The Sorbitol Pathway: Enzyme Localization and Content in Normal and Diabetic Nerve and Cord

No abstract is available for this paper.

• Publication year

  1968

• Venue

  Diabetes

• Publication date

  1968-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.2337/diab.17.5.239PMID 4384869
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sorbitol Pathway: Presence in Nerve and Cord with Substrate Accumulation in Diabetes

  1966cited by this paper
• Aldose reductase activity in the lens and other tissues

  1966cited by this paper
• Free sugars in alloxan diabetic rat nerve.

  1966cited by this paper
• SCHWANN-CELL ABNORMALITIES IN DIABETIC NEUROPATHY.

  1965cited by this paper
• ISOLATION AND PROPERTIES OF LENS ALDOSE REDUCTASE.

  1965cited by this paper
• Polyol dehydrogenases. 4. Crystallization of the L-iditol dehydrogenase of sheep liver.

  1962cited by this paper
• Enzymic studies on TPN L-hexonate dehydrogenase from rat liver.

  1961cited by this paper
• Formation of Polyols by the Lens of the Rat with ‘Sugar’ Cataract

  1959cited by this paper
• A BIOCHEMICAL AND MORPHOLOGIC STUDY OF MYELINATION AND DEMYELINATION

  1958cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper
• Quantitative histology of Wallerian degeneration: I. Nuclear population in rabbit sciatic nerve.

  1946cited by this paper

• Urine Sorbitol and Xylitol for the Diagnosis of Sorbitol Dehydrogenase Deficiency-Related Neuropathy.

  2025cites this paper
• The ratio of extracellular water to total body water serves as a potential predictor of diabetic peripheral neuropathy in patients

  2025cites this paper
• Role of the Polyol Pathway in Locomotor Recovery and Wallerian Degeneration after Spinal Cord Contusion Injury

  2021cites this paper
• EMERGENCE OF BENZOTHIAZOLE AND ITS DERIVATIVES AS A POTENTIAL ANTIDIABETIC PROBE

  2020cites this paper
• Diabetic polyneuropathy and the risk of developing carpal tunnel syndrome: A nationwide, population‐based study

  2020cites this paper
• Potency of inhibitors depends upon the accessibility of their aromatic rings within the hydrophobic specificity pocket: a novel avenue for future aldose reductase inhibitor design

  2020cites this paper
• A highly sensitive and distinctly selective d-sorbitol biosensor using SDH enzyme entrapped Ta2O5 nanoflowers assembly coupled with fiber optic SPR

  2017cites this paper
• Goji fruit (Lycium barbarum) protects sciatic nerve function against crush injury in a model of diabetic stress.

  2016cites this paper
• Obesity Influence on Insulin Activity and Resting Metabolic Rate in Type 2 Diabetes

  2016cites this paper
• Anoxia-induced changes in optimal substrate for peripheral nerve.

  2015cites this paper
• Three-dimensional quantitative structure-activity relationships and docking studies of some structurally diverse flavonoids and design of new aldose reductase inhibitors

  2015cites this paper
• Mechanisms of diabetic neuropathy: Schwann cells.

  2014cites this paper
• Ultrasonography of palm to elbow segment of median nerve in different degrees of diabetic polyneuropathy.

  2014cites this paper
• Calcium signalling in sensory neurones and peripheral glia in the context of diabetic neuropathies.

  2014cites this paper
• Pathophysiology, diagnosis and treatment of intermittent claudication in patients with lumbar canal stenosis.

  2014cites this paper
• Sonography of the Median Nerve in Carpal Tunnel Syndrome with Diabetic Neuropathy

  2014cites this paper
• Inhibitory Effect of the Phenolic Compounds from Geranium thunbergii on Rat Lens Aldose Reductase and Galactitol Formation

  2012cites this paper
• A crossover study on the glucose metabolism between treatment with olanzapine and risperidone in schizophrenic patients.

  2010cites this paper
• HPLC with pulsed amperometric detection for sorbitol as a biomarker for diabetic neuropathy.

  2009cites this paper
• Blood flow analysis of compressed nerve root after intravenous injection of lipo‐prostaglandin E1

  2009cites this paper
• Glucose metabolism in Japanese schizophrenia patients treated with risperidone or olanzapine.

  2009cites this paper
• Aldose reductase, still a compelling target for diabetic neuropathy.

  2008cites this paper
• Protective Effect of Hesperidin, a Citrus Bioflavonoid, on Diabetes-Induced Brain Damage in Rats

  2008cites this paper
• [Does normalization of metabolism in diabetes mellitus cause regression of the neuropathy?].

