The biology of extracellular vesicles with focus on platelet microparticles and their role in cancer development and progression

Extracellular vesicles (EVs) are a heterogeneous group of structures which can be classified into smaller in size and relatively homogenous exosomes (EXSMs)—spherical fragments of lipid bilayers from inner cell compartments—and bigger in size ectosomes (ECSMs)—a direct consequence of cell-membrane blebbing. EVs can be found in body fluids of healthy individuals. Their number increases in cancer and other pathological conditions. EVs can originate from various cell types, including leukocytes, erythrocytes, thrombocytes, and neoplastic cells. Platelet microparticles (PMPs) are the most abundant population of EVs in blood. It is well documented that PMPs, being a crucial element of EVs signaling, are involved in tumor growth, metastasis, and angiogenesis and may participate in the development of multidrug resistance by tumor cells. The aim of this review is to present the role of PMPs in carcinogenesis. The biology and functions of PMPs with a particular emphasis on the most recent scientific reports on EV properties are also characterized.

• Publication year

  2016

• Venue

  Tumor Biology

• Publication date

  2016-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s13277-016-5358-6PMID 27629289PMCID 5126185
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Exosomes – Structure, Biogenesis and Biological Role in Non‐Small‐Cell Lung Cancer

  2015influential reference
• Small But Mighty: Microparticles as Mediators of Tumor Progression

  2014cited by this paper
• Exosome and microvesicle mediated phene transfer in mammalian cells.

  2014cited by this paper
• Extracellular vesicles as drug delivery systems: lessons from the liposome field.

  2014cited by this paper
• Role of Exosomes Released by Dendritic Cells and/or by Tumor Targets: Regulation of NK Cell Plasticity

  2014cited by this paper
• MicroRNA-126, -145, and -155: a therapeutic triad in atherosclerosis?

  2013cited by this paper
• Intercellular Communication by Exosome-Derived microRNAs in Cancer

  2013cited by this paper
• Endothelial Microparticle Uptake in Target Cells Is Annexin I/Phosphatidylserine Receptor Dependent and Prevents Apoptosis

  2012cited by this paper
• Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials.

  2012cited by this paper
• Exosomes in Cancer Microenvironment and Beyond: have we Overlooked these Extracellular Messengers?

  2012cited by this paper
• Microparticles: major transport vehicles for distinct microRNAs in circulation

  2012cited by this paper
• Tumor cell-derived exosomes: a message in a bottle.

  2012influential reference
• Potential role of HER2‐overexpressing exosomes in countering trastuzumab‐based therapy

  2012cited by this paper
• Microparticles in tumor progression.

  2012influential reference
• Docetaxel-Resistance in Prostate Cancer: Evaluating Associated Phenotypic Changes and Potential for Resistance Transfer via Exosomes

  2012cited by this paper
• Microvesicles as mediators of intercellular communication in cancer—the emerging science of cellular ‘debris’

  2011cited by this paper
• Microparticles: a critical component in the nexus between inflammation, immunity, and thrombosis

  2011cited by this paper
• Exosomes: immune properties and potential clinical implementations

  2011cited by this paper
• Microparticles in angiogenesis: therapeutic potential.

  2011cited by this paper
• Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

  2011influential reference
• Platelet membrane phospholipid asymmetry: from the characterization of a scramblase activity to the identification of an essential protein mutated in Scott syndrome

  2011cited by this paper
• Microvesicles and Viral Infection

  2011cited by this paper
• Protein Targeting to Exosomes/Microvesicles by Plasma Membrane Anchors*

  2011cited by this paper
• Exosome/microvesicle-mediated epigenetic reprogramming of cells.

  2011cited by this paper
• Clinical relevance of microparticles from platelets and megakaryocytes

  2010influential reference
• Formation of procoagulant microparticles and properties.

  2010cited by this paper
• Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis

  2010cited by this paper
• Microparticles in cancer.

  2010influential reference
• Phospholipid scramblase: An update

  2010cited by this paper
• Exosomes: proteomic insights and diagnostic potential

  2009cited by this paper
• Lung cancer secreted microvesicles: Underappreciated modulators of microenvironment in expanding tumors

  2009cited by this paper
• Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles.

  2009influential reference
• Acid sphingomyelinase activity triggers microparticle release from glial cells

  2009cited by this paper
• Shedding microvesicles: artefacts no more.

  2009influential reference
• Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures.

