Mechanical properties of individual focal adhesions probed with a magnetic microneedle.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2004-01-16

• Fields of study

  Biology, Medicine, Materials Science, Engineering

• Identifiers
  DOI 10.1016/J.BBRC.2003.12.005PMID 14697256
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells.

  2003cited by this paper
• Cells lying on a bed of microneedles: An approach to isolate mechanical force

  2003cited by this paper
• The relationship between force and focal complex development

  2002cited by this paper
• Twisting integrin receptors increases endothelin-1 gene expression in endothelial cells.

  2001cited by this paper
• Transmembrane crosstalk between the extracellular matrix and the cytoskeleton

  2001cited by this paper
• Assembly and mechanosensory function of focal contacts.

  2001cited by this paper
• Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates

  2001cited by this paper
• Rapid stiffening of integrin receptor-actin linkages in endothelial cells stimulated with thrombin: a magnetic bead microrheology study.

  2001cited by this paper
• Focal Contacts as Mechanosensors

  2001cited by this paper
• Focal Contacts as Mechanosensors Externally Applied Local Mechanical Force Induces Growth of Focal Contacts by an Mdia1-Dependent and Rock-Independent Mechanism

  2001cited by this paper
• Receptor-Based Differences in Human Aortic Smooth Muscle Cell Membrane Stiffness

  2001cited by this paper
• Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk.

  2001cited by this paper
• Scaling the microrheology of living cells.

  2001cited by this paper
• Both Platelet-Derived Growth Factor Receptor (PDGFR)-α and PDGFR-β Promote Murine Fibroblast Cell Migration

  2001cited by this paper
• Both platelet-derived growth factor receptor (PDGFR)-alpha and PDGFR-beta promote murine fibroblast cell migration.

  2001cited by this paper
• Mechanical control of cyclic AMP signalling and gene transcription through integrins

  2000cited by this paper
• Mechanical properties of cultured human airway smooth muscle cells from 0.05 to 0.4 Hz.

  2000cited by this paper
• Analysis of cell mechanics in single vinculin-deficient cells using a magnetic tweezer.

  2000influential reference
• Focal adhesions - the cytoskeletal connection.

  2000cited by this paper
• Measurement of local viscoelasticity and forces in living cells by magnetic tweezers.

  1999cited by this paper
• Focal adhesions.

  1999cited by this paper
• Selective regulation of integrin–cytoskeleton interactions by the tyrosine kinase Src

  1999cited by this paper
• Stresses at the cell-to-substrate interface during locomotion of fibroblasts.

  1999cited by this paper
• Cell migration: regulation of force on extracellular-matrix-integrin complexes.

  1998cited by this paper
• Local measurements of viscoelastic parameters of adherent cell surfaces by magnetic bead microrheometry.

  1998cited by this paper
• Integrin binding and mechanical tension induce movement of mRNA and ribosomes to focal adhesions

  1998cited by this paper
• Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages.

  1997cited by this paper
• Vinculin promotes cell spreading by mechanically coupling integrins to the cytoskeleton.

  1997cited by this paper
• Geometric control of cell life and death.

  1997cited by this paper
• Focal adhesions, contractility, and signaling.

  1996cited by this paper
• Rho-stimulated contractility drives the formation of stress fibers and focal adhesions

  1996cited by this paper
• Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex.

  1995cited by this paper
• Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function

  1995cited by this paper
• Integrin function: molecular hierarchies of cytoskeletal and signaling molecules

  1995cited by this paper
• Probing transmembrane mechanical coupling and cytomechanics using magnetic twisting cytometry.

  1995cited by this paper
• Engineering cell shape and function.

  1994cited by this paper
• Mechanotransduction across the cell surface and through the cytoskeleton.

  1993cited by this paper
• Rapid induction and isolation of focal adhesion complexes.

  1993cited by this paper
• Fibronectin controls capillary endothelial cell growth by modulating cell shape.

  1990cited by this paper
• Role of cell shape in growth control

  1978cited by this paper

• At the Pointy End of Mechanobiology: AFM for Transient Biomechanical Analysis

  2025cites this paper
• A viscoelastic-stochastic model of cell adhesion considering matrix morphology and medium viscoelasticity.

  2024cites this paper
• Discrete network models of endothelial cells and their interactions with the substrate

  2024cites this paper
• Living Cells as a Biological Analog of Optical Tweezers -- a Non-Invasive Microrheology Approach.

  2022cites this paper
• Characterizing in situ poroelastic properties of cytoplasm by the translation of a rigid spherical inclusion

  2021cites this paper
• Biophysical origins of viscoelasticity during collective cell migration

  2021cites this paper
• Estrogen depletion on In vivo osteocyte calcium signaling responses to mechanical loading.

  2021cites this paper
• Intrinsic Mechanical Cues and Their Impact on Stem Cells and Embryogenesis

  2021cites this paper
• Cell membrane mechanics and mechanosensory transduction.

