive neurons in rat neostriatum: their morphological types and populations.

  1988cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper

• Ethanol blocks a novel form of iLTD, but not iLTP of inhibitory inputs to VTA GABA neurons

  2023cites this paper
• Differential Impact of Inhibitory G-Protein Signaling Pathways in Ventral Tegmental Area Dopamine Neurons on Behavioral Sensitivity to Cocaine and Morphine

  2021cites this paper
• Drug addiction: from bench to bedside

  2021cites this paper
• GABAergic projections to the ventral tegmental area govern cocaine‐conditioned reward

  2021cites this paper
• GABAB Receptors and Drug Addiction: Psychostimulants and Other Drugs of Abuse.

  2021cites this paper
• Clinical Trials for Stimulant Use Disorders: Addressing Heterogeneities That May Undermine Treatment Outcomes.

  2020cites this paper
• Chemogenetic Manipulation of Dopamine Neurons Dictates Cocaine Potency at Distal Dopamine Transporters

  2020cites this paper
• Augmenter la vitesse d’infusion de la cocaïne par voie intraveineuse induit des changements neurochimiques, neurobiologiques et comportementaux chez le rat : implications pour la toxicomanie

  2019cites this paper
• Role of the orbitofrontal cortex and the dorsal striatum in incentive motivation for cocaine.

  2019cites this paper
• Acupuncture reduces relapse to cocaine‐seeking behavior via activation of GABA neurons in the ventral tegmental area

  2018cites this paper
• Variable Modulation of Inputs to GABA Cells in the Ventral Tegmental Area and Hippocampus

  2018cites this paper
• A New Insight into the Role of CART in Cocaine Reward: Involvement of CaMKII and Inhibitory G-Protein Coupled Receptor Signaling

  2017cites this paper
• Microinjection of baclofen and CGP7930 into the ventral tegmental area suppresses alcohol self‐administration in alcohol‐preferring rats

  2017cites this paper
• Drug discovery for the treatment of substance use disorders: novel targets, repurposing, and the need for new paradigms

  2017cites this paper
• Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice

  2017cites this paper
• Targeting the GABAB Receptor for the Treatment of Substance Use Disorder

  2016cites this paper
• Antagonism of GABA-B but not GABA-A receptors in the VTA prevents stress- and intra-VTA CRF-induced reinstatement of extinguished cocaine seeking in rats.

  2016cites this paper
• Evaluation of the “Pipeline” for Development of Medications for Cocaine Use Disorder: A Review of Translational Preclinical, Human Laboratory, and Clinical Trial Research

  2016cites this paper
• Inhibitory signaling and reward: the role of GIRK channels in the mesocorticolimbic dopamine system

  2015cites this paper
• Involvement of reactive oxygen species in cocaine‐taking behaviors in rats

  2015cites this paper
• GABAB receptors as a therapeutic strategy in substance use disorders: focus on positive allosteric modulators.

  2015cites this paper
• Effects of fendiline on cocaine-seeking behavior in the rat

  2015cites this paper
• Activation and modulation of GABA(B) receptor systems in physiogenic and pathophysiological conditions

  2015cites this paper
• Ventral Tegmental Area Regulation Of Stress-Induced Reinstatement Of Cocaine-Seeking Behavior

  2014cites this paper
• Role of the Nucleus Accumbens and Mesolimbic Dopamine System in Modulating the Memory of Social Defeat in Male Syrian Hamsters (Mesocricetus auratus)

  2014cites this paper
• Glycyrrhizae Radix Methanol Extract Attenuates Methamphetamine-Induced Locomotor Sensitization and Conditioned Place Preference

  2014cites this paper
• Differential development of tolerance to the functional and behavioral effects of repeated baclofen treatment in rats.

  2013cites this paper
• Novel roles for the GABAB receptor in anxiety and cocaine addiction

  2013cites this paper
• Effects of co-administration of the GABAB receptor agonist baclofen and a positive allosteric modulator of the GABAB receptor, CGP7930, on the development and expression of amphetamine-induced locomotor sensitization in rats

  2013cites this paper
• Cocaine-induced adaptations in metabotropic inhibitory signaling in the mesocorticolimbic system

  2012cites this paper
• Drug-evoked synaptic plasticity of GABAB receptor signaling in the ventral tegmental area

  2012cites this paper
• Effects of acupuncture on stress-induced relapse to cocaine-seeking in rats

  2012cites this paper
• Comparison of the effect of the GABAΒ receptor agonist, baclofen, and the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in 3 different lines of alcohol-preferring rats.

