Reactive Oxygen Species as a Signal in Glucose-Stimulated Insulin Secretion

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Diabetes

• Publication date

  2007-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2337/db06-1601PMID 17400930
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• How many transcription factors does it take to turn on the heme oxygenase-1 gene?

  2007cited by this paper
• Mitochondrial Reactive Oxygen Species Are Required for Hypothalamic Glucose Sensing

  2006cited by this paper
• Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells.

  2006cited by this paper
• Cell signaling. H2O2, a necessary evil for cell signaling.

  2006influential reference
• Oxidative stress and impaired insulin secretion in type 2 diabetes.

  2006cited by this paper
• Dose Response Relationship in Anti-Stress Gene Regulatory Networks

  2006cited by this paper
• Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet beta cell.

  2006cited by this paper
• H2O2, a Necessary Evil for Cell Signaling

  2006cited by this paper
• Controlled Elimination of Intracellular H2O2: Regulation of Peroxiredoxin, Catalase, and Glutathione Peroxidase via Post-translational Modification

  2005cited by this paper
• Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets.

  2005cited by this paper
• Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins.

  2005cited by this paper
• Low level, long‐term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratinocytes: Potential role in skin co‐carcinogenesis

  2005cited by this paper
• Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

  2004cited by this paper
• O2 sensing in the human ductus arteriosus: redox-sensitive K+ channels are regulated by mitochondria-derived hydrogen peroxide

  2004cited by this paper
• Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia.

  2004cited by this paper
• β-Cell Glucose Toxicity, Lipotoxicity, and Chronic Oxidative Stress in Type 2 Diabetes

  2004cited by this paper
• Role of nicotinamide quinone oxidoreductase 1 (NQO1) in protection against toxicity of electrophiles and reactive oxygen intermediates.

  2004cited by this paper
• Role of superoxide as a signaling molecule.

  2004cited by this paper
• Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes.

  2004cited by this paper
• Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines.

  2004cited by this paper
• Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells?

  2004cited by this paper
• Visualizing Superoxide Production in Normal and Diabetic Rat Islets of Langerhans*

  2003cited by this paper
• Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection.

  2003cited by this paper
• Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?

  2003cited by this paper
• Regulatory mechanisms controlling gene expression mediated by the antioxidant response element.

  2003cited by this paper
• Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide.

  2003cited by this paper
• Are Oxidative StressActivated Signaling Pathways Mediators of Insulin Resistance and -Cell

  2003cited by this paper
• A role for glutathione peroxidase in protecting pancreatic β cells against oxidative stress in a model of glucose toxicity

  2002cited by this paper
• Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach.

  2002cited by this paper
• Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling.

  2002cited by this paper
• Beta-cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites.

  2002cited by this paper
• Redox potential of GSH/GSSG couple: assay and biological significance.

  2002cited by this paper
• Free radicals in the physiological control of cell function.

  2002cited by this paper
• Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.

  2001cited by this paper
• Activation of the Hexosamine Pathway Leads to Deterioration of Pancreatic β-Cell Function through the Induction of Oxidative Stress*

  2001cited by this paper
• Influence of melatonin on free radical‐induced changes in rat pancreatic beta‐cells in vitro

  2000cited by this paper
• Triggering and amplifying pathways of regulation of insulin secretion by glucose.

  2000influential reference
• Role for Mitochondrial Oxidants as Regulators of Cellular Metabolism

  2000cited by this paper
• Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

  2000cited by this paper
• Hydrogen Peroxide Alters Mitochondrial Activation and Insulin Secretion in Pancreatic Beta Cells*

  1999cited by this paper
• Free radical modulation of insulin release in INS-1 cells exposed to alloxan.

  1999cited by this paper
• Oxygen radicals and signaling.

  1998cited by this paper
• Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats.

  1997cited by this paper
• Functional antioxidant responsive elements.

  1997cited by this paper
• Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells

  1997cited by this paper
• Augmentation of Insulin Release by Glucose in the Absence of Extracellular Ca2+: New Insights Into Stimulus-Secretion Coupling

  1997cited by this paper
• Identification of hydrogen peroxide as the relevant messenger in the activation pathway of transcription factor NF-kappaB.

  1996cited by this paper
• Effects of H2O2 on membrane potential and [Ca2+]i of cultured rat arterial smooth muscle cells.

