The intraspecies diversity of C. albicans triggers qualitatively and temporally distinct host responses that determine the balance between commensalism and pathogenicity

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Mucosal Immunology

• Publication date

  2017-02-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/mi.2017.2PMID 28176789
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Candidalysin is a fungal peptide toxin critical for mucosal infection

  2016cited by this paper
• IL-1 Coordinates the Neutrophil Response to C. albicans in the Oral Mucosa

  2016cited by this paper
• Specific Human and Candida Cellular Interactions Lead to Controlled or Persistent Infection Outcomes during Granuloma-Like Formation

  2016cited by this paper
• Clonal Strain Persistence of Candida albicans Isolates from Chronic Mucocutaneous Candidiasis Patients

  2016cited by this paper
• Antibody blockade of IL‐17 family cytokines in immunity to acute murine oral mucosal candidiasis

  2016cited by this paper
• IL-17 Receptor Signaling in Oral Epithelial Cells Is Critical for Protection against Oropharyngeal Candidiasis.

  2016cited by this paper
• Genome Integrity: Mechanisms and Contribution to Antifungal Resistance

  2015cited by this paper
• Antigen-Specific Th17 Cells Are Primed by Distinct and Complementary Dendritic Cell Subsets in Oropharyngeal Candidiasis

  2015cited by this paper
• β-Defensin 1 Plays a Role in Acute Mucosal Defense against Candida albicans

  2015cited by this paper
• Mechanisms of Antifungal Drug Resistance.

  2015cited by this paper
• Genetic and phenotypic intra-species variation in Candida albicans

  2015cited by this paper
• Interleukin 17-Mediated Host Defense against Candida albicans

  2015cited by this paper
• The evolution of drug resistance in clinical isolates of Candida albicans

  2015cited by this paper
• Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity.

  2015cited by this paper
• IL-17-mediated antifungal defense in the oral mucosa is independent of neutrophils

  2014influential reference
• Microevolution of Candida albicans in Macrophages Restores Filamentation in a Nonfilamentous Mutant

  2014cited by this paper
• Phylogeny and Diversity of Candida albicans Vaginal Isolates from Three Continents

  2014cited by this paper
• Pathogenicity mechanisms and host response during oral Candida albicans infections

  2014cited by this paper
• Role of Neutrophils in IL-17–Dependent Immunity to Mucosal Candidiasis

  2014cited by this paper
• Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections

  2014cited by this paper
• Differential Adaptation of Candida albicans In Vivo Modulates Immune Recognition by Dectin-1

  2013cited by this paper
• Cutting Edge: IL-17–Secreting Innate Lymphoid Cells Are Essential for Host Defense against Fungal Infection

  2013cited by this paper
• Candida albicans is not always the preferential yeast colonizing humans: a study in Wayampi Amerindians.

  2013cited by this paper
• Mouse model of oropharyngeal candidiasis

  2012cited by this paper
• Sensing of mammalian IL-17A regulates fungal adaptation and virulence

  2012cited by this paper
• Th17 cells confer long term adaptive immunity to oral mucosal Candida albicans infections

  2012cited by this paper
• Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis

  2012cited by this paper
• Evaluation of the Role of Candida albicans Agglutinin-Like Sequence (Als) Proteins in Human Oral Epithelial Cell Interactions

  2012cited by this paper
• A Novel Th Cell Epitope of Candida albicans Mediates Protection from Fungal Infection

  2012cited by this paper
• Coevolution of Morphology and Virulence in Candida Species

  2011cited by this paper
• Genetic Diversity among Korean Candida albicans Bloodstream Isolates: Assessment by Multilocus Sequence Typing and Restriction Endonuclease Analysis of Genomic DNA by Use of BssHII

  2011cited by this paper
• From Attachment to Damage: Defined Genes of Candida albicans Mediate Adhesion, Invasion and Damage during Interaction with Oral Epithelial Cells

  2011cited by this paper
• Variable recognition of Candida albicans strains by TLR4 and lectin recognition receptors.

  2010cited by this paper
• Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity

  2010cited by this paper
• Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

  2009cited by this paper
• Property Differences among the Four Major Candida albicans Strain Clades

  2009cited by this paper
• Mating is rare within as well as between clades of the human pathogen Candida albicans.

  2008cited by this paper
• Candidemia and candiduria in critically ill patients admitted to intensive care units in France: incidence, molecular diversity, management and outcome

  2008cited by this paper
• Molecular Phylogenetics of Candida albicans

  2007cited by this paper
• Murine model of concurrent oral and vaginal Candida albicans colonization to study epithelial host-pathogen interactions.

  2007cited by this paper
• Multilocus Sequence Typing Reveals Intrafamilial Transmission and Microevolutions of Candida albicans Isolates from the Human Digestive Tract

  2006cited by this paper
• Critical Role of Bcr1-Dependent Adhesins in C. albicans Biofilm Formation In Vitro and In Vivo

  2006cited by this paper
• New Microsatellite Multiplex PCR for Candida albicans Strain Typing Reveals Microevolutionary Changes

  2005cited by this paper
• Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations

  2004cited by this paper
• Bioactive interleukin-1α is cytolytically released from Candida albicans-infected oral epithelial cells

  2004cited by this paper
• Bioactive interleukin-1alpha is cytolytically released from Candida albicans-infected oral epithelial cells.

