B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2014-02-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1315464111PMID 24516162PMCID PMC3939923
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

  2013cited by this paper
• MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy

  2013cited by this paper
• Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes

  2013influential reference
• TEL (ETV6)‐AML1 (RUNX1) Initiates Self‐Renewing Fetal Pro‐B Cells in Association with a Transcriptional Program Shared with Embryonic Stem Cells in Mice

  2013cited by this paper
• Binding of FoxM1 to G2/M gene promoters is dependent upon B-Myb.

  2012cited by this paper
• The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression.

  2012cited by this paper
• Impaired adult myeloid progenitor CMP and GMP cell function in conditional c-myb-knockout mice

  2012cited by this paper
• Cyclins and cell cycle control in cancer and disease.

  2012influential reference
• The B-MYB Transcriptional Network Guides Cell Cycle Progression and Fate Decisions to Sustain Self-Renewal and the Identity of Pluripotent Stem Cells

  2012cited by this paper
• MYBL2 haploinsufficiency increases susceptibility to age-related haematopoietic neoplasia

  2012cited by this paper
• Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations.

  2012influential reference
• Elevated Cyclin G2 Expression Intersects with DNA Damage Checkpoint Signaling and Is Required for a Potent G2/M Checkpoint Arrest Response to Doxorubicin*

  2012cited by this paper
• Integrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by Myb

  2011cited by this paper
• Genome-wide Analysis of Simultaneous GATA1/2, RUNX1, FLI1, and SCL Binding in Megakaryocytes Identifies Hematopoietic Regulators

  2011cited by this paper
• Cell cycle regulation in hematopoietic stem cells

  2011cited by this paper
• B‐Myb is Critical for Proper DNA Duplication During an Unperturbed S Phase in Mouse Embryonic Stem Cells

  2010cited by this paper
• ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments

  2010cited by this paper
• Hematopoietic stem cell: self‐renewal versus differentiation

  2010cited by this paper
• Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells.

  2010cited by this paper
• c-Myb Is Required for Pro-B Cell Differentiation1

  2009cited by this paper
• Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation

  2009cited by this paper
• Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells.

  2009cited by this paper
• Reduced c‐Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis

  2009cited by this paper
• Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisions.

  2009cited by this paper
• A Lin-9 complex is recruited by B-Myb to activate transcription of G2/M genes in undifferentiated embryonal carcinoma cells

  2009cited by this paper
• Integration of external signaling pathways with the core transcriptional network in embryonic stem cells.

  2008cited by this paper
• An extended transcriptional network for pluripotency of embryonic stem cells.

  2008cited by this paper
• Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells

  2008cited by this paper
• B-MYB Is Essential for Normal Cell Cycle Progression and Chromosomal Stability of Embryonic Stem Cells

  2008cited by this paper
• Myeloid lineage commitment from the hematopoietic stem cell.

  2007cited by this paper
• Transcription factors in myeloid development: balancing differentiation with transformation

  2007cited by this paper
• The transcription factor B-Myb is essential for S-phase progression and genomic stability in diploid and polyploid megakaryocytes

  2006cited by this paper
• Coordination of erythropoiesis by the transcription factor c-Myb.

  2006cited by this paper
• Small molecules that delay S phase suppress a zebrafish bmyb mutant

  2005cited by this paper
• Generation of a conditional allele of the B‐myb gene

  2005cited by this paper
• A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility.

  2005cited by this paper
• Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment.

  2005cited by this paper
• c-Myb is critical for B cell development and maintenance of follicular B cells.

  2005cited by this paper
• Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates

  2005influential reference
• Critical functions for c-Myb at three checkpoints during thymocyte development

  2004cited by this paper
• Requirement of c-myb in T cell development and in mature T cell function.

  2004cited by this paper
• Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha.

  2004cited by this paper
• Cell cycle regulation by the B-Myb transcription factor

  2003cited by this paper
• A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

  2000cited by this paper
• B-myb Is Required for Inner Cell Mass Formation at an Early Stage of Development*

  1999cited by this paper
• Cell cycle regulation of hematopoietic stem cells.

  1998cited by this paper
• Redundant functions of B-Myb and c-Myb in differentiating myeloid cells.

  1997cited by this paper
• Identification of clonogenic common lymphoid progenitors in mouse bone marrow.

  1997cited by this paper
• Cell cycle-regulated repression of B-myb transcription: cooperation of an E2F site with a contiguous corepressor element.

  1996cited by this paper
• Inducible gene targeting in mice

  1995cited by this paper
• Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

  1995cited by this paper
• Transcription regulation by murine B-myb is distinct from that by c-myb.

  1993cited by this paper
• An E2F‐binding site mediates cell‐cycle regulated repression of mouse B‐myb transcription.

  1993cited by this paper
• A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis.

  1991cited by this paper

• Nonlinear transcriptional responses to gradual modulation of transcription factor dosage

  2026cites this paper
• A single-cell atlas and aging clock define biological age and risk-associated stem cell states in human hematopoiesis

  2026cites this paper
• Cell cycle regulator MYBL2 is a distinct vulnerability in acute myeloid leukemia

  2025cites this paper
• Fetal context conveys heritable protection against MLL-rearranged AML that depends on MLL3.

  2025cites this paper
• Dysregulation of MYBL2 impairs extravillous trophoblast lineage development and function, contributing to recurrent spontaneous abortion

  2025cites this paper
• Fetal context conveys heritable protection against MLL-rearranged leukemia that depends on MLL3

  2025cites this paper
• Comprehensive molecular classification predicted microenvironment profiles and therapy response for HCC

  2024cites this paper
• MYBL2 drives prostate cancer plasticity and identifies CDK2 as a therapeutic vulnerability in RB1-loss and neuroendocrine prostate cancer

  2024cites this paper
• Up-regulation of RAN by MYBL2 maintains osteosarcoma cancer stem-like cells population during heterogeneous tumor generation.

