Transcriptional activators enhance polyadenylation of mRNA precursors.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Molecules and Cells

• Publication date

  2011-02-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.molcel.2011.01.022PMID 21329879PMCID PMC3060669
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The tumor suppressor parafibromin is required for posttranscriptional processing of histone mRNA

  2010cited by this paper
• The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis.

  2010cited by this paper
• The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.

  2010cited by this paper
• Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation

  2010cited by this paper
• Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex

  2010cited by this paper
• Crosstalk between mRNA 3' end processing and transcription initiation.

  2010cited by this paper
• DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation.

  2009cited by this paper
• The tumor suppressor, parafibromin, mediates histone H3 K9 methylation for cyclin D1 repression

  2009cited by this paper
• A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.

  2009cited by this paper
• Progressive lengthening of 3′ untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development

  2009cited by this paper
• Molecular architecture of the human pre-mRNA 3' processing complex.

  2009cited by this paper
• The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3′ mRNA processing factors

  2009cited by this paper
• Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing

  2009cited by this paper
• Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells.

  2009cited by this paper
• Ctk1 promotes dissociation of basal transcription factors from elongating RNA polymerase II

  2009cited by this paper
• Transcription termination by nuclear RNA polymerases.

  2009cited by this paper
• The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3

  2008cited by this paper
• The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene

  2008cited by this paper
• HITS-CLIP yields genome-wide insights into brain alternative RNA processing

  2008cited by this paper
• Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites

  2008cited by this paper
• Direct Interactions between the Paf1 Complex and a Cleavage and Polyadenylation Factor Are Revealed by Dissociation of Paf1 from RNA Polymerase II

  2008cited by this paper
• The VP16 Activation Domain Establishes an Active Mediator Lacking CDK8 in Vivo*

  2007cited by this paper
• The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination.

  2007cited by this paper
• Human Pcf11 enhances degradation of RNA polymerase II-associated nascent RNA and transcriptional termination

  2007cited by this paper
• Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.

  2006cited by this paper
• Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3′-UTRs

  2006cited by this paper
• Evidence that Poly(A) Binding Protein C1 Binds Nuclear Pre-mRNA Poly(A) Tails

  2006cited by this paper
• Nuclear and cytoplasmic mRNA quantification by SYBR green based real-time RT-PCR.

  2006cited by this paper
• Phosphorylation and functions of the RNA polymerase II CTD.

  2006cited by this paper
• Pcf11 is a termination factor in Drosophila that dismantles the elongation complex by bridging the CTD of RNA polymerase II to the nascent transcript.

  2006cited by this paper
• CTD-dependent dismantling of the RNA polymerase II elongation complex by the pre-mRNA 3'-end processing factor, Pcf11.

  2005cited by this paper
• The human PAF complex coordinates transcription with events downstream of RNA synthesis.

  2005cited by this paper
• The Parafibromin Tumor Suppressor Protein Is Part of a Human Paf1 Complex

  2005cited by this paper
• Yeast poly(A)-binding protein Pab1 shuttles between the nucleus and the cytoplasm and functions in mRNA export.

  2005cited by this paper
• A posttranscriptional role for the yeast Paf1-RNA polymerase II complex is revealed by identification of primary targets.

  2005cited by this paper
• Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression

  2005cited by this paper
• Role for PSF in Mediating Transcriptional Activator-Dependent Stimulation of Pre-mRNA Processing In Vivo

  2005cited by this paper
• The HRPT2 Tumor Suppressor Gene Product Parafibromin Associates with Human PAF1 and RNA Polymerase II

  2005cited by this paper
• Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition.

  2005cited by this paper
• The transcriptional coactivator PC4/Sub1 has multiple functions in RNA polymerase II transcription

  2005cited by this paper
• Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.

  2005cited by this paper
• Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes.

  2004cited by this paper
• The immobilized template assay for measuring cooperativity in eukaryotic transcription complex assembly.

  2004cited by this paper
• Phosphorylation of serine 2 within the RNA polymerase II C-terminal domain couples transcription and 3' end processing.

  2004cited by this paper
• RanBP2/Nup358 Provides a Major Binding Site for NXF1-p15 Dimers at the Nuclear Pore Complex and Functions in Nuclear mRNA Export

  2004cited by this paper
• HSF1 Modulation of Hsp70 mRNA Polyadenylation via Interaction with Symplekin*

  2004cited by this paper
• The Paf1 complex has functions independent of actively transcribing RNA polymerase II.

  2004cited by this paper
• The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation.

  2003cited by this paper
• The RNA polymerase II elongation complex.