  1995cited by this paper
• Hydrogen peroxide mediates amyloid beta protein toxicity.

  1994cited by this paper
• Flow cytometric analysis of nitric oxide production in human neutrophils using dichlorofluorescein diacetate in the presence of a calmodulin inhibitor

  1992cited by this paper
• Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells.

  1992cited by this paper
• Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing.

  1988cited by this paper
• Cysteine Analogues Potentiate Glucose-Induced Insulin Release In Vitro

  1986cited by this paper

• Differential effects of isopropyl alcohol on glucose-induced insulin secretion in INS-1 and MIN6 cells.

  2026cites this paper
• Development of a radioiodinated boronic acid probe for the detection of hydrogen peroxide and peroxynitrite

  2026cites this paper
• Co-expression of superoxide and peroxide scavenging antioxidant enzymes rescues β cells from hypoxia and hyperglycemia-induced oxidative damage

  2026cites this paper
• A color-tailored fluorogenic sensor for hydrogen peroxide.

  2025cites this paper
• Prospective study of oil spill cleanup-related exposure to volatile organic compounds and glycemic dysregulation

  2025cites this paper
• Synthesis of a novel hydrogen peroxide-responsive cyanine-based near-infrared fluorescent probe and its applications in cellular and in vivo imaging.

  2025cites this paper
• Expression, localization and regulation of NADPH oxidases in pancreatic beta cells

  2025cites this paper
• Mitochondrial homeostasis in stem cell senescence

  2025cites this paper
• Thermosensitive TRPM2: The regulatory mechanisms of its temperature sensitivity and physiological functions

  2025cites this paper
• Physiological Fatty Acid-Stimulated Insulin Secretion and Redox Signaling Versus Lipotoxicity

  2025cites this paper
• β-Cell Mitochondrial Dysfunction: Underlying Mechanisms and Potential Therapeutic Strategies

  2025cites this paper
• Origins of Ultrasensitivity and Complex Signaling Dynamics of Cellular Hydrogen Peroxide and Peroxiredoxin

  2025cites this paper
• Mitochondrial calcium uniporter is required for thermogenic adaptation mediated by reactive oxygen species signaling

  2025cites this paper
• Intrauterine growth restriction (IUGR) modifies the hypothalamic response to a systemic glucose load in adult male rats, as assessed by proteomic analysis

  2025cites this paper
• Regulation of m6A methylation in the immune microenvironment in the development of diabetes mellitus

  2025cites this paper
• Adaptive mechanisms in pancreatic islets counteract mitochondrial dysfunction in Barth syndrome

  2025cites this paper
• A Smart Triple-Signal Fluorescent Probe for Real-Time Differential Imaging of HClO, H2O2, and Their Mixture in Diabetic Models

  2025cites this paper
• Methylglyoxal Formation—Metabolic Routes and Consequences

  2025cites this paper
• An ICT-FRET fluorescent probe for ratiometric recognition of hydrogen peroxide utilizing coumarin-naphthalimide derivative

  2025cites this paper
• Indolin‐2‐Ones: A New Approach to Inflammation, Targeting LPS via GSK3β/NLRP3

  2025cites this paper
• Low-intensity therapeutic ultrasound effects on intracellular sodium and reactive oxygen species in ex vivo human islets for control of insulin release.

  2025cites this paper
• Sensitive chemiluminescence detection platform for H2O2 and glucose through facile inorganic salt etching of cobalt Prussian blue analogues

  2025cites this paper
• Studying the Effect of AgNPs Derived from Ag‐Complex on Peroxidase Enzymes in Patients with Type2 Diabetes Caused by White Rabbits

  2025cites this paper
• NADPH Oxidases: Redox Regulation of Cell Homeostasis & Disease.

  2025cites this paper
• Glutathione Induces Keap1 S-Glutathionylation and Mitigates Oscillating Glucose-Induced β-Cell Dysfunction by Activating Nrf2

  2024cites this paper
• Redox Status as a Key Driver of Healthy Pancreatic β-Cells

  2024cites this paper
• REDOX SIGNALLING IN THE PANCREAS IN HEALTH AND DISEASE.

  2024cites this paper
• A bifunctional fluorescent probe for dual-channel detection of H2O2 and HOCl in living cells.

