Proapoptotic activity of new glutathione S-transferase inhibitors.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Cancer Research

• Publication date

  2005-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1158/0008-5472.CAN-04-3903PMID 15867371
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Export pumps for glutathione S-conjugates.

  1999cited by this paper
• Regulation of JNK signaling by GSTp

  1999influential reference
• Tumor efficacy and bone marrow-sparing properties of TER286, a cytotoxin activated by glutathione S-transferase.

  1998cited by this paper
• Inhibitors of glutathione S-transferases as therapeutic agents.

  1997influential reference
• Structure, catalytic mechanism, and evolution of the glutathione transferases.

  1997cited by this paper
• Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP

  1996influential reference
• Multiple pathways for apoptotic nuclear fragmentation.

  1996cited by this paper
• Isozyme-specific glutathione S-transferase inhibitors potentiate drug sensitivity in cultured human tumor cell lines

  1996cited by this paper
• Glutathione-associated enzymes in the human cell lines of the National Cancer Institute Drug Screening Program.

  1996cited by this paper
• A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V.

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  1994cited by this paper
• A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

  1994cited by this paper
• ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein.

  1994cited by this paper
• BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death.

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• Glutathione-S-transferase activates novel alkylating agents.

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• The ATP-dependent glutathione S-conjugate export pump.

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• Effect of buthionine sulfoximine and ethacrynic acid on cytotoxic activity of mitomycin C analogues BMY 25282 and BMY 25067.

  1992cited by this paper
• Sensitization of human melanoma cells to the cytotoxic effect of melphalan by the glutathione transferase inhibitor ethacrynic acid.

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• New colorimetric cytotoxicity assay for anticancer-drug screening.

  1990cited by this paper
• Inhibition of rat and human glutathione S-transferase isoenzymes by ethacrynic acid and its glutathione conjugate.

  1990cited by this paper
• Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines.

  1988cited by this paper
• Gamma-glutamyl transpeptidase.

  1981cited by this paper
• [30] γ-Glutamyl transpeptidase

  1981cited by this paper
• Assays for differentiation of glutathione S-transferases.

  1981cited by this paper
• High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides.

  1980cited by this paper
• γ-Glutamyl-Transpeptidase

  1973cited by this paper

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