  2009cited by this paper
• ExoCarta: A compendium of exosomal proteins and RNA

  2009cited by this paper
• Cell-derived microparticles in haemostasis and vascular medicine

  2009influential reference
• Exosomes--vesicular carriers for intercellular communication.

  2009cited by this paper
• Platelet microparticles: a potential predictive factor of survival in hormone-refractory prostate cancer patients treated with docetaxel-based chemotherapy.

  2009cited by this paper
• Cell‐derived microparticles: a new challenge in neuroscience

  2009cited by this paper
• Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR

  2009cited by this paper
• Flow cytometric analysis of cell membrane microparticles.

  2008cited by this paper
• Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

  2008cited by this paper
• Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles.

  2008cited by this paper
• Plasma membrane microparticles in angiogenesis: role in ischemic diseases and in cancer.

  2008cited by this paper
• Cathepsin B mediates the pH-dependent proinvasive activity of tumor-shed microvesicles.

  2008cited by this paper
• Cell to Cell Signalling via Exosomes Through esRNA

  2007cited by this paper
• Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

  2007cited by this paper
• Tumour-derived microvesicles modulate biological activity of human monocytes.

  2007cited by this paper
• Circulating microparticles: pathophysiology and clinical implications.

  2007cited by this paper
• Direct exosome stimulation of peripheral humanT cells detected by ELISPOT

  2006cited by this paper
• Cellular prion protein is released on exosomes from activated platelets.

  2006cited by this paper
• Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes

  2006cited by this paper
• Circulating CD31+/Annexin V+ Apoptotic Microparticles Correlate With Coronary Endothelial Function in Patients With Coronary Artery Disease

  2006cited by this paper
• Formation and fate of platelet microparticles.

  2006influential reference
• Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication

  2006cited by this paper
• Prospects for exosomes in immunotherapy of cancer

  2006cited by this paper
• Rapid clearance of procoagulant platelet‐derived microparticles from the circulation of rabbits

  2006cited by this paper
• Induction of heat shock proteins in B-cell exosomes

  2005cited by this paper
• Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer

  2005influential reference
• The potential role of platelet microparticles in atherosclerosis

  2005cited by this paper
• Platelets mediate cytotoxic T lymphocyte–induced liver damage

  2005cited by this paper
• Microparticles as regulators of inflammation: novel players of cellular crosstalk in the rheumatic diseases.

  2005cited by this paper
• Membrane microparticles: two sides of the coin.

  2005cited by this paper
• Thrombelastography monitoring of platelet substitution therapy and rFVIIa administration in haemato-oncological patients with severe thrombocytopenia.

  2004cited by this paper
• Platelet microparticles induce angiogenesis in vitro

  2004cited by this paper
• Exosomes: endosomal-derived vesicles shipping extracellular messages.

  2004cited by this paper
• Platelet-derived microparticles induce angiogenesis and stimulate post-ischemic revascularization.

  2004cited by this paper
• Cellular microparticles: new players in the field of vascular disease?

  2004cited by this paper
• Platelet and osteoclast β3 integrins are critical for bone metastasis

  2003cited by this paper
• Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV

  2003cited by this paper
• Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion.

  2003cited by this paper
• Proteomic and Biochemical Analyses of Human B Cell-derived Exosomes

  2003cited by this paper
• Elevated levels of circulating platelet microparticles, VEGF, IL-6 and RANTES in patients with gastric cancer: possible role of a metastasis predictor.

  2003cited by this paper
• Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A

  2003cited by this paper
• Clotting mechanisms and cancer: implications in thrombus formation and tumor progression.

  2003cited by this paper
• Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection1

  2003cited by this paper
• Membrane type-matrix metalloproteinases (MT-MMP).

  2003cited by this paper
• Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis.

  2003cited by this paper
• Interaction of endothelial microparticles with monocytic cells in vitro induces tissue factor-dependent procoagulant activity.

  2002cited by this paper
• Release and Intercellular Transfer of Cell Surface CD81 Via Microparticles1

  2002cited by this paper
• Matrix metalloproteinases: a tail of a frog that became a prince

  2002cited by this paper
• Exosomes: composition, biogenesis and function

  2002cited by this paper
• Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells.

  2002cited by this paper
• Cell-derived Microparticles Circulate in Healthy Humans and Support Low Grade Thrombin Generation

  2001cited by this paper
• Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles1

  2001cited by this paper
• Platelet-released phospholipids link haemostasis and angiogenesis.