  2003cited by this paper
• Transcriptional Activators Control Splicing and 3′-End Cleavage Levels*

  2003cited by this paper
• Ssu72 is a phosphatase essential for transcription termination of snoRNAs and specific mRNAs in yeast

  2003cited by this paper
• Ssu72 Protein Mediates Both Poly(A)-Coupled and Poly(A)-Independent Termination of RNA Polymerase II Transcription

  2003cited by this paper
• Methylation of Histone H3 by Set2 in Saccharomyces cerevisiae Is Linked to Transcriptional Elongation by RNA Polymerase II

  2003cited by this paper
• RNA Polymerase II Elongation Factors of Saccharomyces cerevisiae: a Targeted Proteomics Approach

  2002cited by this paper
• Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo.

  2002cited by this paper
• The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

  2002cited by this paper
• The mRNA assembly line: transcription and processing machines in the same factory.

  2002cited by this paper
• Ctr9, Rtf1, and Leo1 Are Components of the Paf1/RNA Polymerase II Complex

  2002cited by this paper
• Functional interaction of yeast pre-mRNA 3' end processing factors with RNA polymerase II.

  2002cited by this paper
• ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.

  2002cited by this paper
• Integrating mRNA processing with transcription.

  2002cited by this paper
• An extensive network of coupling among gene expression machines

  2002cited by this paper
• Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain.

  2001cited by this paper
• Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1.

  2000cited by this paper
• Complex Protein Interactions within the Human Polyadenylation Machinery Identify a Novel Component

  2000cited by this paper
• RNA polymerase II and the integration of nuclear events.

  2000cited by this paper
• A transcription reinitiation intermediate that is stabilized by activator

  2000cited by this paper
• Synthetic lethal interactions suggest a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation.

  2000cited by this paper
• Phosphorylated RNA polymerase II stimulates pre-mRNA splicing.

  1999cited by this paper
• Promoter Structure and Transcriptional Activation with Chromatin Templates Assembled In Vitro

  1998cited by this paper
• Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation.

  1998cited by this paper
• RNA polymerase II is an essential mRNA polyadenylation factor

  1998cited by this paper
• Coupling termination of transcription to messenger RNA maturation in yeast.

  1998cited by this paper
• Transcription factor TFIID recruits factor CPSF for formation of 3′ end of mRNA

  1997cited by this paper
• 5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II.

  1997cited by this paper
• Mechanism and regulation of mRNA polyadenylation.

  1997cited by this paper
• The C-terminal domain of RNA polymerase II couples mRNA processing to transcription

  1997cited by this paper
• Paf1p, an RNA polymerase II-associated factor in Saccharomyces cerevisiae, may have both positive and negative roles in transcription

  1996cited by this paper
• The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation.

  1996cited by this paper
• Ribonuclease Protection Assay

  1993cited by this paper
• Small-scale preparation of extracts from radiolabeled cells efficient in pre-mRNA splicing.

  1990cited by this paper
• A multisubunit factor, CstF, is required for polyadenylation of mammalian pre-mRNAs.

  1990cited by this paper
• The C‐terminal 79 amino acids of the herpes simplex virus regulatory protein, Vmw65, efficiently activate transcription in yeast and mammalian cells in chimeric DNA‐binding proteins.

  1989cited by this paper
• Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.

  1988cited by this paper
• GAL4-VP16 is an unusually potent transcriptional activator

  1988cited by this paper
• Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylation.

  1988cited by this paper
• Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.

  1983cited by this paper

• Regulation of gene expression by alternative polyadenylation in health and disease.

  2026cites this paper
• mRNA initiation and termination are spatially coordinated.

  2025cites this paper
• Neuronal RNA processing: cross-talk between transcriptional regulation and RNA-binding proteins

  2024cites this paper
• mRNA initiation and termination are spatially coordinated

  2024cites this paper
• The plant POLYMERASE-ASSOCIATED FACTOR1 complex links transcription and H2B monoubiquitination genome wide

  2024cites this paper
• TFIIB–Termination Factor Interaction Affects Termination of Transcription on Genome-Wide Scale

  2024cites this paper
• Mechanisms and Functions of the RNA Polymerase II General Transcription Machinery during the Transcription Cycle

  2024cites this paper
• Poly(A) tale: From A to A; RNA polyadenylation in prokaryotes and eukaryotes

  2024cites this paper
• Sequential Polyadenylation to Enable Alternative mRNA 3’ End Formation

  2023cites this paper
• Targeting the super elongation complex for oncogenic transcription driven tumor malignancies: Progress in structure, mechanisms and small molecular inhibitor discovery.

