DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells

Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become susceptible to dengue infection after transfection of DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), or its homologue L-SIGN, whereas the infection of dendritic cells is blocked by anti–DC-SIGN antibodies and not by antibodies to other molecules on these cells. Viruses produced by dendritic cells are infectious for DC-SIGN– and L-SIGN–bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection.

• Publication year

  2003

• Venue

  Journal of Experimental Medicine

• Publication date

  2003-04-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20021840PMID 12682107PMCID 2193896
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Flaviviruses

  2008cited by this paper
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  2005cited by this paper
• GITR Activation Induces an Opposite Effect on Alloreactive CD4+ and CD8+ T Cells in Graft-Versus-Host Disease

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• Cell type-dependent retention and transmission of HIV-1 by DC-SIGN.

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  2002influential reference
• Preparation of clinical-grade recombinant canarypox-human immunodeficiency virus vaccine-loaded human dendritic cells.

  2002cited by this paper
• Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection.

  2002cited by this paper
• Differential Transmission of Human Immunodeficiency Virus Type 1 by Distinct Subsets of Effector Dendritic Cells

  2002cited by this paper
• Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century.

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• C-Type Lectins DC-SIGN and L-SIGN Mediate Cellular Entry by Ebola Virus in cis and in trans

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• Hemorrhagic fever viruses as biological weapons: medical and public health management.

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  2002cited by this paper
• Human dendritic cells as targets of dengue virus infection.

  2001cited by this paper
• Human Dendritic Cells Are Activated by Dengue Virus Infection: Enhancement by Gamma Interferon and Implications for Disease Pathogenesis

  2001cited by this paper
• cis Expression of DC-SIGN Allows for More Efficient Entry of Human and Simian Immunodeficiency Viruses via CD4 and a Coreceptor

  2001cited by this paper
• A Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin (Dc-Sign)–Related Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection

  2001cited by this paper
• DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans

  2001cited by this paper
• Infection of Human Dendritic Cells by Dengue Virus Causes Cell Maturation and Cytokine Production1

  2001cited by this paper
• DC-SIGN–ICAM-2 interaction mediates dendritic cell trafficking

  2000cited by this paper
• DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.

  2000cited by this paper
• Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses.

  2000cited by this paper
• Human skin Langerhans cells are targets of dengue virus infection

  2000cited by this paper
• Analysis of the steps involved in Dengue virus entry into host cells.

  1999cited by this paper
• Bacterial Lipopolysaccharide Inhibits Dengue Virus Infection of Primary Human Monocytes/Macrophages by Blockade of Virus Entry via a CD14-Dependent Mechanism

  1999cited by this paper
• Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application.

  1999cited by this paper
• Dengue and Dengue Hemorrhagic Fever

  1998cited by this paper
• Exotic Viral Infections

  1998cited by this paper
• Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate

  1997cited by this paper
• Dengue 1 virus binding to human hepatoma HepG2 and simian Vero cell surfaces differs.

  1996cited by this paper
• Dengue and dengue haemorrhagic fever.

  1993cited by this paper
• Antibody-dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic fever.

  1989cited by this paper
• A prospective study of dengue infections in Bangkok.

  1988cited by this paper
• Variation in susceptibility to oral infection with dengue viruses among geographic strains of Aedes aegypti.

  1979cited by this paper
• Dengue viruses and mononuclear phagocytes. II. Identity of blood and tissue leukocytes supporting in vitro infection

  1977cited by this paper
• Antibody-enhanced dengue virus infection in primate leukocytes

  1977cited by this paper
• Isolation of a temperature-sensitive dengue-2 virus under conditions suitable for vaccine development

  1976cited by this paper

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  2025cites this paper
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  2025cites this paper
• Classification of C‐Type Lectins and Recognition of Pathogens

  2025cites this paper
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  2025cites this paper
• Urine of Cats with Severe Fever with Thrombocytopenia Syndrome: A Potential Source of Infection Transmission

  2025cites this paper
• Recent Advances in Dengue Fever Based on Serotypes, Virulence Factors, Prevention, and Treatment: A Comprehensive Review

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• Dysregulated immune cell responses in severe dengue pathogenesis

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  2023cites this paper
• Ocular Manifestations of Flavivirus Infections

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