The rifamycins--relation of chemical structure and action on RNA polymerase.

No abstract is available for this paper.

• Publication year

  1969

• Venue

  Biochimica et Biophysica Acta

• Publication date

  1969-05-20

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/0005-2787(69)90516-4PMID 4893414
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The X-ray analysis of the structure of rifamycin B

  2005cited by this paper
• STREPTOVARICIN- AND RIFAMPIGIN-RESISTANGE OF RNA POLYMERASE IN A RESISTANT CLONE OF ESCHERICHIA COLI B

  1968cited by this paper
• Altered characteristics of mammalian RNA polymerase following solubilization from nuclei.

  1968cited by this paper
• Interaction of rifamycin with bacterial RNA polymerase.

  1968cited by this paper
• The influence of the carboxyl group upon the antibacterial activity of rifamycins.

  1968cited by this paper
• Inhibition of DNA-dependent RNA synthesis by rifamycins.

  1968cited by this paper
• Action of rifamycin on RNA-polymerase from sensitive and resistant bacteria.

  1968cited by this paper
• Action of rifamycins on RNA polymerase.

  1968cited by this paper
• Mutant of E. coli containing an Altered DNA-dependent RNA Polymerase

  1968cited by this paper
• Streptovaricin- and rifampicin-resistance of RNA polymerase in a resistant clone of Escherichia coli B.

  1968cited by this paper
• Mutations affecting RNA Polymerase associated with Rifampicin Resistance in Escherichia coli

  1968cited by this paper
• Biogenesis of rifamycins. The conversion of rifamycin B into rifamycin Y

  1967cited by this paper
• [Rifomycin Y and its transformation products].

  1967cited by this paper
• [On the configuration of rifamycin B and related rifamycins].

  1964cited by this paper
• The X-ray analysis of the structure of rifamycin Y

  1964cited by this paper
• RIFAMYCINS. XXXV. AMIDES AND HYDRAZIDES OF RIFAMYCIN B3.

  1964cited by this paper
• [The composition of rifamycin B and related rifamycins].

  1964cited by this paper
• ANTIBACTERIAL ACTIVITY OF RIFAMYCINS.

  1963cited by this paper

• Rifamycin W Analogues from Amycolatopsis mediterranei S699 Δrif-orf5 Strain

  2021cites this paper
• Rifampin.

  2021cites this paper
• 8-Deoxy-Rifamycin Derivatives from Amycolatopsis mediterranei S699 ΔrifT Strain

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• Inhibition of RNA Polymerase by Rifampicin and Rifamycin-Like Molecules

  2020cites this paper
• Spiropiperidyl rifabutins: expanded in vitro testing against ESKAPE pathogens and select bacterial biofilms

  2020cites this paper
• Mechanisms of antibiotics inhibiting bacterial RNA polymerase.

  2019cites this paper
• Isolation of 11,12- seco-Rifamycin W Derivatives Reveals a Cleavage Pattern of the Rifamycin Ansa Chain.

  2019cites this paper
• Characterization of a novel antibiotic isolated from Xenorhabdus khoisanae and encapsulation of vancomycin in nanoparticles

  2018cites this paper
• The relationship between target-class and the physicochemical properties of antibacterial drugs

  2015cites this paper
• Synthesis and structure-activity relationships of novel substituted 8-amino, 8-thio, and 1,8-pyrazole congeners of antitubercular rifamycin S and rifampin.

  2011cites this paper
• Rifamycins e Obstacles and opportunities

  2010cites this paper
• Rifamycins--obstacles and opportunities.

  2010cites this paper
• A possible role of rifampicin in prolonging remission duration in acute myelogenous leukaemia.

  2009cites this paper
• Bacterial RNA polymerase inhibitors: an organized overview of their structure, derivatives, biological activity and current clinical development status.

  2009cites this paper
• The Inhibition of α −Amanitin Uptake in Perfused Rat Liver Blokowanie wątrobowego wychwytu α −amanityny w modelu pozaustrojowej perfuzji wątroby szczura

  2007cites this paper
• New rifabutin analogs: synthesis and biological activity against Mycobacterium tuberculosis.

  2006cites this paper
• Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.

  2005cites this paper
• Identification of tailoring genes involved in the modification of the polyketide backbone of rifamycin B by Amycolatopsis mediterranei S699.

  2005cites this paper
• Short-Course Chemotherapy for Tuberculosis

  2005cites this paper
• Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699.

  2003cites this paper
• Topology of the RNA polymerase active center probed by chimeric rifampicin-nucleotide compounds.