  2012cites this paper
• Role for ventral pallidal GABAergic mechanisms in the regulation of ethanol self-administration

  2012cites this paper
• Chronic ethanol drinking by alcohol-preferring rats increases the sensitivity of the mesolimbic dopamine system to the reinforcing and stimulating effects of cocaine

  2012cites this paper
• Promising medications for cocaine dependence treatment.

  2011cites this paper
• Differential involvement of GABAA and GABAB receptors in propofol self-administration in rats

  2011cites this paper
• The GABA‐B positive modulator GS39783 decreases psychostimulant conditioned‐reinforcement and conditioned‐reward

  2011cites this paper
• Addiction and brain reward and antireward pathways.

  2011cites this paper
• Reinforcing efficacy of fat, as assessed by progressive ratio responding, depends upon availability not amount consumed.

  2010cites this paper
• GABAB receptors in reward processes.

  2010cites this paper
• The GABA-B antagonist 2-hydroxysaclofen reverses the effects of baclofen on the discriminative stimulus effects of D-amphetamine in the conditioned taste aversion procedure.

  2009cites this paper
• Effects of GABA_B receptor agonists on cocaine hyperlocomotor and sensitizing effects in rats

  2009cites this paper
• Baclofen prevents drug-induced reinstatement of extinguished nicotine-seeking behaviour and nicotine place preference in rodents.

  2009cites this paper
• Temporary inactivation of ventral tegmental area neurons with either muscimol or baclofen reversibly disrupts maternal behavior in rats through different underlying mechanisms.

  2009cites this paper
• Development of Medications for Heroin and Cocaine Addiction and Regulatory Aspects of Abuse Liability Testing

  2008cites this paper
• Neurobiology of addiction. An integrative review.

  2008cites this paper
• Regionally selective changes in neurotransmitter receptors in the brain of the 5-HT1B knockout mouse.

  2008cites this paper
• GABAB Receptor-Positive Modulation Decreases Selective Molecular and Behavioral Effects of Cocaine

  2007cites this paper
• How to make a rat addicted to cocaine.

  2007cites this paper
• Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawal.

  2007cites this paper
• Estrogen Receptor β, but not α, Mediates Estrogen's Effect on Cocaine-Induced Reinstatement of Extinguished Cocaine-Seeking Behavior in Ovariectomized Female Rats

  2007cites this paper
• Effects of GABA(B) receptor antagonist, agonists and allosteric positive modulator on the cocaine-induced self-administration and drug discrimination.

  2007cites this paper
• Estrogen receptor beta, but not alpha, mediates estrogen's effect on cocaine-induced reinstatement of extinguished cocaine-seeking behavior in ovariectomized female rats.

  2007cites this paper
• Neurochemistry and molecular neurobiology of reward

  2007cites this paper
• Inhibition of pain behavior by GABA(B) receptors in the thalamic ventrobasal complex: effect on normal rats subjected to the formalin test of nociception.

  2006cites this paper
• Bingeing rats: a model of intermittent excessive behavior?

  2006cites this paper
• Effects of baclofen on operant performance for food pellets and vegetable shortening after a history of binge-type behavior in non-food deprived rats.

  2006influential citation
• Involvement of GABA(B) receptors of the dorsal hippocampus on the acquisition and expression of morphine-induced place preference in rats.

  2006cites this paper
• Effects of Baclofen on Cocaine Self-Administration: Opioid- and Nonopioid-Dependent Volunteers

  2006cites this paper
• Administration of baclofen, a γ‐aminobutyric acid type B agonist in the thalamic ventrobasal complex, attenuates allodynia in monoarthritic rats subjected to the ankle‐bend test

  2006cites this paper
• Randomized, placebo-controlled trial of baclofen and gabapentin for the treatment of methamphetamine dependence.

  2006cites this paper
• Repeated Administration of the GABAB Receptor Agonist CGP44532 Decreased Nicotine Self-Administration, and Acute Administration Decreased Cue-Induced Reinstatement of Nicotine-Seeking in Rats

  2005cites this paper
• Critical assessment of how to study addiction and its treatment: human and non-human animal models.

