Reversal of Profound, High-dose Rocuronium–induced Neuromuscular Blockade by Sugammadex at Two Different Time Points: An International, Multicenter, Randomized, Dose-finding, Safety Assessor–blinded, Phase II Trial

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Anesthesiology

• Publication date

  2008-08-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/ALN.0b013e31817f5bc7PMID 18648227
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Early Reversal of Profound Rocuronium-induced Neuromuscular Blockade by Sugammadex in a Randomized Multicenter Study: Efficacy, Safety, and Pharmacokinetics

  2007influential reference
• A Randomized, Dose-Finding, Phase II Study of the Selective Relaxant Binding Drug, Sugammadex, Capable of Safely Reversing Profound Rocuronium-Induced Neuromuscular Block

  2007cited by this paper
• Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision

  2007cited by this paper
• Effects of Butorphanol on Morphine-induced Itch and Analgesia in Primates

  2007cited by this paper
• Prolonged residual paralysis after a single intubating dose of rocuronium.

  2007cited by this paper
• The predisposition to inspiratory upper airway collapse during partial neuromuscular blockade.

  2007cited by this paper
• The doughnut and the hole: a new pharmacological concept for anaesthetists.

  2006cited by this paper
• Sugammadex: a revolutionary approach to neuromuscular antagonism.

  2006cited by this paper
• Reversal of Rocuronium-induced Neuromuscular Block by the Selective Relaxant Binding Agent Sugammadex: A Dose-finding and Safety Study

  2006cited by this paper
• Antagonism of neuromuscular blockade but not muscle relaxation affects depth of anaesthesia.

  2005cited by this paper
• First Human Exposure of Org 25969, a Novel Agent to Reverse the Action of Rocuronium Bromide

  2005influential reference
• Intubation conditions after rocuronium or succinylcholine for rapid sequence induction with alfentanil and propofol in the emergency patient

  2005cited by this paper
• Reversal of Neuromuscular Blockade and Simultaneous Increase in Plasma Rocuronium Concentration after the Intravenous Infusion of the Novel Reversal Agent Org 25969

  2003cited by this paper
• A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host.

  2002cited by this paper
• Rapid Tracheal Intubation with Large-Dose Rocuronium: A Probability-Based Approach

  2000cited by this paper
• A large simple randomized trial of rocuronium versus succinylcholine in rapid‐sequence induction of anaesthesia along with propofol

  1999cited by this paper
• Rapid tracheal intubation with rocuronium: a probability approach to determining dose.

  1999cited by this paper
• Comparison of rocuronium and suxamethonium for use during rapid sequence induction of anaesthesia

  1998cited by this paper
• The Cerebral and Systemic Effects of Movement in Response to a Noxious Stimulus in Lightly Anesthetized Dogs Possible Modulation of Cerebral Function by Muscle Afferents

  1994cited by this paper
• Comparison of Rocuronium, Succinylcholine, and Vecuronium for Rapid‐sequence Induction of Anesthesia in Adult Patients

  1993cited by this paper
• Evaluation of the endotracheal intubating conditions of rocuronium (ORG 9426) and succinylcholine in outpatient surgery.

  1992cited by this paper
• Sinus arrest complicating a bitemporal approach to the treatment of pan-facial fractures.

  1990cited by this paper

• Recurarization after sugammadex reversal in a patient with amyotrophic lateral sclerosis: Case report

  2026cites this paper
• A New Algorithm for Management of Unanticipated Difficult Tracheal Intubation in Adults

  2025influential citation
• The Potential Renoprotective Effect of Sugammadex in Renal Ischemia-reperfusion Injury

  2025influential citation
• Urgent Use of Sugammadex in a Patient With Occult Bronchopleural Fistula Manifested Following Anesthesia Induction

  2025cites this paper
• Selection of anesthetic agents for obstructive jaundice: An update for anesthesiologists

  2025cites this paper
• When Our “Best” Isn’t Good Enough: Asleep Paralyzed Fiberoptic Intubation After a Failed Awake Fiberoptic at an Outside Hospital

  2025cites this paper
• All India Difficult Airway Association 2025 Guidelines for the management of unanticipated difficult airway in adults under general anaesthesia

  2025cites this paper
• Hyperkalemic emergency department patients intubated with rocuronium or succinylcholine: Retrospective study of clinical outcomes.

