Localization of Pacemaker Channels in Lipid Rafts Regulates Channel Kinetics

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Circulation Research

• Publication date

  2004-05-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/01.RES.0000127621.54132.AEPMID 15073040
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• And now for something completely different

  2017cited by this paper
• The caveolae in rabbit sinus node and atrium

  2004cited by this paper
• Molecular Basis of the Effect of Potassium on Heterologously Expressed Pacemaker (HCN) Channels

  2003cited by this paper
• Lipid rafts make for slippery platforms

  2003cited by this paper
• Nicotinic acetylcholine receptor α7 regulates cAMP signal within lipid rafts

  2003cited by this paper
• Hyperpolarization-activated cation currents: from molecules to physiological function.

  2003cited by this paper
• KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents

  2003cited by this paper
• Nicotinic acetylcholine receptor alpha 7 regulates cAMP signal within lipid rafts.

  2003cited by this paper
• Lead poisoning: case studies.

  2002cited by this paper
• Relationships between caveolae and eNOS: everything in proximity and the proximity of everything.

  2002cited by this paper
• Comparison of the affinity of beta-blockers for two states of the beta 1-adrenoceptor in ferret ventricular myocardium.

  2002cited by this paper
• Discrete Microdomains with High Concentration of cAMP in Stimulated Rat Neonatal Cardiac Myocytes

  2002cited by this paper
• Comparison of the affinity of β‐blockers for two states of the β1‐adrenoceptor in ferret ventricular myocardium

  2002cited by this paper
• From funny current to HCN channels: 20 years of excitation.

  2002cited by this paper
• TrpC1 Is a Membrane-Spanning Subunit of Store-Operated Ca2+ Channels in Native Vascular Smooth Muscle Cells

  2001cited by this paper
• Compartmentation of G protein-coupled signaling pathways in cardiac myocytes.

  2001cited by this paper
• Isoform-specific Localization of Voltage-gated K+Channels to Distinct Lipid Raft Populations

  2001cited by this paper
• C Terminus-mediated Control of Voltage and cAMP Gating of Hyperpolarization-activated Cyclic Nucleotide-gated Channels*

  2001cited by this paper
• MinK-Related Peptide 1: A &bgr; Subunit for the HCN Ion Channel Subunit Family Enhances Expression and Speeds Activation

  2001cited by this paper
• Effects of membrane cholesterol on the sensitivity of the GABA(A) receptor to GABA in acutely dissociated rat hippocampal neurones.

  2001cited by this paper
• MinK-Related Peptide 1

  2001cited by this paper
• Integrated Allosteric Model of Voltage Gating of Hcn Channels

  2001cited by this paper
• Differential Targeting of Shaker-like Potassium Channels to Lipid Rafts*

  2000cited by this paper
• Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway.

  2000cited by this paper
• Dual allosteric modulation of pacemaker (f) channels by cAMP and voltage in rabbit SA node

  1999cited by this paper
• A Role for Caveolin and the Urokinase Receptor in Integrin-mediated Adhesion and Signaling

  1999cited by this paper
• Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues.

  1999cited by this paper
• The human gene coding for HCN2, a pacemaker channel of the heart.

  1999cited by this paper
• Inaugural editorial: a new era for Circulation Research.

  1999cited by this paper
• Dual effect of nitric oxide on the hyperpolarization-activated inward current (I(f)) in sino-atrial node cells of the rabbit.

  1998cited by this paper
• Differential control of the hyperpolarization‐activated current (i(f)) by cAMP gating and phosphatase inhibition in rabbit sino‐atrial node myocytes.

  1997cited by this paper
• The effect of membrane cholesterol content on ion transport processes in plasma membranes

  1997cited by this paper
• The effect of membrane cholesterol content on ion transport processes in plasma membranes.

  1997cited by this paper
• Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains.

  1997cited by this paper
• Activation of f‐channels by cAMP analogues in macropatches from rabbit sino‐atrial node myocytes

  1997cited by this paper
• cAMP compartmentation is responsible for a local activation of cardiac Ca2+ channels by beta-adrenergic agonists.

  1996cited by this paper
• Beta-adrenergic and muscarinic cholinergic receptor densities in the human sinoatrial node: identification of a high beta 2-adrenergic receptor density.

  1996cited by this paper
• Activation of the hyperpolarization-activated current (if) in sino-atrial node myocytes of the rabbit by vasoactive intestinal peptide

  1996cited by this paper
• β‐Adrenergic and Muscarinic Cholinergic Receptor Densities in the Human Sinoatrial Node:

  1996cited by this paper
• Relative densities of muscarinic cholinergic and beta-adrenergic receptors in the canine sinoatrial node and their relation to sites of pacemaker activity.