  2023cites this paper
• Sites of transcription initiation drive mRNA isoform selection

  2023cites this paper
• Alternative polyadenylation regulation: insights from sequential polyadenylation

  2022cites this paper
• Context-specific regulation and function of mRNA alternative polyadenylation

  2022cites this paper
• RNA Metabolism in T Lymphocytes

  2022cites this paper
• Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation.

  2021cites this paper
• The Paf1 Complex: a keystone of nuclear regulation operating at the interface of transcription and chromatin.

  2021cites this paper
• CFIm25 regulates human stem cell function independently of its role in mRNA alternative polyadenylation

  2021cites this paper
• Comprehensive mapping of alternative polyadenylation site usage and its dynamics at single-cell resolution

  2021cites this paper
• Crosstalk Between mRNA 3'-End Processing and Epigenetics

  2021cites this paper
• Integrator enforces the fidelity of transcriptional termination at protein-coding genes

  2021cites this paper
• A BRD4-mediated elongation control point primes transcribing RNA polymerase II for 3'-processing and termination.

  2021cites this paper
• Alternative polyadenylation: methods, mechanism, function, and role in cancer

  2021cites this paper
• Isoform-specific regulation of rhythmic gene expression by alternative polyadenylation

  2020cites this paper
• So close, no matter how far: multiple paths connecting transcription to mRNA translation in eukaryotes

  2020cites this paper
• Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms

  2020cites this paper
• PAF1 facilitates RNA polymerase II ubiquitination by the Elongin A complex through phosphorylation by CDK12

  2020cites this paper
• Alternative polyadenylation and the stress response

  2019cites this paper
• The mRNA Export Receptor NXF1 Coordinates Transcriptional Dynamics, Alternative Polyadenylation, and mRNA Export.

  2019cites this paper
• Tissue‐specific mechanisms of alternative polyadenylation: Testis, brain, and beyond (2018 update)

  2019cites this paper
• Transcriptional regulation in model organisms: recent progress and clinical implications

  2019cites this paper
• Genetic association and functional characterization of MCPH1 gene variation in bipolar disorder and schizophrenia

  2019cites this paper
• Analysis of alternative cleavage and polyadenylation in mature and differentiating neurons using RNA-seq data

  2018cites this paper
• Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation

  2018cites this paper
• Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals.

  2018cites this paper
• The plant RNA polymerase II elongation complex: A hub coordinating transcript elongation and mRNA processing

  2018cites this paper
• The translational regulation of maternal mRNAs in time and space

  2018cites this paper
• Posttranscriptional Regulation of HLA-A Protein Expression by Alternative Polyadenylation Signals Involving the RNA-Binding Protein Syncrip

  2017cites this paper
• Alternative polyadenylation in the regulation and dysregulation of gene expression.

  2017cites this paper
• Emerging Insights into the Roles of the Paf1 Complex in Gene Regulation.

  2017cites this paper
• Overexpressed HSF1 cancer signature genes cluster in human chromosome 8q

  2017cites this paper
• The Composition of the Arabidopsis RNA Polymerase II Transcript Elongation Complex Reveals the Interplay between Elongation and mRNA Processing Factors[OPEN]

  2017cites this paper
• Cleavage and polyadenylation: Ending the message expands gene regulation

  2017cites this paper
• Translational Regulation in the Mammalian Oocyte.

  2017cites this paper
• Alterations in mRNA 3′UTR Isoform Abundance Accompany Gene Expression Changes in Huntington's Disease

  2017cites this paper
• Alternative polyadenylation of mRNA precursors

  2016cites this paper
• The polyadenylation complex of Trypanosoma brucei: Characterization of the functional poly(A) polymerase

  2016cites this paper
• In the Driver’s Seat

  2016cites this paper
• Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1α.

  2016cites this paper
• Processing and transcriptome expansion at the mRNA 3′ end in health and disease: finding the right end

  2016cites this paper
• Oxidative stress controls the choice of alternative last exons via a Brahma–BRCA1–CstF pathway

  2016cites this paper
• Alternative cleavage and polyadenylation in spermatogenesis connects chromatin regulation with post-transcriptional control

  2016cites this paper
• Title Deposition of 5-Methylcytosine on Enhancer RNAs Enables theCoactivator Function of PGC-1 α

  2016cites this paper
• PAF Complex Plays Novel Subunit-Specific Roles in Alternative Cleavage and Polyadenylation

  2016cites this paper
• Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut

  2016cites this paper
• The effect of the polyadenylation inhibitor Cordycepin on MCF-7 cells

  2015cites this paper
• Alternative mRNA transcription, processing, and translation: insights from RNA sequencing

  2015cites this paper
• Alternative mRNA transcription, processing, and translation: insights from RNA sequencing.

