TRP channel–associated factors are a novel protein family that regulates TRPM8 trafficking and activity

D. Gkika,L. Lemonnier,G. Shapovalov,D. Gordienko,C. Poux,M. Bernardini,A. Bokhobza,G. Bidaux,C. Degerny,Kathye Verreman,B. Guarmit,M. Benahmed,Y. De Launoit,R. Bindels,A. F. Pla,N. Prevarskaya

Published 2015 in Journal of Cell Biology

ABSTRACT

TCAF1 and TCAF2 bind to TRPM8 and promote its cell surface trafficking but differentially regulate its gating properties, leading to opposing effects on prostate cancer cell migration.

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