Two rheumatoid arthritis–specific autoantigens correlate microbial immunity with autoimmune responses in joints

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Journal of Clinical Investigation

• Publication date

  2017-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI93450PMID 28650341PMCID PMC5531397
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis.

  2016cited by this paper
• Do antibodies select a healthy microbiota?

  2016cited by this paper
• The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

  2015cited by this paper
• A Highly Expressed Human Protein, Apolipoprotein B-100, Serves as an Autoantigen in a Subgroup of Patients With Lyme Disease.

  2015cited by this paper
• Evaluating relationships between symptom duration and persistence of rheumatoid arthritis: does a window of opportunity exist? Results on the Leiden Early Arthritis Clinic and ESPOIR cohorts

  2015cited by this paper
• Annexin A2 is a target of autoimmune T and B cell responses associated with synovial fibroblast proliferation in patients with antibiotic-refractory Lyme arthritis.

  2015cited by this paper
• Earlier Time to Remission Predicts Sustained Clinical Remission in Early Rheumatoid Arthritis — Results from the Canadian Early Arthritis Cohort (CATCH)

  2014cited by this paper
• Characterization of Glycosaminoglycan (GAG) Sulfatases from the Human Gut Symbiont Bacteroides thetaiotaomicron Reveals the First GAG-specific Bacterial Endosulfatase*

  2014cited by this paper
• Periodontitis and Porphyromonas gingivalis in Patients With Rheumatoid Arthritis

  2014cited by this paper
• Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

  2013influential reference
• Immune-Mediated Pore-Forming Pathways Induce Cellular Hypercitrullination and Generate Citrullinated Autoantigens in Rheumatoid Arthritis

  2013cited by this paper
• Clinical correlations with Porphyromonas gingivalis antibody responses in patients with early rheumatoid arthritis

  2013cited by this paper
• A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease.

  2013cited by this paper
• The pathogenesis of rheumatoid arthritis.

  2011cited by this paper
• Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

  2011cited by this paper
• Sulfatases and a Radical S-Adenosyl-l-methionine (AdoMet) Enzyme Are Key for Mucosal Foraging and Fitness of the Prominent Human Gut Symbiont, Bacteroides thetaiotaomicron*

  2011cited by this paper
• Filamin A mediates interactions between cytoskeletal proteins that control cell adhesion

  2011cited by this paper
• 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative.

  2010cited by this paper
• Rheumatoid arthritis classifi cation criteria : an American College of Rheumatology / European League Against Rheumatism collaborative initiative

  2010cited by this paper
• Peptides Presented by HLA-DR Molecules in Synovia of Patients with Rheumatoid Arthritis or Antibiotic-Refractory Lyme Arthritis*

  2010cited by this paper
• Immunity to citrullinated proteins in rheumatoid arthritis.

  2008cited by this paper
• Meta-analysis: Diagnostic Accuracy of Anti–Cyclic Citrullinated Peptide Antibody and Rheumatoid Factor for Rheumatoid Arthritis

  2008cited by this paper
• Duration of preclinical rheumatoid arthritis-related autoantibody positivity increases in subjects with older age at time of disease diagnosis

  2007cited by this paper
• The pathogenesis of rheumatoid arthritis.

  2007cited by this paper
• Meta-analysis: Diagnostic Accuracy of AntiCyclic Citrullinated Peptide Antibody and Rheumatoid Factor for Rheumatoid Arthritis

  2007cited by this paper
• Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.

  2007cited by this paper
• Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.

  2006cited by this paper
• Filamin A (FLNA) is required for cell–cell contact in vascular development and cardiac morphogenesis

  2006cited by this paper
• Predicting subcellular localization of proteins for Gram‐negative bacteria by support vector machines based on n‐peptide compositions

  2004cited by this paper
• Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors.

  2004cited by this paper
• High diagnostic performance of ELISA detection of antibodies to citrullinated antigens in rheumatoid arthritis

  2003cited by this paper
• Glycosaminoglycans are a potential cause of rheumatoid arthritis

  2002cited by this paper
• A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria.

  2000cited by this paper
• Chlamydia infections and heart disease linked through antigenic mimicry.

