Central role of mitochondria and p53 in Fas-mediated apoptosis of rheumatoid synovial fibroblasts.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Rheumatology

• Publication date

  2004-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/RHEUMATOLOGY/KEH039PMID 14623946
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Fas-mediated apoptosis is dependent on wild-type p53 status in human cancer cells expressing a temperature-sensitive p53 mutant alanine-143.

  2003cited by this paper
• p53AIP1 regulates the mitochondrial apoptotic pathway.

  2002cited by this paper
• Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane.

  2002cited by this paper
• Regional analysis of p53 mutations in rheumatoid arthritis synovium

  2002cited by this paper
• Apoptosis as a therapeutic tool in rheumatoid arthritis

  2002influential reference
• p53 negatively regulates intestinal immunity by delaying mucosal T cell cycling.

  2002cited by this paper
• Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis.

  2002cited by this paper
• CD27 and CD40 Inhibit p53-independent Mitochondrial Pathways in Apoptosis of B Cells Induced by B Cell Receptor Ligation*

  2002influential reference
• Regulation of rheumatoid synoviocyte proliferation by endogenous p53 induction

  2001cited by this paper
• Invasiveness of synovial fibroblasts is regulated by p53 in the SCID mouse in vivo model of cartilage invasion.

  2001cited by this paper
• Apoptosis in rheumatoid arthritis – expression of Fas, Fas‐L, p53, and Bcl‐2 in rheumatoid synovial tissues

  2001cited by this paper
• Jun NH2-Terminal Kinase Phosphorylation of p53 on Thr-81 Is Important for p53 Stabilization and Transcriptional Activities in Response to Stress

  2001cited by this paper
• Gene transfer of p53 to arthritic joints stimulates synovial apoptosis and inhibits inflammation.

  2001cited by this paper
• Differential regulation of Fas-mediated apoptosis of rheumatoid synoviocytes by tumor necrosis factor alpha and basic fibroblast growth factor is associated with the expression of apoptosis-related molecules.

  2000cited by this paper
• Analysis of p53 tumour suppressor gene somatic mutations in rheumatoid arthritis synovium.

  2000cited by this paper
• Novel gene therapy for rheumatoid arthritis by FADD gene transfer: induction of apoptosis of rheumatoid synoviocytes but not chondrocytes

  2000cited by this paper
• p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.

  2000cited by this paper
• CD95's deadly mission in the immune system

  2000cited by this paper
• Defying death after DNA damage

  2000cited by this paper
• Fas-associated death domain protein is a Fas-mediated apoptosis modulator in synoviocytes.

  2000cited by this paper
• p53: death star.

  2000cited by this paper
• p53 in rheumatoid arthritis: friend or foe?

  2000cited by this paper
• Human and Mouse Fas (APO-1/CD95) Death Receptor Genes Each Contain a p53-responsive Element That Is Activated by p53 Mutants Unable to Induce Apoptosis*

  2000cited by this paper
• Rheumatoid arthritis viewed using a headache paradigm

  2000cited by this paper
• Surfing the p53 network

  2000cited by this paper
• p53 overexpression in synovial tissue from patients with early and longstanding rheumatoid arthritis compared with patients with reactive arthritis and osteoarthritis.

  1999cited by this paper
• Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

  1999cited by this paper
• Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death*

  1999cited by this paper
• Tumor necrosis factor alpha regulation of the FAS-mediated apoptosis-signaling pathway in synovial cells.

  1999influential reference
• Analysis of the p53 tumor suppressor gene in rheumatoid arthritis synovial fibroblasts.

  1999cited by this paper
• Mutations of the p53 tumour suppressor gene in erosive rheumatoid synovial tissue

  1998cited by this paper
• Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.

  1998cited by this paper
• A matter of life and cell death.

  1998cited by this paper
• Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.

  1998cited by this paper
• Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.

  1998cited by this paper
• MEKK1/JNK signaling stabilizes and activates p53.

