Endotoxemia is associated with rapid and marked declines in serum levels of LDL and HDL by unknown mechanisms. Six normal volunteers received a single, small intravenous (iv) dose of endotoxin (Escherichia coli 0113, 2 ng/kg) or saline in a random order, cross-over design. After endotoxin treatment, volunteers had mild, transient flu-like symptoms and markedly increased serum levels of tumor necrosis factor and its soluble receptors, interleukin-6, cortisol, serum amyloid A, and C-reactive protein. Triglyceride (TG), VLDL-TG, and nonesterified fatty acid increased (peak at 3–4 h), then TG declined (nadir at 9 h), and then cholesterol, LDL cholesterol, apolipoprotein B (apoB), and phospholipid declined (nadirs at 12–24 h). HDL cholesterol and apoA-I levels were not affected, but half of the decrease in phospholipid was HDL phospholipid. Lipopolysaccharide binding protein (LBP) rose 3-fold (peak at 12 h), with smaller and later decreases in the activities of phospholipid transfer protein and cholesteryl ester transfer protein. In conclusion, a decline in LDL was rapidly induced in normal volunteers with a single iv dose of endotoxin. The selective loss of phospholipid from HDL may have been mediated by LBP and, after more intense or prolonged inflammation, could result in increased HDL clearance and reduced HDL levels.
A single intravenous dose of endotoxin rapidly alters serum lipoproteins and lipid transfer proteins in normal volunteers Published, JLR Papers in Press, May 16, 2003. DOI 10.1194/jlr.M200440-JLR200
L. Hudgins,T. Parker,D. Levine,B. Gordon,S. Saal,Xian-Cheng Jiang,C. Seidman,Jolanta D. Tremaroli,J. Lai,A. Rubin
Published 2003 in Journal of Lipid Research
ABSTRACT
PUBLICATION RECORD
- Publication year
2003
- Venue
Journal of Lipid Research
- Publication date
2003-08-01
- Fields of study
Medicine, Chemistry
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
CITATION MAP
EXTRACTION MAP
CLAIMS
CONCEPTS
- apoa-i
The principal apolipoprotein of HDL that was measured in serum during the challenge.
Aliases: apolipoprotein A-I
- apolipoprotein b
The main structural apolipoprotein of LDL and VLDL measured in serum during the challenge.
Aliases: apoB
- endotoxin
An intravenous bacterial endotoxin challenge used to trigger an acute inflammatory response in the volunteers.
Aliases: lipopolysaccharide, LPS
- hdl phospholipid
The phospholipid fraction carried on HDL particles and measured as part of serum lipoprotein composition.
Aliases: HDL phospholipids
- high-density lipoprotein cholesterol
The cholesterol fraction associated with high-density lipoprotein particles that was measured in serum during the challenge.
Aliases: HDL cholesterol, HDL
- lipopolysaccharide binding protein
An acute-phase plasma protein that binds lipopolysaccharide and was measured in serum after endotoxin exposure.
Aliases: LBP
- low-density lipoprotein cholesterol
The cholesterol fraction associated with low-density lipoprotein particles that was tracked in serum over time.
Aliases: LDL cholesterol, LDL
- triglyceride
A circulating neutral lipid measured repeatedly in serum after the infusion challenge.
Aliases: TG
REFERENCES
Showing 1-59 of 59 references · Page 1 of 1