  1995cited by this paper
• Modulation of single hyperpolarization‐activated channels (i(f)) by cAMP in the rabbit sino‐atrial node.

  1994cited by this paper
• Pacemaker mechanisms in cardiac tissue.

  1993cited by this paper
• Direct activation of cardiac pacemaker channels by intracellular cyclic AMP

  1991cited by this paper
• Regional differences of beta 1- and beta 2-adrenoceptor-mediated functions in feline heart. A beta 2-adrenoceptor-mediated positive inotropic effect possibly unrelated to cyclic AMP.

  1991cited by this paper
• Regional differences of β1- and β2-adrenoceptor-mediated functions in feline heart

  1991cited by this paper
• Intracoronary Injections of Salbutamol Demonstrate the Presence of Functional ft-Adrenoceptors in the Human Heart

  1989cited by this paper
• Muscarinic control of the hyperpolarization‐activated current (if) in rabbit sino‐atrial node myocytes.

  1988cited by this paper
• Acetylcholine inhibits activation of the cardiac hyperpolarizing-activated current,if

  1987cited by this paper
• Characterization of single pacemaker channels in cardiac sino-atrial node cells

  1986cited by this paper
• Properties of the hyperpolarizing‐activated current (if) in cells isolated from the rabbit sino‐atrial node.

  1986cited by this paper
• Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes.

  1983cited by this paper
• The Plasma Membrane of Leading Pacemaker Cells in the Rabbit Sinus Node: A Qualitative and Quantitative Ultrastructural Analysis

  1979cited by this paper
• How does adrenaline accelerate the heart?

  1979cited by this paper

• High‐Specificity Spatiotemporal Cholesterol Detection by Quadrature Phase‐Shifted Polarization Stimulated Raman Imaging

  2025cites this paper
• IGF-1 promotes cell surface expression of HCN4 pacemaker channels contributing to tachycardia.

  2025cites this paper
• Sequential Membrane Remodeling by Cholesterol Distinctly Modulates HCN Channels in Naïve and Neuropathic DRG Neurons

  2025cites this paper
• Structure mirroring function: What's the 'matter' with the funny current?

  2025cites this paper
• The role of interplay between the plant plasma membrane H+-ATPase and its lipid environment.

  2024cites this paper
• Electrocontractile remodeling of isolated cardiomyocytes induced during early-stage hypercholesterolemia

  2024cites this paper
• The cardiac conduction system: History, development, and disease.

  2024cites this paper
• Efficient killing of intracellular bacteria by cationic heme-mimetic gallium porphyrin in vivo

  2024cites this paper
• Membrane lipid nanodomains modulate HCN pacemaker channels in nociceptor DRG neurons

  2023cites this paper
• DIRECT REGULATION OF THE VOLTAGE-SENSING DOMAIN OF HCN CHANNELS BY MEMBRANE LIPID COMPARTMENTALIZATION

  2023influential citation
• Compartmentalized cAMP signalling and control of cardiac rhythm

  2023cites this paper
• Direct regulation of the voltage sensor of HCN channels by membrane lipid compartmentalization

  2023influential citation
• Ca2+ dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract.

  2023cites this paper
• Cross-talk between cAMP and Ca2+ signalling in cardiac pacemaker cells involves IP3-evoked Ca2+ release and stimulation of adenylyl cyclase 1

  2022cites this paper
• Chinese natural compound decreases pacemaking of rabbit cardiac sinoatrial cells by targeting second messenger regulation of f-channels

  2022cites this paper
• Computational Prediction of Phosphoinositide Binding to Hyperpolarization-Activated Cyclic-Nucleotide Gated Channels

  2022cites this paper
• Inhibition of adenylyl cyclase 1 by ST034307 inhibits IP3-evoked changes in sino-atrial node beat rate

  2022cites this paper
• Review: HCN Channels in the Heart

  2022cites this paper
• Cyclic nucleotide signaling and pacemaker activity.

