Integrating cytosolic calcium signals into mitochondrial metabolic responses

No abstract is available for this paper.

• Publication year

  1998

• Venue

  EMBO Journal

• Publication date

  1998-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/emboj/17.17.4987PMID 9724635PMCID PMC1170827
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1996influential reference
• The hormonal regulation of pyruvate dehydrogenase complex.

  1996cited by this paper
• A Reevaluation of the Role of Mitochondria in Neuronal Ca2+ Homeostasis

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• Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity.

  1996influential reference
• Mitochondria Support Inositol 1,4,5-Trisphosphate-mediated Ca2+ Waves in Cultured Oligodendrocytes*

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• Decoding of cytosolic calcium oscillations in the mitochondria.

  1995influential reference
• Transfected Aequorin in the Measurement of Cytosolic Ca2+ Concentration ([Ca2+]c)

  1995cited by this paper
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• Nuclear targeting of aequorin. A new approach for measuring nuclear Ca2+ concentration in intact cells.

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  1993influential reference
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  1993cited by this paper
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• Chapter 18 Hormonal regulation of cellular energy metabolism

  1992cited by this paper
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  1991cited by this paper
• Role of calcium ions in regulation of mammalian intramitochondrial metabolism.

  1990cited by this paper
• Ca2(+)-binding to citrate cycle dehydrogenases.

  1990cited by this paper
• Control of respiration and oxidative phosphorylation in isolated rat liver cells.

  1990influential reference
• Characterization of cytosolic calcium oscillations induced by phenylephrine and vasopressin in single fura-2-loaded hepatocytes.

  1989influential reference
• The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism.

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  1986influential reference
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• On the role of the calcium transport cycle in heart and other mammalian mitochondria

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• Effects of calcium ions on the activation of gluconeogenesis by norepinephrine in perfused rat liver.

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• The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex.

  1979influential reference
• The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria.

  1978cited by this paper
• Activation of pyruvate dehydrogenase in the perfused rat liver by vasopressin.

  1978cited by this paper
• Stable enhancement of calcium retention in mitochondria isolated from rat liver after the administration of glucagon to the intact animal.

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  1978influential reference
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids.

  1974cited by this paper
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  1972cited by this paper
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  1969cited by this paper
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  1964cited by this paper
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  1962cited by this paper

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