Improved reliability of lymphoma diagnostics via PCR-based clonality testing: — Report of the BIOMED-2 Concerted Action BHM4-CT98-3936

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Leukemia

• Publication date

  2007-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.leu.2404467PMID 17170732
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Non-Hodgkin lymphoma: an update.

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• Clonality analysis for antigen receptor genes: preliminary results from the Biomed-2 concerted action PL 96-3936.

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• E.S. Jaffe, N.L. Harris, H. Stein, J.W. Vardiman (eds). World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues

  2002cited by this paper
• Molecular genetic methods in the diagnosis of hematologic neoplasms.

  2002cited by this paper
• The World Health Organization (WHO) classification of the myeloid neoplasms.

  2002cited by this paper
• Ordered recombination of immunoglobulin light chain genes occurs at the IGK locus but seems less strict at the IGL locus.

  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• Detection of immunoglobulin heavy-chain gene rearrangements by Southern blot analysis: recommendations for optimal results.

  1993cited by this paper
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  1991cited by this paper
• Analysis of immunoglobulin and T cell receptor genes. Part II: Possibilities and limitations in the diagnosis and management of lymphoproliferative diseases and related disorders.

  1991cited by this paper
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  1990cited by this paper
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  1988cited by this paper
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  1987cited by this paper
• Analysis of immunoglobulin genes and T cell receptor genes as a diagnostic tool for the detection of lymphoid malignancies.

  1987cited by this paper
• Circulating monoclonal B lymphocytes in non-Hodgkin's lymphoma.

  1984cited by this paper
• Somatic generation of antibody diversity.

  1976cited by this paper

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  2025cites this paper
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