  2024cites this paper
• Nonlinear transcriptional responses to gradual modulation of transcription factor dosage

  2024cites this paper
• Targeting purine metabolism-related enzymes for therapeutic intervention: A review from molecular mechanism to therapeutic breakthrough.

  2024cites this paper
• MYBL2 Drives Prostate Cancer Plasticity: Inhibiting Its Transcriptional Target CDK2 for RB1-Deficient Neuroendocrine Prostate Cancer

  2024cites this paper
• Fatecode enables cell fate regulator prediction using classification-supervised autoencoder perturbation

  2024cites this paper
• Ectopic MYBL2-Mediated Regulation of Androglobin Gene Expression

  2024cites this paper
• Haploinsufficient Transcription Factors in Myeloid Neoplasms.

  2023cites this paper
• Enhanced fetal hematopoiesis in response to symptomatic SARS-CoV-2 infection during pregnancy

  2023cites this paper
• APEX1 Nuclease and Redox Functions are Both Essential for Adult Mouse Hematopoietic Stem and Progenitor Cells

  2023cites this paper
• Hoxb5 reprogrammes murine multipotent blood progenitors into haematopoietic stem cell‐like cells

  2022cites this paper
• Fatecode: Cell fate regulator prediction using classification autoencoder perturbation

  2022cites this paper
• TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis

  2022cites this paper
• Hematopoietic Stem Cell Factors: Their Functional Role in Self-Renewal and Clinical Aspects

  2022influential citation
• WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer

  2021cites this paper
• Multi-omic profiling of primary mouse neutrophils predicts a pattern of sex- and age-related functional regulation

  2021cites this paper
• Deep learning-based enhancement of epigenomics data with AtacWorks

  2021cites this paper
• MYBL2 Gene Polymorphism Is Associated With Acute Lymphoblastic Leukemia Susceptibility in Children

  2021cites this paper
• Hoxb5 reprograms murine multipotent blood progenitors into hematopoietic stem cell-like cells

  2021cites this paper
• MYB interacts with androgen receptor, sustains its ligand-independent activation and promotes castration resistance in prostate cancer

  2021cites this paper
• Intricate crosstalk between MYB and noncoding RNAs in cancer

  2021cites this paper
• Machine learning uncovers cell identity regulator by histone code

  2020cites this paper
• WNT inhibition creates a BRCA-like state in Wnt-addicted cancer

  2020cites this paper
• Multi-omic profiling of primary mouse neutrophils reveals a pattern of sex and age-related functional regulation

  2020influential citation
• The Master Regulator Protein BAZ2B Can Reprogram Human Hematopoietic Lineage-Committed Progenitors into a Multipotent State.

  2020cites this paper
• 髓系造血分化核心转录因子研究进展

  2019cites this paper
• Hematopoietic stem and progenitor cell proliferation and differentiation requires the trithorax protein Ash2l

  2019cites this paper
• Transcriptome and DNA Methylome Signatures Associated With Retinal Müller Glia Development, Injury Response, and Aging.

  2019cites this paper
• Single-cell tracing of the first hematopoietic stem cell generation in human embryos

  2019cites this paper
• Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing

  2019cites this paper
• Rigosertib ameliorates the effects of oncogenic KRAS signaling in a murine model of myeloproliferative neoplasia

  2019cites this paper
• Distinguishing features of microglia- and monocyte-derived macrophages after stroke

  2018influential citation
• The molecular biology of sickle cell anaemia

  2018cites this paper
• Quantification of differential transcription factor activity and multiomics-based classification into activators and repressors: diffTF

  2018influential citation
• Using 3D epigenomic maps of primary olfactory neuronal cells from living individuals to understand gene regulation

  2018cites this paper
• Demethylzeylasteral inhibits glioma growth by regulating the miR-30e-5p/MYBL2 axis

  2018cites this paper
• BMI1 enhancer polymorphism underlies chromosome 10p12.31 association with childhood acute lymphoblastic leukemia

  2018influential citation
• Use of Gene Expression Analysis for Discrimination of Primary and Secondary Adenocarcinoma of the Liver

  2018cites this paper
• Improving leukemic CD34+/CD38− blasts characterization with single-cell transcriptome sequencing

  2017cites this paper
• Downregulation of B‐myb promotes senescence via the ROS‐mediated p53/p21 pathway, in vascular endothelial cells

  2017cites this paper
• MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis

  2017cites this paper
• Construction of an integrated gene regulatory network link to stress-related immune system in cattle

  2017cites this paper
• Inactivation of 3-hydroxybutyrate dehydrogenase 2 delays zebrafish erythroid maturation by conferring premature mitophagy

  2016cites this paper
• Dpy 30 is critical for maintaining the identity and function of adult hematopoietic stem cells

  2016cites this paper
• Dpy30 is critical for maintaining the identity and function of adult hematopoietic stem cells

  2016cites this paper
• MYBL2 is an independent prognostic marker that has tumor-promoting functions in colorectal cancer.

  2015cites this paper
• Low Molecular Weight Fraction of Commercial Human Serum Albumin Induces Morphologic and Transcriptional Changes of Bone Marrow‐Derived Mesenchymal Stem Cells

  2015cites this paper
• MicroRNA and mRNA cargo of extracellular vesicles from porcine adipose tissue-derived mesenchymal stem cells.

  2014cites this paper