RHOB influences lung adenocarcinoma metastasis and resistance in a host‐sensitive manner

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Molecular Oncology

• Publication date

  2014-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.molonc.2013.11.001PMID 24321314PMCID PMC5528549
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A gene signature of bone metastatic colonization sensitizes for tumor-induced osteolysis and predicts survival in lung cancer

  2014cited by this paper
• RHOB influences lung adenocarcinoma metastasis and resistance in a host‐sensitive manner

  2014cited by this paper
• RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis.

  2013cited by this paper
• RhoB regulates cell migration through altered focal adhesion dynamics

  2012cited by this paper
• RhoB regulates uPAR signalling

  2012cited by this paper
• A CXCL1 paracrine network links cancer chemoresistance and metastasis.

  2012cited by this paper
• Receptor of activated protein C promotes metastasis and correlates with clinical outcome in lung adenocarcinoma.

  2012cited by this paper
• PDGFR signaling blockade in marrow stroma impairs lung cancer bone metastasis.

  2011cited by this paper
• A distinct role of RhoB in gastric cancer suppression

  2011cited by this paper
• Tumor–stromal interactions of the bone microenvironment: in vitro findings and potential in vivo relevance in metastatic lung cancer models

  2011cited by this paper
• Cancer Statistics, 2010

  2010cited by this paper
• Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer.

  2010cited by this paper
• Tumor-Stromal Interactions Influence Radiation Sensitivity in Epithelial- versus Mesenchymal-Like Prostate Cancer Cells

  2010cited by this paper
• siRNA-Mediated Downregulation of MMP-9 and uPAR in Combination with Radiation Induces G2/M Cell-Cycle Arrest in Medulloblastoma

  2010cited by this paper
• Microenvironmental regulation of metastasis

  2009cited by this paper
• ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis.

  2009cited by this paper
• MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer.

  2009cited by this paper
• Loss of RhoB expression promotes migration and invasion of human bronchial cells via activation of AKT1.

  2009cited by this paper
• WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis.

  2009cited by this paper
• MTDH Activation by 8 q 22 Genomic Gain Promotes Chemoresistance and Metastasis of Poor-Prognosis Breast Cancer

  2008cited by this paper
• SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis

  2008cited by this paper
• αvβ3 and αvβ5 integrins control glioma cell response to ionising radiation through ILK and RhoB

  2008cited by this paper
• A novel lung cancer signature mediates metastatic bone colonization by a dual mechanism.

  2008cited by this paper
• SATB 1 reprogrammes gene expression to promote breast tumour growth and metastasis

  2008cited by this paper
• In vivo restoration of RhoB expression leads to ovarian tumor regression

  2008cited by this paper
• Wnt5a Control of Cell Polarity and Directional Movement by Polarized Redistribution of Adhesion Receptors

  2008cited by this paper
• Class III β-Tubulin Mediates Sensitivity to Chemotherapeutic Drugs in Non–Small Cell Lung Cancer

  2007cited by this paper
• Mediators of vascular remodelling co-opted for sequential steps in lung metastasis

  2007cited by this paper
• RhoB is frequently downregulated in non‐small‐cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line

  2007cited by this paper
• Class III beta-tubulin mediates sensitivity to chemotherapeutic drugs in non small cell lung cancer.

  2007cited by this paper
• Oncogenic pathway signatures in human cancers as a guide to targeted therapies

  2006cited by this paper
• Metastatic patterns in adenocarcinoma

  2006cited by this paper
• OROPHARYNGEAL ASPIRATION OF A SILICA SUSPENSION PRODUCES A SUPERIOR MODEL OF SILICOSIS IN THE MOUSE WHEN COMPARED TO INTRATRACHEAL INSTILLATION

  2006cited by this paper
• Activation of RhoB by hypoxia controls hypoxia-inducible factor-1alpha stabilization through glycogen synthase kinase-3 in U87 glioblastoma cells.

  2006cited by this paper
• Genes that mediate breast cancer metastasis to lung

  2005cited by this paper
• RhoB regulates endosome transport by promoting actin assembly on endosomal membranes through Dia1

  2005cited by this paper
• Rho GTPases: biochemistry and biology.

  2005cited by this paper
• Akt Mediates Ras Downregulation of RhoB, a Suppressor of Transformation, Invasion, and Metastasis

  2004cited by this paper
• Loss of RhoB Expression in Human Lung Cancer Progression

  2004cited by this paper
• Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis.

  2004cited by this paper
• The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

  2003cited by this paper
• Inhibition of Rho pathways induces radiosensitization and oxygenation in human glioblastoma xenografts

  2003cited by this paper
• A multigenic program mediating breast cancer metastasis to bone.

  2003cited by this paper
• RhoB controls the 24 kDa FGF-2-induced radioresistance in HeLa cells by preventing post-mitotic cell death

  2002cited by this paper
• Rho GTPases in transformation and metastasis.

  2002cited by this paper
• RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage

  2001cited by this paper
• RhoB Is Dispensable for Mouse Development, but It Modifies Susceptibility to Tumor Formation as Well as Cell Adhesion and Growth Factor Signaling in Transformed Cells

  2001cited by this paper
• Actin' up: RhoB in cancer and apoptosis

  2001cited by this paper
• Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics

  2001cited by this paper
• TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development.

