The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Molecular Endocrinology

• Publication date

  2006-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/ME.2005-0324PMID 16373395
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Androgen receptor corepressors: An overview

  2005cited by this paper
• Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor*

  2005cited by this paper
• The Androgen Receptor Recruits Nuclear Receptor CoRepressor (N-CoR) in the Presence of Mifepristone via Its N and C Termini Revealing a Novel Molecular Mechanism for Androgen Receptor Antagonists*

  2005cited by this paper
• The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor*

  2005cited by this paper
• Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor.

  2004cited by this paper
• Transcriptional repression by the thyroid hormone receptor: function of corepressor complexes

  2004cited by this paper
• Coregulator recruitment and histone modifications in transcriptional regulation by the androgen receptor.

  2004cited by this paper
• Expression and function of androgen receptor coactivators in prostate cancer.

  2004cited by this paper
• Differential modulation of androgen receptor transcriptional activity by the nuclear receptor co-repressor (N-CoR).

  2004cited by this paper
• Agonist-antagonist induced coactivator and corepressor interplay on the human androgen receptor.

  2003cited by this paper
• Role of the androgen receptor axis in prostate cancer.

  2003cited by this paper
• Regulation of Androgen Receptor Activity by the Nuclear Receptor Corepressor SMRT*

  2003cited by this paper
• Recent advances in androgen receptor action

  2003cited by this paper
• Androgen receptors in prostate cancer.

  2003cited by this paper
• Purification and functional characterization of the human N‐CoR complex: the roles of HDAC3, TBL1 and TBLR1

  2003cited by this paper
• Androgen-induced recruitment of RNA polymerase II to a nuclear receptor–p160 coactivator complex

  2003cited by this paper
• N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso.

  2003cited by this paper
• RU486-induced Glucocorticoid Receptor Agonism Is Controlled by the Receptor N Terminus and by Corepressor Binding*

  2002cited by this paper
• Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα

  2002cited by this paper
• N-CoR controls differentiation of neural stem cells into astrocytes

  2002cited by this paper
• Nuclear receptor-dependent transcription with chromatin. Is it all about enzymes?

  2002cited by this paper
• Analysis of gene function in somatic mammalian cells using small interfering RNAs.

  2002cited by this paper
• The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2.

  2002cited by this paper
• Minireview: Nuclear Receptor Coactivators-An Update.

  2002cited by this paper
• Androgen receptors in prostate cancer.

  2002cited by this paper
• Androgen Receptor Acetylation Governs trans Activation and MEKK1-Induced Apoptosis without Affecting In Vitro Sumoylation and trans-Repression Function

  2002cited by this paper
• Formation of the androgen receptor transcription complex.

  2002cited by this paper
• The amino terminus of the human AR is target for corepressor action and antihormone agonism.

  2002cited by this paper
• Androgen receptor (AR) coregulators: an overview.

  2002cited by this paper
• Biological roles and mechanistic actions of co-repressor complexes.

  2002cited by this paper
• Inhibition of the dihydrotestosterone-activated androgen receptor by nuclear receptor corepressor.

  2002cited by this paper
• The program of androgen-responsive genes in neoplastic prostate epithelium

  2002cited by this paper
• Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

  2001cited by this paper
• Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone

  2001cited by this paper
• Transcriptional repression by nuclear hormone receptors.

  2000cited by this paper
• A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.

  2000cited by this paper
• Both corepressor proteins SMRT and N‐CoR exist in large protein complexes containing HDAC3

  2000cited by this paper
• Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription.

  2000cited by this paper
• Cancer statistics, 2000

  2000cited by this paper
• Combinatorial roles of the nuclear receptor corepressor in transcription and development.

  2000cited by this paper
• p300 Requires Its Histone Acetyltransferase Activity and SRC-1 Interaction Domain To Facilitate Thyroid Hormone Receptor Activation in Chromatin

  2000cited by this paper
• The coregulator exchange in transcriptional functions of nuclear receptors.

  2000cited by this paper
• Multiple Signal Input and Output Domains of the 160-Kilodalton Nuclear Receptor Coactivator Proteins

  1999cited by this paper
• The biology of hormone refractory prostate cancer. Why does it develop?

  1999cited by this paper
• The AF1 and AF2 Domains of the Androgen Receptor Interact with Distinct Regions of SRC1

  1999cited by this paper
• The Androgen Receptor Amino-Terminal Domain Plays a Key Role in p160 Coactivator-Stimulated Gene Transcription

  1999cited by this paper
• Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes.

