Chapter 15. Mechanism of Action of Antibiotics

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• Publication year

  1970

• Venue

  Annual Reports in Medicinal Chemistry

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0065-7743(08)60338-3
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• The ribosomal protein altered in spectinomycin resistant Escherichia coli

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• Rifamycin insensitivity of RNA synthesis in yeast

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• Substrate and antibiotic binding sites at the peptidyl transferase centre of E. coli ribosomes

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• Studies on the formation of transfer ribonucleic acid-ribosome complexes. IX. Effect of antibiotics on translocation and peptide bond formation.

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• Products of aminolysis and enzymic hydrolysis of the cephalosporins.

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• The preparation of iodinated vancomycin and its distribution in bacteria treated with the antibiotic.

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• Kasugamycin Resistance: 30S Ribosomal Mutation with an Unusual Location on the Escherichia coli Chromosome

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• Catalysis of peptidyl transfer by human tonsil ribosomes and effects of some antibiotics

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• Changes in proton-magnetic-resonance spectra during aminolysis and enzymic hydrolysis of cephalosporins.

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• Chemistry and molecular biology of flavins and flavoproteins

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• Studies on the formation of transfer ribonucleic acid-ribosome complexes. 8. Survey of the effect of antibiotics of N-acetyl-phenylalanyl-puromycin formation: possible mechanism of chloramphenicol action.

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• Rifampicin Poxvirus and Trachoma Agent: Rifampicin and Poxvirus Replication

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• Cyclic Re-use of the RNA Polymerase Sigma Factor

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• Proteins of Mitochondrial and Cytoplasmic Ribosomes from Neurospora crassa

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• Isolation and characterization of streptolydigin resistant RNA polymerase.

  1969cited by this paper
• Mechanism of Inhibition of Ribosomes by Streptomycin

  1969cited by this paper
• Streptomycin Action: Greater Inhibition of Escherichia coli Ribosome Function with Exogenous than with Endogenous Messenger Ribonucleic Acid

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• Stabilization of N-acetylphenylalanyl transfer ribonucleic acid binding to ribosomes by sparsomycin.

  1969cited by this paper
• The molecular structure and some transport properties of valinomycin.

  1969cited by this paper
• Comparative studies on the mechanism of action of lincomycin, streptomycin, and erythromycin.

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• Mode of action of berninamycin. An inhibitor of protein biosynthesis.

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• Escherichia coli: reversion from streptomycin dependence, a mutation in a specific 30 s ribosomal protein.

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• Phylogenetic differences in the sensitivity of mitochondrial protein synthesising systems to antibiotics

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• Identification and Functional Characterization of the Protein controlled by the Streptomycin-resistant Locus in E. coli

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• Chemical Structure of Bacterial Penicillinases

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• Rifampicin Sensitivity of the Components of DNA-dependent RNA Polymerase

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• Rifampicin Poxvirus and Trachoma Agent: Rifampicin Inhibition of Trachoma Agent in vivo

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• Action of Sparsomycin on Ribosome-catalysed Peptidyl Transfer

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• Some effects of various tetracyclines on incorporation of amino acids into polypeptides by Escherichia coli extracts.

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• The rifamycins--relation of chemical structure and action on RNA polymerase.

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• Mechanism of cycloheximide inhibition of protein synthesis in a cell-free system prepared from rat liver.

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• Interaction of kanchanomycin with nucleic acids. II. Optical rotatory dispersion and circular dichroism.

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• Studies on the formation of transfer ribonucleic acid-ribosome complexes. X. Phenylalanyl-oligonucleotide binding to ribosomes and the mechanism of chloramphenicol action.

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• Effect of echinomycin and olivomycin on RNA synthesis in ehrlich ascites tumour cells

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• The effect of rifamycin on RNA synthesis in the rat liver mitochondria.

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• Chemical aspects of penicillin allergy.

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• Inhibition of the Peptide Bond Synthesizing Cycle by Chloramphenicol

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• Studies on the mechanism of action of gougerotin. II. Effect of various factors on gougerotin action.

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• Two types of binding of erythromycin to ribosomes from antibiotic-sensitive and -resistant Bacillus subtilis 168.

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• The effect of antibiotics on the coded binding of peptidyl-tRNA to the ribosome and on the transfer of the peptidyl residue to puromycin.

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• The inhibition of nucleic acid synthesis by mycophenolic acid.

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• Incorporation in vivo of 14C-labelled amino acids into the proteins of mitochondrial ribosomes from Neurospora crassa sensitive to cycloheximide and insensitive to Chloramphenicol.

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• Metabolism of macromolecules in bacteria treated with virginiamycin.

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• Ribosomal Protein Conferring Sensitivity to the Antibiotic Spectinomycin in Escherichia coli

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• The reactionf benzylpenicillenic acid with thiol-containingcompounds. The formation of a possible penicillin antigenic determinant.

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• Specificity of combination between mucopeptide precursors and vancomycin or ristocetin.

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• Mode of Action of Streptolydigin

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• Vaccinia virus directed RNA and protein synthesis in the presence of rifampicin.

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• Functional interdependence of ribosomal components of Escherichia coli.