  2001cited by this paper
• Microparticles from Patients with Multiple Organ Dysfunction Syndrome and Sepsis Support Coagulation through Multiple Mechanisms

  2001cited by this paper
• Exosome: from internal vesicle of the multivesicular body to intercellular signaling device.

  2000cited by this paper
• Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: A mechanism for cellular human immunodeficiency virus 1 infection

  2000cited by this paper
• Leukocyte-leukocyte interactions mediated by platelet microparticles under flow.

  2000cited by this paper
• Polymorphonuclear Leukocyte Apoptosis Is Inhibited by Platelet-released Mediators, Role of TGFβ-1

  2000cited by this paper
• Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts.

  2000cited by this paper
• Sphingosine 1‐phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis

  2000cited by this paper
• Laboratory markers of platelet activation and their clinical significance.

  1999cited by this paper
• Platelet microparticles: a wide-angle perspective.

  1999cited by this paper
• In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant.

  1999cited by this paper
• Moesin, the major ERM protein of lymphocytes and platelets, differs from ezrin in its insensitivity to calpain

  1999cited by this paper
• Arachidonic Acid in Platelet Microparticles Up-regulates Cyclooxygenase-2-dependent Prostaglandin Formation via a Protein Kinase C/Mitogen-activated Protein Kinase-dependent Pathway*

  1999cited by this paper
• Mechanisms of Cellular Activation by Platelet Microparticles

  1999cited by this paper

• Pazopanib-associated remodeling of platelet-immune cell crosstalk and immune suppressive platelet-derived extracellular vesicles in metastatic RCC

  2026cites this paper
• Platelet-Rich Plasma from the Research to the Clinical Arena: A Journey Toward the Precision Regenerative Medicine

  2026cites this paper
• Platelets and platelet-derived extracellular vesicles: their role in lung cancer dissemination and premetastatic niche formation

  2025cites this paper
• Plant vs mammal extracellular vesicles: new tools in therapeutic drug delivery

  2025cites this paper
• Advances in the role of extracellular vesicles in circulating microRNA biomarker discovery for lung cancer

  2025cites this paper
• Deciphering the Contributions of Extracellular Vesicles to Cancer Metastasis: Mechanisms and therapeutic implications.

  2025cites this paper
• Platelet-Rich Plasma - A Comprehensive Review of Isolation, Activation, and Application.

  2025cites this paper
• Ex Vivo Removal of CD41 positive platelet microparticles from Plasma by a Medical Device containing a Galanthus nivalis agglutinin (GNA) affinity resin

  2025influential citation
• Platelets: Novel Biomaterials for Cancer Diagnosis and Therapeutic Delivery

  2025cites this paper
• The Mechanism of Lactic Acid Regulating Platelet-Derived Microparticles to Affect the Biological Characteristics of Human Lung Adenocarcinoma

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• Salivary apoptotic microvesicles as biomarkers for prognostic non-healing oral ulcers and oral cancer: a cross-sectional study

  2025cites this paper
• Extracellular mitochondria: a potential player involved in exercise health benefits.

  2025cites this paper
• Extracellular vesicles as tools and targets in therapy for diseases

  2024cites this paper
• Harmonising cellular conversations: decoding the vital roles of extracellular vesicles in respiratory system intercellular communications

  2024cites this paper
• Review of exosomes and their potential for veterinary medicine.

  2024cites this paper
• Platelet-derived extracellular vesicles for drug delivery.

  2023cites this paper
• Revealing profile of cancer-educated platelets and their factors to foster immunotherapy development

  2023cites this paper
• The value of platelet-rich plasma-derived extracellular vesicles in modern medicine

  2023cites this paper
• Cryopreservation affects platelet macromolecular composition over time after thawing and differently impacts on cancer cells behavior in vitro

  2023cites this paper
• Platelet-Based Nanoparticles with Stimuli-Responsive for Anti-Tumor Therapy

  2023cites this paper
• Plant and mammalian-derived extracellular vesicles: a new therapeutic approach for the future

  2023cites this paper
• Platelet‐derived microvesicles induce intracellular calcium mobilization in human platelets

  2023cites this paper
• Ultrasound-Targeted Microbubble Destruction Assisted Delivery of Platelet-Rich Plasma-Derived Exosomes Promoting Peripheral Nerve Regeneration

  2023cites this paper
• Engineered Extracellular Vesicles for Drug Delivery in Therapy of Stroke

  2023cites this paper
• The prospects of microphysiological systems in modeling platelet pathophysiology in cancer

  2023cites this paper
• Platelet-Derived Microparticles and Autoimmune Diseases

  2023cites this paper
• Enhanced in vivo and ex vivo thrombin generation after lower-leg trauma, but not after knee arthroscopy

  2023cites this paper
• Extracellular microvesicles: biologic properties, biogenesis, and applications in leukemia

  2023cites this paper
• Extracellular vesicles from blood of breast cancer women induce angiogenic processes in HUVECs.

