Small molecules that delay S phase suppress a zebrafish bmyb mutant

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Nature Chemical Biology

• Publication date

  2005-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/NCHEMBIO749PMID 16372403
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility.

  2005cited by this paper
• BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.

  2005cited by this paper
• tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.

  2005cited by this paper
• E2Fs link the control of G1/S and G2/M transcription

  2004cited by this paper
• Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation

  2004cited by this paper
• Many Ribosomal Protein Genes Are Cancer Genes in Zebrafish

  2004cited by this paper
• A central role for DNA replication forks in checkpoint activation and response.

  2003cited by this paper
• Zebrafish-based small molecule discovery.

  2003cited by this paper
• Chemical discovery and global gene expression analysis in zebrafish

  2003cited by this paper
• Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

  2003cited by this paper
• Cancer genetics and drug discovery in the zebrafish

  2003cited by this paper
• Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening.

  2003cited by this paper
• Cell cycle regulation by the B-Myb transcription factor

  2003cited by this paper
• Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

  2003cited by this paper
• Caffeine Inhibits Checkpoint Responses without Inhibiting the Ataxia-Telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) Protein Kinases*

  2003cited by this paper
• An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication.

  2003cited by this paper
• Myc-Induced T Cell Leukemia in Transgenic Zebrafish

  2003cited by this paper
• Myb controls G2/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc

  2002cited by this paper
• Activation of mammalian Chk1 during DNA replication arrest

  2001cited by this paper
• Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul.

  2001cited by this paper
• ATM and ATR: networking cellular responses to DNA damage.

  2001cited by this paper
• DNA replication: stable driving prevents fatal smashes.

  2001cited by this paper
• Regulation of the cell cycle by B-Myb.

  2001cited by this paper
• Effective targeted gene ‘knockdown’ in zebrafish

  2000cited by this paper
• Small molecule developmental screens reveal the logic and timing of vertebrate development.

  2000cited by this paper
• B‐Myb protein in cellular proliferation, transcription control, and cancer: Latest developments

  1999cited by this paper
• The myb gene family in cell growth, differentiation and apoptosis

  1999cited by this paper
• Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation

  1997cited by this paper

• Catalyst-Free Aza-Michael Addition of Azoles To 3-Hydroxypyridine-Based Quinone Methides

  2022cites this paper
• CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene setd5 Leads to Social Impairments in Zebrafish

  2022cites this paper
• Zebrafish - The Neurobehavioural Model in Trend.

  2022cites this paper
• Telomerase and alternative lengthening of telomeres coexist in the regenerating zebrafish caudal fins

  2021cites this paper
• Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials

  2021cites this paper
• Nanomaterials to Overcome Emergence and Re-Emergence of Superbugs

  2021cites this paper
• Chemical Genetics Screen Identifies Epigenetic Mechanisms Involved in Dopaminergic and Noradrenergic Neurogenesis in Zebrafish

  2020cites this paper
• Antifungal drug screening: thinking outside the box to identify novel antifungal scaffolds.

  2020cites this paper
• Basic Neurobiology Techniques

  2020cites this paper
• Mitochondrial and metabolic alterations are an early adaptation for pre-neoplastic cells during tumour initiation in a zebrafish model

  2019cites this paper
• Using Zebrafish to Study and Visualize Barriers of the CNS

  2019cites this paper
• Zebra Fish as a Cancer Model

  2019cites this paper
• Developing zebrafish disease models for in vivo small molecule screens.

  2019cites this paper
• Lack of Cyclin B1 in zebrafish causes lengthening of G2 and M phases.

  2019cites this paper
• Zebrafish Models of Cancer—New Insights on Modeling Human Cancer in a Non-Mammalian Vertebrate

  2019cites this paper
• Modeling Cancer with Flies and Fish.

  2019cites this paper
• Zebrafish as an Emerging Model for Bioassay-Guided Natural Product Drug Discovery for Neurological Disorders

  2019cites this paper
• PRP4K IS A NOVEL HER2-REGULATED MODIFIER OF ANOIKIS AND TAXANE RESISTANCE

  2018cites this paper
• An FDA-Approved Drug Screen for Compounds Influencing Craniofacial Skeletal Development and Craniosynostosis

  2018cites this paper
• Cancer and Zebrafish: Mechanisms, Techniques, and Models: Chemical Genetics

  2018cites this paper
• Zebrafish assay development for cardiovascular disease mechanism and drug discovery.