  2005cites this paper
• Baclofen reduces fat intake under binge-type conditions.

  2005cites this paper
• GABA(B) receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental area.

  2005cites this paper
• Increased gabaergic input to ventral tegmental area dopaminergic neurons associated with decreased cocaine reinforcement in mu-opioid receptor knockout mice.

  2005cites this paper
• Prolonged nicotine exposure does not alter GABA(B) receptor-mediated regulation of brain reward function.

  2005cites this paper
• Recent Advances in the Development of Treatments for Alcohol and Cocaine Dependence

  2005cites this paper
• GABAB receptor modulators potentiate baclofen‐induced depression of dopamine neuron activity in the rat ventral tegmental area

  2005cites this paper
• Attenuation of d-amphetamine self-administration by baclofen in the rat: behavioral and neurochemical correlates

  2005influential citation
• Preclinical evidence for GABAB agonists as a pharmacotherapy for cocaine addiction.

  2005cites this paper
• Effect of GABA Agonists and GABA-A Receptor Modulators on Cocaine- and Food-Maintained Responding and Cocaine Discrimination in Rats

  2005influential citation
• Smoked cocaine discrimination in humans: effects of gabapentin.

  2005cites this paper
• Molecular Structure and Physiological Functions of GABAB Receptors

  2004cites this paper
• The GABAB agonist baclofen blocks the expression of sensitisation to the locomotor stimulant effect of amphetamine

  2004cites this paper
• Effects of positive allosteric modulators of the GABAB receptor on cocaine self-administration in rats

  2004cites this paper
• Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area

  2004cites this paper
• Gabapentin maintenance decreases smoked cocaine-related subjective effects, but not self-administration by humans.

  2004cites this paper
• Baclofen for alcohol dependence: a preliminary open-label study.

  2004cites this paper
• Contribution of the ventral tegmental area to cocaine‐seeking maintained by a drug‐paired conditioned stimulus in rats

  2004cites this paper
• Molecular structure and physiological functions of GABA(B) receptors.

  2004cites this paper
• Injection of the 5-HT2C Receptor Agonist Ro60-0175 into the Ventral Tegmental Area Reduces Cocaine-Induced Locomotor Activity and Cocaine Self-Administration

  2004cites this paper
• Effects of Baclofen on Cue-induced Reinstatement of Cocaine Self-Administration

  2004cites this paper
• Cocaine alters GABAB‐mediated G‐protein activation in the ventral tegmental area of female rats: Modulation by estrogen

  2004cites this paper
• Effect of HD-23, a potent long acting cocaine-analog, on cocaine self-administration in rats

  2003cites this paper
• Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on cocaine discrimination in rats.

  2003cites this paper
• Effect of baclofen on alcohol and sucrose self-administration in rats.

  2003cites this paper
• Reinforcing versus anticonvulsant drugs: effects on intracranial self-stimulation rate-frequency M50 indices.

  2003cites this paper
• The GABAB Receptor Agonist Baclofen Attenuates Cocaine- and Heroin-Seeking Behavior by Rats

  2003influential citation
• GABAB receptor gene expression is not altered in cocaine‐sensitized rats

  2002cites this paper
• GABA(B) receptor agonists for the treatment of drug addiction: a review of recent findings.

  2002cites this paper
• A potential role for GABA(B) agonists in the treatment of psychostimulant addiction.

  2002influential citation
• In vivo modulation of ventral tegmental area dopamine and glutamate efflux by local GABA(B) receptors is altered after repeated amphetamine treatment.

  2002cites this paper
• International Union of Pharmacology. XXXIII. Mammalian γ-Aminobutyric AcidB Receptors: Structure and Function

  2002cites this paper
• The effects of ventral tegmental administration of GABA(A), GABA(B), NMDA and AMPA receptor agonists on ventral pallidum self-stimulation.

  2002cites this paper
• Mammalian-Aminobutyric AcidB Receptors : Structure and Function

  2002cites this paper
• The GABAB antagonist CGP56433A attenuates the effect of baclofen on cocaine but not heroin self-administration in the rat

  2002cites this paper
• Repeated cocaine administration increases GABAB(1) subunit mRNA in rat brain

  2002cites this paper
• GABA(B) receptor agonist baclofen attenuates the development and expression of d-methamphetamine-induced place preference in rats.

  2001cites this paper