  2021cites this paper
• Dual Activation of Phosphodiesterase 3 and 4 Regulates Basal Cardiac Pacemaker Function and Beyond

  2021cites this paper
• A detailed characterization of the hyperpolarization-activated “funny” current (If) in human-induced pluripotent stem cell (iPSC)–derived cardiomyocytes with pacemaker activity

  2021cites this paper
• The Role of Cholesterol in Membrane Localization of TRPV5 Calcium Channels in Jurkat Human T Cells

  2020cites this paper
• Human Cell Modeling for Cardiovascular Diseases

  2020cites this paper
• Lipid levels and risk of new‐onset atrial fibrillation: A systematic review and dose‐response meta‐analysis

  2020cites this paper
• The Treatment of Arterial Hypertension

  2019cites this paper
• Functional Microdomains in Heart’s Pacemaker: A Step Beyond Classical Electrophysiology and Remodeling

  2018cites this paper
• Advances in Understanding of Structure, Function and Plasticity of HCN Channels

  2018cites this paper
• Dual Activation of Phosphodiesterases 3 and 4 Regulates Basal Spontaneous Beating Rate of Cardiac Pacemaker Cells: Role of Compartmentalization?

  2018cites this paper
• Hyperpolarization-activated cyclic-nucleotide-gated channels: pathophysiological, developmental, and pharmacological insights into their function in cellular excitability.

  2018cites this paper
• Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells Is Regulated by Dual Activation of PDEs (Phosphodiesterases) 3 and 4

  2018cites this paper
• The expression of the rare caveolin-3 variant T78M alters cardiac ion channels function and membrane excitability

  2017cites this paper
• Long-QT syndrome-associated caveolin-3 mutations differentially regulate the hyperpolarization-activated cyclic nucleotide gated channel 4.

  2017influential citation
• The Hyperpolarization-Activated Cyclic Nucleotide–Gated Channels: from Biophysics to Pharmacology of a Unique Family of Ion Channels

  2017cites this paper
• Mitochondrial calcium uniporter is a nodal regulator of physiological and pathological stress responses in myocardium

  2016cites this paper
• Biopacemaking : new targets and new mechanisms

  2016cites this paper
• Current understanding of the pathophysiological mechanisms responsible for inappropriate sinus tachycardia: role of the If “funny” current

  2016cites this paper
• Ca(2+)/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function.

  2016cites this paper
• translocation into lipid rafts Ceramide modulates HERG potassium channel gating by

  2016cites this paper
• Heterogeneous Inhibition in Macroscopic Current Responses of Four Nicotinic Acetylcholine Receptor Subtypes by Cholesterol Enrichment

  2016cites this paper
• Electrophysiology and metabolism of caveolin-3-overexpressing mice

  2016cites this paper
• Gap junction modifiers regulate electrical activities of the sinoatrial node and pulmonary vein: Therapeutic implications in atrial arrhythmogenesis.

  2016cites this paper
• Molecular mechanism of cyclic nucleotide action on HCN pacemaker channels

  2016cites this paper
• Updates on HCN Channels in the Heart: Function, Dysfunction and Pharmacology.

  2015cites this paper
• Myocardial tissue caveolae.

  2015cites this paper
• Targeting membrane proteins to inner segments of vertebrate photoreceptors

  2015cites this paper
• Abnormal Cardiac Macromolecular Interactions Mechanisms of Human Arrhythmia Syndromes

  2015cites this paper
• Isoform dependent regulation of human HCN channels by cholesterol

  2015cites this paper
• Cooperative gating between ion channels.

  2014cites this paper
• Inhibition of cardiac pacemaker channel hHCN2 depends on intercalation of lipopolysaccharide into channel‐containing membrane microdomains

  2014influential citation
• Functional Expression and Regulation of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels (HCN) in Mouse iPS Cell-derived Cardiomyocytes after UTF1-Neo Selection

  2014cites this paper
• Cellular cardiac electrophysiological effects of HCN channel blockers

  2014cites this paper
• HCN4, Sinus Bradycardia and Atrial Fibrillation.

  2014cites this paper
• Defective interactions of protein partner with ion channels and transporters as alternative mechanisms of membrane channelopathies.

  2014cites this paper
• Deletion of integrin linked kinase in endothelial cells results in defective RTK signaling caused by caveolin 1 mislocalization

  2013cites this paper
• Caveolae and Arrhythmogenesis

  2013cites this paper
• Kv, modulation by polyunsaturated fatty acids. Functional study of a new Kv7.1 mutation associated to short QT syndrome

  2013cites this paper
• - Genetic and Epigenetic Basis of Myocardial Ischemia and Reperfusion Injury: Protection by Dietary Antioxidants and Chromatin-Modifying Compounds

  2013cites this paper
• Multifactorial Impact of Channel Beta‐Subunit Gene Mutation on Automaticity

  2013cites this paper
• Molecular and Functional Evidence of HCN4 and Caveolin-3 Interaction During Cardiomyocyte Differentiation from Human Embryonic Stem Cells

  2013influential citation
• Energetic and structural impact of cyclic nucleotide binding to hyperpolarization-activated cyclic nucleotide-gated channels

  2013cites this paper
• PREDESTINATION: PRimary vEntricular fibrillation and suDden dEath during a firST myocardIal iNfArcTION: Genetic basis

  2013cites this paper
• Ion channel TRPM4 activity and cardiac conduction disease

  2012cites this paper
• Cholesterol Regulation of Cardiac Ion Channels

  2012cites this paper
• Caveolae create local signalling domains through their distinct protein content, lipid profile and morphology.

