Relaxin‐3 inputs target hippocampal interneurons and deletion of hilar relaxin‐3 receptors in “floxed‐RXFP3” mice impairs spatial memory

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Hippocampus

• Publication date

  2017-05-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1002/hipo.22709PMID 28100033
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The dentate gyrus

  2016cited by this paper
• Inactivation of nucleus incertus impairs passive avoidance learning and long term potentiation of the population spike in the perforant path-dentate gyrus evoked field potentials in rats.

  2016cited by this paper
• Role of relaxin-3/RXFP3 system in stress-induced binge-like eating in female rats.

  2016cited by this paper
• Somatostatin and Somatostatin-Containing Neurons in Shaping Neuronal Activity and Plasticity

  2016cited by this paper
• Septal projections to nucleus incertus in the rat: Bidirectional pathways for modulation of hippocampal function

  2015cited by this paper
• Turning a Negative into a Positive: Ascending GABAergic Control of Cortical Activation and Arousal

  2015cited by this paper
• Sex-specific effects of relaxin-3 on food intake and brain expression of corticotropin-releasing factor in rats.

  2015cited by this paper
• Nucleus incertus inactivation impairs spatial learning and memory in rats.

  2015influential reference
• Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice.

  2015cited by this paper
• Memory and Space: Towards an Understanding of the Cognitive Map

  2015cited by this paper
• Relaxin-3 Receptor (RXFP3) Signalling Mediates Stress-Related Alcohol Preference in Mice

  2015cited by this paper
• Dendritic Inhibition in the Hippocampus Supports Fear Learning

  2014cited by this paper
• Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases?

  2014cited by this paper
• Regulation of expression of relaxin-3 and its receptor RXFP3 in the brain of diet-induced obese rats.

  2014cited by this paper
• A Reorganized GABAergic Circuit in a Model of Epilepsy: Evidence from Optogenetic Labeling and Stimulation of Somatostatin Interneurons

  2013cited by this paper
• Heterogeneous responses of nucleus incertus neurons to corticotrophin‐releasing factor and coherent activity with hippocampal theta rhythm in the rat

  2013cited by this paper
• Hilar mossy cells of the dentate gyrus: a historical perspective

  2013cited by this paper
• Sex differences in the effects of chronic stress and food restriction on body weight gain and brain expression of CRF and relaxin‐3 in rats

  2013cited by this paper
• Learning Increases Intrinsic Excitability of Hippocampal Interneurons

  2013cited by this paper
• Hilar interneuron vulnerability distinguishes aged rats with memory impairment

  2013cited by this paper
• Central relaxin-3 receptor (RXFP3) activation decreases anxiety- and depressive-like behaviours in the rat.

  2013cited by this paper
• Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus

  2012cited by this paper
• Distribution and targets of the relaxin‐3 innervation of the septal area in the rat

  2012cited by this paper
• Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1.

  2012cited by this paper
• Dissecting Spatial Knowledge from Spatial Choice by Hippocampal NMDA Receptor Deletion

  2012cited by this paper
• Somatostatin and cognitive function in neurodegenerative disorders.

  2012cited by this paper
• Learning-related feedforward inhibitory connectivity growth required for memory precision

  2011cited by this paper
• Relaxin-3-Deficient Mice Showed Slight Alteration in Anxiety-Related Behavior

  2011cited by this paper
• Relaxin-3 systems in the brain--the first 10 years.

  2011cited by this paper
• Swim stress excitation of nucleus incertus and rapid induction of relaxin-3 expression via CRF1 activation.

  2010cited by this paper
• Immunochemical characterization of inhibitory mouse cortical neurons: Three chemically distinct classes of inhibitory cells

  2010cited by this paper
• Intermittent access to sucrose increases sucrose-licking activity and attenuates restraint stress-induced activation of the lateral septum.

  2010cited by this paper
• Apolipoprotein E4 Causes Age- and Tau-Dependent Impairment of GABAergic Interneurons, Leading to Learning and Memory Deficits in Mice

  2010cited by this paper
• Distribution of relaxin‐3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain

  2010cited by this paper
• Hippocampal theta oscillations are travelling waves

  2009cited by this paper
• Somatostatin, Alzheimer's disease and cognition: an old story coming of age?