  2022cites this paper
• Liquid biopsy: Decoding cancer in blood

  2022cites this paper
• Circulating Extracellular Vesicles Are Increased in Newly Diagnosed Celiac Disease Patients

  2022cites this paper
• Research landscape of exosomes in platelets from 2000 to 2022: A bibliometric analysis

  2022cites this paper
• Natural cell based biomimetic cellular transformers for targeted therapy of digestive system cancer

  2022cites this paper
• Platelet detection as a new liquid biopsy tool for human cancers

  2022cites this paper
• Canine B Cell Lymphoma- and Leukemia-Derived Extracellular Vesicles Moderate Differentiation and Cytokine Production of T and B Cells In Vitro

  2022cites this paper
• Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics

  2022cites this paper
• Tumour Derived Extracellular Vesicles: Challenging Target to Blunt Tumour Immune Evasion

  2022cites this paper
• Circulating Microparticles as Indicators of Cardiometabolic Risk in PCOS.

  2022cites this paper
• Extracellular Vesicles as Biomarkers and Therapeutic Targets in Cancers

  2022cites this paper
• Platelet Extracellular Vesicles Are Taken up by Canine T Lymphocytes but Do Not Play a Role in Their Proliferation, Differentiation and Cytokine Production In Vitro

  2022cites this paper
• Microparticles in Diabetic Kidney Disease.

  2022cites this paper
• Horizontal MicroRNA Transfer by Platelets – Evidence and Implications

  2021cites this paper
• Diets and Cellular-Derived Microparticles: Weighing a Plausible Link With Cerebral Small Vessel Disease

  2021cites this paper
• Effects and Side Effects of Platelet Transfusion

  2021cites this paper
• Extracellular Vesicles: Novel Opportunities to Understand and Detect Neoplastic Diseases

  2021cites this paper
• Engineered Small Extracellular Vesicles as a FGL1/PD‐L1 Dual‐Targeting Delivery System for Alleviating Immune Rejection

  2021cites this paper
• COVID-19 Infection and Circulating Microparticles—Reviewing Evidence as Microthrombogenic Risk Factor for Cerebral Small Vessel Disease

  2021cites this paper
• Platelet-Cancer Interplay: Molecular Mechanisms and New Therapeutic Avenues

  2021cites this paper
• SARS-CoV-2 Initiates Programmed Cell Death in Platelets

  2021cites this paper
• Liquid Biopsy, the hype vs. hope in molecular and clinical oncology.

  2021cites this paper
• Platelet Microparticles Accelerate Proliferation and Growth of Mesenchymal Stem Cells through Longevity-Related Genes.

  2021cites this paper
• Proteomic analysis of human umbilical cord serum exosomes using mass spectrometry and preliminary study of their biological activities in liver cancer cell lines

  2021cites this paper
• A panel of platelet-associated circulating long non-coding RNAs as potential biomarkers for colorectal cancer.

  2021cites this paper
• Circulating platelets as liquid biopsy sources for cancer detection

  2020cites this paper
• Platelet Microparticle Controversial Role in Cancer

  2020cites this paper
• Complementary roles of platelet αIIbβ3 integrin, phosphatidylserine exposure and cytoskeletal rearrangement in the release of extracellular vesicles.

  2020cites this paper
• Cell Biology and Translational Medicine, Volume 9: Stem Cell-Based Therapeutic Approaches in Disease

  2020cites this paper
• Platelets Extracellular Vesicles as Regulators of Cancer Progression—An Updated Perspective

  2020influential citation
• Glioma-derived exosomes drive the differentiation of neural stem cells to astrocytes

  2020cites this paper
• Cellular Dust as a Novel Hope for Regenerative Cancer Medicine.

  2020cites this paper
• Mediating effects of platelet-derived extracellular vesicles on PM2.5-induced vascular endothelial injury.

  2020cites this paper
• Microparticles in the pathogenesis of TB: Novel perspectives for diagnostic and therapy management ofMycobacterium tuberculosisinfection.