  2012cites this paper
• A caveolin-binding domain in the HCN4 channels mediates functional interaction with caveolin proteins.

  2012influential citation
• Thy1 associates with the cation channel subunit HCN4 in adult rat retina.

  2012cites this paper
• HCN Channels and Heart Rate

  2012cites this paper
• Distinct perinatal features of the hyperpolarization-activated non-selective cation current Ih in the rat cortical plate

  2012cites this paper
• Adrenergic Regulation of HCN4 Channel Requires Protein Association with β2-Adrenergic Receptor*

  2012cites this paper
• Alterations in membrane caveolae and BKCa channel activity in skin fibroblasts in Smith-Lemli-Opitz syndrome.

  2011cites this paper
• Creation of a Biopacemaker: Lessons from the Sinoatrial Node

  2011cites this paper
• Selective pharmacological inhibition of the pacemaker channel isoforms (HCN1-4) as new possible therapeutical targets.

  2011cites this paper
• A full range of mouse sinoatrial node AP firing rates requires protein kinase A-dependent calcium signaling.

  2011cites this paper
• Isolation and Characterization of Atrioventricular Nodal Cells From Neonate Rabbit Heart

  2011cites this paper
• Characterisation of Subsidiary Pacemaker Tissue in an Ex Vivo Model of Sick Sinus Syndrome and its Utility for Biopacemaking.

  2011cites this paper
• The Funny Current in Cardiac Non-Pacemaker Cells: Functional Role and Pharmacological Modulation

  2011cites this paper
• Bradyarrhythmia Therapies: The Creation of Biological Pacemakers and Restoring Atrioventricular Node Function

  2011cites this paper
• Hyperpolarization-activated ion channels as targets for nitric oxide signalling in deep cerebellar nuclei

  2010cites this paper
• HCN-related channelopathies

  2010cites this paper
• Genetics of heart failure and sudden death.

  2010cites this paper
• The cardiac pacemaker current.

  2010cites this paper
• Acute Cholesterol-induced Anti-natriuretic Effects

  2010cites this paper
• Cycling in the Mechanism of Pacemaking Cardiac Pacemaking : Historical Overview and Future Directions

  2010cites this paper
• Defining a new paradigm for human arrhythmia syndromes: phenotypic manifestations of gene mutations in ion channel- and transporter-associated proteins.

  2010cites this paper
• Acción de la simvastatina en la contracción de músculo liso de anillo traqueal inducida por estímulo químico y térmico

  2010cites this paper
• SYMPOSIUM REVIEW: Lipid microdomains and the regulation of ion channel function

  2010cites this paper
• Cholesterol and cardiac arrhythmias

  2010cites this paper
• Trafficking, lateral mobility and segregation of the plant K channel KAT1.

  2010cites this paper
• Ceramide modulates HERG potassium channel gating by translocation into lipid rafts.

  2010cites this paper
• Roles of voltage-gated ion channels in regulating the responses of principal neurons of the medial superior olive

  2009cites this paper
• Modification of cardiovascular ion channels by gene therapy

  2009cites this paper
• More seafood to control heart rate?

  2009cites this paper
• The “Funny” Pacemaker Current

  2009influential citation
• Distribution of the pacemaker HCN4 channel mRNA and protein in the rabbit sinoatrial node.

  2009cites this paper
• Antifibrillatory agents and potassium channels in the atria: pore block versus channel trafficking.

  2009cites this paper
• Regulation of ATP-sensitive K+ channels by caveolin-enriched microdomains in cardiac myocytes.

  2009cites this paper
• Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes.

  2009cites this paper
• Hyperpolarization-activated cation channels: from genes to function.

  2009cites this paper
• SPHINGOLIPID-INDUCED ACTIVATION OF THE VOLUME-SENSITIVE Cl− CURRENT IS MEDIATED BY MITOCHONDRIAL REACTIVE OXYGEN SPECIES

  2009cites this paper
• Regulation of ATP -sensitive potassium channels in the heart

  2009influential citation