  2009cited by this paper
• Adult-Generated Hippocampal Neurons Allow the Flexible Use of Spatially Precise Learning Strategies

  2009cited by this paper
• RELAXIN AND RELATED PEPTIDES: FIFTH INTERNATIONAL CONFERENCE Distribution of Relaxin-3 mRNA and Immunoreactivity and RXFP3-Binding Sites in the Brain of the Macaque, Macaca fascicularis

  2009influential reference
• Modulation of hippocampal theta oscillations and spatial memory by relaxin-3 neurons of the nucleus incertus.

  2009cited by this paper
• Localization of relaxin‐3 in brain of Macaca fascicularis: Identification of a nucleus incertus in primate

  2009cited by this paper
• Contribution of hippocampal and extra-hippocampal NR2B-containing NMDA receptors to performance on spatial learning tasks.

  2008cited by this paper
• Mouse Behavioral Tasks Relevant to Autism: Phenotypes of Ten Inbred Strains

  2008cited by this paper
• The role of the GluR-A (GluR1) AMPA receptor subunit in learning and memory.

  2008cited by this paper
• Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains.

  2007cited by this paper
• The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies).

  2007cited by this paper
• Relaxin-3 in GABA projection neurons of nucleus incertus suggests widespread influence on forebrain circuits via G-protein-coupled receptor-135 in the rat.

  2007cited by this paper
• R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization.

  2007cited by this paper
• R3(BΔ23–27)R/I5 Chimeric Peptide, a Selective Antagonist for GPCR135 and GPCR142 over Relaxin Receptor LGR7

  2007cited by this paper
• Relaxin-3: improved synthesis strategy and demonstration of its high-affinity interaction with the relaxin receptor LGR7 both in vitro and in vivo.

  2006cited by this paper
• Nucleus incertus contribution to hippocampal theta rhythm generation

  2006cited by this paper
• T-maze alternation in the rodent

  2006cited by this paper
• Morris water maze: procedures for assessing spatial and related forms of learning and memory

  2006cited by this paper
• Distinct Subtypes of Somatostatin-Containing Neocortical Interneurons Revealed in Transgenic Mice

  2006cited by this paper
• Effects of Morris water maze testing on the neuroendocrine stress response and intrahypothalamic release of vasopressin and oxytocin in the rat.

  2006cited by this paper
• Neurons expressing relaxin 3/INSL 7 in the nucleus incertus respond to stress

  2005cited by this paper
• Place cells, spatial maps and the population code for memory.

  2005cited by this paper
• Relaxin-3/Insulin-Like Peptide 5 Chimeric Peptide, a Selective Ligand for G Protein-Coupled Receptor (GPCR)135 and GPCR142 over Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 7

  2005cited by this paper
• Hippocampal lesions, species-typical behaviours and anxiety in mice.

  2005cited by this paper
• Hippocampal theta rhythm: A tag for short‐term memory

  2005cited by this paper
• Interneuron Diversity series: Interneuronal neuropeptides--endogenous regulators of neuronal excitability.

  2004cited by this paper
• GABAergic neurons containing somatostatin-like immunoreactivity in the rat hippocampus and dentate gyrus

  2004cited by this paper
• Regional dissociations within the hippocampus--memory and anxiety.

  2004cited by this paper
• Production of recombinant human relaxin 3 in AtT20 cells.

  2003cited by this paper
• The mouse brain in stereotaxic coordinates

  2003cited by this paper
• Cytoarchitecture and efferent projections of the nucleus incertus of the rat

  2003cited by this paper
• Interneurons are the local targets of hippocampal inhibitory cells which project to the medial septum

  2003cited by this paper
• Identification of Relaxin-3/INSL7 as an Endogenous Ligand for the Orphan G-protein-coupled Receptor GPCR135*

  2003cited by this paper
• Formation of dendritic spines with GABAergic synapses induced by whisker stimulation in adult mice.

  2002cited by this paper
• Somatostatin depresses long-term potentiation and Ca2+ signaling in mouse dentate gyrus.

  2002cited by this paper
• The human hippocampus and spatial and episodic memory.