  1998cited by this paper
• Gene silencing by chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is mediated by transcriptional corepressors, nuclear receptor-corepressor (N-CoR) and silencing mediator for retinoic acid receptor and thyroid hormone receptor (SMRT).

  1997cited by this paper
• Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex.

  1997cited by this paper
• Dehydroepiandrosterone activates mutant androgen receptors expressed in the androgen-dependent human prostate cancer xenograft CWR22 and LNCaP cells.

  1997cited by this paper
• We regret to inform you.

  1997cited by this paper
• Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen.

  1997cited by this paper
• The nuclear receptor superfamily: the second decade.

  1995cited by this paper
• A transcriptional co-repressor that interacts with nuclear hormone receptors

  1995cited by this paper
• Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

  1995cited by this paper
• Aberrant response in vitro of hormone‐responsive prostate cancer cells to antiandrogens

  1989cited by this paper

• Deciphering the Role of siRNA in Anxiety and Depression.

  2024cites this paper
• TLR4-associated IRF-7 and NFĸB signaling acts as a molecular link between androgen and metformin activities and cytokine synthesis in the PCOS endometrium.

  2020cites this paper
• Baboon placental heparin-binding epidermal growth factor-like growth factor.

  2020cites this paper
• Vascular Endothelial Growth Factor Delivery to Placental Basal Plate Promotes Uterine Artery Remodeling in the Primate.

  2019cites this paper
• The effects of flutamide on cell-cell junctions in the testis, epididymis, and prostate.

  2018cites this paper
• Identification of putative regulatory regions and transcription factors associated with intramuscular fat content traits

  2018cites this paper
• Evolution of the androgen-induced male phenotype

  2017cites this paper
• Transcriptional regulation of the Nkx3.1 gene in prostate luminal stem cell specification and cancer initiation via its 3' genomic region.

  2017cites this paper
• Transcriptional regulation of the Nkx3.1 gene in prostate luminal stem cell specification and cancer initiation via its 3′ genomic region

  2017cites this paper
• Nkx 3 . 1 in prostate stem cells and cancer 1 Transcriptional regulation of Nkx 3 . 1 in prostate luminal stem cell specification and cancer initiation via its 3 ’ genomic region

  2017cites this paper
• Tissue control of androgen action: The ups and downs of androgen receptor expression.

  2017cites this paper
• The Androgen Receptor Regulates PPARγ Expression and Activity in Human Prostate Cancer Cells

  2016cites this paper
• Chapter 5 – Perinatal Neurohormonal Programming and Endocrine Disruption

  2016cites this paper
• Neuroepigenetics of Sexual Differentiation of Brain and Behavior

  2016cites this paper
• Inhibition effect of cypermethrin mediated by co-regulators SRC-1 and SMRT in interleukin-6-induced androgen receptor activation.

  2016cites this paper
• The co-regulators SRC-1 and SMRT are involved in interleukin-6-induced androgen receptor activation

  2016cites this paper
• Androgen receptor signaling in castration-resistant prostate cancer: a lesson in persistence.

  2016cites this paper
• Similarities and Distinctions in Actions of Surface-Directed and Classic Androgen Receptor Antagonists

  2015cites this paper
• Inhibition of the Androgen Receptor by Antiandrogens in Spinobulbar Muscle Atrophy

  2015cites this paper
• New Insights in the Role of Androgen-to-Estrogen Ratios, Specific Growth Factors and Bone Cell Microenvironment to Potentiate Prostate Cancer Bone Metastasis

  2015cites this paper
• TMPRSS2 promoter driven enzyme-prodrug therapy for the treatment of PCa

  2015cites this paper
• EPI-002 and enzalutamide combination therapy as a potential therapeutic benefit for castration-resistant prostate cancer patients

  2014influential citation
• Antiandrogen flutamide protects male mice from androgen-dependent toxicity in three models of spinal bulbar muscular atrophy.

  2014cites this paper
• Androgen receptor functions in prostate cancer development and progression

  2014cites this paper
• Review Article Nuclear receptor corepressor complexes in cancer: mechanism, function and regulation

  2014cites this paper
• Nuclear receptor corepressor complexes in cancer: mechanism, function and regulation.

  2014cites this paper
• Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis

  2014cites this paper
• The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity.

  2013cites this paper
• Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN

  2013cites this paper
• Emerging roles of the corepressors NCoR1 and SMRT in homeostasis.