  2025cites this paper
• Weight-Based Standardized Sugammadex Dosing in Pediatrics: A Quality Improvement Initiative to Improve Compliance with Dosing Guidelines and Reduce Waste and Cost

  2024cites this paper
• Asystolic cardiac arrest secondary to sugammadex administration in a young patient

  2024cites this paper
• The safety and efficacy of sugammadex for reversing neuromuscular blockade in younger children and infants

  2024cites this paper
• Suspected Sinus Arrest After Sugammadex Administration: A Case Report.

  2024cites this paper
• Reversing the triad of anaesthesia in a cannot intubate, cannot oxygenate emergency.

  2024cites this paper
• Onset time, duration of action, and intubating conditions after mivacurium in elderly and younger patients

  2024cites this paper
• The arousal effect of sugammadex reversal of neuromuscular blockade differs with anesthetic depth in propofol-remifentanil anesthesia: a randomized controlled trial

  2023cites this paper
• Rapid sequence induction of anesthesia: works in progress and steps forward with focus to oxygenation and monitoring techniques.

  2023cites this paper
• Monitoring Depth of Neuromuscular Blockade and Adequacy of Reversal: Clinical and Pharmacoeconomic Implications

  2023influential citation
• A retrospective observational cross-sectional study of intraoperative neuromuscular blocking agent choice and dosing in a US paediatric referral hospital before and after introduction of sugammadex☆.

  2023cites this paper
• Changes in bispectral index and patient state index during sugammadex reversal of neuromuscular blockade under steady-state sevoflurane anesthesia

  2023cites this paper
• Neurologic Examination Facilitated by Reversal of Rocuronium with Sugammadex

  2023cites this paper
• When reversal agent goes wrong – anaphylaxis with sugammadex

  2023cites this paper
• Evaluation of Sugammadex Dosing for Neurological Examination in the Emergency Department

  2023influential citation
• Remifentanil vs Neuromuscular Blockers During Rapid Sequence Intubation Among Patients at Risk of Aspiration.

  2023cites this paper
• 2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade: A Report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade

  2023cites this paper
• Type‐2 diabetes mellitus and recovery of rocuronium‐induced neuromuscular blockade

  2022cites this paper
• Sugammadex versus neostigmine for neuromuscular blockade reversal in outpatient surgeries: A randomized controlled trial to evaluate efficacy and associated healthcare cost in an academic center

  2022cites this paper
• Comparison of onset time, duration of action, and intubating conditions after cisatracurium 0.15 mg/kg in young and elderly patients

  2022cites this paper
• Possible effects of some anaesthetic agents in rat hepatotoxicity: Histological and biochemical study

  2022cites this paper
• Characterizing the Heart Rate Effects From Administration of Sugammadex to Reverse Neuromuscular Blockade: An Observational Study in Patients

  2022cites this paper
• Does the Use of Rocuronium-Sugammadex Instead of Succinylcholine in Electroconvulsive Therapy Affect Seizure Duration?

  2022cites this paper
• Half-Dose Sugammadex After Neostigmine Versus Neostigmine as a Routine Reversal Agent: A Pilot Randomized Trial.

  2022cites this paper
• Reversal of rocuronium‐induced intense neuromuscular blockade by sugammadex in Korean children: A pharmacokinetic and pharmacodynamic analysis

  2022cites this paper
• Sugammadex-associated asystole in young obese patient: Case report

  2022cites this paper
• Should rocuronium and sugammadex replace succinylcholine for airway emergencies in class B ambulatory anesthesia settings? A systematic review.

