Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Development

• Publication date

  1995-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 8582296
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cold Spring Harbor Laboratory.

  2014cited by this paper
• Targeted Disruption of Retinoic Acid Receptor a (RARa) and RARg Results in Receptor-Specific Alterations in Retinoic Acid-Mediated Differentiation and Retinoic Acid Metabolism

  1995cited by this paper
• The GATA-4 transcription factor transactivates the cardiac-specific troponin C promoter-enhancer in non-muscle cells.

  1995cited by this paper
• Targeted disruption of retinoic acid receptor alpha (RAR alpha) and RAR gamma results in receptor-specific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism

  1995cited by this paper
• Initiation of hematopoiesis and vasculogenesis in murine yolk sac explants.

  1995cited by this paper
• The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo.

  1995cited by this paper
• Development of hematopoietic cells lacking transcription factor GATA-1.

  1995cited by this paper
• Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells.

  1994influential reference
• An early haematopoietic defect in mice lacking the transcription factor GATA-2

  1994influential reference
• Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos.

  1994influential reference
• Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system.

  1994cited by this paper
• Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst.

  1994cited by this paper
• msd is required for mesoderm induction in mice.

  1994cited by this paper
• Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus.

  1994cited by this paper
• GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.

  1994influential reference
• Muscle cell differentiation of embryonic stem cells reflects myogenesis in vivo: developmentally regulated expression of myogenic determination genes and functional expression of ionic currents.

  1994cited by this paper
• Murine yolk sac endoderm- and mesoderm-derived cell lines support in vitro growth and differentiation of hematopoietic cells.

  1994cited by this paper
• Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene

  1994cited by this paper
• A hormone-encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription

  1994cited by this paper
• Retinoids and vertebrate development.

  1994cited by this paper
• Regulation of rat brain natriuretic peptide transcription. A potential role for GATA-related transcription factors in myocardial cell gene expression.

  1994cited by this paper
• The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells

  1994cited by this paper
• Implantation and the placenta: key pieces of the development puzzle.

  1994cited by this paper
• Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis.

  1994cited by this paper
• Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac development.

  1994cited by this paper
• High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis.

  1993influential reference
• GATA-4 is a novel transcription factor expressed in endocardium of the developing heart.

  1993cited by this paper
• Loss of retinoic acid receptor gamma function in F9 cells by gene disruption results in aberrant Hoxa-1 expression and differentiation upon retinoic acid treatment.

  1993cited by this paper
• Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart

  1993cited by this paper
• Gastric DNA-binding proteins recognize upstream sequence motifs of parietal cell-specific genes.

  1993influential reference
• In vitro chamber specification during embryonic stem cell cardiogenesis. Expression of the ventricular myosin light chain-2 gene is independent of heart tube formation.

  1993cited by this paper
• Production of chimeras and genetically defined offspring from targeted ES cells.

  1993cited by this paper
• Targeted deletion of beta 1 integrins in F9 embryonal carcinoma cells affects morphological differentiation but not tissue-specific gene expression

  1993influential reference
• Hematopoietic commitment during embryonic stem cell differentiation in culture.

  1993cited by this paper
• Production of targeted embryonic stem cell clones.

  1993cited by this paper
• GATA-binding transcription factors in hematopoietic cells.

  1992cited by this paper
• Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine H beta 58 embryonic lethal transgene insertion.

  1992cited by this paper
• Embryonic stem cell-derived cystic embryoid bodies form vascular channels: an in vitro model of blood vessel development.

  1992cited by this paper
• Production of homozygous mutant ES cells with a single targeting construct

  1992influential reference
• Rescue of erythroid development in gene targeted GATA–1− mouse embryonic stem cells

  1992cited by this paper
• Characterization of gap junction genes expressed in F9 embryonic carcinoma cells: molecular cloning of mouse connexin31 and -45 cDNAs.

  1992influential reference
• Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene.

  1991cited by this paper
• Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3 suggest different developmental functions in vivo.

  1991cited by this paper
• Angioblast differentiation and morphogenesis of the vascular endothelium in the mouse embryo.

  1991cited by this paper
• Myosin heavy chain gene expression in mouse embryoid bodies. An in vitro developmental study.

  1991cited by this paper
• Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

  1991cited by this paper
• Development, morphology, and function of the yolk-sac placenta of laboratory rodents.

