Metabolic Gene Remodeling and Mitochondrial Dysfunction in Failing Right Ventricular Hypertrophy Secondary to Pulmonary Arterial Hypertension

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Circulation: Heart Failure

• Publication date

  2013-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCHEARTFAILURE.111.966127PMID 23152488PMCID PMC3790960
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertension.

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  2012cited by this paper
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  2012cited by this paper
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• Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapy.

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  2011cited by this paper
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  2011cited by this paper
• Staphylococcus aureus sepsis and mitochondrial accrual of the 8-oxoguanine DNA glycosylase DNA repair enzyme in mice.

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• Adrenergic Receptor Blocker Improves Metabolic Remodeling In Experimental Right Ventricular Failure Due To Pulmonary Hypertension

  2011cited by this paper
• Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy.

  2011cited by this paper
• Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension.

  2010cited by this paper
• A proposed mitochondrial-metabolic mechanism for initiation and maintenance of pulmonary arterial hypertension in fawn-hooded rats: the Warburg model of pulmonary arterial hypertension.

  2010cited by this paper
• Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure

  2010cited by this paper
• Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats.

  2010cited by this paper
• Defective DNA Replication Impairs Mitochondrial Biogenesis In Human Failing Hearts

  2010influential reference
• The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension.

  2009cited by this paper
• Chronic Pulmonary Artery Pressure Elevation Is Insufficient to Explain Right Heart Failure

  2009cited by this paper
• The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle

  2009cited by this paper
• Metabolic remodelling of the failing heart: beneficial or detrimental?

  2009cited by this paper
• Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation

  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
• Induction of mitochondrial biogenesis is a maladaptive mechanism in mitochondrial cardiomyopathies.

  2007cited by this paper
• Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure.

  2006cited by this paper
• Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha.

  2006cited by this paper
• Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-γ coactivator 1α

  2006cited by this paper
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  2006influential reference
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  2005cited by this paper
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  2005cited by this paper
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  2002cited by this paper
• Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis.

  2000cited by this paper
• Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth.

  2000cited by this paper
• A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program.

  1997cited by this paper
• Detection of impaired fatty acid metabolism in right ventricular hypertrophy: Assessment by I-123 β-methyl iodophenyl pentadecanoic acid (BMIPP) myocardial single-photon emission computed tomography

  1997influential reference
• Myocardial ischemia decreases oxidative phosphorylation through cytochrome oxidase in subsarcolemmal mitochondria.

  1997cited by this paper
• Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage.

  1995cited by this paper
• Survival in primary pulmonary hypertension. Validation of a prognostic equation.

  1994influential reference
• Oxidative damage and mitochondrial decay in aging.

  1994cited by this paper
• Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis.

  1994cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

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  2024cites this paper
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  2024cites this paper
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• Blood Pressure Levels, Prevalence, and Innovative Approaches to Prevent Arterial Hypertension in Adolescent and Young Adult Populations

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• Pulmonary Hypertension and Right Ventricle: A Pathophysiological Insight

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  2023cites this paper
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  2023cites this paper
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• Comparative Metabolomics in Single Ventricle Patients after Fontan Palliation: A Strong Case for a Targeted Metabolic Therapy

  2023cites this paper
• Mitochondrial Integrity Is Critical in Right Heart Failure Development

  2023cites this paper
• Management of the Critically Ill Patient with Pulmonary Arterial Hypertension and Right Heart Failure.

  2022cites this paper
• Understanding How Heart Metabolic Derangement Shows Differential Stage Specificity for Heart Failure with Preserved and Reduced Ejection Fraction

  2022cites this paper
• Use of Prostaglandin E1 in the Management of Congenital Diaphragmatic Hernia–A Review

  2022cites this paper
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• Loss of cardiac myosin light chain kinase contributes to contractile dysfunction in right ventricular pressure overload

  2022cites this paper
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• Persistent Pulmonary Hypertension of the Newborn: Pathophysiological Mechanisms and Novel Therapeutic Approaches

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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2018cites this paper
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  2017cites this paper