Prion-induced neuronal damage--the mechanisms of neuronal destruction in the subacute spongiform encephalopathies.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Current Topics in Microbiology and Immunology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/978-3-662-10356-2_10PMID 11417136
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Degenerative hippocampal pathology in mice infected with scrapie

  2004cited by this paper
• Evidence of Presynaptic Location and Function of the Prion Protein

  1999cited by this paper
• Expression of proteins linked to exocytosis and neurotransmission in patients with Creutzfeldt-Jakob disease.

  1999cited by this paper
• Neuronal apoptosis in Creutzfeldt-Jakob disease.

  1999cited by this paper
• Copper binding to the prion protein: structural implications of four identical cooperative binding sites.

  1999cited by this paper
• Identification of Microglial Signal Transduction Pathways Mediating a Neurotoxic Response to Amyloidogenic Fragments of β-Amyloid and Prion Proteins

  1999cited by this paper
• Classification of sporadic Creutzfeldt‐Jakob disease based on molecular and phenotypic analysis of 300 subjects

  1999cited by this paper
• Normal prion protein has an activity like that of superoxide dismutase.

  1999cited by this paper
• Nuclear DNA fragmentation in Creutzfeldt-Jakob disease: does a mere positive in situ nuclear end-labeling indicate apoptosis?

  1999cited by this paper
• Transmissible and genetic prion diseases share a common pathway of neurodegeneration

  1999cited by this paper
• Microglial cells respond to amyloidogenic PrP peptide by the production of inflammatory cytokines.

  1999cited by this paper
• A 2-year longitudinal study of swimming navigation in mice devoid of the prion protein: no evidence for neurological anomalies or spatial learning impairments.

  1998cited by this paper
• Neuronal Apoptosis in Fatal Familial Insomnia

  1998cited by this paper
• Eight prion strains have PrPSc molecules with different conformations

  1998cited by this paper
• Prion's Progress: Patterns and Rates of Molecular Evolution in Relation to Spongiform Disease

  1998cited by this paper
• Severe, Early and Selective Loss of a Subpopulation of GABAergic Inhibitory Neurons in Experimental Transmissible Spongiform Encephalopathies

  1998cited by this paper
• Nobel Lecture: Prions

  1998cited by this paper
• Prion protein selectively binds copper(II) ions.

  1998cited by this paper
• Role of Microglia in Neuronal Cell Death in Prion Disease

  1998cited by this paper
• A transmembrane form of the prion protein in neurodegenerative disease.

  1998cited by this paper
• Strain-dependent Differences in β-Sheet Conformations of Abnormal Prion Protein*

  1998cited by this paper
• Cell death in prion disease.

  1997cited by this paper
• Spongiform encephalopathies: B lymphocytes and neuroinvasion

  1997cited by this paper
• Biochemical typing of scrapie strains

  1997cited by this paper
• Typing prion isoforms

  1997cited by this paper
• The cellular prion protein binds copper in vivo

  1997cited by this paper
• A neurotoxic and gliotrophic fragment of the prion protein increases plasma membrane microviscosity.

  1997cited by this paper
• Effect of flupirtine on Bcl-2 and glutathione level in neuronal cells treated in vitro with the prion protein fragment (PrP106-126).

  1997cited by this paper
• Channel Formation by a Neurotoxic Prion Protein Fragment*

  1997cited by this paper
• In vivo toxicity of prion protein in murine scrapie: ultrastructural and immunogold studies

  1997cited by this paper
• Increase of intracellular free Ca2+ in microglia activated by prion protein fragment

  1997cited by this paper
• Apoptosis and necrosis in toxicology: a continuum or distinct modes of cell death?

  1997cited by this paper
• PrP deposition, microglial activation, and neuronal apoptosis in murine scrapie.

  1997cited by this paper
• Immunocytochemical appearance of cytokines, prostaglandin E2 and lipocortin-1 in the CNS during the incubation period of murine scrapie correlates with progressive PrP accumulations.

  1997cited by this paper
• Postmortem delay and temperature conditions affect the in situ end-labeling (ISEL) assay in brain tissue of mice.

  1997cited by this paper
• Scrapie infection alters the membrane and synaptic properties of mouse hippocampal CA1 pyramidal neurones.

  1997cited by this paper
• Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity.

  1997cited by this paper
• Lipid Composition in Scrapie‐Infected Mouse Brain: Prion Infection Increases the Levels of Dolichyl Phosphate and Ubiquinone

  1996cited by this paper
• Molecular basis of phenotypic variability in sporadc creudeldt‐jakob disease

  1996cited by this paper
• Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD

  1996cited by this paper
• Normal host prion protein necessary for scrapie-induced neurotoxicity

  1996cited by this paper
• Prion protein (PrP) with amino‐proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

  1996cited by this paper
• Role of microglia and host prion protein in neurotoxicity of a prion protein fragment

  1996cited by this paper
• Sequential appearance and accumulation of pathognomonic markers in the central nervous system of hamsters orally infected with scrapie.