  2024cites this paper
• Reusable magnetic nanoparticles for dual-mode sensing of hydrogen peroxide and glucose in human serum

  2024cites this paper
• Mitonuclear Communication in Stem Cell Function

  2024cites this paper
• Beyond glucose: The crucial role of redox signaling in β-cell metabolic adaptation.

  2024cites this paper
• Mitochondria to plasma membrane redox signaling is essential for fatty acid β-oxidation-driven insulin secretion

  2024cites this paper
• Redox Chemistry: Implications for Necrotizing Enterocolitis

  2024cites this paper
• An antireductant approach ameliorates misfolded proinsulin-induced hyperglycemia and glucose intolerance in male Akita mice

  2024cites this paper
• Mitochondrial Dysfunction, Oxidative Stress, and Inter-Organ Miscommunications in T2D Progression

  2024cites this paper
• Redox Status as a Key Driver of Healthy Pancreatic Beta-Cells.

  2024cites this paper
• The role of anaplerotic metabolism of glucose and glutamine in insulin secretion: A model approach.

  2024cites this paper
• Mitochondrial bioenergetics, metabolism, and beyond in pancreatic β-cells and diabetes

  2024cites this paper
• Zein/MnO2 Nanosheet Composites Integrated with a Smartphone for Colorimetric Sensors for On-Site Detection of Adulterants in Milk

  2024cites this paper
• Aging and “Age-Related” Diseases - What Is the Relation?

  2024cites this paper
• Environment-Friendly and Efficient Colorimetric Sensing of Hydrogen Peroxide Based on Dalbergia sissoo Sawdust-Deposited Nickel Nanoparticles

  2024cites this paper
• Obesogens: a unifying theory for the global rise in obesity

  2024cites this paper
• Mitochondrial Physiology of Cellular Redox Regulations.

  2024cites this paper
• Insulin Secretion and the β-Cell 102 Years After the Discovery of the Hormone

  2024cites this paper
• Persistent organic pollutants disrupt the oxidant/antioxidant balance of INS-1E pancreatic β-cells causing their physiological dysfunctions.

  2024cites this paper
• An autocatalytically-activatable hydrogen peroxide photoacoustic sensor for in situ visualization precise diagnosis and drug intervention tracing in diabetes syndrome.

  2023cites this paper
• Mineralocorticoid Receptor-Associated Mechanisms in Diabetic Kidney Disease and Clinical Significance of Mineralocorticoid Receptor Antagonists

  2023cites this paper
• m6A mRNA methylation: Biological features, mechanisms, and therapeutic potentials in type 2 diabetes mellitus

  2023cites this paper
• Beta cell stress and endocrine function during T1D: what's next to discover?

  2023cites this paper
• Anti-oxidant effect of nitrite in the pancreatic islets of type 2 diabetic male rats

  2023cites this paper
• The Effect of Arsenic on the Prevalence of Diabetes

  2023cites this paper
• Reactive oxygen species: role in obesity and mitochondrial energy efficiency

  2023cites this paper
• Interdependencies of Gene Expression and Function between Two Redox Enzymes and REG Family Proteins in Murine Pancreatic Islets and Human Pancreatic Cells

  2023cites this paper
• SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver

  2023cites this paper
• Hydrogen peroxide detoxification through the peroxiredoxin/thioredoxin antioxidant system: A look at the pancreatic β-cell oxidant defense.

  2023cites this paper
• Redox Balance in Type 2 Diabetes: Therapeutic Potential and the Challenge of Antioxidant-Based Therapy

  2023cites this paper
• Design, synthesis, in vitro anti-oxidant evaluation, a-amylase inhibition assay, and molecular docking analysis of 2-(2-benzylidenehydrazinyl)-4,4-diphenyl-1H-imidazol-5(4H)-ones

  2023cites this paper
• Sulforaphane induced NRF2 activation in obese pregnancy attenuates developmental redox imbalance and improves early-life cardiovascular function in offspring

  2023cites this paper
• Mitochondrial calcium uniporter regulates odor learning and memory by controlling neuropeptide release

  2023cites this paper
• Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy.

