microRNAs: tiny regulators of synapse function in development and disease

S. Bicker,G. Schratt

Published 2008 in Journal of Cellular and Molecular Medicine

ABSTRACT

•  Introduction •  miRNA biogenesis and mode of action •  Regulation of miRNA expression •  miRNAs as regulators in the developing nervous system •  Synapse development and plasticity in vertebrates •  miRNAs as regulators in post‐mitotic neurons •  miRNA transport to the dendrite •  miRNAs in diseases of the nervous system ‐  Tourette's syndrome ‐  Spinal muscular atrophy ‐  Williams syndrome ‐  Rett syndrome ‐  Schizophrenia ‐  Neurodegenerative diseases ‐  Parkinson's disease ‐  Alzheimer's disease ‐  Triplet repeat expansion disorders ‐  Fragile X mental retardation syndrome ‐  Spinocerebellar ataxia type 3 ‐  Cancer in the CNS ‐  Genomic imprinting •  Diagnostic and therapeutic persDiagnostic and therapeutic perspectives •  Conclusion

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