  1999cited by this paper
• Molecular Mimicry by Herpes Simplex Virus-Type 1:Autoimmune Disease After Viral Infection

  1999cited by this paper
• Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices

  1999influential reference
• Viral and Bacterial Infections Interfere with Peripheral Tolerance Induction and Activate CD8+ T Cells to Cause Immunopathology

  1998cited by this paper
• Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology.

  1998cited by this paper
• Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry

  1998cited by this paper
• Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies.

  1998cited by this paper
• Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection.

  1998cited by this paper
• Natural Autoantibodies, Tolerance, and Autoimmunity

  1997cited by this paper
• Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

  1997cited by this paper
• Natural autoantibodies.

  1995cited by this paper
• Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity.

  1989cited by this paper
• The incidence of rheumatoid arthritis is predicted by rheumatoid factor titer in a longitudinal population study.

  1988cited by this paper
• The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis.

  1987cited by this paper

• Gut microbiota in early and established stages of rheumatoid arthritis: from pathogenesis to promising prevention and treatment

  2026cites this paper
• The Antibody-Microbiota Interface in Autoimmune Diseases.

  2026cites this paper
• The role of gut flora-driven Th cell responses in preclinical rheumatoid arthritis.

  2025cites this paper
• The role of the gut and intestinal dysbiosis in the pathogenesis of Spondyloarthritis.

  2025cites this paper
• Chikungunya virus drives gut microbiota shifts and IFN-Mediated intestinal repair: insights into microbiota-immune interplay

  2025cites this paper
• Immunomodulatory properties of the gut microbiome: diagnostic and therapeutic potential for rheumatoid arthritis

  2025cites this paper
• RNA immunotherapy: revolutionizing cancer and autoimmune disease treatments.

  2025cites this paper
• Interaction between haploinsufficiency of PTPN2 and patient microbiome promotes autoimmune arthritis in mice.

  2025cites this paper
• Gut microbiota in rheumatoid arthritis: Mechanistic insights, clinical biomarkers, and translational perspectives.

  2025cites this paper
• Mikrobiom, Ernährung und Rheuma

  2025cites this paper
• Modulating the gut-immune axis to alleviate rheumatoid arthritis: mechanistic insights and therapeutic potential of traditional Chinese medicine

  2025cites this paper
• Microbial threads in the tapestry of rheumatoid arthritis

  2025cites this paper
• Cigarette Smoking: A Modifiable Environmental Factor in the Pathogenesis of Rheumatoid Arthritis

  2025influential citation
• Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut-joint axis’ (Review)

  2025cites this paper
• Gut Microbiota in Rheumatoid Arthritis: Unraveling Pathogenic Mechanisms and Therapeutic Opportunities

  2025cites this paper
• Linking microbial communities to rheumatoid arthritis: focus on gut, oral microbiome and their extracellular vesicles.

  2025cites this paper
• Microbial imbalance in the gut: a new frontier in Rheumatoid arthritis research

  2025influential citation
• Association Between Ultraprocessed Food Intake and Self-Reported Arthritis

  2025cites this paper
• Molecular mimicry-driven autoimmunity in chronic rhinosinusitis with nasal polyps.

  2025cites this paper
• Protective effect of a combination of multiple strains of Lactobacillus acidophilus on collagen-induced arthritis.

  2025cites this paper
• Molecular mimicry in the pathogenesis of autoimmune rheumatic diseases

  2025cites this paper
• Role of polyphenolics in the management of rheumatoid arthritis through intracellular signaling pathways: a mechanistic review

  2025cites this paper
• Inflammasomes and their roles in autoimmune diseases

  2024cites this paper
• Gut Microbiota Modulation: A Novel Strategy for Rheumatoid Arthritis Therapy

  2024cites this paper
• The intestinal flora: The key to unraveling heterogeneity in immune thrombocytopenia?

  2024cites this paper
• Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases

  2024cites this paper
• Investigating the causal impact of gut microbiota on arthritis via inflammatory proteins using mendelian randomization

  2024cites this paper
• Microbial pathways contributing to the pathogenesis of rheumatoid arthritis.

  2024cites this paper
• The gut microbiome-helminth-immune axis in autoimmune diseases.

  2024cites this paper
• Altered serum metabolome is associated with disease activity and immune responses in rheumatoid arthritis

  2024cites this paper
• Type 17 immunity: novel insights into intestinal homeostasis and autoimmune pathogenesis driven by gut-primed T cells

  2024cites this paper
• Gut Dysbiosis and Dietary Interventions in Rheumatoid Arthritis—A Narrative Review

  2024cites this paper
• Microbiome modulation of antigen presentation in tolerance and inflammation.

