53BP1 promotes ATM activity through direct interactions with the MRN complex

No abstract is available for this paper.

• Publication year

  2010

• Venue

  EMBO Journal

• Publication date

  2010-02-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/emboj.2009.372PMID 20010693PMCID PMC2830698
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

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  2009influential reference
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• Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

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• ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.

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• Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.

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• Chromosome breakage after G2 checkpoint release

  2007influential reference
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• The GAR Motif of 53BP1 is Arginine Methylated by PRMT1 and is Necessary for 53BP1 DNA Binding Activity

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• 53BP1, an activator of ATM in response to DNA damage.

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• Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

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• Human PTIP Facilitates ATM-mediated Activation of p53 and Promotes Cellular Resistance to Ionizing Radiation*

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• Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.

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• Involvement of Brca1 in S-Phase and G2-Phase Checkpoints after Ionizing Irradiation

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• An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

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• Negative Cell Cycle Regulation and DNA Damage-inducible Phosphorylation of the BRCT Protein 53BP1*

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• A mechanistic basis for Mre11-directed DNA joining at microhomologies.

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