Lessons from lactose permease.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Annual Review of Biophysics and Biomolecular Structure

• Publication date

  2006-05-11

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1146/ANNUREV.BIOPHYS.35.040405.102005PMID 16689628PMCID PMC2802108
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Bioorganic Chemistry: Carbohydrates

  2008cited by this paper
• Translocations through natural membranes.

  2006cited by this paper
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  2005cited by this paper
• Monitoring Conformational Rearrangements in the Substrate-binding Site of a Membrane Transport Protein by Mass Spectrometry*

  2004cited by this paper
• Direct Evidence for Substrate-induced Proton Release in Detergent-solubilized EmrE, a Multidrug Transporter*

  2004cited by this paper
• Binding affinity of lactose permease is not altered by the H+ electrochemical gradient.

  2004cited by this paper
• Sugar Recognition by the Lactose Permease of Escherichia coli*

  2004cited by this paper
• Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: members of the major facilitator superfamily.

  2004cited by this paper
• Exploiting luminescence spectroscopy to elucidate the interaction between sugar and a tryptophan residue in the lactose permease of Escherichia coli

  2003cited by this paper
• Structure and Mechanism of the Lactose Permease of Escherichia coli

  2003cited by this paper
• Aromatic stacking in the sugar binding site of the lactose permease.

  2003cited by this paper
• Intermolecular thiol cross-linking via loops in the lactose permease of Escherichia coli

  2003cited by this paper
• A mutation in the lactose permease of Escherichia coli that decreases conformational flexibility and increases protein stability.

  2003cited by this paper
• Three‐dimensional crystallization of the Escherichia coli glycerol‐3‐phosphate transporter: A member of the major facilitator superfamily

  2003cited by this paper
• Elucidation of substrate binding interactions in a membrane transport protein by mass spectrometry

  2003cited by this paper
• Maltose transport through the inner membrane of E. coli.

  2003cited by this paper
• The sodium/glucose cotransport family SLC5

  2003cited by this paper
• Manipulating conformational equilibria in the lactose permease of Escherichia coli.

  2002cited by this paper
• Surface-exposed positions in the transmembrane helices of the lactose permease of Escherichia coli determined by intermolecular thiol cross-linking

  2002cited by this paper
• An approach to membrane protein structure without crystals

  2002cited by this paper
• The E. coli BtuCD Structure: A Framework for ABC Transporter Architecture and Mechanism

  2002cited by this paper
• A new spin on protein dynamics.

  2002cited by this paper
• Changing the lactose permease of Escherichia coli into a galactose-specific symporter

  2002cited by this paper
• Helices VII and X in the lactose permease of Escherichia coli: proximity and ligand-induced distance changes.

  2002cited by this paper
• Binding of hydrophobic D-galactopyranosides to the lactose permease of Escherichia coli.

  2002cited by this paper
• The C-4 hydroxyl group of galactopyranosides is the major determinant for ligand recognition by the lactose permease of Escherichia coli.

  2001cited by this paper
• The kamikaze approach to membrane transport

  2001cited by this paper
• Arg-302 facilitates deprotonation of Glu-325 in the transport mechanism of the lactose permease from Escherichia coli

  2001cited by this paper
• Functional estimation of loop-helix boundaries in the lactose permease of Escherichia coli by single amino acid deletion analysis.

  2001cited by this paper
• Molecular characterization of substrate-binding sites in the glutamate transporter family.

  2001cited by this paper
• Site-directed sulfhydryl labeling of the lactose permease of Escherichia coli: helices IV and V that contain the major determinants for substrate binding.

  2001cited by this paper
• Functional estimation of loop-helix boundaries in the lactose permease of Escherichia coli by single amino acid deletion analysis.

  2001cited by this paper
• Structure-function relationships of integral membrane proteins: membrane transporters vs channels.

  2000cited by this paper
• Thiol cross-linking of transmembrane domains IV and V in the lactose permease of Escherichia coli.