  2002cited by this paper
• Human Relaxin Gene 3 (H3) and the Equivalent Mouse Relaxin (M3) Gene

  2002cited by this paper
• Spatial memory dissociations in mice lacking GluR1

  2002cited by this paper
• Restricted, but abundant, expression of the novel rat gene‐3 (R3) relaxin in the dorsal tegmental region of brain

  2002cited by this paper
• Sleep-related increase in activity of mesopontine neurons in old rats.

  2002cited by this paper
• Immunocytochemical characterization of hippocamposeptal projecting GABAergic nonprincipal neurons in the mouse brain: a retrograde labeling study.

  2002cited by this paper
• The neurobiological basis of spontaneous alternation.

  2002cited by this paper
• Patterns of expression of calcium binding proteins and neuronal nitric oxide synthase in different populations of hippocampal GABAergic neurons in mice

  2002cited by this paper
• Impaired spatial and sequential learning in rats treated neonatally with d‐fenfluramine

  2002cited by this paper
• Effects of cytotoxic hippocampal lesions in mice on a cognitive test battery.

  2002cited by this paper
• Connections of the nucleus incertus

  2001cited by this paper
• Commissurally projecting inhibitory interneurons of the rat hippocampal dentate gyrus: A colocalization study of neuronal markers and the retrograde tracer fluoro‐gold

  2001cited by this paper
• Theta synchronization in the limbic system: the role of Gudden's tegmental nuclei

  2001cited by this paper
• Ventral tegmental nucleus of Gudden: A pontine hippocampal theta generator?

  2001cited by this paper
• Conditional transgenic technologies.

  2001cited by this paper
• Regional expression of a gene encoding a neuron-specific Na(+)-dependent inorganic phosphate cotransporter (DNPI) in the rat forebrain.

  2000cited by this paper
• Projections of the median raphe nucleus in the rat

  1999cited by this paper
• The opposite effects of cysteamine on the acquisition of two different tasks in mice are associated with bidirectional testing-induced changes in hippocampal adenylyl cyclase activity.

  1998cited by this paper
• Interneurons of the hippocampus

  1998cited by this paper
• Brainstem-diencephalo-septohippocampal systems controlling the theta rhythm of the hippocampus.

  1997cited by this paper
• Sequence of single neuron changes in CA1 hippocampus of rabbits during acquisition of trace eyeblink conditioned responses.

  1997cited by this paper
• Phase relations of rhythmic neuronal firing in the supramammillary nucleus and mammillary body to the hippocampal theta activity in urethane anesthetized rats

  1997cited by this paper
• Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

  1996influential reference
• Maze procedures: the radial-arm and water maze compared.

  1996cited by this paper
• FK960 N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate ameliorates the memory deficits in rats through a novel mechanism of action.

  1996cited by this paper
• The septohippocampal pathway: structure and function of a central cholinergic system.

  1995cited by this paper
• T-maze spontaneous alternation rate is decreased in S100 beta transgenic mice.

  1994cited by this paper
• Hippocampus, theta, and spatial memory.

  1993cited by this paper
• Postsynaptic targets of GABAergic hippocampal neurons in the medial septum-diagonal band of broca complex

  1993cited by this paper
• The Human Hippocampus

  1988cited by this paper
• GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus

  1988cited by this paper

• From Structure to Function: Development of Relaxin‐3 Analogs and their Role in RXFP3 Signaling

  2025cites this paper
• Relaxin family peptide receptors in GtoPdb v.2025.3

  2025cites this paper
• Modulation of contextual fear acquisition and extinction by acute and chronic relaxin-3 receptor (RXFP3) activation in the rat retrosplenial cortex.

  2024cites this paper
• Relaxin family peptide receptor 3 (RXFP3) expressing cells in the zona incerta/lateral hypothalamus augment behavioural arousal

  2024cites this paper
• Unveiling a novel memory center in human brain: neurochemical identification of the nucleus incertus, a key pontine locus implicated in stress and neuropathology

  2024cites this paper
• Involvement of relaxin-family peptide-3 receptor (RXFP3) in the ventral dentate gyrus of the hippocampus in spatial and fear memory in rats.