  2020cites this paper
• Detection of Platelet-Derived Microparticles in Blood Samples by Flow Cytometry: The Importance of Choosing the Adequate Control

  2020cites this paper
• Extracellular Vesicles Are Key Regulators of Tumor Neovasculature

  2020cites this paper
• Label-free characterization and real-time monitoring of cell uptake of extracellular vesicles.

  2020cites this paper
• The role of extracellular vesicles in neointima formation post vascular injury.

  2020cites this paper
• The Role of Platelets in Tumor Growth, Metastasis, and Immune Evasion

  2019cites this paper
• Increased salivary microvesicles are associated with the prognosis of patients with oral squamous cell carcinoma

  2019cites this paper
• Tumor-educated platelets.

  2019cites this paper
• Cell membrane capsule: a novel natural tool for antitumour drug delivery

  2019cites this paper
• Platelets and Platelet‐Derived Extracellular Vesicles in Liver Physiology and Disease

  2019cites this paper
• Platelet microvesicles promote the recovery of neurological function in mouse model of cerebral infarction by inducing angiogenesis.

  2019cites this paper
• Mesenchymal Stem Cell-Derived Extracellular Vesicles as Mediators of Anti-inflammatory Effects

  2019cites this paper
• Extracellular Vesicles in the Blood of Dogs with Cancer—A Preliminary Study

  2019cites this paper
• Platelet Inflammatory Response to Stress

  2019cites this paper
• Characterization and function of medium and large extracellular vesicles from plasma and urine by surface antigens and Annexin V

  2019cites this paper
• Procoagulant Effects of Low-Level Platelet Activation and Its Inhibition by Colchicine

  2018cites this paper
• CD18‐mediated adhesion is required for the induction of a proinflammatory phenotype in lung epithelial cells by mononuclear cell‐derived extracellular vesicles

  2018cites this paper
• Platelet Microparticles and miRNA Transfer in Cancer Progression: Many Targets, Modes of Action, and Effects Across Cancer Stages

  2018cites this paper
• Exosome-Based Cell-Cell Communication in the Tumor Microenvironment

  2018cites this paper
• The Biology and Therapeutic Applications of Red Blood Cell Extracellular Vesicles

  2018cites this paper
• TMEM16F activation by Ca2+ triggers plasmalemma expansion and directs PD-1 trafficking

  2018cites this paper
• Vésicules extracellulaires : biomarqueurs et véhicules de propagation de protéinopathies

  2018cites this paper
• Cancer-Associated Thrombosis in Cirrhotic Patients with Hepatocellular Carcinoma

  2018cites this paper
• Monocytes of Different Subsets in Complexes with Platelets in Patients with Myocardial Infarction

  2018cites this paper
• Lipid rafts are essential for release of phosphatidylserine-exposing extracellular vesicles from platelets

  2018cites this paper
• Neurohormonal Regulation of Tumor Growth

  2018cites this paper
• Contact System Activation and Cancer: New Insights in the Pathophysiology of Cancer-Associated Thrombosis

  2018cites this paper
• Extracellular vesicles: pathogenetic, diagnostic and therapeutic value in traumatic brain injury

  2018cites this paper
• Molecular interactions at the surface of extracellular vesicles

  2018cites this paper
• Isolation of Extracellular Vesicles: General Methodologies and Latest Trends

  2018influential citation
• Initiation and Propagation of Vascular Calcification Is Regulated by a Concert of Platelet- and Smooth Muscle Cell-Derived Extracellular Vesicles

  2018influential citation
• CD18-mediated adhesion is required for lung inflammation induced by mononuclear cell-derived extracellular vesicles

  2017cites this paper
• Antiplatelet agents for cancer treatment: a real perspective or just an echo from the past?

  2017cites this paper
• New Insights on Platelets and Platelet-Derived Microparticles in Systemic Lupus Erythematosus

  2017cites this paper
• Platelet-targeted pharmacologic treatments as anti-cancer therapy

  2017cites this paper
• Platelets, circulating tumor cells, and the circulome

  2017cites this paper
• Microvesicles Released from Human Red Blood Cells: Properties and Potential Applications

  2017influential citation
• Glioma cells promote angiogenesis through the release of exosomes containing long non-coding RNA POU3F3.

  2017cites this paper
• Étude génomique et protéomique des concentrés plaquettaires ayant induit une réaction post-transfusionnelle

  2016cites this paper