  1998cited by this paper
• Apoptosis in rheumatoid arthritis: a novel pathway in the regulation of synovial tissue.

  1998cited by this paper
• p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs

  1998cited by this paper
• Induction of apoptosis in the rheumatoid synovium by Fas ligand gene transfer

  1998cited by this paper
• Two CD95 (APO‐1/Fas) signaling pathways

  1998cited by this paper
• Fas Induces Cytoplasmic Apoptotic Responses and Activation of the MKK7-JNK/SAPK and MKK6-p38 Pathways Independent of CPP32-like Proteases

  1997cited by this paper
• Daxx, a novel Fas-binding protein that activates JNK and apoptosis.

  1997cited by this paper
• Selective activation of the JNK/AP-1 pathway in Fas-mediated apoptosis of rheumatoid arthritis synoviocytes.

  1997cited by this paper
• Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.

  1997cited by this paper
• Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium.

  1997cited by this paper
• Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice.

  1996cited by this paper
• Apoptosis in rheumatoid arthritis: p53 overexpression in rheumatoid arthritis synovium.

  1996cited by this paper
• Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis.

  1996cited by this paper
• Adriamycin activates c-jun N-terminal kinase in human leukemia cells: a relevance to apoptosis.

  1996cited by this paper
• The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat.

  1996cited by this paper
• Persistent Activation of c-Jun N-terminal Kinase 1 (JNK1) in γ Radiation-induced Apoptosis (*)

  1996cited by this paper
• Expression of Fas antigen and Fas ligand in the rheumatoid synovial tissue.

  1996cited by this paper
• Apoptosis in rheumatoid arthritis synovium.

  1995cited by this paper
• Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes.

  1995cited by this paper
• Establishment and characterization of synovial cell clones with integrated human T-cell leukemia virus type-I.

  1994cited by this paper
• Rheumatoid arthritis. Pathophysiology and implications for therapy.

  1990cited by this paper
• Prognosis in rheumatoid arthritis. A longitudinal study of newly diagnosed younger adult patients.

  1979cited by this paper
• The prevalence of rheumatoid arthritis. Follow-up evaluation of the effect of criteria on rates in Sudbury, Massachusetts.

  1972cited by this paper

• Regulation of epithelial transitional states in murine and human pulmonary fibrosis

  2023cites this paper
• Integrating Network Pharmacology with Molecular Docking to Unravel the Active Compounds and Potential Mechanism of Simiao Pill Treating Rheumatoid Arthritis

  2020cites this paper
• MiR-20a regulates fibroblast-like synoviocyte proliferation and apoptosis in rheumatoid arthritis.

  2020cites this paper
• Effect of electroacupuncture at the ST36 and GB39 acupoints on apoptosis by regulating the p53 signaling pathway in adjuvant arthritis rats

  2019cites this paper
• A new glycoprotein SPG-8700 isolated from sweet potato with potential anti-cancer activity against colon cancer

  2019cites this paper
• Uncovering Cellular retinoic acid-binding protein 2 as a potential target for rheumatoid arthritis synovial hyperplasia

  2018cites this paper
• Cell Death and Development of Fibrotic Alterations in Lung Granuloma of BALB/c Mice during Chronic BCG-Induced Granulomatosis

  2018cites this paper
• Recent advances in electrochemical and electrochemiluminescence based determination of the activity of caspase-3

  2017cites this paper
• MiR-20a regulates fibroblast-like synoviocyte proliferation and apoptosis in rheumatoid arthritis.

  2017cites this paper
• A reliable self-assembled peptide based electrochemical biosensor for detection of caspase 3 activity and apoptosis

  2015cites this paper
• Anti-apoptotic roles for the mutant p53R248Q through suppression of p53-regulated apoptosis-inducing protein 1 in the RA-derived fibroblast-like synoviocyte cell line MH7A.