  2004cited by this paper
• Endogenous IL-17 as a Mediator of Neutrophil Recruitment Caused by Endotoxin Exposure in Mouse Airways1

  2003cited by this paper
• Collaborative Consensus for Optimized Multilocus Sequence Typing of Candida albicans

  2003cited by this paper
• Chronic mucocutaneous candidiasis.

  2001cited by this paper
• Analysis of Microsatellite Markers ofCandida albicans Used for Rapid Typing

  2001cited by this paper
• Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways.

  1999cited by this paper
• Cell Wall and Secreted Proteins ofCandida albicans: Identification, Function, and Expression

  1998cited by this paper
• IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines.

  1998cited by this paper
• Altered extent of cross-linking of beta1,6-glucosylated mannoproteins to chitin in Saccharomyces cerevisiae mutants with reduced cell wall beta1,3-glucan content

  1997cited by this paper
• Nonfilamentous C. albicans mutants are avirulent.

  1997cited by this paper
• The KNH1 gene of Saccharomyces cerevisiae is a functional homolog of KRE9

  1996cited by this paper
• The yeast Candida albicans has a clonal mode of reproduction in a population of infected human immunodeficiency virus-positive patients.

  1993cited by this paper
• Characterization of an estrogen-binding protein in the yeast Candida albicans.

  1989cited by this paper
• Characteristics of four new human cell lines derived from squamous cell carcinomas of the head and neck.

  1985cited by this paper
• Chronic mucocutaneous candidiasis.

  1983cited by this paper
• Interaction of Candida albicans with Human Leukocytes and Serum

  1969cited by this paper
• COLORIMETRIC METHOD FOR DETER-MINATION OF SUGAR AND RELATED SUBSTANCE

  1956cited by this paper

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  2026cites this paper
• Local albumin excess exacerbates Candida albicans-induced inflammasome activation linked with hyperinflammation during vulvovaginal candidiasis

  2026cites this paper
• Candida albicans synergizes with Fusobacteriumnucleatum in colorectal cancer progression via the Flo9-RadD interaction.

  2026cites this paper
• Abundant Yet Aberrant T Helper Cell Responses to Candida albicans Underlie Mucosal Candidiasis in Humans and Mice

  2025cites this paper
• Dynamic expression of candidalysin facilitates oral colonization of Candida albicans in mice

  2025cites this paper
• Host albumin redirects Candida albicans metabolism to engage an alternative pathogenicity pathway

  2025cites this paper
• Strain background interacts with chromosome 7 aneuploidy to determine commensal and virulence phenotypes in Candida albicans

  2025cites this paper
• Strain background interacts with chromosome 7 aneuploidy to determine commensal and virulence phenotypes in Candida albicans

  2025cites this paper
• Image-based quantification of Candida albicans filamentation and hyphal length using the open-source visual programming language JIPipe

  2025cites this paper
• Commensalism and pathogenesis of Candida albicans at the mucosal interface

  2025cites this paper
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  2025cites this paper
• IL-17-mediated antifungal immunity restricts Candida albicans pathogenicity in the oral cavity

  2025cites this paper
• Candida albicans natural diversity: a resource to dissect fungal commensalism and pathogenesis.

  2024cites this paper
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  2024cites this paper
• Non-canonical IL-22 receptor signaling remodels the mucosal barrier during fungal immunosurveillance

  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
• Identification of an active RNAi pathway in Candida albicans

  2024cites this paper
• Myeloid C-type lectin receptors in innate immune recognition.

  2024cites this paper
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  2024cites this paper
• Regulatory features of Candida albicans hemin-induced filamentation

  2024cites this paper
• Powder diet exacerbates oropharyngeal candidiasis in a mouse model

  2024cites this paper
• Activation of leukotriene B4 receptor 1 is a prerequisite for complement receptor 3-mediated antifungal responses of neutrophils

  2024cites this paper
• RFX transcription factor in the human‐associated yeast Candida albicans regulates adhesion to oral epithelium

  2024influential citation
• Mycobiota profile of oral fungal infections in head and neck cancer patients receiving radiotherapy: A 6-year retrospective MALDI-TOF mass spectrometry study.

  2023cites this paper
• Candida albicans selection for human commensalism results in substantial within-host diversity without decreasing fitness for invasive disease

  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
• Mucosal Immunity to Gut Fungi in Health and Inflammatory Bowel Disease

  2023influential citation
• The pathogenic and colonization potential of Candida africana.

  2023cites this paper
• Current Trends in Prevention of Denture Stomatitis: Denture Base Materials with Antimicrobial Effect

  2023cites this paper
• [Species diversity of the genus Candida in the oral cavity of cancer patients in Barranquilla, Colombia].

  2022cites this paper
• Host’s Immunity and Candida Species Associated with Denture Stomatitis: A Narrative Review

  2022cites this paper
• Immunosurveillance of Candida albicans commensalism by the adaptive immune system

  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
• A gut-oral microbiome–driven axis controls oropharyngeal candidiasis through retinoic acid

  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
• Interleukin-17 in Antifungal Immunity

  2019cites this paper
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  2019influential citation
• Candida albicans at Host Barrier Sites: Pattern Recognition Receptors and Beyond

  2019influential citation
• Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction.

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• Genomic and Phenotypic Variation in Morphogenetic Networks of Two Candida albicans Isolates Subtends Their Different Pathogenic Potential

  2018cites this paper
• Modulation of the Fungal-Host Interaction by the Intra-Species Diversity of C. albicans

  2018influential citation