  2022cites this paper
• A Clinical and Budgetary Impact Analysis of Introducing Sugammadex for Routine Reversal of Neuromuscular Blockade in a Hypothetical Cohort in the US

  2021cites this paper
• Carboxymethyl-γ-cyclodextrin, a novel selective relaxant binding agent for the reversal of neuromuscular block induced by aminosteroid neuromuscular blockers: an ex vivo laboratory study

  2021cites this paper
• Emergency Airway Management Outside the Operating Room: Current Evidence and Management Strategies.

  2021cites this paper
• Sugammadex induced bradycardia and hypotension

  2021influential citation
• Rocuronium Reversal in the Emergency Department: Retrospective Evaluation of Hemodynamic Instability Following Administration of Sugammadex Versus Neostigmine With Glycopyrrolate

  2021cites this paper
• DDDT_A_328682 3893..3901

  2021cites this paper
• Sugammadex, the Guardian of Deep Muscle Relaxation During Conventional and Robot-Assisted Laparoscopic Surgery: A Narrative Review

  2021cites this paper
• Anesthetic management of obese and morbidly obese parturients

  2021cites this paper
• Randomised controlled trial of sugammadex or neostigmine for reversal of neuromuscular block on the incidence of pulmonary complications in older adults undergoing prolonged surgery.

  2020cites this paper
• Guidelines on muscle relaxants and reversal in anaesthesia adductor pollicis *, *.

  2020cites this paper
• Individual pharmacometric analysis for sugammadex reversal and re-administration of neuromuscular blockade

  2020cites this paper
• Sugammadex Administration in Pregnant Women and in Women of Reproductive Potential: A Narrative Review

  2020cites this paper
• Long QT Syndrome and Perioperative Torsades de Pointes: What the Anesthesiologist Should Know.

  2020cites this paper
• Advantages and pitfalls of clinical application of sugammadex

  2020cites this paper
• Appropriate dosing of sugammadex and rocuronium for reversal of neuromuscular blockade and reparalysis

  2020cites this paper
• Rapid Sequence Induction With a Standard Intubation Dose of Rocuronium After Magnesium Pretreatment Compared With Succinylcholine: A Randomized Clinical Trial

  2020cites this paper
• What is the Role of Sugammadex in the Emergency Department?

  2020cites this paper
• Prevention of Postoperative Nausea and Vomiting by Use of Rapid Sequence Intubation

  2019cites this paper
• STRUCTURAL CHARACTERISTICS OF SUGAMMADEX

  2019cites this paper
• Safe and Efficient Anesthesia: The Role of Quantitative Neuromuscular Monitoring

  2019cites this paper
• Reversal of neuromuscular blockade with sugammadex during continuous administration of anaesthetic agents: a double‐blind randomised crossover study using the bispectral index

  2019influential citation
• The potential risks of sugammadex

  2019cites this paper
• Obesity And Obstetric Anesthesia: Current Insights

  2019cites this paper
• Effect of Sugammadex and Rocuronium Combination on Cranial Neurotoxicity in Rats : Experimental Study

  2019cites this paper
• Safety of sugammadex for reversal of neuromuscular block

  2019cites this paper
• Sugammadex associated profound bradycardia and sustained hypotension in patient with the slow recovery of neuromuscular blockade - A case report -

  2019cites this paper
• Successful Sugammadex Reversal of An Inadvertent Massive Overdose of Rocuronium in an Adult Patient

  2019cites this paper
• Neuromuscular Blockers and Reversal Drugs

  2019cites this paper
• Case series of 331 cases of sugammadex compared to neostigmine in patients under 2 years of age

  2019cites this paper
• Algorithmusbasierte Präventionsstrategien zur Vermeidung neuromuskulärer Restblockaden

  2019cites this paper
• The Role of Neuroinflammation in Postoperative Cognitive Dysfunction: Moving From Hypothesis to Treatment

  2019cites this paper
• Sugammadex For Reversal of Neuromuscular Blockade: Uses and Limitations.

  2019cites this paper
• Delayed neuromuscular recovery after use of sugammadex in a patient with amyotrophic lateral sclerosis: a case report

  2019cites this paper
• Prolonged neuromuscular blockade and insufficient reversal after sugammadex administration in cesarean section under general anesthesia: a case report

  2019cites this paper
• Profound Bradycardia and Cardiac Arrest After Sugammadex Administration in a Previously Healthy Patient: A Case Report.