  2013cites this paper
• Androgen receptor epigenetics

  2013cites this paper
• Anti-androgen effects of the pyrethroid pesticide cypermethrin on interactions of androgen receptor with corepressors.

  2013cites this paper
• Microdoses Levels of Butadiene Diepoxide (BDO2) Induced Toxicity in Prostate Cancer Cells

  2013cites this paper
• Different effect of sodium butyrate on cancer and normal prostate cells.

  2013cites this paper
• Protein Kinase A phosphorylates NCoR to enhance its nuclear translocation and repressive function in human prostate cancer cells

  2013cites this paper
• The Inhibitory Effect on Androgen Receptor-Dependent Prostate Cancer Cell Growth by Anti-Histone Acetyltransferase Activity from Terminalia chebula Retz. Fruit Methanol Extract

  2013cites this paper
• Androgens and Skeletal Biology: Basic Mechanisms

  2013cites this paper
• EGCG suppresses prostate cancer cell growth modulating acetylation of androgen receptor by anti-histone acetyltransferase activity.

  2012cites this paper
• Prematurely elevating estradiol in early baboon pregnancy suppresses uterine artery remodeling and expression of extravillous placental vascular endothelial growth factor and α1β1 and α5β1 integrins.

  2012cites this paper
• Prostate Cancer Cells clone-27 Loss on Androgen-Regulated Transcription in Genome-Wide Impact of Androgen Receptor Trapped

  2012cites this paper
• Altered corepressor SMRT expression and recruitment to target genes as a mechanism that change the response to androgens in prostate cancer progression.

  2012cites this paper
• PA1 Protein, a New Competitive Decelerator Acting at More than One Step to Impede Glucocorticoid Receptor-mediated Transactivation*

  2012cites this paper
• Radiation, Inflammation, and Immune Responses in Cancer

  2012cites this paper
• The road less traveled: new views of steroid receptor action from the path of dose-response curves.

  2012cites this paper
• miR-125b Regulation of Androgen Receptor Signaling Via Modulation of the Receptor Complex Co-Repressor NCOR2

  2012influential citation
• Sexually selected traits: a fundamental framework for studies on behavioral epigenetics.

  2012cites this paper
• Epigenetic distortion to VDR transcriptional regulation in prostate cancer cells

  2012cites this paper
• Biology of castration-recurrent prostate cancer.

  2012cites this paper
• Structure-based Virtual Screening and Identification of a Novel Androgen Receptor Antagonist*

  2012cites this paper
• Sexually Selected Traits: A Fundamental Framework for Studies on Behavioral

  2012cites this paper
• Androgen receptor coregulators: recruitment via the coactivator binding groove.

  2012cites this paper
• New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer

  2011cites this paper
• Grape Seed Extract Regulates Androgen Receptor-Mediated Transcription in Prostate Cancer Cells Through Potent Anti–Histone Acetyltransferase Activity

  2011cites this paper
• Chromosome 12q24.31-q24.33 deletion causes multiple dysmorphic features and developmental delay: First mosaic patient and overview of the phenotype related to 12q24qter defects

  2011cites this paper
• Characterisation of the co-chaperone small glutamine-rich tetratricopeptide repeat containing protein alpha as a regulator of androgen receptor activity in prostate cancer cells.

  2011cites this paper
• Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer.

  2011cites this paper
• Procyanidin B3, an inhibitor of histone acetyltransferase, enhances the action of antagonist for prostate cancer cells via inhibition of p300‐dependent acetylation of androgen receptor

  2011cites this paper
• Epigenetic organization of brain sex differences and juvenile social play behavior.

  2011cites this paper
• Intronic DNA elements regulate androgen-dependent expression of the murine Nkx3.1 gene.

  2011cites this paper
• FBI-1 functions as a novel AR co-repressor in prostate cancer cells

  2011cites this paper
• Corepressor effect on androgen receptor activity varies with the length of the CAG encoded polyglutamine repeat and is dependent on receptor/corepressor ratio in prostate cancer cells.

  2011cites this paper
• Tumor and Stem Cell Biology Decreased Expression and Androgen Regulation of the Tumor Suppressor Gene INPP 4 B in Prostate Cancer

  2011cites this paper
• Sex differences in epigenetic mechanisms may underlie risk and resilience for mental health disorders

  2011cites this paper
• Androgen receptor cofactors in prostate cancer: potential therapeutic targets of castration-resistant prostate cancer.

