Molecular Mimicry by Herpes Simplex Virus-Type 1:Autoimmune Disease After Viral Infection

1. Zhao ZS, 2. Granucci F, 3. Yeh L, 4. Schaffer PA, 5. Cantor H (1998) Science. 279:1344–1347. [OpenUrl][1][Abstract/FREE Full Text][2] #### Purpose of the Study The onset of autoimmune disease sometimes follows an acute viral infection. One possible explanation for this phenomenon is “molecular mimicry.” According to this hypothesis, a virus could trigger autoimmunity if one of the viral proteins is very similar in structure … [1]: {openurl}?query=rft.jtitle%253DScience%26rft.stitle%253DScience%26rft.issn%253D0036-8075%26rft.aulast%253DZhao%26rft.auinit1%253DZ.%26rft.volume%253D279%26rft.issue%253D5355%26rft.spage%253D1344%26rft.epage%253D1347%26rft.atitle%253DMolecular%2BMimicry%2Bby%2BHerpes%2BSimplex%2BVirus-Type%2B1%253A%2BAutoimmune%2BDisease%2BAfter%2BViral%2BInfection%26rft_id%253Dinfo%253Adoi%252F10.1126%252Fscience.279.5355.1344%26rft_id%253Dinfo%253Apmid%252F9478893%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=sci&resid=279/5355/1344&atom=%2Fpediatrics%2F104%2FSupplement_2%2F403.2.atom

• Publication year

  1999

• Venue

  Pediatrics

• Publication date

  1999-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1542/peds.104.2.S1.403a
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• No references are available for this paper.

• Immunoinformatics prediction of potential immunodominant epitopes from human coronaviruses and association with autoimmunity

  2022cites this paper
• Pathogenesis of herpes simplex keratitis: The host cell response and ocular surface sequelae to infection and inflammation.

  2019cites this paper
• Two rheumatoid arthritis–specific autoantigens correlate microbial immunity with autoimmune responses in joints

  2017cites this paper
• Loss of Anti-Viral Immunity by Infection with a Virus Encoding a Cross-Reactive Pathogenic Epitope

  2012cites this paper
• Viruses and multiple sclerosis.

  2012cites this paper
• Why must T cells be cross-reactive?

  2012cites this paper
• Infectious diseases and autoimmunity.

  2011cites this paper
• De Novo Autoimmune Hepatitis after Liver Transplantation

  2011cites this paper
• 99th Dahlem Conference on Infection, Inflammation and Chronic Inflammatory Disorders: Triggering of autoimmune diseases by infections

  2010cites this paper
• Lymphocytic Choriomeningitis Virus-Induced Mortality in Mice Is Triggered by Edema and Brain Herniation

  2009cites this paper
• Autoimmune Processes in the Central Nervous System

  2008cites this paper
• The Pathogenesis of Biliary Atresia: Evidence for a Virus-Induced Autoimmune Disease

  2007cites this paper
• Molecular Mimicry in Multiple Sclerosis: Role of MHC-Altered Peptide Ligands (MAPL)

  2007cites this paper
• Pathogenic epitopes, heterologous immunity and vaccine design

  2007cites this paper
• Memory of mice and men: CD8+ T‐cell cross‐reactivity and heterologous immunity

  2006cites this paper
• In Celiac Disease, a Subset of Autoantibodies against Transglutaminase Binds Toll-Like Receptor 4 and Induces Activation of Monocytes

  2006cites this paper
• The role of bystander T cells in CNS pathology and pathogen clearance.

  2005cites this paper
• Analysis of regulatory CD8 T cells in Qa-1-deficient mice

  2004cites this paper
• Cytokines and Chemokines in Infectious Diseases Handbook

  2003influential citation
• Genotyping of herpes simplex virus type 1 strains isolated from ocular materials of patients with herpetic keratitis

  2003cites this paper
• A potential role for CXCR3 chemokines in the response to ocular HSV infection

  2003cites this paper
• T cell‐dependent and ‐independent pathways to tissue destruction following herpes simplex virus‐1 infection

  2002cites this paper
• Hepatitis B Vaccination and First Central Nervous System Demyelinating Event: A Case-Control Study

  2002cites this paper
• Effect of Herpes Simplex Virus‐1 gD or gD‐IL‐2 DNA Vaccine on Herpetic Keratitis

  2002cites this paper
• Bacterial induction of autoantibodies to beta2-glycoprotein-I accounts for the infectious etiology of antiphospholipid syndrome.

  2002cites this paper
• Are virus infections triggers for autoimmune disease?

  2002cites this paper
• Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?

  2001cites this paper
• Mechanisms for the induction of autoimmunity by infectious agents.

  2001cites this paper
• Virus-Induced Autoimmunity: Potential Role of Viruses in Initiation, Perpetuation, and Progression of T-Cell–Mediated Autoimmune Disease

  2001cites this paper
• Molecular Mimicry in Lyme Arthritis Demonstrated at the Single Cell Level: LFA-1αL Is a Partial Agonist for Outer Surface Protein A-Reactive T Cells1

  2001cites this paper
• Introduction: Epitope mimicry as a component cause of autoimmune disease

  2000cites this paper
• Molecular mimicry mediated by MHC class Ib molecules after infection with Gram-negative pathogens

  2000cites this paper
• Systemic sclerosis immunoglobulin G autoantibodies bind the human cytomegalovirus late protein UL94 and induce apoptosis in human endothelial cells

  2000cites this paper
• Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with Type I diabetes mellitus

  2000cites this paper
• The Stimulation of Low-Affinity, Nontolerized Clones by Heteroclitic Antigen Analogues Causes the Breaking of Tolerance Established to an Immunodominant T Cell Epitope

  1999cites this paper
• La reconnaissance immunologique du soi : quelles frontières entre autoréactivité physiologique et pathologie autoimmune ?

  1999cites this paper
• Bystander activation of CD4+ T cells can represent an exclusive means of immunopathology in a virus infection

  1999cites this paper
• Different modes of pathogenesis in T‐cell‐dependent autoimmunity: clues from two TCR transgenic systems

  1999cites this paper
• Ontogeny of synonymous T cell populations with specificity for a self MHC epitope mimicked by a bacterial homologoue: an antigen‐specific T cell analysis in a non‐transgenic system

  1999cites this paper
• Diversification of response to hsp65 during the course of autoimmune arthritis is regulatory rather than pathogenic

  1998cites this paper