  2019cites this paper
• Allgemeinanästhesie

  2019cites this paper
• Sugammadex is associated with better respiratory recovery than neostigmine following reversal of anaesthesia-associated neuromuscular blockade in the morbidly obese patients following elective laparoscopic surgery

  2018cites this paper
• Lower intra-abdominal pressure has no cardiopulmonary benefits during laparoscopic colorectal surgery: a double-blind, randomized controlled trial

  2018cites this paper
• Anesthesia in the Elderly Patient Undergoing Otolaryngology Head and Neck Surgery.

  2018cites this paper
• Anesthesia for Patients with Obstructive Jaundice

  2018cites this paper
• Recent advances in neuromuscular block during anesthesia

  2018cites this paper
• Sugammadex-induced bradycardia and asystole: how great is the risk?

  2018cites this paper
• Clinical Pharmacology of Drugs Acting at the Neuromuscular Junction

  2018cites this paper
• [Update on muscle relaxation : What comes after succinylcholine, rocuronium and sugammadex?]

  2017cites this paper
• Optimal anesthetic regimen for ambulatory laser microlaryngeal surgery

  2017cites this paper
• Intraoperative management of critical arrhythmia

  2017cites this paper
• Drug interactions in the context of neuromuscular blockade: clinical implications and safety issues

  2017cites this paper
• Muscle Relaxants and Neuromuscular Blockade

  2017cites this paper
• Design and evaluation of artificial receptors for the reversal of neuromuscular block.

  2017cites this paper
• Bradycardia in a Pediatric Heart Transplant Recipient: Is It the Sugammadex?

  2017cites this paper
• Profound Bradycardia and Hypotension after Sugammadex Administration

  2017influential citation
• Neuromuscular Blocking Drugs: Physiology, Pharmacology and Clinical Aspects

  2017cites this paper
• Sugammadex efficacy for reversal of rocuronium- and vecuronium-induced neuromuscular blockade: A pooled analysis of 26 studies.

  2017cites this paper
• Notfallnarkose beim Erwachsenen: Immer mit Rocuronium!

  2016cites this paper
• Recovery of laryngeal nerve function with sugammadex after rocuronium-induced profound neuromuscular block.

  2016cites this paper
• Preclinical Pharmacology of CW002: A Nondepolarizing Neuromuscular Blocking Drug of Intermediate Duration, Degraded and Antagonized by l-cysteine—Additional Studies of Safety and Efficacy in the Anesthetized Rhesus Monkey and Cat

  2016cites this paper
• Inducción de secuencia rápida para intubación orotraqueal en Urgencias

  2016cites this paper
• Sugammadex and neostigmine dose-fi nding study for reversal of residual neuromuscular block at a train-of-four ratio of 0 . 2 ( SUNDRO 20 ) † , #

  2016cites this paper
• Elderly Patients Require Higher Doses of Sugammadex for Rapid Recovery from Deep Neuromuscular Block

  2016cites this paper
• Sugammadex and neostigmine dose-finding study for reversal of residual neuromuscular block at a train-of-four ratio of 0.2 (SUNDRO20)†,.

  2016cites this paper
• Sugammadex: watch out for new side effects

  2016cites this paper
• Appropriate dosing of sugammadex to reverse deep rocuronium‐induced neuromuscular blockade in morbidly obese patients

  2016cites this paper
• The Use of Sugammadex in Clinical Practice: Which Patients Are Most Likely to Benefit?

  2016cites this paper
• Efficacy and safety of sugammadex compared to neostigmine for reversal of neuromuscular blockade: a meta-analysis of randomized controlled trials.

  2016cites this paper
• Sugammadex: A Review of Neuromuscular Blockade Reversal

  2016cites this paper
• Is deep neuromuscular block beneficial in laparoscopic surgery? No, probably not

  2016cites this paper