  2024cites this paper
• Fear memory recall involves hippocampal somatostatin interneurons

  2023cites this paper
• Unveiling a Novel Memory Center in Humans: Neurochemical Identification of the Nucleus Incertus, a Key Pontine Locus Implicated in Stress and Neuropathology

  2023cites this paper
• Training and Injury Considerations in Female-Identifying Cyclists

  2023cites this paper
• Nucleus incertus projections to rat medial septum and entorhinal cortex: rare collateralization and septal-gating of temporal lobe theta rhythm activity

  2023cites this paper
• Functional Neuroanatomy of the Rat Nucleus Incertus–Medial Septum Tract: Implications for the Cell-Specific Control of the Septohippocampal Pathway

  2022cites this paper
• The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease

  2022cites this paper
• Bidirectional Communication between the Pontine Nucleus Incertus and the Medial Septum Is Carried Out by Electrophysiologically-Distinct Neuronal Populations

  2022cites this paper
• Curcumin improves memory deficits by inhibiting HMGB1‐RAGE/TLR4‐NF‐κB signalling pathway in APPswe/PS1dE9 transgenic mice hippocampus

  2021cites this paper
• Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory

  2021influential citation
• Relaxin-3 Innervation From the Nucleus Incertus to the Parahippocampal Cortex of the Rat

  2021influential citation
• The putative role of the relaxin-3/RXFP3 system in clinical depression and anxiety: a systematic literature review.

  2021cites this paper
• Functional Neuroanatomy of Relaxin-3/RXFP3 Systems in the Brain: Implications for Integrated Neuroendocrine and Behavioural Control

  2021cites this paper
• Relaxin family peptide receptors in GtoPdb v.2021.3

  2021cites this paper
• Rln3a is a prerequisite for spermatogenesis and fertility in male fish.

  2020cites this paper
• MAP/ERK Signaling in Developing Cognitive and Emotional Function and Its Effect on Pathological and Neurodegenerative Processes

  2020cites this paper
• Diversity and function of corticopetal and corticofugal GABAergic projection neurons

  2020cites this paper
• Mapping Cell Types and Efferent Pathways in the Ascending Relaxin-3 System of the Nucleus Incertus

  2020cites this paper
• Chronic activation of the relaxin‐3 receptor on GABA neurons in rat ventral hippocampus promotes anxiety and social avoidance

  2019cites this paper
• Nucleus incertus ablation disrupted conspecific recognition and modified immediate early gene expression patterns in ‘social brain’ circuits of rats

  2019cites this paper
• The role of relaxin-3/RXFP3 system in hyperphagia

  2019cites this paper
• Targeted viral vector transduction of relaxin-3 neurons in the rat nucleus incertus using a novel cell-type specific promoter

  2019cites this paper
• Brainstem nucleus incertus controls contextual memory formation

  2019cites this paper
• Chronic Activation of the Relaxin-3 Receptor (RXFP3) on GABA Neurons in Rat Ventral Hippocampus Promotes Anxiety and Social Avoidance

  2019cites this paper
• Septal GABA and Glutamate Neurons Express RXFP3 mRNA and Depletion of Septal RXFP3 Impaired Spatial Search Strategy and Long-Term Reference Memory in Adult Mice

  2019cites this paper
• Un nuevo agente en los mecanismos de la adicción al alcohol y la ingesta: el núcleo incertus y el neuropéptido relaxina-3

  2018cites this paper
• Modulation of forebrain function by nucleus incertus and relaxin‐3/RXFP3 signaling

  2018cites this paper
• Differential effects of relaxin-3 and a selective relaxin-3 receptor agonist on food and water intake and hypothalamic neuronal activity in rats.

  2018cites this paper
• Central relaxin-3 receptor (RXFP3) activation impairs social recognition and modulates ERK-phosphorylation in specific GABAergic amygdala neurons

  2018cites this paper
• Interactions between hypothalamic and brainstem arousal circuits: anatomical, electrophysiological, and behavioural studies

  2017cites this paper
• Relaxin-3/RXFP3 signalling in mouse hypothalamus: no effect of RXFP3 activation on corticosterone, despite reduced presynaptic excitatory input onto paraventricular CRH neurons in vitro

  2017cites this paper