  2008cites this paper
• A comparison of ultrastructural changes on endomyocardial biopsy specimens obtained from patients with diabetes mellitus with and without hypertension

  2007cites this paper
• Long-term effects of ranirestat (AS-3201) on peripheral nerve function in patients with diabetic sensorimotor polyneuropathy.

  2006cites this paper
• The Leptin-Deficient (ob/ob) Mouse

  2006cites this paper
• Novel sites of aldose reductase immunolocalization in normal and streptozotocin‐diabetic rats

  2006influential citation
• Aldose reductase inhibition by AS-3201 in sural nerve from patients with diabetic sensorimotor polyneuropathy.

  2004cites this paper
• Sural nerve sorbitol in patients with diabetic sensorimotor polyneuropathy.

  2004cites this paper
• Galactose neuropathy

  2004cites this paper
• Schwann cells in diabetic neuropathy

  2003cites this paper
• Inhibitor of apoptosis proteins and ovarian dysfunction in galactosemic rats

  2003cites this paper
• Recent studies of aldose reductase enzyme inhibition for diabetic complications.

  2003cites this paper
• Diabetic neuropathy and nerve regeneration.

  2003cites this paper
• Improvement of corneal fluorescein staining in post cataract surgery of diabetic patients by an oral aldose reductase inhibitor, ONO-2235

  2002cites this paper
• Polyol pathway and diabetic peripheral neuropathy.

  2002cites this paper
• The therapeutic effect of lipo PGE1 on diabetic neuropathy-changes in endothelin and various angiopathic factors.

  2001cites this paper
• Expression of aldose reductase and sorbitol dehydrogenase genes in Schwann cells isolated from rat: effects of high glucose and osmotic stress.

  2001cites this paper
• Continuous inhibition of excessive polyol pathway flux in peripheral nerves by aldose reductase inhibitor fidarestat leads to improvement of diabetic neuropathy.

  1999cites this paper
• Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis.

  1999cites this paper
• Depletion of Phospholipid Arachidonoyl‐Containing Molecular Species in a Human Schwann Cell Line Grown in Elevated Glucose and Their Restoration by an Aldose Reductase Inhibitor

  1998cites this paper
• Functional significance of cell volume regulatory mechanisms.

  1998cites this paper
• The Diversity of Volume Regulatory Mechanisms

  1998cites this paper
• NT-3 Attenuates Functional and Structural Disorders in Sensory Nerves of Galactose-fed Rats

  1998cites this paper
• Synthesis, activity, and molecular modeling of new 2, 4-dioxo-5-(naphthylmethylene)-3-thiazolidineacetic acids and 2-thioxo analogues as potent aldose reductase inhibitors.

  1998cites this paper
• Schwann cell changes induced as early as one week after galactose intoxication

  1997cites this paper
• Sorbitol accumulation and transmembrane efflux in osmotically stressed JS1 schwannoma cells.

  1997cites this paper
• Autonomic Function in a Cohort of Children with Diabetes

  1997cites this paper
• Effects of diabetes on anterior ocular structure and function

  1997cites this paper
• Effect of Sorbinil and Ascorbic Acid on myo‐Inositol Transport in Cultured Rat Schwann Cells Exposed to Elevated Extracellular Glucose

  1997cites this paper
• Nerve fiber regeneration following axotomy in the diabetic biobreeding Worcester rat: the effect of ARI treatment.

  1996cites this paper
• Increased vulnerability to demyelination in streptozotocin diabetic rats

  1996cites this paper
• Tolrestat improves nerve regeneration after crush injury in streptozocin-induced diabetic rats.

  1996cites this paper
• Polyol accumulation versus diabetic retinopathy and nephropathy in transgenic mice expressing human aldose reductase

  1996cites this paper
• Improvement of Corneal Sensation and Tear Dynamics in Diabetic Patients by Oral Aldose Reductase Inhibitor, ONO-2235: A Preliminary Study

  1996cites this paper
• Polyol pathway and osmoregulation in JS1 Schwann cells grown in hyperglycemic and hyperosmotic conditions.

  1996cites this paper
• Molecular genetic analysis of the human sorbitol dehydrogenase gene

  1995cites this paper
• Nerve Microvessel Changes in Diabetes are Prevented by Aldose Reductase Inhibition

  1995cites this paper
• Reversal of abnormal corneal epithelial cell morphologic characteristics and reduced corneal sensitivity in diabetic patients by aldose reductase inhibitor, CT-112.

  1995cites this paper
• Implication of insulin-like growth factors in the pathogenesis of diabetic neuropathy.

