The protective roles of autophagy in ischemic preconditioning

Autophagy, a process for the degradation of protein aggregates and dysfunctional organelles, is required for cellular homeostasis and cell survival in response to stress and is implicated in endogenous protection. Ischemic preconditioning is a brief and nonlethal episode of ischemia, confers protection against subsequent ischemia-reperfusion through the up-regulation of endogenous protective mechanisms. Emerging evidence shows that autophagy is associated with the protective effect of ischemic preconditioning. This review summarizes recent progress in research on the functions and regulations of the autophagy pathway in preconditioning-induced protection and cellular survival.

• Publication year

  2013

• Venue

  Acta Pharmacologica Sinica

• Publication date

  2013-04-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/aps.2013.18PMID 23603984PMCID 4002876
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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