  1999cited by this paper
• Geranylgeranylated RhoB mediates suppression of human tumor cell growth by farnesyltransferase inhibitors.

  1999cited by this paper
• PRK1 Is Targeted to Endosomes by the Small GTPase, RhoB*

  1998cited by this paper
• RhoB Is Stabilized by Transforming Growth Factor β and Antagonizes Transcriptional Activation*

  1998cited by this paper
• Incidence of local recurrence and second primary tumors in resected stage I lung cancer.

  1995cited by this paper
• Critical role of Rho in cell transformation by oncogenic Ras.

  1995cited by this paper
• Cancer statistics

  1989cited by this paper
• Sites of recurrence in resected stage I non-small-cell lung cancer: a guide for future studies.

  1984cited by this paper

• A new single chain, genetically encoded biosensor for RhoB GTPase based on FRET, useful for live-cell imaging

  2026cites this paper
• A New Single-Chain, Genetically Encoded Biosensor for RhoB GTPase Based on FRET, Useful for Live-Cell Imaging.

  2026cites this paper
• RhoB-Rab1A forms a mechanobiology module that couples cytoskeletal organization to nuclear mechanics and β-catenin access in epithelial cells.

  2026cites this paper
• Comprehensive analysis of a machine learning prognostic model for the interaction between mitochondrial function and lactylation in lung adenocarcinoma

  2025cites this paper
• Dual ENPP1/ATM depletion blunts DNA damage repair boosting radioimmune efficacy to abrogate triple-negative breast cancer

  2025cites this paper
• TNIK Regulates Cytoskeletal Organization to Promote Focal Adhesion Turnover and Mitosis in Lung Adenocarcinoma.

  2025cites this paper
• MiR-21-5p knockdown inhibits epithelial to mesenchymal transition in A549 lung adenocarcinoma cells by upregulating RhoB

  2024cites this paper
• CERS4 predicts positive anti-PD-1 response and promotes immunomodulation through Rhob-mediated suppression of CD8+Tim3+ exhausted T cells in non-small cell lung cancer.

  2023cites this paper
• Metastatic Lung Cancer to the Head and Neck: A Clinico-Pathological Study on 21 Cases with Narrative Review of the Literature

  2023cites this paper
• Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer

  2022cites this paper
• Perinatal Exposure to Nicotine Alters Sperm RNA Profiles in Rats

  2022cites this paper
• Tensor Decomposition of Largest Convolutional Eigenvalues Reveals Pathological Predictive Power of RhoB in Rectal Cancer Biopsy.

  2021cites this paper
• Rho GTPases: Promising Candidates for Overcoming Chemotherapeutic Resistance.

  2020cites this paper
• Primary tumor and metastasis—sectioning the different steps of the metastatic cascade

  2020cites this paper
• Rho GTPases in cancer radiotherapy and metastasis

  2020cites this paper
• MiR-223-3p regulates cell viability, migration, invasion, and apoptosis of non-small cell lung cancer cells by targeting RHOB

  2020cites this paper
• Regulation of RhoB Gene Expression during Tumorigenesis and Aging Process and Its Potential Applications in These Processes

  2019cites this paper
• The critical role of dysregulated RhoB signaling pathway in radioresistance of colorectal cancer.

  2019cites this paper
• Transcriptional and post-transcriptional regulation of the genes encoding the small GTPases RhoA, RhoB, and RhoC: implications for the pathogenesis of human diseases

  2018cites this paper
• Cytoplasmic p27Kip1 promotes tumorigenesis via suppression of RhoB activity

  2018cites this paper
• Blockade of the Complement C5a/C5aR1 Axis Impairs Lung Cancer Bone Metastasis by CXCL16‐mediated Effects

  2018cites this paper
• Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation

  2018cites this paper
• RhoB: Team Oncogene or Team Tumor Suppressor?

  2018cites this paper
• The mechanisms and significance of up‐regulation of RhoB expression by hypoxia and glucocorticoid in rat lung and A549 cells

  2016cites this paper
• Microtubule and Actin Interplay Drive Intracellular c-Src Trafficking

  2016cites this paper
• Progression and metastasis of lung cancer

  2016cites this paper
• Sp1-driven up-regulation of miR-19a decreases RHOB and promotes pancreatic cancer

  2015cites this paper
• Critical functions of RhoB in support of glioblastoma tumorigenesis.

  2015influential citation
• Construction and analysis of three networks of genes and microRNAs in adenocarcinoma.

  2015cites this paper
• RhoB Determines Tumor Aggressiveness in a Murine EGFRL858R-Induced Adenocarcinoma Model and Is a Potential Prognostic Biomarker for Lepidic Lung Cancer

  2014cites this paper
• Biology of Human Tumors RhoB Determines Tumor Aggressiveness in a Murine EGFRL 858 R-Induced Adenocarcinoma Model and Is a Potential Prognostic Biomarker for Lepidic Lung Cancer

  2014cites this paper
• miRNA cargo within exosome‐like vesicle transfer influences metastatic bone colonization

  2014cites this paper
• RHOB influences lung adenocarcinoma metastasis and resistance in a host‐sensitive manner

  2014cites this paper