  2024cites this paper
• Protective and Stochastic Correlation Between Infectious Diseases and Autoimmune Disorders.

  2024cites this paper
• CHIKV infection drives shifts in the gastrointestinal microbiome and metabolites in rhesus monkeys

  2024cites this paper
• Gut microbiota and rheumatic diseases: new insights into pathogenesis

  2024cites this paper
• Complex Interactions between the Human Major Histocompatibility Complex (MHC) and Microbiota: Their Roles in Disease Pathogenesis and Immune System Regulation

  2024cites this paper
• Epidemiologic and genetic associations between primary biliary cholangitis and extrahepatic rheumatic diseases.

  2024cites this paper
• Exploring the Role of the Microbiome in Rheumatoid Arthritis—A Critical Review

  2024cites this paper
• Unraveling the gut microbiota’s role in Rheumatoid arthritis: dietary pathways to modulation and therapeutic potential

  2024cites this paper
• Exploring the relationship between infectious agents and autoimmune diseases: a review

  2024cites this paper
• Interplay between the Chaperone System and Gut Microbiota Dysbiosis in Systemic Lupus Erythematosus Pathogenesis: Is Molecular Mimicry the Missing Link between Those Two Factors?

  2024cites this paper
• Unraveling the intricate dance of the Mediterranean diet and gut microbiota in autoimmune resilience

  2024cites this paper
• Treatment for Rheumatoid Arthritis Associated With Alterations in the Gastrointestinal Microbiota

  2024cites this paper
• Influence of Maqian essential oil on gut microbiota and immunoresponses in type 1 diabetes: In silico study

  2024cites this paper
• Associations between rheumatoid arthritis and intestinal flora, with special emphasis on RA pathologic mechanisms to treatment strategies.

  2024cites this paper
• Microbial Mechanisms of Rheumatoid Arthritis Pathogenesis

  2024cites this paper
• The gut ecosystem and immune tolerance.

  2023cites this paper
• Targeting the Gut–Eye Axis: An Emerging Strategy to Face Ocular Diseases

  2023cites this paper
• Immune-mediated inflammatory diseases: Common and different pathogenic and clinical features.

  2023cites this paper
• Peptidyl arginine deiminase inhibition alleviates angiotensin II-induced fibrosis.

  2023cites this paper
• Microbial Imbalance and Intestinal Permeability in the Pathogenesis of Rheumatoid Arthritis: A Mechanism Review with a Focus on Bacterial Translocation, Citrullination, and Probiotic Intervention.

  2023cites this paper
• Serological markers of rheumatoid arthritis in patients with primary biliary cholangitis and the vice versa: A Tunisian study.

  2023cites this paper
• Toddalia asiatica extract attenuates adjuvant-induced arthritis by modulating colon Th17/Treg balance and colony homeostasis.

  2023cites this paper
• Elucidating a fresh perspective on the interplay between exosomes and rheumatoid arthritis

  2023cites this paper
• The role of the microbiome in rheumatoid arthritis: a review

  2023cites this paper
• Gut microbiota in pre-clinical rheumatoid arthritis: From pathogenesis to preventing progression.

  2023cites this paper
• The Cross-Talk between Microbiome and Metabolome in Rheumatoid Arthritis

  2023cites this paper
• Relationship between gut microbiota and rheumatoid arthritis: A bibliometric analysis

  2023cites this paper
• The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries.

  2023cites this paper
• Characteristics of the (Auto)Reactive T Cells in Rheumatoid Arthritis According to the Immune Epitope Database

  2023cites this paper
• Comprehensive multi-omics analysis reveals the core role of glycerophospholipid metabolism in rheumatoid arthritis development

  2023cites this paper
• PLGA Particles in Immunotherapy

  2023cites this paper
• Gut-joint axis: Gut dysbiosis can contribute to the onset of rheumatoid arthritis via multiple pathways

  2023cites this paper
• Gut bacteriome, mycobiome and virome alterations in rheumatoid arthritis

  2023cites this paper
• A potential role for chlamydial infection in rheumatoid arthritis development