  1994cites this paper
• Prediction of antibacterial activity of some diarylheptanoids isolated from Garuga species by molecular mechanics and molecular orbital calculations

  1993cites this paper
• Hydrogenation of the ansa‐Chain of Rifamycins. X‐ray crystal structure of (16S)‐16,17,18,19‐tetrahydrorifamycin S

  1993cites this paper
• [Protective action of rifampicin in experimental rabies infection of albino mice].

  1989cites this paper
• Mechanism of inhibition of DNA-dependent RNA polymerase of Escherichia coli by rifamycins

  1989cites this paper
• Rifampin-resistant RNA polymerase in spirochetes

  1986cites this paper
• A resonance Raman study on the interaction of rifampicin with Escherichia coli RNA polymerase.

  1985cites this paper
• Chemical modifications of the aliphatic bridge of ansamycins. 2. Synthesis and activity of 23-epi-25-deacetylrifamycin S.

  1985cites this paper
• Protein synthesis in Escherichia coli during recovery from exposure to low levels of Cd2+

  1984cites this paper
• Oxygen Enhancement of bactericidal activity of rifamycin SV on Escherichia coli and aerobic oxidation of rifamycin SV to rifamycin S catalyzed by manganous ions: the role of superoxide.

  1982cites this paper
• Structure-activity relationships in the ansamycins. Molecular structure and activity of 3-carbomethoxy rifamycin S.

  1982cites this paper
• 16,17-dihdrorifamycin S and 16,17-dihydro-17-hydroxyrifamycin S. Two novel rifamycins from a recombinant strain C 5/42 of Nocardia mediterranei.

  1982cites this paper
• PCILO calculation on the ansa conformation of hexahydrorifamycin S

  1981cites this paper
• Early intermediates in the biosynthesis of ansamycins. III. Isolation and identification of further 8-deoxyansamycins of the rifamycin-type.

  1980cites this paper
• Mechanism of Action of Antibacterial Agents

  1979cites this paper
• Indor and 1H‐NMR. Studies of the Ansa Conformation of Hexahydrorifamycin S

  1979cites this paper
• EARLY INTERMEDIATES IN THE BIOSYNTHESIS OF ANSAMYCINS

  1979cites this paper
• Inhibitors of bacterial DNA-dependent RNA polymerase

  1978cites this paper
• Structure-activity relationships in the ansamycins: the crystal structure of tolypomycinone.

  1978cites this paper
• The chlamydia: molecular biology of procaryotic obligate parasites of eucaryocytes

  1978cites this paper
• Kinetic studies of the interaction between rifampicin and DNA-dependent RNA polymerase of Escherichia coli.

  1977cites this paper
• Ansamycins. Chemistry, biosynthesis and biological activity.

  1977cites this paper
• Synthesis and antibacterial activity of some derivatives of tolypomycinone. Relationship between structure and activity in ansamycins.

  1977cites this paper
• DNA-polymerase inhibitors. Rifamycin derivatives.

  1977cites this paper
• Structure of a derivative of streptovaricin C triacetate. Crystal and molecular structure of the atropisomer of the cyclic p-bromobenzeneboronate ester of streptovaricin C triacetate: methylene dichloride 1:1 solvate.

  1976cites this paper
• Rifampicin binding as a probe for subunit interactions in Escherchia coli RNA polymerase.

  1976cites this paper
• Mechanism of action of distamycin A and other antibiotics with antiviral activity.

  1976cites this paper
• Short-course chemotherapy for tuberculosis.

  1976cites this paper
• Chemistry of the ansamycin antibiotics.

  1976cites this paper
• Mechanism of action of rifamazine, a member of a new class of (dimeric) rifamycins.

  1975cites this paper
• A reinvestigation of the sites of transcription and translation of Euglena chloroplastic phenylalanyl-tRNA synthetase

  1975cites this paper
• Inhibitors of Nucleic Acid Synthesis

  1975cites this paper
• The rifamycin derivative AF/013 is cytolytic.

  1975cites this paper
• Determination of the solution conformation of rifamycin S and derivatives by nuclear magnetic resonance.

  1975cites this paper
• Nitrocellulose filter retention method for studying drug-nucleic acid interactions.

  1974cites this paper
• Inhibitors of RNA Synthesis Interacting with RNA Polymerases

  1974cites this paper
• Rifamycins: an insight into biological activity based on structural investigations.

  1974cites this paper
• [Pharmaceutical view of rifampicin (author's transl)].

  1974cites this paper
• Inhibition of three nucleotide polymerases by rifamycin derivatives.

  1974cites this paper
• Effect of rifamycin-SV derivatives on immunologic responses in culture.