  1990cited by this paper
• Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development.

  1989cited by this paper
• Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies.

  1988cited by this paper
• Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

  1988cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Teratocarcinomas and embryonic stem cells : a practical approach

  1987influential reference
• Experimental approaches to mammalian embryonic development: Molecular and biochemical aspects

  1987cited by this paper
• Reactivity of five N-acetylgalactosamine-recognizing lectins with preimplantation embryos, early postimplantation embryos, and teratocarcinoma cells of the mouse.

  1985influential reference
• The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium.

  1985influential reference
• Fluorescein-conjugated Bandeiraea simplicifolia lectin as a marker of endodermal, yolk sac, and trophoblastic differentiation in the mouse embryo.

  1983influential reference
• Origin and differentiation of extraembryonic tissues in the mouse.

  1983cited by this paper
• Role of laminin in epithelium formation by F9 aggregates

  1983cited by this paper
• Origin and differentiation of extraembryonic tissues in the mouse.

  1983cited by this paper
• Teratocarcinoma stem cells

  1983cited by this paper
• Cell interactions and endoderm differentiation in cultured mouse embryos.

  1981cited by this paper
• Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).

  1978cited by this paper
• Tissue interaction and the formation of the first erythroblasts of the chick embryo.

  1969cited by this paper
• Erythropoiesis in the Chick Embryo: The Role of Endoderm

  1965cited by this paper
• Embryonic gene expression patterns of TGF /ft, f$2 and p3 suggest different developmental functions in vivo

  year unknowninfluential reference

• Characterization of somatic testicular cells during human development: fetal, peripubertal, adolescent and adult human testis from healthy and infertility related disease.

  2025cites this paper
• Nuclear compression-mediated DNA damage drives ATR-dependent Lamin expression and mouse ESC differentiation

  2025cites this paper
• KINDLE: Knowledge-Guided Distillation for Prior-Free Gene Regulatory Network Inference

  2025cites this paper
• Evolutionarily conserved Wnt/Sp5 signaling is critical for anterior-posterior axis patterning in sea urchin embryos

  2023cites this paper
• Extensive co-binding and rapid redistribution of NANOG and GATA6 during emergence of divergent lineages

  2022cites this paper
• Journey of the mouse primitive endoderm: from specification to maturation

  2022cites this paper
• Klf4 methylated by Prmt1 restrains the commitment of primitive endoderm

  2022cites this paper
• Extensive co-binding and rapid redistribution of NANOG and GATA6 during emergence of divergent lineages

  2022cites this paper
• Specification and role of extraembryonic endoderm lineages in the periimplantation mouse embryo.

  2021cites this paper
• Rapid redistribution and extensive binding of NANOG and GATA6 at shared regulatory elements underlie specification of divergent cell fates

  2021cites this paper
• Hepatic Differentiation of Marmoset Embryonic Stem Cells and Functional Characterization of ESC-Derived Hepatocyte-Like Cells

  2020cites this paper
• Hepatic Differentiation of Marmoset Embryonic Stem Cells and Functional Characterization of ESC-Derived Hepatocyte-Like Cells

  2020cites this paper
• WNT signalling supported by MEK/ERK inhibition is essential to maintain pluripotency in bovine preimplantation embryo.

  2020cites this paper
• Klf4 methylated by Prmt1 is required for lineage segregation of epiblast and primitive endoderm

  2020cites this paper
• DNA methylation patterns expose variations in enhancer-chromatin modifications during embryonic stem cell differentiation

  2020cites this paper
• Identification of novel transcription factors in the development and function of the Drosophila renal tubule

  2019cites this paper
• Inhibitory action of an ERK1/2 inhibitor on primitive endoderm cell differentiation from mouse embryonic stem cells.

  2019cites this paper
• The role of CXC receptors signaling in early stages of mouse embryonic stem cell differentiation.

  2019cites this paper
• The Impact of Endothelial Transcription Factors in Sprouting Angiogenesis

  2019cites this paper
• Utilising embryonic and extra-embryonic stem cells to model early mammalian embryogenesis in vitro

  2018cites this paper
• Mitochondrial ROS direct the differentiation of murine pluripotent P19 cells.

  2018cites this paper
• Pre-implantation Development of Domestic Animals.

