Post-Transcriptional Trafficking and Regulation of Neuronal Gene Expression

Intracellular messenger RNA (mRNA) traffic and translation must be highly regulated, both temporally and spatially, within eukaryotic cells to support the complex functional partitioning. This capacity is essential in neurons because it provides a mechanism for rapid input-restricted activity-dependent protein synthesis in individual dendritic spines. While this feature is thought to be important for synaptic plasticity, the structures and mechanisms that support this capability are largely unknown. Certainly specialized RNA binding proteins and binding elements in the 3′ untranslated region (UTR) of translationally regulated mRNA are important, but the subtlety and complexity of this system suggests that an intermediate “specificity” component is also involved. Small non-coding microRNA (miRNA) are essential for CNS development and may fulfill this role by acting as the guide strand for mediating complex patterns of post-transcriptional regulation. In this review we examine post-synaptic gene regulation, mRNA trafficking and the emerging role of post-transcriptional gene silencing in synaptic plasticity.

• Publication year

  2011

• Venue

  Molecular Neurobiology

• Publication date

  2011-12-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s12035-011-8222-0PMID 22167484PMCID 3259350
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells

  2011cited by this paper
• Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia.

  2011cited by this paper
• Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132.

  2010cited by this paper
• MicroRNA-mediated switching of chromatin-remodelling complexes in neural development

  2009cited by this paper
• MicroRNAs: Target Recognition and Regulatory Functions

  2009cited by this paper
• A MicroRNA gene is hosted in an intron of a schizophrenia-susceptibility gene.

  2009cited by this paper
• Characterization of small RNAs in Aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB.

  2009cited by this paper
• Schizophrenia is associated with an increase in cortical microRNA biogenesis

  2009cited by this paper
• A three-dimensional view of the molecular machinery of RNA interference

  2009cited by this paper
• Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets

  2009cited by this paper
• Mef2-mediated transcription of the miR379–410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels

  2009cited by this paper
• Differential expression of Dicer and Argonaute genes duringthe differentiation of human neuroblastoma cells

  2009cited by this paper
• Down-regulation of miR-17 family expression in response to retinoic acid induced neuronal differentiation.

  2009cited by this paper
• MicroRNA-125b Promotes Neuronal Differentiation in Human Cells by Repressing Multiple Targets

  2009cited by this paper
• A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

  2009cited by this paper
• A microRNA imparts robustness against environmental fluctuation during development.

  2009cited by this paper
• hat are the roles of microRNAs at the mammalian synapse ?

  2009cited by this paper
• miR-124 regulates adult neurogenesis in the SVZ stem cell niche

  2009cited by this paper
• Expression of microRNAs and their precursors in synaptic fractions of adult mouse forebrain

  2008influential reference
• Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

  2008cited by this paper
• Dendrites of Mammalian Neurons Contain Specialized P-Body-Like Structures That Respond to Neuronal Activation

  2008cited by this paper
• miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex

  2008cited by this paper
• The Steady-State Level of the Nervous-System-Specific MicroRNA-124a Is Regulated by dFMR1 in Drosophila

  2008cited by this paper
• MicroRNA processing pathway regulates olfactory neuron morphogenesis.

  2008cited by this paper
• Dynamic Interaction between P-Bodies and Transport Ribonucleoprotein Particles in Dendrites of Mature Hippocampal Neurons

  2008influential reference
• microRNAs: tiny regulators of synapse function in development and disease

  2008cited by this paper
• P bodies: at the crossroads of post-transcriptional pathways

  2007cited by this paper
• Nuclear RNA export factor 7 is localized in processing bodies and neuronal RNA granules through interactions with shuttling hnRNPs

  2007cited by this paper
• The role of GW/P-bodies in RNA processing and silencing

  2007cited by this paper
• P-Body Formation Is a Consequence, Not the Cause, of RNA-Mediated Gene Silencing

  2007cited by this paper
• RNA localisation in the nervous system.

  2007cited by this paper
• Dicer expression and localization in post-mitotic neurons.

  2007cited by this paper
• A brain-specific microRNA regulates dendritic spine development

  2006cited by this paper
• Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies.

  2006influential reference
• Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila.

  2006cited by this paper
• Neuronal RNA granules: movers and makers.

  2006cited by this paper
• The mRNA for Elongation Factor 1α Is Localized in Dendrites and Translated in Response to Treatments That Induce Long-Term Depression

  2005cited by this paper
• Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution.

  2005cited by this paper
• Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain‐dependent manner

  2005influential reference
• MicroRNAs Regulate Brain Morphogenesis in Zebrafish

  2005cited by this paper
• Stress granules and processing bodies are dynamically linked sites of mRNP remodeling

  2005cited by this paper
• BDNF Regulates the Translation of a Select Group of mRNAs by a Mammalian Target of Rapamycin-Phosphatidylinositol 3-Kinase-Dependent Pathway during Neuronal Development

  2004cited by this paper
• Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

  2003cited by this paper
• Neurotrophin-Induced Transport of a -Actin mRNP Complex Increases -Actin Levels and Stimulates Growth Cone Motility

  2001cited by this paper
• Neurotrophin-induced transport of a beta-actin mRNP complex increases beta-actin levels and stimulates growth cone motility.