  1996cited by this paper
• Copper biochemistry and molecular biology.

  1996cited by this paper
• Altered circadian activity rhythms and sleep in mice devoid of prion protein

  1996cited by this paper
• Diagnostic criteria for sporadic Creutzfeldt-Jakob disease.

  1996cited by this paper
• Neuronal Cell Death in Scrapie‐Infected Mice Is Due to Apoptosis

  1995cited by this paper
• Prion protein gene variation among primates.

  1995cited by this paper
• Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier.

  1995cited by this paper
• Copper binding to the N-terminal tandem repeat regions of mammalian and avian prion protein.

  1995cited by this paper
• Detection of apoptosis in murine scrapie.

  1995cited by this paper
• Prion protein is necessary for normal synaptic function

  1994cited by this paper
• No propagation of prions in mice devoid of PrP

  1994cited by this paper
• High Prion and PrPSc Levels but Delayed Onset of Disease in Scrapie-Inoculated Mice Heterozygous for a Disrupted PrP Gene

  1994cited by this paper
• PrP in pathology and pathogenesis in scrapie-infected mice

  1994cited by this paper
• Cell-free formation of protease-resistant prion protein

  1994cited by this paper
• Characterization of the microglial response in murine scrapie

  1994cited by this paper
• Mouse cortical cells lacking cellular PrP survive in culture with a neurotoxic PrP fragment

  1994cited by this paper
• Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy

  1994cited by this paper
• Conformational polymorphism of the amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein.

  1994cited by this paper
• No propagation of prions in mice devoid of PrP.

  1994cited by this paper
• Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie-infected mice.

  1994cited by this paper
• Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons.

  1994cited by this paper
• Activation of cerebral cytokine gene expression and its correlation with onset of reactive astrocyte and acute-phase response gene expression in scrapie

  1994cited by this paper
• Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing.

  1993cited by this paper
• Prions and nucleic acids: search for "residual" nucleic acids and screening for mutations in the PrP-gene.

  1993cited by this paper
• Cytoprotective effect of NMDA receptor antagonists on prion protein (PrionSc)-induced toxicity in rat cortical cell cultures.

  1993cited by this paper
• Neurotoxicity of a prion protein fragment

  1993cited by this paper
• Genetic and infectious prion diseases.

  1993cited by this paper
• Detection of DNA fragmentation in apoptosis: application of in situ nick translation to cell culture systems and tissue sections.

  1993cited by this paper
• Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

  1993cited by this paper
• Molecular characteristics of a protease-resistant, amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein.

  1993cited by this paper
• Scrapie strain variation and mutation.

  1993cited by this paper
• Analysis of nucleic acids in purified scrapie prion preparations.

  1993cited by this paper
• Processing of a cellular prion protein: identification of N- and C-terminal cleavage sites.

  1993cited by this paper
• Diversity in the neuropathology of scrapie-like diseases in animals.

  1993cited by this paper
• Mice devoid of PrP are resistant to scrapie.

  1993cited by this paper
• Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

  1992cited by this paper
• Nearly ubiquitous tissue distribution of the scrapie agent precursor protein

  1992cited by this paper
• The prion protein gene: a role in mouse embryogenesis?

  1992cited by this paper
• Purification and properties of the cellular prion protein from Syrian hamster brain

  1992cited by this paper
• Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

  1992cited by this paper
• Further analysis of nucleic acids in purified scrapie prion preparations by improved return refocusing gel electrophoresis.

  1992cited by this paper
• Proteinase‐resistant prion protein accumulation in Syrian hamster brain correlates with regional pathology and scrapie infectivity

  1991cited by this paper
• The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.

  1991cited by this paper
• Unusual topogenic sequence directs prion protein biogenesis.

  1990cited by this paper
• Differential release of cellular and scrapie prion proteins from cellular membranes by phosphatidylinositol-specific phospholipase C.

  1990cited by this paper
• Permethylation and tandem mass spectrometry of oligosaccharides having free hexosamine: analysis of the glycoinositol phospholipid anchor glycan from the scrapie prion protein.

  1990cited by this paper
• Cellular isoform of the scrapie agent protein participates in lymphocyte activation.