  2000cited by this paper
• Proteomics on full-length membrane proteins using mass spectrometry.

  2000cited by this paper
• Ligand recognition by the lactose permease of Escherichia coli: specificity and affinity are defined by distinct structural elements of galactopyranosides.

  2000cited by this paper
• Thiol cross-linking of transmembrane domains IV and V in the lactose permease of Escherichia coli.

  2000cited by this paper
• Unraveling the mechanism of the lactose permease of Escherichia coli.

  2000cited by this paper
• Characterization of Glu126 and Arg144, two residues that are indispensable for substrate binding in the lactose permease of Escherichia coli.

  1999cited by this paper
• Estimating Loop−Helix Interfaces in a Polytopic Membrane Protein by Deletion Analysis†

  1999cited by this paper
• Proximity between Glu126 and Arg144 in the lactose permease of Escherichia coli.

  1999cited by this paper
• Nitroxide scanning electron paramagnetic resonance of helices IV and V and the intervening loop in the lactose permease of Escherichia coli.

  1999cited by this paper
• Toward the bilayer proteome, electrospray ionization-mass spectrometry of large, intact transmembrane proteins.

  1999cited by this paper
• Estimating loop-helix interfaces in a polytopic membrane protein by deletion analysis.

  1999cited by this paper
• Major Facilitator Superfamily

  1998cited by this paper
• Cys‐scanning mutagenesis: a novel approach to structure—function relationships in polytopic membrane proteins

  1998cited by this paper
• Fourier transform infrared analysis of purified lactose permease: a monodisperse lactose permease preparation is stably folded, alpha-helical, and highly accessible to deuterium exchange.

  1998cited by this paper
• The substrate-binding site in the lactose permease of Escherichia coli.

  1998cited by this paper
• Electrospray‐ionization mass spectrometry of intact intrinsic membrane proteins

  1998cited by this paper
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  1998cited by this paper
• Fourier transform infrared spectroscopy reveals a rigid alpha-helical assembly for the tetrameric Streptomyces lividans K+ channel.

  1998cited by this paper
• The lipid bilayer determines helical tilt angle and function in lactose permease of Escherichia coli.

  1997cited by this paper
• Interaction between residues Glu269 (helix VIII) and His322 (helix X) of the lactose permease of Escherichia coli is essential for substrate binding.

  1997cited by this paper
• Structural foundation for the design of receptor antagonists targeting Escherichia coli heat-labile enterotoxin.

  1997cited by this paper
• From membrane to molecule to the third amino acid from the left with a membrane transport protein

  1997cited by this paper
• A molecular mechanism for energy coupling in a membrane transport protein, the lactose permease of Escherichia coli.

  1997cited by this paper
• Proximity of periplasmic loops in the lactose permease of Escherichia coli determined by site-directed cross-linking.

  1997cited by this paper
• Cysteine-scanning mutagenesis of helix IV and the adjoining loops in the lactose permease of Escherichia coli: Glu126 and Arg144 are essential. off.

  1997cited by this paper
• Interaction between residues Glu269 (helix VIII) and His322 (helix X) of the lactose permease of Escherichia coli is essential for substrate binding.

  1997cited by this paper
• The lac Operon: A Short History of a Genetic Paradigm

  1996cited by this paper
• Probing the conformation of the lactose permease of Escherichia coli by in situ site-directed sulfhydryl modification.

  1996cited by this paper
• Engineering a metal binding site within a polytopic membrane protein, the lactose permease of Escherichia coli.

  1995cited by this paper
• Use of designed metal-binding sites to study helix proximity in the lactose permease of Escherichia coli. 1. Proximity of helix VII (Asp237 and Asp240) with helices X (Lys319) and XI (Lys358).

  1995cited by this paper
• Helix packing in the sucrose permease of Escherichia coli: properties of engineered charge pairs between helices VII and XI.

  1995cited by this paper
• Membrane topology of helices VII and XI in the lactose permease of Escherichia coli studied by lacY-phoA fusion analysis and site-directed spectroscopy.