  2001cited by this paper
• Two cis-acting elements in the 3′ untranslated region of α-CaMKII regulate its dendritic targeting

  2000cited by this paper
• Identification of a cis-Acting Dendritic Targeting Element in MAP2 mRNAs

  1999influential reference
• Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites.

  1998cited by this paper
• Transport and Localization Elements in Myelin Basic Protein mRNA

  1997cited by this paper
• A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity

  1996cited by this paper
• Determinants of BDNF-induced hippocampal synaptic plasticity: role of the Trk B receptor and the kinetics of neurotrophin delivery.

  1996cited by this paper
• Neurotrophic factors and synaptic plasticity

  1995cited by this paper
• Neurotrophic factors and synaptic plasticity.

  1995cited by this paper
• Development of subcellular mRNA compartmentation in hippocampal neurons in culture

  1994cited by this paper
• Developmental mechanisms that generate precise patterns of neuronal connectivity.

  1993cited by this paper
• Pairing the cholinergic agonist carbachol with patterned Schaffer collateral stimulation initiates protein synthesis in hippocampal CA1 pyramidal cell dendrites via a muscarinic, NMDA-dependent mechanism

  1993cited by this paper
• Demonstration of local protein synthesis within dendrites using a new cell culture system that permits the isolation of living axons and dendrites from their cell bodies

  1992cited by this paper
• Evidence that protein constituents of postsynaptic membrane specializations are locally synthesized: analysis of proteins synthesized within synaptosomes

  1991cited by this paper
• Evidence that protein constituents of postsynaptic membrane specializations are locally synthesized: Time course of appearance of recently synthesized proteins in synaptic junctions

  1991cited by this paper
• The establishment of polarity by hippocampal neurons in culture

  1988cited by this paper
• Preferential localization of polyribosomes under the base of dendritic spines in granule cells of the dentate gyrus

  1982cited by this paper
• Materials and Methods Figs. S1 to S4 Tables S1 to S5 References and Notes Micrornas Regulate Brain Morphogenesis in Zebrafish

  year unknowncited by this paper

• Analysis of microRNA-transcript regulatory networks in the hippocampus of the BTBR mouse model of autism

  2025cites this paper
• Omega-3 fatty acid normalizes postsynaptic density related miRNAs and proteins in hippocampus and prevents DEHP-induced impairment of learning and memory in mice

  2025cites this paper
• Next-Generation Biosensor Technologies for Alzheimer's Disease: Innovations in Diagnosis, Monitoring, and Treatment.

  2025cites this paper
• Unveiling the Relationship between Cannabidiol, Apo-lipoprotein and Neurological Disorders: A Comprehensive Review of Molecular Targets and Current Findings

  2024cites this paper
• Analysis of ROQUIN, Tristetraprolin (TTP), and BDNF/miR-16/TTP regulatory axis in late onset Alzheimer’s disease

  2022cites this paper
• The miR-146a-5p and miR-125b-5p levels as biomarkers for early prediction of Alzheimer's disease

  2022cites this paper
• Differential expression of miR-148b, miR-129-2 and miR-296 in animal models of schizophrenia-Relevance to NMDA receptor hypofunction.

  2022cites this paper
• Potential mechanisms underlying the association between type II diabetes mellitus and cognitive dysfunction in rats: a link between miRNA-21 and Resveratrol’s neuroprotective action

  2022cites this paper
• An exon junction complex-independent function of Barentsz in neuromuscular synapse growth

  2021cites this paper
• Novel microRNAs targeting NMDA receptor subunits in animal models of schizophrenia

  2021cites this paper
• High-fidelity, efficient, and reversible labeling of endogenous proteins using CRISPR-based designer exon insertion

  2020cites this paper
• Non-coding RNAs and Pain: From Bench to Bedside

  2020cites this paper
• Non-coding RNAs in neuropathic pain

  2020cites this paper
• OBSOLETE: Non-coding RNAs and Pain: From Bench to Bedside

  2020cites this paper
• MicroRNA‐135a‐5p reduces P2X7‐dependent rise in intracellular calcium and protects against excitotoxicity

  2019cites this paper
• A Dicing Machine for Micrornas in Neurons

  2019cites this paper
• miR-152 promotes spinal cord injury recovery via c-jun amino terminal kinase pathway.

  2019cites this paper
• Exosomal microRNA and stroke: A review

  2019cites this paper
• MiR-219-5p promotes spinal cord injury recovery by inhibiting NEUROD2-regulated inflammation and oxidative stress.

  2019cites this paper
• Transcriptional and Genomic Advances on the Pathophysiology of Stem Cell Repairment After Intracerebral Hemorrhage

  2018cites this paper
• Étude du rôle physiologique et pathologique de la famille miR-132/212 dans le cerveau

  2018cites this paper
• Overexpression of miR-381-3p promotes the recovery of spinal cord injury.

  2018cites this paper
• Abnormalities in Prefrontal Cortical Gene Expression Profiles Relevant to Schizophrenia in MK-801-Exposed C57BL/6 Mice.