  2015cites this paper
• ‘Mediator‐ing’ messenger RNA processing

  2015cites this paper
• ELAV links paused Pol II to alternative polyadenylation in the Drosophila nervous system.

  2015cites this paper
• Message ends: RNA 3' processing and flowering time control.

  2014cites this paper
• Coupling mRNA processing with transcription in time and space

  2014cites this paper
• The “ Histone Mimicry ” by Pathogens

  2014cites this paper
• In vitro analysis of transcriptional activators and polyadenylation.

  2014cites this paper
• Towards the Construction of a Transcriptional Landscape of the Human Genome: Data Analysis and Data Compression

  2014cites this paper
• Integrating RNA polymerase II dynamics with alternative polyadenylation

  2014cites this paper
• The SLE Transcriptome Exhibits Evidence of Chronic Endotoxin Exposure and Has Widespread Dysregulation of Non-Coding and Coding RNAs

  2014cites this paper
• New Links between mRNA Polyadenylation and Diverse Nuclear Pathways

  2014cites this paper
• RNA-binding proteins in regulation of alternative cleavage and polyadenylation.

  2014cites this paper
• Transcription coupled repair at the interface between transcription elongation and mRNP biogenesis.

  2013cites this paper
• Alterations in Polyadenylation and Its Implications for Endocrine Disease

  2013cites this paper
• The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states.

  2013cites this paper
• Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors

  2013cites this paper
• Co-regulated expression of alpha and beta mRNAs encoding HLA-DR surface heterodimers is mediated by the MHCII RNA operon

  2013cites this paper
• The nucleosome regulates the usage of polyadenylation sites in the human genome

  2013cites this paper
• The "histone mimicry" by pathogens.

  2013cites this paper
• mRNA 3′end processing: A tale of the tail reaches the clinic

  2013cites this paper
• Alternative cleavage and polyadenylation: the long and short of it.

  2013cites this paper
• αCP Poly(C) Binding Proteins Act as Global Regulators of Alternative Polyadenylation

  2013cites this paper
• UV damage regulates alternative polyadenylation of the RPB2 gene in yeast

  2013cites this paper
• Mutual relationships between transcription and pre‐mRNA processing in the synthesis of mRNA

  2013cites this paper
• RNA polymerase II transcription elongation control.

  2013cites this paper
• Regulation of the alternative polyadenylation in T cells

  2013cites this paper
• Alternative cleavage and polyadenylation: extent, regulation and function

  2013cites this paper
• Identification of Chromatin-Associated Regulators of MSL Complex Targeting in Drosophila Dosage Compensation

  2012cites this paper
• Alternative polyadenylation: new insights from global analyses.

  2012cites this paper
• Transcription termination between polo and snap, two closely spaced tandem genes of D. melanogaster

  2012cites this paper
• RNA polymerase backtracking in gene regulation and genome instability.

  2012cites this paper
• An in-depth map of polyadenylation sites in cancer

  2012cites this paper
• Paf1 Restricts Gcn4 Occupancy and Antisense Transcription at the ARG1 Promoter

  2012cites this paper
• Genome-wide alternative polyadenylation in animals: insights from high-throughput technologies.

  2012cites this paper
• The Paf1 Complex Subunit Rtf1 Buffers Cells Against the Toxic Effects of [PSI+] and Defects in Rkr1-Dependent Protein Quality Control in Saccharomyces cerevisiae

  2012cites this paper
• RNA polymerase II elongation control.

  2012cites this paper
• Histone H3R17me2a mark recruits human RNA Polymerase-Associated Factor 1 Complex to activate transcription

  2012cites this paper
• mRNA 3′ End Processing Factors: A Phylogenetic Comparison

  2012cites this paper
• The RNA polymerase II CTD coordinates transcription and RNA processing.

  2012cites this paper
• Inhibition of polyadenylation reduces inflammatory gene induction.

  2012cites this paper
• Yeast pheromone receptor genes STE2 and STE3 are differently regulated at the transcription and polyadenylation level

  2011cites this paper
• Transcriptional and epigenetic regulation of B cell development

  2011cites this paper
• The roles of the Saccharomyces cerevisiae Paf1 complex in regulating transcriptional repression

  2011influential citation
• Inferring regulatory mechanisms from patterns of evolutionary divergence

  2011cites this paper