  2018cites this paper
• A Gata4 nuclear GFP transcriptional reporter to study endoderm and cardiac development in the mouse

  2018cites this paper
• Suppression of ERK signalling abolishes primitive endoderm formation but does not promote pluripotency in rabbit embryo

  2017influential citation
• DOT1L inhibitor improves early development of porcine somatic cell nuclear transfer embryos

  2017cites this paper
• Abrogation of Gap Junctional Communication in ES Cells Results in a Disruption of Primitive Endoderm Formation in Embryoid Bodies

  2017cites this paper
• Embryonic Stem Cell Differentiation and Morphogenesis

  2017cites this paper
• The landscape of accessible chromatin in mammalian preimplantation embryos

  2016cites this paper
• DNA methylation markers for early detection of colorectal cancer : clinical applicability and biological function

  2016cites this paper
• Cell fate in animal and human blastocysts and the determination of viability.

  2016cites this paper
• The emerging role of GATA transcription factors in development and disease

  2016cites this paper
• The Germ Cell Fate of Cynomolgus Monkeys Is Specified in the Nascent Amnion.

  2016cites this paper
• Gata6 potently initiates reprograming of pluripotent and differentiated cells to extraembryonic endoderm stem cells

  2015influential citation
• Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern

  2015cites this paper
• Embryonic stem cell differentiation requires full length Chd1

  2015cites this paper
• Generation of mineralised cellular constructs using mouse embryonic stem cells encapsulated in alginate hydrogels and cultured within a custom-made rotating wall vessel perfusion bioreactor

  2015cites this paper
• Sox17 Regulates Dynamic Gene Regulatory Networks to Specify Cell Fates in Pluripotent Stem Cells

  2015cites this paper
• Characterization of the finch embryo supports evolutionary conservation of the naive stage of development in amniotes

  2015cites this paper
• Molecular role of Pelota (PELO) in differentiation of embryonic and germ stem cells

  2015cites this paper
• Sox7 is dispensable for primitive endoderm differentiation from mouse ES cells

  2015cites this paper
• Embryoid body size-mediated differential endodermal and mesodermal differentiation using polyethylene glycol (PEG) microwell array

  2015cites this paper
• Correction: Formation of a Polarised Primitive Endoderm Layer in Embryoid Bodies Requires Fgfr/Erk Signalling

  2015cites this paper
• Lessons from the heart: mirroring electrophysiological characteristics during cardiac development to in vitro differentiation of stem cell derived cardiomyocytes.

  2014cites this paper
• Primitive endoderm differentiation: from specification to epithelium formation

  2014cites this paper
• Cell fate specification and polarisation in mouse preimplantation epithelia

  2014influential citation
• Formation of a Polarised Primitive Endoderm Layer in Embryoid Bodies Requires Fgfr/Erk Signalling

  2014cites this paper
• The role of GATA factors in development, differentiation, and

  2014cites this paper
• Role of GATA factors in development, differentiation, and homeostasis of the small intestinal epithelium.

  2014cites this paper
• Pelota regulates the development of extraembryonic endoderm through activation of bone morphogenetic protein (BMP) signaling.

  2014cites this paper
• Endoderm Complexity in the Mouse Gastrula Is Revealed Through the Expression of Spink3

  2014cites this paper
• miR-200c and GATA binding protein 4 regulate human embryonic stem cell renewal and differentiation.

  2014cites this paper
• Unilateral cryptorchidism induces morphological changes of testes and hyperplasia of Sertoli cells in a dog

  2014cites this paper
• Tbx1 Modulates Endodermal and Mesodermal Differentiation from Mouse Induced Pluripotent Stem Cells

  2014cites this paper
• The formation of proximal and distal definitive endoderm populations in culture requires p38 MAPK activity

  2014cites this paper
• Expression analysis of BORIS during pluripotent, differentiated, cancerous, and non-cancerous cell states.

  2014cites this paper
• Signaling Events During Extraembryonic Endoderm Differentiation

  2014cites this paper
• Dissecting the Role of the Stem Cell Niche in Driving Conversion Between Pluripotent States

  2014cites this paper
• SCM 1 8 8 1 24 2 18 14 0 24 3

  2014cites this paper
• Early cell fate decisions in the mouse embryo.

  2013cites this paper
• Lamin A/C Haploinsufficiency Modulates the Differentiation Potential of Mouse Embryonic Stem Cells

  2013cites this paper
• Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.