  2018cites this paper
• Zebrafish: an emerging real-time model system to study Alzheimer’s disease and neurospecific drug discovery

  2018cites this paper
• How Surrogate and Chemical Genetics in Model Organisms Can Suggest Therapies for Human Genetic Diseases

  2018cites this paper
• A high-resolution mRNA expression time course of embryonic development in zebrafish

  2017cites this paper
• Thermolysis of Geminal Diazides: Reagent-Free Synthesis of 3-Hydroxypyridines.

  2017cites this paper
• Chemical screening in zebrafish for novel biological and therapeutic discovery.

  2017cites this paper
• Small molecule screen in embryonic zebrafish using modular variations to target segmentation

  2017cites this paper
• Toxicity, teratogenicity and antibacterial activity of posterior salivary gland (PSG) toxin from the cuttlefish Sepia pharaonis (Ehrenberg, 1831).

  2017cites this paper
• ARQiv-HTS, a versatile whole-organism screening platform enabling in vivo drug discovery at high-throughput rates

  2016cites this paper
• Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish.

  2016cites this paper
• ATR promotes cilia signalling: links to developmental impacts

  2016cites this paper
• A Quantitative System for Studying Metastasis Using Transparent Zebrafish.

  2015cites this paper
• A fresh look at zebrafish from the perspective of cancer research

  2015cites this paper
• Oncogenic KRAS promotes malignant brain tumors in zebrafish

  2015cites this paper
• Toxic effects of aflatoxin B1 on embryonic development of zebrafish (Danio rerio): potential activity of piceatannol encapsulated chitosan/poly (lactic acid) nanoparticles.

  2015cites this paper
• Liver Regeneration in Zebrafish

  2015cites this paper
• A Zebrafish Model of Uveal Melanoma

  2015cites this paper
• Zebrafish Models of Congenital Myopathy

  2015cites this paper
• TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis

  2015cites this paper
• One Fish, Two Fish, Red Fish, Blue Fish: The Analysis of the Specter Cell Cycle Mutant in Zebrafish

  2015influential citation
• Zebrafish as tools for drug discovery

  2015cites this paper
• Optimizing methods for the study of intravascular lipid metabolism in zebrafish.

  2015cites this paper
• Bridging integrator 1 (Bin1) deficiency in zebrafish results in centronuclear myopathy.

  2014cites this paper
• B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development

  2014cites this paper
• Engineering Xenopus embryos for phenotypic drug discovery screening.

  2014cites this paper
• Zebrafish: predictive model for targeted cancer therapeutics from nature.

  2014cites this paper
• Repairing quite swimmingly: advances in regenerative medicine using zebrafish

  2014cites this paper
• Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era

  2014cites this paper
• Mosaic analysis and tumor induction in zebrafish by microsatellite instability-mediated stochastic gene expression

  2014cites this paper
• Genetic and Chemical Dissection of Blood-Brain Barrier Development in Zebrafish

  2014cites this paper
• Cannabinoid Receptor 2 Suppresses Leukocyte Inflammatory Migration by Modulating the JNK/c-Jun/Alox5 Pathway*

  2013cites this paper
• Zebrafish cancer: the state of the art and the path forward

  2013cites this paper
• Zebrafish based small molecule screens for novel DMD drugs.

  2013cites this paper
• Optimisation of Embryonic and Larval ECG Measurement in Zebrafish for Quantifying the Effect of QT Prolonging Drugs

  2013cites this paper
• Fish in a Dish: Drug Discovery for Hearing Habilitation.

  2013cites this paper
• Integrated compound profiling screens identify the mitochondrial electron transport chain as the molecular target of the natural products manassantin, sesquicillin, and arctigenin.

  2013cites this paper
• Zebrafish as a model system to study heritable skin diseases.