  1974cites this paper
• Intermediates of Bacteriophage MS2 Assembly In Vivo

  1974cites this paper
• The action of rifampicin on stabilized cell lines HEp-2 and HeLa

  1974cites this paper
• The Mode of Action of Rifamycins and Related Compounds on Poxvirus

  1973cites this paper
• A direct effect of some rifamycin derivatives on the morphology of mammalian mitochondria.

  1973cites this paper
• Carbon-13 NMR spectra of rifamycins

  1973cites this paper
• Zur Kenntnis von Rifamycin‐S. Reaktionen des chinoiden Nucleus. Modifikationen von Antibiotica, 9. Mitteilung [1]

  1973cites this paper
• Inhibitors of the transcribing enzymes

  1973cites this paper
• [Understanding of rifamycin S. Reactions of the ansa-rings. Modifications of antibiotics. 8].

  1973cites this paper
• Zur Kenntnis von Rifamycin‐S.‐Reaktionen des Ansaringes. Modifikationen von Antibiotica, 8. Mitteilung [1]

  1973cites this paper
• Some properties of a DNA-dependent RNA polymerase from Halobacterium cutirubrum.

  1973cites this paper
• [Understanding of rifamycin S. Reactions of the quinoid nucleus. Modifications of antibiotics. 9].

  1973cites this paper
• Ribonucleic Acid and Protein Synthesis During Germination of Myxococcus xanthus Myxospores

  1973cites this paper
• [Effect of antibiotics with different mechanisms of action on the incorporation of labeled deoxynucleoside triphosphates into the DNA of isolated rat liver mitochondria].

  1972cites this paper
• Rifamycins: a general view.

  1972cites this paper
• Rifamycin derivatives strongly inhibiting RNA leads to DNA polymerase (reverse transcriptase) of murine sarcoma viruses.

  1972cites this paper
• DNA dependent DNA polymerase from Verongia aerophoba.

  1972cites this paper
• Rifamycins: Modulation of Specific Anti-Poxviral Activity by Small Substitutions on the Piperazinyliminomethyl Side Chain

  1972cites this paper
• Mechanism of action of a rifamycin derivative (AF-013) which is active on the nucleic acid polymerases insensitive to rifampicin.

  1972cites this paper
• Iron transport in Escherichia coli and its relation to the repression of 2,3-dihydroxy-N-benzoyl-L-serine synthetase.

  1971cites this paper
• RNA polymerase.

  1971cites this paper
• Rifampicin, a general review.

  1971cites this paper
• Similar Effect of Rifampin and Other Rifamycin Derivatives on Vaccinia Virus Morphogenesis

  1971cites this paper
• Streptovaricins inhibit focus formation by MSV (MLV) complex.

  1971cites this paper
• [Effect of rifampicin on staphylococci and gram negative bacilli isolated from clinical sources].

  1971cites this paper
• Actions of the rifamycins.

  1971cites this paper
• Antibiotics and nucleic acids.

  1971cites this paper
• Effect of Rifamycins and Related Antibiotics on the Deoxyribonucleic Acid-Dependent Ribonucleic Acid Polymerase of Vaccinia Virus Particles

  1971cites this paper
• Antitrachoma Activity of Rifamycin B and 8-O-Acetylrifamycin S

  1971cites this paper
• Structure and function of DNA-dependent RNA-polymerase.

  1971cites this paper
• Actions of the rifamycins

  1971cites this paper
• Inhibitors acting on nucleic acid synthesis in an oncogenic RNA virus.

  1971cites this paper
• In vitro biosynthesis of membrane proteins in isolated mitochondria from Saccharomyces carlsbergensis.

  1970cites this paper
• Chapter 15. Mechanism of Action of Antibiotics

  1970cites this paper
• Anti-poxvirus Activity of Rifampicin associated with Hydrazone Side Chain

  1970cites this paper
• Der Ansatzpunkt der verschiedenen Therapeutica im Stoffwechsel des Tuberkelbacteriums

  1970cites this paper
• Rifampicin Inhibition of Ribonucleic Acid and Protein Synthesis in Normal and Ethylenediaminetetraacetic Acid-Treated Escherichia coli

  1970cites this paper
• Anti-trachoma Activity of Rifampicin and Rifamycin SV Derivatives

  1970cites this paper
• Ribonucleic Acid Polymerase Induced by Vaccinia Virus: Lack of Inhibition by Rifampicin and α-Amanitin

  1970cites this paper
• α Amanitin, a specific inhibitor of transcription by mammalian RNA-polymerase

  1969cites this paper
• The effect of rifampin on the production of beta22 phage by Bacillus subtilis.

  1969cites this paper