  2013influential citation
• Atypical protein kinase C couples cell sorting with primitive endoderm maturation in the mouse blastocyst

  2013cites this paper
• Mutation p.S335X in GATA4 reduces its DNA binding affinity and enhances cell apoptosis associated with ventricular septal defect.

  2013cites this paper
• Understanding the electrophysiological maturation of human adult cardiomyocytes: lessons from the heart to be used for differentiation of pluripotent stem cells into cardiomyocytes

  2013cites this paper
• Troika of the mouse blastocyst: lineage segregation and stem cells.

  2012cites this paper
• ES cell potency fluctuates with endogenous retrovirus activity

  2012cites this paper
• GATA6 and FOXA2 Regulate Wnt6 Expression During Extraembryonic Endoderm Formation

  2012cites this paper
• Dissecting the Role of Morphogenesis in the Origins of the First Two Cell Lineages in the Mouse Embryo

  2012cites this paper
• TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells

  2012cites this paper
• Mechanisms of cardiogenesis in cardiovascular progenitor cells.

  2012cites this paper
• Regulation of cell fate and cell behaviour during primitive endoderm formation in the early mouse embryo

  2012cites this paper
• The endogenous retrovirus ENS-1 provides active binding sites for transcription factors in embryonic stem cells that specify extra embryonic tissue

  2012cites this paper
• Using mouse embryonic fibroblast (MEF) as feeder cells for production of embryonic stem cell (ESC) line in the murine and caprine / Goh Siew Ying

  2012cites this paper
• A repetitive elements perspective in Polycomb epigenetics

  2012cites this paper
• Cell fate regulation in early mammalian development

  2012cites this paper
• A System to Enrich for Primitive Streak-Derivatives, Definitive Endoderm and Mesoderm, from Pluripotent Cells in Culture

  2012cites this paper
• Intercellular interactions, position, and polarity in establishing blastocyst cell lineages and embryonic axes.

  2012cites this paper
• Transgenic mouse analysis of Sry expression during the pre‐ and peri‐implantation stage

  2012cites this paper
• Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states

  2012cites this paper
• LINE-1 Based Insertional Mutagenesis Screens to Identify Genes Involved in Embryonic Stem Cell Differentiation

  2012cites this paper
• Congenital Heart Disease–Causing Gata4 Mutation Displays Functional Deficits In Vivo

  2012cites this paper
• Le peptide natriurétique auriculaire induit la différenciation cardiaque dans les cellules souches embryonnaires carcinomateuses de souris P19

  2012cites this paper
• Vertebrate intestinal endoderm development

  2011cites this paper
• Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation

  2011cites this paper
• Fibroblast Growth Factor 2 Promotes Primitive Endoderm Development in Bovine Blastocyst Outgrowths1

  2011cites this paper
• Ablation of Dido 3 compromises lineage commitment of stem cells in vitro and during early embryonic development

  2011cites this paper
• Forward and reverse genetics through derivation of haploid mouse embryonic stem cells.

  2011cites this paper
• Transcriptional Networks of Embryonic Stem Cell-Derived Cardiomyogenesis

  2011cites this paper
• An evolutionarily conserved kernel of gata5, gata6, otx2 and prdm1a operates in the formation of endoderm in zebrafish.

  2011cites this paper
• The conserved role and divergent regulation of foxa, a pan-eumetazoan developmental regulatory gene.

  2011cites this paper
• Mouse Models of Menopause and Ovarian Cancer Risks

  2011cites this paper
• Transcriptional sexual dimorphism in elongating bovine embryos: implications for XCI and sex determination genes.

  2011cites this paper
• Sequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fates

  2011cites this paper
• Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development

  2011cites this paper
• Anterior Visceral Endoderm SMAD4 Signaling Specifies Anterior Embryonic Patterning and Head Induction in Mice

  2010cites this paper
• A role for PDGF signaling in expansion of the extra-embryonic endoderm lineage of the mouse blastocyst

  2010influential citation
• Foxm1 transcription factor is required for maintenance of pluripotency of P19 embryonal carcinoma cells

  2010cites this paper
• Transcriptional control of hepatocyte differentiation.

  2010cites this paper
• Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal.

  2010cites this paper
• Facteurs génétiques impliqués dans la différenciation de l'endoderme primitif au cours du développement préimplantatoire chez la souris

  2010cites this paper