Acción de la simvastatina en la contracción de músculo liso de anillo traqueal inducida por estímulo químico y térmico

La contraccion del musculo liso traqueal esta vinculada a la entrada de Ca2+ al interior celular y la deplecion de los depositos intracelulares. Simvastatina, relaja la arteria basilar por disminucion de la concentracion intracelular de Ca2+. El objetivo del trabajo fue conocer el efecto de la simvastatina sobre la contraccion de la musculatura lisa de traquea aislada de rata, antes y despues del estimulo con acetilcolina y agua fria. Se emplearon 8 ratas anestesiadas con tiobarbital sodico 60 mg/Kg i.p, para extraer la traquea, se cortaron los anillos, se estimularon con acetilcolina 10-3 M y agua fria 18 °C con y sin simvastatina. Las mediciones se realizaron por ImageTool V. 3.0 (UTHSCSA). Las medias aritmeticas del diametro del musculo traqueal sin la incubacion en simvastatina disminuyeron significativamente para el estimulo de acetilcolina y agua fria (p = 0,000 y p = 0,046) respectivamente; al agregar simvastatina se encuentra disminucion del diametro traqueal con el estimulo de agua fria la cual es estadisticamente significativa (p = 0,002) para la acetilcolina no es estadisticamente significativa (p = 0,084). Las medias de las velocidades de contraccion de la traquea al incubar acetilcolina/simvastatina y agua fria/simvastatina, no fueron significativos estadisticamente (p=0,082797 y p = 0,797599). Se concluye que hay disminucion del diametro traqueal al estimular la traquea con agua fria y acetilcolina. Al agregarsimvastatina y agua fria, se produce el efecto constrictor y disminucion del diametro traqueal ya que se utilizan otras vias de entrada de calcio que no dependen del colesterol.

• Publication year

  2010

• Venue

  Revista Médica de la Universidad de Costa Rica

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers
  DOI 10.15517/RMU.V4I1.7820
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  Open on Semantic Scholar

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  Semantic Scholar

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