  2013cites this paper
• Discovery of Biologically Active Oncologic and Immunologic Small Molecule Therapies using Zebrafish: Overview and Example of Modulation of T Cell Activation

  2013influential citation
• Zebrafish egg manipulation using ultrasound microbeam

  2013cites this paper
• From phenotype to mechanism after zebrafish small molecule screens.

  2013cites this paper
• Zebrafish based small molecule screens for novel DMD drugs.

  2013cites this paper
• Zebrafish as a genetic model in pre-clinical drug testing and screening.

  2013cites this paper
• Zebrafish Chemical Screening Reveals the Impairment of Dopaminergic Neuronal Survival by Cardiac Glycosides

  2012cites this paper
• Advances in zebrafish chemical screening technologies.

  2012cites this paper
• against leukemia Zebrafish screen identifies novel compound with selective toxicity

  2012cites this paper
• An in vivo platform for rapid high-throughput antitubercular drug discovery.

  2012cites this paper
• Zebrafish Models of Heme Synthesis and Iron Metabolism

  2012cites this paper
• Screening of anti-cancer agent using zebrafish: comparison with the MTT assay.

  2012cites this paper
• Zebrafish screen identifies novel compound with selective toxicity against leukemia.

  2012cites this paper
• Zebrafish Model for NF1

  2012cites this paper
• In Situ Hybridization Assay‐Based Small‐Molecule Screening in Zebrafish

  2012cites this paper
• Zebrafish as potential model for developmental neurotoxicity testing: a mini review.

  2012cites this paper
• Small molecule screening in zebrafish: swimming in potential drug therapies

  2012cites this paper
• Progesterone and AdipoQ Receptor 11 Links Ras Signaling to Cardiac Development in Zebrafish

  2012cites this paper
• Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling.

  2011cites this paper
• Analysis of cell proliferation, senescence, and cell death in zebrafish embryos.

  2011cites this paper
• A New System for the Rapid Collection of Large Numbers of Developmentally Staged Zebrafish Embryos

  2011cites this paper
• ISOLATION AND TRANSCRIPTOME ANALYSIS OF ADULT ZEBRAFISH CELLS ENRICHED FOR SKELETAL MUSCLE PROGENITORS

  2011cites this paper
• Zebrafish: a model system to study heritable skin diseases.

  2011cites this paper
• Drug screening in a zebrafish model of Duchenne muscular dystrophy

  2011cites this paper
• Zebrafish: a model system for the study of vertebrate renal development, function, and pathophysiology

  2011cites this paper
• Zebrafish models of Tauopathy.

  2011cites this paper
• A high-content screening assay in transgenic zebrafish identifies two novel activators of fgf signaling.

  2011cites this paper
• Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms

  2011cites this paper
• Chemical approaches to angiogenesis in development and regeneration.

  2011cites this paper
• Image-Based Fluidic Sorting System for Automated Zebrafish Egg Sorting into Multiwell Plates

  2011cites this paper
• Chemical screening in zebrafish for novel biological and therapeutic discovery.

  2011cites this paper
• Zebrafish as a model for analysis of signaling pathways involved in cell growth, proliferation and development

  2011cites this paper
• Automated microinjection with integrated cell sorting, immobilization and collection

  2011cites this paper
• Zebrafish as a model for the study of human cancer.

  2011cites this paper
• Chemical screening with zebrafish embryos.

  2011cites this paper
• Small molecule screening in zebrafish: an in vivo approach to identifying new chemical tools and drug leads

  2010cites this paper
• Using Zinc Finger Nucleases for Targeted Genome Modification in the Zebrafish

  2010cites this paper
• Open Access Review

  2010cites this paper
• Defective glycinergic synaptic transmission in zebrafi sh motility mutants

  2010cites this paper
• Zebrafish as a Biological System for Identifying and Validating Therapeutic Targets and Compounds

  2010cites this paper
• A Chemical Genetic Screen in Zebrafish for Pathways Interacting with cdx4 in Primitive Hematopoiesis

  2010cites this paper
• Zebrafish: A tool for chemical screens.

  2010cites this paper
• Zebrafish as a model for vertebrate hematopoiesis.

  2010cites this paper
• Identification of Novel Inhibitors of Dietary Lipid Absorption Using Zebrafish

  2010cites this paper