  1990cited by this paper
• Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein

  1990cited by this paper
• Scrapie Infection Diminishes Spines and Increases Varicosities of Dendrites in Hamsters: A Quantitative Golgi Analysis

  1987cited by this paper
• Changes in the localization of brain prion proteins during scrapie infection

  1987cited by this paper
• Scrapie prion protein contains a phosphatidylinositol glycolipid.

  1987cited by this paper
• Separation and properties of cellular and scrapie prion proteins.

  1986cited by this paper
• Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains

  1986cited by this paper
• Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene.

  1986cited by this paper
• Scrapie prion proteins are synthesized in neurons.

  1986cited by this paper
• A cellular gene encodes scrapie PrP 27-30 protein.

  1985cited by this paper
• Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain

  1985cited by this paper

• The Anti-Apoptotic Activity of β-Synuclein Mediated via Akt Signaling Is Severely Lost During Prion Infection

  2026cites this paper
• Mesenchymal Stem Cell Secretome Attenuates PrP106-126-Induced Neurotoxicity by Suppressing Neuroinflammation and Apoptosis and Enhances Cell Migration

  2025cites this paper
• Prion-induced ferroptosis is facilitated by RAC3

  2025cites this paper
• PHB2 Alleviates Neurotoxicity of Prion Peptide PrP106–126 via PINK1/Parkin-Dependent Mitophagy

  2023cites this paper
• Chemical Inactivation of Prions Is Altered by Binding to the Soil Mineral Montmorillonite.

  2021cites this paper
• Therapeutic Assay with the Non-toxic C-Terminal Fragment of Tetanus Toxin (TTC) in Transgenic Murine Models of Prion Disease

  2021cites this paper
• Novel regulators of PrPC expression as potential therapeutic targets in prion diseases

  2020cites this paper
• THE ROLE OF PRIONS AND CHAPERONES IN THE DEVELOPMENT OF NEURODEGENERATIVE PATHOLOGY

  2017cites this paper
• Experimental and Theoretical Insights into the Inhibition Mechanism of Prion Fibrillation by Resveratrol and its Derivatives.

  2017cites this paper
• STRUCTURAL CHANGES OF SKIN LIMBS OF LIMBS IN LOCAL COOLING ON THE BACKGROUND OF ANTIOXIDANT INTRODUCTION

  2017cites this paper
• Cell Death and Autophagy in Prion Diseases

  2017cites this paper
• Discovery of small molecules binding to the normal conformation of prion by combining virtual screening and multiple biological activity evaluation methods

  2017cites this paper
• Differentially expressed genes in the brain of TgElk mice with chronic wasting disease

  2016cites this paper
• Proteomics applications in prion biology and structure

  2015cites this paper
• Einfluss der Kupferbindung an der Aminosäureposition 95 im Prionprotein auf den Krankheitsverlauf nach Prioninfektion

  2014cites this paper
• Dysfunction of the PI3K–Akt–GSK‐3 pathway is a common feature in cell culture and in vivo models of prion disease

  2014cites this paper
• Could Intracrine Biology Play a Role in the Pathogenesis of Transmissable Spongiform Encephalopathies, Alzheimer’s Disease and Other Neurodegenerative Diseases?

  2014cites this paper
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  2014cites this paper
• Development and application of NMR methods for challenges in drug discovery

  2013cites this paper
• Synthesis of benzamide derivatives and their evaluation as antiprion agents.

  2012cites this paper
• Oxidative stress, perturbed calcium homeostasis, and immune dysfunction in Alzheimer’s disease

  2011cites this paper
• Neuropathological changes correlate temporally but not spatially with selected neuromodulatory responses in natural scrapie

  2011cites this paper
• Gene Expression Profiling and Association with Prion-Related Lesions in the Medulla Oblongata of Symptomatic Natural Scrapie Animals

  2011cites this paper
• Mechanisms for Prion Strain Targeting in the Central Nervous System

  2010cites this paper
• Aquaporins and Neurodegenerative Diseases

  2010cites this paper
• A candidate anti-prion disease agent, 2,2′-biquinoline, decreases expression of prion protein and mRNA in prion-infected cells.

  2009cites this paper
• Dipartimento di Scienze Zootecniche Dottorato di Ricerca in Scienze e Tecnologie Zootecniche

  2009cites this paper
• Medikamente zur Hemmung der Aggregation von Proteinen bei Krankheiten, die mit Proteinaggregation und/oder neurodegenerativen Erkrankungen in Zusammenhang stehen

  2009cites this paper
• New insights into cellular prion protein (PrPc) functions: the "ying and yang" of a relevant protein.

  2009cites this paper
• Induction of apoptosis and necrosis in leukemic cells by purified IgG of blood serum of mice which were fed with cattle brain for a long time

  2008cites this paper
• Role of Erk1/2 activation in prion disease pathogenesis: absence of CCR1 leads to increased Erk1/2 activation and accelerated disease progression.