  2014cites this paper
• PE-induced apoptosis in SMMC-7721 cells: Involvement of Erk and Stat signalling pathways

  2014cites this paper
• Aloperine induces G2/M phase cell cycle arrest and apoptosis in HCT116 human colon cancer cells.

  2014cites this paper
• Fas/FasL promoter gene polymorphism in patients with rheumatoid arthritis.

  2012cites this paper
• Hypoxia: a critical regulator of early human tendinopathy

  2011cites this paper
• DcR3 induces cell proliferation through MAPK signaling in chondrocytes of osteoarthritis.

  2011cites this paper
• Multicentric reticulohistiocytosis and urologic carcinomas: a possible paraneoplastic association

  2011cites this paper
• Cell cycle arrest and apoptosis induced by methyl 3,5-dicaffeoyl quinate in human colon cancer cells: Involvement of the PI3K/Akt and MAP kinase pathways.

  2011cites this paper
• Histone Deacetylase Inhibitors Sensitize Human Non-small Cell Lung Cancer Cells to Ionizing Radiation Through Acetyl p53-Mediated c-myc Down-Regulation

  2011cites this paper
• Small molecules regulating apoptosis in the synovium in rheumatoid arthritis

  2010cites this paper
• Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage

  2010influential citation
• Arsenic trioxide up-regulates Fas expression in human osteosarcoma cells.

  2010cites this paper
• Suppression of hypoxia-inducible factor 2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells.

  2009cites this paper
• Susceptibility of rheumatoid arthritis synovial fibroblasts to FasL- and TRAIL-induced apoptosis is cell cycle-dependent

  2009cites this paper
• DcR3 protects THP-1 macrophages from apoptosis by increasing integrin alpha4.

  2009cites this paper
• Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors.

  2009cites this paper
• Coculture of osteoclast precursors with rheumatoid synovial fibroblasts induces osteoclastogenesis via transforming growth factor beta-mediated down-regulation of osteoprotegerin.

  2008cites this paper
• Changes in calcium‐dependent membrane permeability properties in mitochondria of livers from arthritic rats

  2008cites this paper
• Targeting human 8-oxoguanine DNA glycosylase to mitochondria protects cells from 2-methoxyestradiol-induced-mitochondria-dependent apoptosis

  2008cites this paper
• Effect of total flavonoids of Chrysanthemum indicum on the apoptosis of synoviocytes in joint of adjuvant arthritis rats.

  2008cites this paper
• Mechanism of Fibroblast‐Like Synoviocyte Apoptosis Induced by Recombinant Human Endostatin in Rats with Adjuvant Arthritis

  2008cites this paper
• The functional haplotype of peptidylarginine deiminase IV (S55G, A82V and A112G) associated with susceptibility to rheumatoid arthritis dominates apoptosis of acute T leukemia Jurkat cells

  2007cites this paper
• Decoy receptor 3 expressed in rheumatoid synovial fibroblasts protects the cells against Fas-induced apoptosis.

  2007cites this paper
• Cytotoxicity of taurine metabolites depends on the cell type.

  2006cites this paper
• Fas (CD95)-related apoptosis and rheumatoid arthritis.

  2006cites this paper
• Expression pattern of cell cycle-related gene products in synovial stroma and synovial lining in active and quiescent stages of rheumatoid arthritis.

  2005cites this paper
• Fas ( CD 95 )-related apoptosis and rheumatoid arthritis

  2005cites this paper
• Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells.

  2005cites this paper
• Inflammation and conjugated linoleic acid: mechanisms of action and implications for human health

  2005cites this paper
• Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression

  2004cites this paper
• Apoptosis as a mechanism of autoimmune inflammation in human knee joint

  2004cites this paper
• Apoptosis a relevant therapeutic target in rheumatoid arthritis?

  2004cites this paper
• Down-regulation of FLIP sensitizes rheumatoid synovial fibroblasts to Fas-mediated apoptosis.

  2004cites this paper