Neuroligin‐1 performs neurexin‐dependent and neurexin‐independent functions in synapse validation

No abstract is available for this paper.

• Publication year

  2009

• Venue

  EMBO Journal

• Publication date

  2009-10-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/emboj.2009.249PMID 19730411PMCID PMC2771087
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Transsynaptic modulation of the synaptic vesicle cycle by cell‐adhesion molecules

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• Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation.

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  2007influential reference
• Postsynaptic neuroligin enhances presynaptic inputs at neuronal nicotinic synapses.

  2007cited by this paper
• Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95–neuroligin

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• Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion.

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  2006cited by this paper
• Neuroligins and neurexins: linking cell adhesion, synapse formation and cognitive function.

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  2005influential reference
• Neuronal activation by GPI-linked neuroligin-1 displayed in synthetic lipid bilayer membranes.

  2005cited by this paper
• Dissection of Synapse Induction by Neuroligins

  2005cited by this paper
• Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter

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• A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins.

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• Disorder-associated mutations lead to functional inactivation of neuroligins.

  2004influential reference
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  2001cited by this paper
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  2000influential reference
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  1999influential reference
• Dimerization as a regulatory mechanism in signal transduction.

  1998cited by this paper
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  1996cited by this paper
• Definition of the readily releasable pool of vesicles at hippocampal synapses.

  1996cited by this paper
• Neuroligin 1: a splice site-specific ligand for beta-neurexins.

  1995cited by this paper
• Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons.

  1995cited by this paper
• Conserved domain structure of beta-neurexins. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins.

  1994cited by this paper
• Neurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms.

  1993cited by this paper
• Exo-endocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neurons

  1992cited by this paper
• Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin.

  1992cited by this paper
• Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans.

  1991cited by this paper
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  1979cited by this paper
• Conserved Domain Structure of P-Neurexins

  year unknowncited by this paper

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