  2020cites this paper
• Tensegrity representation of microtubule objects using unified particle objects and springs

  2020cites this paper
• Quantified forces between HepG2 hepatocarcinoma and WA07 pluripotent stem cells with natural biomaterials correlate with in vitro cell behavior

  2019cites this paper
• In situ determination of exerted forces in magnetic pulling cytometry

  2019cites this paper
• Endothelial EphB4 maintains vascular integrity and transport function in adult heart

  2019cites this paper
• Mechanical stress influences the viability and morphology of human parametrial ligament fibroblasts.

  2017cites this paper
• 5.6 Effects of Mechanical Stress on Cells

  2017cites this paper
• Dimerization of Cell-Adhesion Molecules Can Increase Their Binding Strength.

  2017cites this paper
• Biophysical Tools to Study Cellular Mechanotransduction

  2017cites this paper
• Monitoring in real-time focal adhesion protein dynamics in response to a discrete mechanical stimulus.

  2017cites this paper
• Experimental Approaches to Study Endothelial Responses to Shear Stress

  2016cites this paper
• Molecular and Cellular Mechanobiology

  2016cites this paper
• A viscoelastic–stochastic model of the effects of cytoskeleton remodelling on cell adhesion

  2016cites this paper
• Illuminating Cell Adhesion: Modern Microscopy Approaches to Study Integrin-Based Focal Adhesions

  2016cites this paper
• Manipulating Cell Nanomechanics Using Micropatterns

  2016cites this paper
• High-resolution cell manipulation for longstanding load on red blood cells

  2016cites this paper
• Mechanical properties of peripheral stress fibers in adherent cells spreading on patterned substrates

  2015cites this paper
• Cortical actin regulation modulates vascular contractility and compliance in veins

  2015cites this paper
• Magnetomotive optical coherence elastography for biomedical applications

  2015cites this paper
• Investigation of shear force of a single adhesion cell using a self-sensitive cantilever and fluorescence microscopy

  2015cites this paper
• Lipid bilayer control of nascent adhesion formation

  2015cites this paper
• Molecular characterization of adult stem cells' adaptations to mechanical signals during adipogenic commitment

  2015cites this paper
• Lipid bilayer control of nascent adhesion formation

  2015cites this paper
• Reverse engineering the mechanical and molecular pathways in stem cell morphogenesis

  2015cites this paper
• Measurement of shear force and adhesion force of a single adhesion cell using atomic force microscopy with a self-sensitive cantilever

  2015cites this paper
• Subcellular stretch-induced cytoskeletal response of single fibroblasts within 3D designer scaffolds.

  2015cites this paper
• The behaviour of osteocyte dendritic processes in bone under cyclic load

  2014cites this paper
• The RhoA Guanine Nucleotide Exchange Factor, LARG, Mediates ICAM-1–Dependent Mechanotransduction in Endothelial Cells To Stimulate Transendothelial Migration

  2014cites this paper
• Inter- and Intracellular Effects of Traumatic Axonal Injury

  2014cites this paper
• Local viscoelastic properties of live cells investigated using dynamic and quasi-static atomic force microscopy methods.

  2014cites this paper
• Loss of Focal Adhesion Kinase Enhances Endothelial Barrier Function and Increases Focal Adhesions

  2013cites this paper
• Mesenchymal stem cell mechanobiology and emerging experimental platforms

  2013cites this paper
• Biotensegrity: A Unifying Theory of Biological Architecture With Applications to Osteopathic Practice, Education, and Research—A Review and Analysis

  2013cites this paper
• The Focal Adhesion: A Regulated Component of Aortic Stiffness

  2013cites this paper
• Review on Cell Mechanics: Experimental and Modeling Approaches

  2013cites this paper
• experimental platforms Mesenchymal stem cell mechanobiology and emerging

  2013influential citation
• Strain-induced Differentiation of Fetal Type II Epithelial Cells Is Mediated via the Integrin α6β1-ADAM17/Tumor Necrosis Factor-α-converting Enzyme (TACE) Signaling Pathway*

  2013cites this paper
• Single-Cell Force Spectroscopy, an Emerging Tool to Quantify Cell Adhesion to Biomaterials

  2013cites this paper
• RhoA goes GLOBAL

  2013cites this paper
• The mechanostability of isolated focal adhesions is strongly dependent on pH.

  2012cites this paper
• Mechanical regulation of cellular phenotype: implications for vascular tissue regeneration.

  2012cites this paper
• Mechanotransduction in cardiac stem cells: role of YAP/TAZ in the cellular response to the microenvironment

  2012cites this paper
• From mechanical force to RhoA activation.

  2012cites this paper
• Ventilator-induced lung injury: role of protein-protein interaction in mechanosensation.

  2012cites this paper
• Mechanotransduction in cardiac stem cells : role of YAP/TAZ in the cellular response to the microenvironment

  2012cites this paper
• Mechanobiology in lung epithelial cells: measurements, perturbations, and responses.

