Causes of Neurodegeneration in Diabetes: Possible Culprits and Therapeutic Targets

Diabetes, a global epidemic, has been shown to be linked to incidence of neurodegenerative disorders. Hyperglycemia is linked to cognitive decline, Alzheimer’s disease, dementia and neurodegeneration in general. The mechanisms of diabetes/hyperglycemia-mediated neurodegeneration are largely unknown. This review sheds light on mechanisms that could possibly lead to hyperglycemia-mediated neurodenegeration namely apoptosis, oxidative stress, AGE, etc. Additionally relevant therapeutic strategies are also discussed.

• Publication year

  2014

• Venue

  Brain disorders & therapy

• Publication date

  2014-06-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4172/2168-975X.1000130
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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