  2023cites this paper
• Machine learning strategy for identifying altered gut microbiomes for diagnostic screening in myasthenia gravis

  2023cites this paper
• Advances in the implications of the gut microbiota on the treatment efficacy of disease-modifying anti-rheumatic drugs in rheumatoid arthritis

  2023cites this paper
• Rheumatoide Arthritis und das intestinale Mikrobiom – Ein potentieller Faktor in der Pathogenese der RA

  2023cites this paper
• Nutraceuticals in the Modulation of the Intestinal Microbiota: Current Status and Future Directions

  2022cites this paper
• Gut Microbiota From Sjögren syndrome Patients Causes Decreased T Regulatory Cells in the Lymphoid Organs and Desiccation-Induced Corneal Barrier Disruption in Mice

  2022cites this paper
• Functional Analysis of Autoantibody Signatures in Rheumatoid Arthritis

  2022cites this paper
• New Druggable Targets for Rheumatoid Arthritis Based on Insights From Synovial Biology

  2022cites this paper
• Disease mechanisms in preclinical rheumatoid arthritis: A narrative review

  2022influential citation
• Contribution of HLA DRB1, PTPN22, and CTLA4, to RA dysbiosis.

  2022cites this paper
• Bifidobacterium breve CCFM1078 Alleviates Collagen-Induced Arthritis in Rats via Modulating the Gut Microbiota and Repairing the Intestinal Barrier Damage.

  2022cites this paper
• Sinus of Valsalva Aneurysm in Females.

  2022cites this paper
• The metabolomics approach revealed a distinctive metabolomics pattern associated with hyperthyroidism treatment

  2022cites this paper
• Microbiota-assisted therapy for systemic inflammatory arthritis: advances and mechanistic insights

  2022cites this paper
• Antigenic mimicry - The key to autoimmunity in immune privileged organs.

  2022cites this paper
• Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum

  2022cites this paper
• Intestinal microbiome–rheumatoid arthritis crosstalk: The therapeutic role of probiotics

  2022cites this paper
• Association of Antibodies to Prevotella copri in Anti–Cyclic Citrullinated Peptide‐Positive Individuals At Risk of Developing Rheumatoid Arthritis and in Patients With Early or Established Rheumatoid Arthritis

  2022cites this paper
• Safety and efficacy of fecal microbiota transplantation for autoimmune diseases and autoinflammatory diseases: A systematic review and meta-analysis

  2022cites this paper
• Development of a 64Cu-labeled CD4+ T cell targeting PET tracer: evaluation of CD4 specificity and its potential use in collagen-induced arthritis

  2022cites this paper
• Gut microbiota and rheumatoid arthritis: From pathogenesis to novel therapeutic opportunities

  2022cites this paper
• Biomolecular Mechanisms of Autoimmune Diseases and Their Relationship with the Resident Microbiota: Friend or Foe?

  2022cites this paper
• GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review

  2022cites this paper
• Dual IgA/IgG family autoantibodies from individuals at-risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum

  2022cites this paper
• Comparison of Intestinal Microbes in Noninfectious Anterior Scleritis Patients With and Without Rheumatoid Arthritis

  2022cites this paper
• Gut microbiome and autoimmune disorders.

  2022cites this paper
• From Insect Bites to a Skin Autoimmune Disease: A Conceivable Pathway to Endemic Pemphigus Foliaceus

  2022cites this paper
• The impact of the gut microbiome on extra-intestinal autoimmune diseases

  2022cites this paper
• Gut Microbial Antigenic Mimicry in Autoimmunity

  2022influential citation
• Isolation of HLA-DR-naturally presented peptides identifies T-cell epitopes for rheumatoid arthritis

  2022cites this paper
• Genetic obstacles to developing and tolerizing human B cells.

  2022cites this paper
• Tissue microbiota: a 'secondary-self', first target of autoimmunity?

  2021cites this paper
• Transcriptome and Metabolome Analyses of Sea Cucumbers Apostichopus japonicus in Southern China During the Summer Aestivation Period

  2021cites this paper
• Modulation of inflammatory responses by gastrointestinal Prevotella spp. - From associations to functional studies.

  2021cites this paper
• Congruent microbiome signatures in fibrosis-prone autoimmune diseases: IgG4-related disease and systemic sclerosis

  2021cites this paper