  1969cited by this paper
• Polyribosome metabolism in Escherichia coli treated with chloramphenicol, neomycin, spectinomycin or tetracycline.

  1969cited by this paper
• Effects of ionophorous antibiotics on the light-induced internal and external hydrogen ion changes and phosphorylation in bacterial chromatophores.

  1969cited by this paper
• Studies on the formation of transfer ribonucleic acid-ribosome complexes. XI. Antibiotic effects on phenylalanyl-oligonucleotide binding to ribosomes.

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• Sensitivity and Resistance to Spectinomycin in Escherichia coli

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• Studies of the energy-transfer system of submitochondrial particles. Kinetic studies of the effect of oligomycin on the respiratory chain of EDTA particles.

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• Polyribosomes of Escherichia coli. II. Experiments to determine the in vivo distribution of polysomes, ribosomes and ribosomal subunits.

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• The intermolecular complex of erythromycin and ribosome.

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• Polyribosome depletion and blockage of the ribosome cycle by streptomycin in Escherichia coli.

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• Inhibition by pactamycin of the initiation of protein synthesis. Effect on the 30S ribosomal subunit.

  1969cited by this paper
• The effect of rifampin on the production of beta22 phage by Bacillus subtilis.

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• Model catalysts which simulate penicillinase. IV. Steric and electronic effects in the catalysis of hydrolysis of penicillins and cephalothin by aminoalkylcatechols.

  1969cited by this paper
• A ribosomal ambiguity mutation.

  1969cited by this paper
• The effect of fusidic acid on protein synthesis in a mammalian system.

  1969cited by this paper
• Inhibiton of protein synthesis in mammalian cells by actinobolin.

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• The mechanism of cycloheximide inhibition of protein synthesis in rabbit reticulocytes.

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• Inhibition by pactamycin of the initiation of protein synthesis. Binding of N-acetylphenylalanyl transfer ribonucleic acid and polyuridylic acid to ribosomes.

  1969cited by this paper
• Interaction of kanchanomycin with nucleic acids. I. Physical properties of the complex.

  1969cited by this paper
• Structure of the K+ complex with enniatin B, a macrocyclic antibiotic with K+ transport properties.

  1969cited by this paper
• Antibiotics and polyribosomes. II. Some effects of lincomycin, spiramycin, and streptogramin A in vivo.

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• Formation of the ribosome-G factor-GDP complex in the presence of fusidic acid.

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• Interaction of the RNA polymerase inhibitor chromomycin with DNA.

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• Mikro-Disk-elektrophoretische Analyse reiner DNA-abhängiger RNA-Polymerase aus Escherichia coli, III. Differenzierung zwischen Syntheseort und Bindungsort für die Matrize

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• A rifampicin resistent rna‐polymerase from E. coli altered in the β‐subunit

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• Drugs which affect the Structure and Function of DNA

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• Escherichia coli: High Resistance or Dependence on Streptomycin Produced by the Same Allele

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• Antibiotics as inhibitors of nucleic acid and protein synthesis.

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• Inhibition of mitochondrial electron transport by piericidin A and related compounds.

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• Biological characterization of prasinomycin, a phosphorus-containing antibiotic.

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• The role of ribosomal protein for the binding of dihydrostreptomycin to ribosomes.

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• Competitive Effects of Phleomycin and Mercuric Chloride in vivo

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• Action of rifamycin on RNA-polymerase from sensitive and resistant bacteria.

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• Moenomycin, an inhibitor of cell wall synthesis.

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• Mutations affecting RNA Polymerase associated with Rifampicin Resistance in Escherichia coli

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• Studies of the energy-transfer system of submitochondrial particles. 2. Effects of oligomycin and aurovertin.

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• Primary Site of Reaction in the in vitro Complex of Phleomycin in DNA

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• Inhibition of DNA-dependent RNA synthesis by rifamycins.

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• Inhibition of formylmethionyl-transfer RNA binding to ribosomes by tetracycline.

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• Interaction of rifamycin with bacterial RNA polymerase.

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• Streptomycin Resistance Mutation in Escherichia coli: Altered Ribosomal Protein

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• The structure of nigericin.

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• STREPTOVARICIN- AND RIFAMPIGIN-RESISTANGE OF RNA POLYMERASE IN A RESISTANT CLONE OF ESCHERICHIA COLI B

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• Localization of kanamycin sensitivity in the 23S core of 30S ribosomes of E. coli.

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• Rapid inhibition of polypeptide chain extension by streptomycin.

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• Mapping and complementation of three genes specifying 30S ribosomal components in Escherichia coli

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• Mechanism of action of phenomycin, a tumor-inhibitory polypeptide.

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• Mechanism of action of streptomycin in E. coli: interruption of the ribosome cycle at the initiation of protein synthesis.

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• Stoffwechselprodukte von Mikroorganismen. 66.Mitteilung [1]. Die Struktur des Granaticins und des Granaticins B. 1. Teil: Spektroskopische Eigenschaften und chemischer Abbau

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• Binding of dihydrostreptomycin to ribosomal subunits.

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• Inhibition by kasugamycin of protein synthesis in Piricularia oryzae.

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• The inhibition of bacterial RNA synthesis by the rifamycin antibiotics.

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