  2012cites this paper
• Probing cellular traction forces with magnetic nanowires and microfabricated force sensor arrays

  2012cites this paper
• Interplay between Cytoskeletal Stresses and Cell Adaptation under Chronic Flow

  2012cites this paper
• Keratin 8/18 Regulation of Cell Stiffness-Extracellular Matrix Interplay through Modulation of Rho-Mediated Actin Cytoskeleton Dynamics

  2012cites this paper
• Closed-looped nano stimulation microscope for living cell membrane

  2012cites this paper
• A silicone-based stretchable micropost array membrane for monitoring live-cell subcellular cytoskeletal response.

  2012cites this paper
• 5.506 – Effects of Mechanical Stress on Cells

  2011cites this paper
• Electron-beam direct processing on living cell membrane

  2011cites this paper
• A hitchhiker's guide to mechanobiology.

  2011cites this paper
• 16. Intermediate Filaments

  2011cites this paper
• Direct observation of dynamic force propagation between focal adhesions of cells on microposts by atomic force microscopy

  2011cites this paper
• Focal Adhesion Induction at the Tip of a Functionalized Nanoelectrode

  2011cites this paper
• Characterization of the Interface between the Mouse Mammary Epithelium and its Microenvironment during Morphogenesis

  2011cites this paper
• Directing Cell Fate Through Biomaterial Microenvironments

  2011cites this paper
• Mechanobiology of Epidermal Keratinocytes: Desmosomes, Hemidesmosomes, Keratin Intermediate Filaments, and Blistering Skin Diseases

  2011cites this paper
• Biological Microelectromechanical Systems (BioMEMS) Devices

  2011cites this paper
• Integrin mediated mechanotransduction in renal vascular smooth muscle cells

  2010cites this paper
• What makes cells move: requirements and obstacles for spontaneous cell motility.

  2010cites this paper
• A mechanical model of actin stress fiber formation and substrate elasticity sensing in adherent cells

  2010cites this paper
• Young’s modulus of elasticity of Schlemm’s canal endothelial cells

  2010cites this paper
• Cyclic Force Applied to FAs Induces Actin Recruitment Depending on the Dynamic Loading Pattern

  2010cites this paper
• Simulation of cell motility that reproduces the force–velocity relationship

  2010cites this paper
• Synthesis and manipulation of multifunctional, fluorescent-magnetic nanoparticles for single molecule tracking

  2010influential citation
• From Cellular Mechanotransduction to Biologically Inspired Engineering

  2010cites this paper
• Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins.

  2010cites this paper
• A tiny touch: activation of cell signaling pathways with magnetic nanoparticles.

  2010cites this paper
• Cell Palpation System Based on a Force Measurement by Optical Tweezers for Investigation of Local Mechanical Properties of a Cell Membrane

  2009cites this paper
• Mechanical control of cAMP signaling through integrins is mediated by the heterotrimeric Gαs protein

  2009cites this paper
• Biomimetic F-actin cortex models.

  2009cites this paper
• Quantifying adhesive interactions between cells and extracellular matrix by single-cell force spectroscopy

  2009cites this paper
• Two-dimensional effects of hydrogel self-organized from IKVAV-containing peptides on growth and differentiation of NSCs

  2009cites this paper
• The Cytoskeleton of the Living Cell as an Out-of-Equilibrium System

  2008cites this paper
• Force induced dissociation of molecular bonds

  2008cites this paper
• Exciting cytoskeleton-membrane waves.

  2008cites this paper
• Optimization of force produced by electromagnet needles acting on superparamagnetic microparticles

  2008cites this paper
• Force Spectroscopy with Optical and Magnetic Tweezers

  2008cites this paper
• Nanomagnetic actuation of receptor-mediated signal transduction.

  2008cites this paper
• Biophysical Basis of Airway Smooth Muscle Contraction and Hyperresponsiveness in Asthma

  2008cites this paper
• smooth muscle contraction and hyperresponsiveness in asthma

  2008cites this paper
• THE ACOUSTIC WAVE SENSOR AND SOFT LITHOGRAPHY TECHNOLOGIES FOR CELL BIOLOGICAL STUDIES

  2008cites this paper
• Keratin contribution to cellular mechanical stress response at focal adhesions as assayed by laser tweezers.

  2008influential citation
• Cell membrane deformations under magnetic force modulation characterized by optical tracking and non‐interferometric widefield profilometry

  2008cites this paper
• Investigating complexity of protein-protein interactions in focal adhesions.

  2008cites this paper
• An endothelial cell compatible biosensor fabricated using optically thin indium tin oxide silicon nitride electrodes.

  2007cites this paper
• Simulation and experimental verification of nanoscale motion in a 2-axis quasi-passive platform

  2007cites this paper
• Green fluorescent protein as a mechanical sensor

  2007cites this paper
• The effects of substrate stiffness on mesenchymal stem cell proliferation and differentiation

  2007cites this paper