  2011cites this paper
• Formation of AR-SMRT binding in prostate cancer cells treated with natural histone deacetylase inhibitor

  2010cites this paper
• MicroRNAs Are Mediators of Androgen Action in Prostate and Muscle

  2010cites this paper
• HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells

  2010cites this paper
• Binding of AR to SMRT/N-CoR complex and its co-operation with PSA promoter in prostate cancer cells treated with natural histone deacetylase inhibitor NaB.

  2010cites this paper
• Histone acetyltransferase inhibitory activity of Bokbunja (Rubus coreanus Miq.) ethanol extract on androgen receptor-dependent prostate cancer cell growth

  2010cites this paper
• Androgen Receptor Survival Signaling Is Blocked by Anti-β2-microglobulin Monoclonal Antibody via a MAPK/Lipogenic Pathway in Human Prostate Cancer Cells*

  2010cites this paper
• Effect of anabolic-androgenic steroids and glucocorticoids on the kinetics of hAR and hGR nucleocytoplasmic translocation.

  2010cites this paper
• The nuclear receptor corepressor has organizational effects within the developing amygdala on juvenile social play and anxiety-like behavior.

  2010cites this paper
• Glucocorticoid receptor cofactors as therapeutic targets.

  2010cites this paper
• Prostate cancer patients on androgen deprivation therapy develop persistent changes in adaptive immune responses.

  2010cites this paper
• Estrogen Receptors Recruit SMRT and N-CoR Corepressors through Newly Recognized Contacts between the Corepressor N Terminus and the Receptor DNA Binding Domain

  2010cites this paper
• The PPARγ ligand ciglitazone regulates androgen receptor activation differently in androgen-dependent versus androgen-independent human prostate cancer cells.

  2010cites this paper
• Up-regulation of circadian clock gene Period 2 in the prostate mesenchymal cells during flutamide-induced apoptosis

  2010cites this paper
• Estrogen regulation of placental angiogenesis and fetal ovarian development during primate pregnancy.

  2010cites this paper
• Aberrant activation of the androgen receptor by NF-kappaB2/p52 in prostate cancer cells.

  2010cites this paper
• HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells

  2010cites this paper
• Cooperative activation of cyclin D1 and progesterone receptor gene expression by the SRC-3 coactivator and SMRT corepressor.

  2010cites this paper
• Androgen Action in Bone: Basic Cellular and Molecular Aspects

  2010cites this paper
• Prostate Cancer Patients Treated with Androgen Deprivation Therapy Develop Persistent Changes in Adaptive Immune Responses

  2010cites this paper
• The histone methyltransferase, NSD2, enhances androgen receptor‐mediated transcription

  2009cites this paper
• Microarray coupled to quantitative RT–PCR analysis of androgen-regulated genes in human LNCaP prostate cancer cells

  2009cites this paper
• Repressive Effects of Resveratrol on Androgen Receptor Transcriptional Activity

  2009cites this paper
• Ligand-selective transactivation and transrepression via the glucocorticoid receptor: role of cofactor interaction.

  2009cites this paper
• Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6

  2009cites this paper
• The effect of cyclin G associated kinase on androgen receptor function and prostate cancer progression

  2009cites this paper
• Corepressors, nuclear receptors, and epigenetic factors on DNA: a tail of repression.

  2009cites this paper
• Crosstalk between signaling pathways in hormonal progression of prostate cancer

  2009cites this paper
• A novel androgen receptor-binding element modulates Cdc6 transcription in prostate cancer cells during cell-cycle progression

  2009cites this paper
• The Epigenetics of Sex Differences in the Brain

  2009cites this paper
• Identification of novel androgen-responsive genes by sequencing of LongSAGE libraries

  2009cites this paper
• Loss of the SMRT/NCoR2 corepressor correlates with JAG2 overexpression in multiple myeloma.

  2009cites this paper
• Deleted in Breast Cancer 1, a Novel Androgen Receptor (AR) Coactivator That Promotes AR DNA-binding Activity*

  2009cites this paper
• Androgen Receptor Coregulators and Their Role in Prostate Cancer

  2009cites this paper
• Neuroactive steroids: an update of their roles in central and peripheral nervous system.

  2009cites this paper
• Expressions of androgen receptor and its co‐regulators in carcinoma ex pleomorphic adenoma of salivary gland

  2009cites this paper
• Genome-wide impact of androgen receptor trapped clone-27 loss on androgen-regulated transcription in prostate cancer cells.

  2009cites this paper