  1995cited by this paper
• Use of designed metal-binding sites to study helix proximity in the lactose permease of Escherichia coli. 2. Proximity of helix IX (Arg302) with helix X (His322 and Glu325).

  1995cited by this paper
• Properties of permease dimer, a fusion protein containing two lactose permease molecules from Escherichia coli.

  1994cited by this paper
• Role of glutamate-269 in the lactose permease of Escherichia coli.

  1994cited by this paper
• Cysteine 148 in the lactose permease of Escherichia coli is a component of a substrate binding site. 1. Site-directed mutagenesis studies.

  1994cited by this paper
• Functional roles of Glu-269 and Glu-325 within the lactose permease of Escherichia coli.

  1994cited by this paper
• Expression of lactose permease in contiguous fragments as a probe for membrane-spanning domains.

  1994cited by this paper
• Properties of interacting aspartic acid and lysine residues in the lactose permease of Escherichia coli.

  1993cited by this paper
• Properties and purification of an active biotinylated lactose permease from Escherichia coli.

  1993cited by this paper
• Role of the charge pair aspartic acid-237-lysine-358 in the lactose permease of Escherichia coli.

  1993cited by this paper
• Use of site-directed fluorescence labeling to study proximity relationships in the lactose permease of Escherichia coli.

  1993cited by this paper
• Functional complementation of internal deletion mutants in the lactose permease of Escherichia coli.

  1992cited by this paper
• Isotope effects on enzyme-catalyzed reactions

  1992cited by this paper
• Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography

  1992cited by this paper
• Possible salt bridges between transmembrane alpha-helices of the lactose carrier of Escherichia coli.

  1992cited by this paper
• Functional interactions between putative intramembrane charged residues in the lactose permease of Escherichia coli.

  1992cited by this paper
• The interaction between aspartic acid 237 and lysine 358 in the lactose carrier of Escherichia coli.

  1991cited by this paper
• lac permease of Escherichia coli: topology and sequence elements promoting membrane insertion.

  1990cited by this paper
• Reconstitution of an active lactose carrier in vivo by simultaneous synthesis of two complementary protein fragments

  1990cited by this paper
• In vivo expression of the lacY gene in two segments leads to functional lac permease.

  1990cited by this paper
• The lactose permease of Escherichia coli.

  1990cited by this paper
• Site-directed mutagenesis of tyrosine residues in the lac permease of Escherichia coli.

  1989cited by this paper
• lac permease of Escherichia coli containing a single histidine residue is fully functional.

  1988cited by this paper
• Purified lac permease and cytochrome o oxidase are functional as monomers.

  1987cited by this paper
• Size and shape of the Escherichia coli lactose permease measured in filamentous arrays.

  1987cited by this paper
• Molecular biology of active transport: from membrane to molecule to mechanism.

  1987cited by this paper
• Molecular biology of active transport: from membrane to molecule to mechanism.

  1987cited by this paper
• Escherichia Coli and Salmonella: Typhimurium Cellular and Molecular Biology

  1987cited by this paper
• lac permease of Escherichia coli: arginine-302 as a component of the postulated proton relay.

  1987cited by this paper
• lac permease of Escherichia coli: histidine-205 and histidine-322 play different roles in lactose/H+ symport.

  1986cited by this paper
• The size of the lactose permease derived from rotational diffusion measurements.

  1985cited by this paper
• Site-specific mutagenesis of histidine residues in the lac permease of Escherichia coli.

  1985cited by this paper
• Topological Studies of Lactose Permease of Escherichia coli by Protein Sequence Analysis a

  1985cited by this paper
• The structure of the lactose permease derived from Raman spectroscopy and prediction methods.

  1985cited by this paper
• cys154 Is important for lac permease activity in Escherichia coli.

  1985cited by this paper
• Morphology of proteoliposomes reconstituted with purified lac carrier protein from Escherichia coli.

  1984cited by this paper

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