  2008cites this paper
• Infection of metallothionein 1+2 knockout mice with Rocky Mountain Laboratory scrapie.

  2008cites this paper
• Gene expression profile of quinacrine‐cured prion‐infected mouse neuronal cells

  2008cites this paper
• Induced neuroprotection independently from PrPSc accumulation in a mouse model for prion disease treated with simvastatin.

  2008cites this paper
• Cell death and autophagy in prion diseases (transmissible spongiform encephalopathies).

  2008cites this paper
• Biology and neuropathology of prion diseases.

  2008cites this paper
• Vacuolar degeneration affecting brain macrophages/microglia in variant CJD: a report on two cases

  2007cites this paper
• Structural characterization of beta-sheeted oligomers formed on the pathway of oxidative prion protein aggregation in vitro.

  2007cites this paper
• Expression of transcription factors CREB and c-Fos in the brains of terminal Creutzfeldt-Jakob disease cases.

  2007cites this paper
• BSE infection in bovine PrP transgenic mice leads to hyperphosphorylation of tau-protein.

  2006cites this paper
• The brain immune response in human prion diseases. Microglial activation and microglial disease. I. Sporadic Creutzfeldt-Jakob disease.

  2006cites this paper
• Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP transgenic mice

  2006cites this paper
• Group I mGluR signaling in BSE-infected bovine-PrP transgenic mice.

  2006cites this paper
• Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice.

  2006cites this paper
• Immunohistochemical approach to the pathogenesis of bovine spongiform encephalopathy in its early stages.

  2006cites this paper
• Encefalopatías Espongiformes Transmisibles

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• Central Pathogenesis of Prion Diseases

  2005cites this paper
• Pathogenesis of prion diseases

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• The Molecular Basis of Prion Protein-Mediated Neuronal Damage

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• Cytokines and Neurodegeneration

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• Single particle analysis of manganese-induced prion protein aggregates.

  2005cites this paper
• Interleukin 4 and interleukin 10 levels are elevated in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.

  2005cites this paper
• Systematic Identification of Antiprion Drugs by High-Throughput Screening Based on Scanning for Intensely Fluorescent Targets

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• Cell culture models of oxidative stress and injury in the central nervous system.

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• Metabotropic glutamate receptor/phospholipase C pathway: a vulnerable target to Creutzfeldt-Jakob disease in the cerebral cortex.

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• Biophysikalische Untersuchungen zur physiologischen Bedeutung des Prionproteins als Metalloprotein

  2004cites this paper
• Molecular approaches to mechanisms of prion diseases.

  2004cites this paper
• Prion protein accumulation and neuroprotection in hypoxic brain damage.

  2004cites this paper
• Neuropathology and molecular biology of variant Creutzfeldt-Jakob disease.

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• Prions can infect primary cultured neurons and astrocytes and promote neuronal cell death.

  2004cites this paper
• Effect of metal ions on de novo aggregation of full-length prion protein.

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• The Molecular Pathology of Prion Diseases

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• Identification of Differentially Expressed Genes in Scrapie-Infected Mouse Brains by Using Global Gene Expression Technology

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• Neuronal cell death in transmissible spongiform encephalopathies (prion diseases) revisited: from apoptosis to autophagy.

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• Involvement of gut-associated lymphoid tissue of ruminants in the spread of transmissible spongiform encephalopathies.

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• Neuronal and Vascular Plasticity

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• Dimethyl sulfoxide delays PrP sc accumulation and disease symptoms in prion-infected hamsters.

  2003cites this paper
• The Future of Brain Protection: Natural Alternatives

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• Infectious agents and age-related neurodegenerative disorders

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• [Creutzfeldt-Jakob disease. Lack or correlation between cerebral cortex histology and clinical course of the disease in 22 autopsy cases].

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• Synaptic pathology and cell death in the cerebellum in Creutzfeldt-Jakob disease

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• Creutzfeldt-Jakob-Krankheit

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• Vasoactive intestinal peptide and pituitary adenylate cyclase‐activating polypeptide inhibit chemokine production in activated microglia

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• How do neurons degenerate in prion diseases or transmissible spongiform encephalopathies (TSEs): neuronal autophagy revisited.

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• Abnormal synaptic protein expression and cell death in murine scrapie

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• CHAPTER 22 – Transmissible Spongiform Encephalopathies

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• Phenothiazines and prion diseases: a potential mechanism of action towards oxidative stress.

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• A route for prion neuroinvasion.

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• Phenothiazines: potential management of Creutzfeldt-Jacob disease and its variants.

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