  2018cites this paper
• Distal Axonal Proteins and Their Related MiRNAs in Cultured Cortical Neurons

  2018cites this paper
• The Role of microRNA in Ischemic and Hemorrhagic Stroke.

  2017cites this paper
• MicroRNA: Small RNA mediators of the brains genomic response to environmental stress.

  2016cites this paper
• Monoaminergic tone supports conductance correlations and stabilizes activity features in pattern generating neurons of the lobster, Panulirus interruptus

  2015cites this paper
• Cronobacter sakazakii infection alters serotonin transporter and improved fear memory retention in the rat

  2015cites this paper
• Genetics and the Language Sciences

  2015cites this paper
• The evolving roles of pericyte in early brain injury after subarachnoid hemorrhage.

  2015cites this paper
• The double-edged sword of long non-coding RNA: The role of human brain-specific BC200 RNA in translational control, neurodegenerative diseases, and cancer.

  2015cites this paper
• Pro-opiomelanocortin gene and melanin-based colour polymorphism in a reptile

  2014cites this paper
• Transcription Control Pathways Decode Patterned Synaptic Inputs into Diverse mRNA Expression Profiles

  2014cites this paper
• MicroRNAs regulate neuronal plasticity and are involved in pain mechanisms

  2014cites this paper
• Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise

  2014cites this paper
• Dopaminergic tone persistently regulates voltage-gated ion current densities through the D1R-PKA axis, RNA polymerase II transcription, RNAi, mTORC1, and translation

  2014cites this paper
• Synaptic adaptations by alcohol and drugs of abuse: changes in microRNA expression and mRNA regulation

  2014cites this paper
• An RNA Binding Protein Promotes Axonal Integrity in Peripheral Neurons by Destabilizing REST

  2014influential citation
• Ontogeny of small RNA in the regulation of mammalian brain development

  2014cites this paper
• MicroRNA dysregulation in spinal cord injury: causes, consequences and therapeutics

  2014cites this paper
• Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons

  2014cites this paper
• MicroRNAs in Neuronal Communication

  2014influential citation
• Exosomes/miRNAs as mediating cell-based therapy of stroke

  2014cites this paper
• A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly(A) tail length

  2014cites this paper
• hnRNPA2/B1 and nELAV proteins bind to a specific U-rich element in CDK5R1 3'-UTR and oppositely regulate its expression.

  2014cites this paper
• Understanding complex transcriptome dynamics in schizophrenia and other neurological diseases using RNA sequencing.

  2014cites this paper
• Dysregulation of the axonal trafficking of nuclear‐encoded mitochondrial mRNA alters neuronal mitochondrial activity and mouse behavior

  2014cites this paper
• Maturation of the human dorsolateral prefrontal cortex coincides with a dynamic shift in microRNA expression.

  2014cites this paper
• Neuroanatomical characterization of a growth hormone secretagogue receptor‐green fluorescent protein reporter mouse

  2014cites this paper
• The neuronal RNA binding protein HuB as a potential tumor suppressor in glioblastoma

  2013cites this paper
• Context-specific microRNA function in developmental complexity.

  2013cites this paper
• Developmental and Functional Expression of miRNA-Stability Related Genes in the Nervous System

  2013cites this paper
• Opposing actions of environmental enrichment and Alzheimer's disease on the expression of hippocampal microRNAs in mouse models

  2013cites this paper
• Genomic characterisation of small RNA-mediated post-transcriptional gene regulation

  2013cites this paper
• Design and interpretation of microRNA-reporter gene activity.

  2013cites this paper
• Axonal trafficking of an antisense RNA transcribed from a pseudogene is regulated by classical conditioning

  2013cites this paper
• MicroRNAs as effectors of brain function.

  2013cites this paper
• Improvement in functional recovery with administration of Cerebrolysin after experimental closed head injury.

  2013cites this paper
• Regulating the many to benefit the few: role of weak small RNA targets.

  2013cites this paper
• MicroRNA in Alzheimer’s disease: an exploratory study in brain, cerebrospinal fluid and plasma

  2013cites this paper
• MiR‐133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome‐Enriched Extracellular Particles

  2013cites this paper
• ELAV proteins along evolution: back to the nucleus?

  2013cites this paper
• Anxiety-associated alternative polyadenylation of the serotonin transporter mRNA confers translational regulation by hnRNPK

  2013cites this paper
• Transcriptome study of differential expression in schizophrenia.

  2013cites this paper
• Expression of the core exon-junction complex factor eukaryotic initiation factor 4A3 is increased during spatial exploration and striatally-mediated learning.

  2012cites this paper
• New kid on the ID block

  2012cites this paper
• Alternative mRNA fates identified in microRNA-associated transcriptome analysis

  2012cites this paper
• Spinal muscular atrophy: the role of SMN in axonal mRNA regulation.

  2012cites this paper
• Cellular Neuroscience Perspective Article Bdnf and the Maturation of Posttranscriptional Regulatory Networks in Human Sh-sy5y Neuroblast Differentiation

  year unknowncites this paper