  1995cites this paper
• Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats

  1994cites this paper
• Prevention of neuropathy in the pyloric sphincter of streptozotocin-diabetic rats by gangliosides.

  1993cites this paper
• Characterization of the human aldose reductase gene promoter.

  1993cites this paper
• Effects of an aldose reductase inhibitor, SNK-860, on the histopathological changes of retinal tissues in a streptozotocin-induced diabetic rat model.

  1993cites this paper
• Decreased endoneurial fluid electrolytes in normal rat sciatic nerve after aldose reductase inhibition.

  1993cites this paper
• Schwann Cell Injury is Attenuated by Aldose Reductase Inhibition in Galactose Intoxication

  1993cites this paper
• Aldose reductase inhibitors and diabetic complications.

  1992cites this paper
• Changes in Aldose Reductase After Crush Injury of Normal Rat Sciatic Nerve

  1992cites this paper
• Peripheral and autonomic nerve function in 259 diabetic patients with peripheral neuropathy treated with ponalrestat (an aldose reductase inhibitor) or placebo for 18 months. United Kingdom/Scandinavian Ponalrestat Trial.

  1992cites this paper
• Effects of a new aldose reductase inhibitor, (2S, 4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-ca rboxamid e (SNK-860), on the slowing of motor nerve conduction velocity and metabolic abnormalities in the peripheral nerve in acute streptozotocin-induced diabetic rats.

  1992cites this paper
• A new proposed model of aldose reductase enzyme inhibition on the basis of an artificial intelligence approach: A computer automated structure evaluation (case) study

  1991cites this paper
• A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners.

  1991cites this paper
• Renal medullary organic osmolytes.

  1991cites this paper
• Effects of novel aldose reductase inhibitors, M16209 and M16287, on streptozotocin-induced diabetic neuropathy in rats.

  1991cites this paper
• Sorbinil does not prevent galactose-induced glomerular capillary basement membrane thickening in the rat

  1990cites this paper
• Effects of NaCl, glucose, and aldose reductase inhibitors on cloning efficiency of renal medullary cells.

  1990cites this paper
• Proteins of slow axonal transport in sciatic motoneurones of rats with streptozotocin-induced diabetes or galactosaemia.

  1990cites this paper
• Role of the Blood-Nerve Barrier in Experimental Nerve Edema

  1990cites this paper
• Treatment of diabetic neuropathy with inhibitors of the aldose reductase enzyme.

  1990cites this paper
• Sorbitol pathway activity and utilization of polyols in astroglia‐rich primary cultures

  1990cites this paper
• Aldose Reductase Inhibitors

  1990cites this paper
• Nonpolar interactions in the modification of an essential sulfhydryl of sorbitol dehydrogenase by N-alkylmaleimides.

  1989cites this paper
• Osmoregulatory fluxes of myo-inositol and betaine in renal cells.

  1989cites this paper
• Diabetic neuropathy.

  1989cites this paper
• Vascular Connective Matrices and Haemostasis in Diabetic Angiopathy

  1989cites this paper
• Effects of Aldose Reductase Inhibitor Sorbinil on Neuroaxonal Dystrophy and Levels of myo-inositol and Sorbitol in Sympathetic Autonomic Ganglia of Streptozocin-Induced Diabetic Rats

  1989cites this paper
• Treatment of hypertension in diabetes mellitus.

  1989cites this paper
• Aldose Reductase Inhibitors: Structure–Activity Relationships and Therapeutic Potential

  1989cites this paper
• Prevention of Nerve Edema and Increased Blood-Nerve Barrier Permeability–Surface Area Product in Galactosemic Rats by Aldose Reductase or Thromboxane Synthetase Inhibitors

  1989cites this paper
• The effect of ponalrestat on sorbitol levels in the lens of obese and diabetic mice.

  1989cites this paper
• Survey of osmolytes in renal cell lines.

  1988cites this paper
• Statil-sensitive polyol formation in nerve of galactose-fed mice.

  1988cites this paper
• Galactose and cataract.

  1988cites this paper
• Role of aldose reductase and sorbitol in maintaining the medullary intracellular milieu.

  1988cites this paper
• Disposition of the aldose reductase inhibitor AL01576 in rats.

  1988cites this paper
• Aldose Reductase Expression in Human Diabetic Retina and Retinal Pigment Epithelium

  1988cites this paper
• Nerve glucose, fructose, sorbitol, myo-inositol, and fiber degeneration and regeneration in diabetic neuropathy.

  1988cites this paper
• Sorbitol dehydrogenase.

  1988cites this paper
• Dose-dependence of endoneurial fluid sodium and chloride accumulation in galactose intoxication.

  1988cites this paper