  2023cites this paper
• Smartphone-Based Chemiluminescence Glucose Biosensor Employing a Peroxidase-Mimicking, Guanosine-Based Self-Assembled Hydrogel

  2023cites this paper
• Myricitrin and Its Solid Lipid Nanoparticle Increase Insulin Secretion and Content of Isolated Islets from the Pancreas of Male Mice

  2022cites this paper
• Arsenic exposure during pregnancy and postpartum maternal glucose tolerance: evidence from Bangladesh

  2022cites this paper
• Effect of a single dose of oral iron on pancreatic beta-cell function in healthy individuals: a before-and-after (pre-post) study

  2022cites this paper
• PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53

  2022cites this paper
• Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver disease

  2022cites this paper
• Oxidative stress in obesity and insulin resistance

  2022cites this paper
• Single-cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty-Acid-Induced Rat Beta-Cell Proliferation.

  2022cites this paper
• Mitochondrial signal transduction

  2022cites this paper
• In vitro biochemical assessment of mixture effects of two endocrine disruptors on INS-1 cells

  2022cites this paper
• Effects of Allyl Isothiocyanate on Oxidative and Inflammatory Stress in Type 2 Diabetic Rats

  2022cites this paper
• Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction

  2022cites this paper
• Impaired pancreatic beta-cell function after a single dose of oral iron: a before-and-after (pre-post) study.

  2022cites this paper
• Role of Reactive Oxygen Species in Glucose Metabolism Disorder in Diabetic Pancreatic β-Cells

  2022cites this paper
• Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway

  2022cites this paper
• Decreased Sirt3 contributes to cyclic production of reactive oxygen species and islet β-cell apoptosis in high glucose conditions

  2022cites this paper
• Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs β-Cell Function

  2022cites this paper
• Moderate Exercise Training Combined With a High-Fat and Sucrose Diet Protects Pancreatic Islet Function in Male C57BL/6J Mice

  2022cites this paper
• Anti-Oxidative Therapy in Islet Cell Transplantation

  2022cites this paper
• TRP Channels as Molecular Targets to Relieve Endocrine-Related Diseases

  2022cites this paper
• The association between oil spill cleanup-related total hydrocarbon exposure and diabetes.

  2022cites this paper
• Obesity Hinders the Protective Effect of Selenite Supplementation on Insulin Signaling

  2022cites this paper
• Mitochondrial defects in pancreatic beta-cell dysfunction and neurodegenerative diseases: Pathogenesis and therapeutic applications.

  2022cites this paper
• Recent Advances in Understanding Nrf2 Agonism and Its Potential Clinical Application to Metabolic and Inflammatory Diseases

  2022cites this paper
• Vanillic acid potentiates insulin secretion and prevents pancreatic β-cells cytotoxicity under H_2O_2-induced oxidative stress

  2022cites this paper
• Oxidative stress and impaired insulin secretion in cystic fibrosis pig pancreas

  2022cites this paper
• HIF-2α Preserves Mitochondrial Activity And Glucose Sensing in Compensating Beta Cells in Obesity.

  2022cites this paper
• Hypothesis: Induction of Autoimmunity in Type 1 Diabetes-A Lipid Focus.

  2022cites this paper
• The Role of p66Shc in Diabetes: A Comprehensive Review from Bench to Bedside

  2022cites this paper
• Lipotoxicity and β-Cell Failure in Type 2 Diabetes: Oxidative Stress Linked to NADPH Oxidase and ER Stress

  2021cites this paper
• The Importance of Proper Oxygenation in 3D Culture

  2021cites this paper
• Redox Homeostasis in Pancreatic β-Cells: From Development to Failure

  2021influential citation
• Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response

  2021cites this paper
• Single-cell RNA sequencing reveals a role for reactive oxygen species and peroxiredoxins in fatty-acid-induced rat ß-cell proliferation

  2021cites this paper
• Relationships between type 2 diabetes, cell dysfunction, and redox signaling: A meta‐analysis of single‐cell gene expression of human pancreatic α‐ and β‐cells

  2021cites this paper
• The Pancreatic β-Cell: The Perfect Redox System

  2021cites this paper
• Mitochondrial Uncoupling Proteins (UCPs) as Key Modulators of ROS Homeostasis: A Crosstalk between Diabesity and Male Infertility?

  2021cites this paper
• Potensi Antidiabetik Ekstrak Kulit Lidah Buaya Pada Tikus Hiperglikemik yang Diinduksi Aloksan

  2021cites this paper
• Protein Kinases Signaling in Pancreatic Beta-cells Death and Type 2 Diabetes.

  2021cites this paper
• Mitochondrial reactive oxygen species in physiology and disease.

  2021cites this paper