Glutathione S-transferase in the formation of cyanide from organic thiocyantes and as an organic nitrate reductase.

No abstract is available for this paper.

• Publication year

  1975

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  1975-05-19

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/0006-291X(75)90349-6PMID 1170853
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Glutathione S-transferase A. A novel kinetic mechanism in which the major reaction pathway depends on substrate concentration.

  1974cited by this paper
• Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.

  1974cited by this paper
• The identity of glutathione S-transferase B with ligandin, a major binding protein of liver.

  1974cited by this paper
• Enzymatic conjugation of epoxides with glutathione.

  1973cited by this paper
• The mechanism of the reaction between glutathione and 1-menaphthyl sulphate catalysed by a glutathione S-transferase from rat liver.

  1973cited by this paper
• Enzymatic mechanisms and toxicological significance of hydrogen cyanide liberation from various organothiocyanates and organonitriles in mice and houseflies

  1972cited by this paper
• Ligandin: a Hepatic Protein which Binds Steroids, Bilirubin, Carcinogens and a Number of Exogenous Organic Anions

  1971cited by this paper
• The reaction of aralkyl sulphate esters with glutathione catalysed by rat liver preparations.

  1971cited by this paper
• The metabolic pathway in the degradation of glyceryl trinitrate.

  1971cited by this paper
• Glutathione S-transferases liberate hydrogen cyanide from organic thiocyanates.

  1971cited by this paper
• On the synthesis and enzymatic reduction of the coenzyme A-glutathione mixed disulfide.

  1966cited by this paper
• The transformation of glyceryl trinitrate and other nitrates by glutathione-organic nitrate reductase.

  1965cited by this paper
• Tissue sulfhydryl groups.

  1959cited by this paper
• METABOLISM OF INORGANIC NITRITE AND NITRATE ESTERS II. THE ENZYMATIC REDUCTION OF NITROGLYCERIN AND ERYTHRITOL TETRANITRATE BY GLUTATHIONE

  1950cited by this paper
• Estimation of Microquantities of Cyanide

  1947cited by this paper

• Glutathione-S-Transferases as Potential Targets for Modulation of Nitric Oxide-Mediated Vasodilation

  2022cites this paper
• Design, synthesis and biological evaluation of novel nitric oxide donors with antioxidative activity.

  2022cites this paper
• The simplest alkynyl thiocyanate HCCSCN and its isomers.

  2021cites this paper
• Biotransformation of organic nitrates by glutathione S-transferases and other enzymes: An appraisal of the pioneering work by William B. Jakoby.

  2020cites this paper
• Evaluation of immunological, inflammatory, and oxidative stress biomarkers in gasoline station attendants

  2019cites this paper
• ASSAYS IN WHOLE ANIMALS

  2017cites this paper
• Synthesis of a new magnetic-MIP for the selective detection of 1-chloro-2,4-dinitrobenzene, a highly allergenic compound.

  2017cites this paper
• Antifungal and antiaflatoxigenic effects of a fumigant, ethanedinitrile, on Aspergillus flavus

  2017cites this paper
• Reactivity and stability of glucosinolates and their breakdown products in foods.

  2014cites this paper
• Reaktivität und Stabilität von Glucosinolaten und ihren Abbauprodukten in Lebensmitteln

  2014cites this paper
• Neuroprotective Effect of Thymoquinone on Repeated Immobilization Stress-Induced Oxidative Stress in Rats

  2013cites this paper
• Metabolism and Cytotoxic Mechanisms of Nitroglycerin in Isolated Rat Hepatocytes

  2012cites this paper
• Investigation into the cancer protective effect of flaxseed in Tg.NK (MMTV/c-neu) mice, a murine mammary tumor model

  2011cites this paper
• THE ROLE OF ALDEHYDE DEHYDROGRENASE 2 IN NITRATE TOLERANCE: INVESTIGATION OF LOW POTENCY NITRATES AND CROSS TOLERANCE

  2011cites this paper
• The effect of nitroglycerin tolerance on oxidative stress and anaerobic sulfur metabolism in rat tissues

  2010cites this paper
• Behavioral effects and oxidative status in brain regions of adult rats exposed to BDE-99.

  2010cites this paper
• Effects of exposure to BDE-99 on oxidative status of liver and kidney in adult rats.

  2010cites this paper
• Role of microsomal glutathione transferase 1 in the mechanism-based biotransformation of glyceryl trinitrate in LLC-PK1 cells.

  2009cites this paper
• Glutathione S-transferase polymorphism does not explain variation in nitroglycerin responsiveness

  2008cites this paper
• The role of lipoic acid in prevention of nitroglycerin tolerance.

  2008cites this paper
• Impaired nitroglycerin biotransformation in patients with chronic heart failure

  2008cites this paper
• Radicals for life : the various forms of nitric oxide

  2007cites this paper
• Organic nitrates and nitrites as stores of NO bioactivity

  2007cites this paper
• Biotransformation of Glyceryl Trinitrate by Rat Hepatic Microsomal Glutathione S-Transferase 1

  2006cites this paper
• Changes in oxidative stress parameters and neurodegeneration markers in the brain of the senescence-accelerated mice SAMP-8.

  2006cites this paper
• Plasma and Intracellular Sulfhydryl Compound Levels In Vivo

  2005cites this paper
• Aldehyde Dehydrogenase 2 Plays a Role in the Bioactivation of Nitroglycerin in Humans

  2005cites this paper
• Serial Review:Mechanisms andNovel Directions in the Biological Applications of Nitric Oxide Donors Serial Review Editor: S. Bruce King NITRATES AND NO RELEASE: CONTEMPORARY ASPECTS IN BIOLOGICAL AND MEDICINAL CHEMISTRY

  2004cites this paper
• Nitrates and NO release: contemporary aspects in biological and medicinal chemistry.

  2004cites this paper
• Übersetzung der europäischen Patentschrift

  2004cites this paper
• A unique autocatalytic process and evidence for a concerted-stepwise mechanism transition in the dissociative electron-transfer reduction of aryl thiocyanates.

  2003cites this paper
• Effect of In Utero-Administered Coumestrol, Equol, and Organic Selenium on Biomarkers for Phase 2 Enzyme Capacity and Redox Status

  2003cites this paper
• Role of mitochondrial aldehyde dehydrogenase in nitrate tolerance.

  2003cites this paper
• SOME BLOOD PARAMETERS AND ANTIOXIDANT DEFENSE ENZYME ACTIVITIES IN THE LIVER OF CARPS (Cyprinus carpio L.) UNDER ACUTE HYPOXIC CONDITIONS

  2002cites this paper
• Effects of glutathione S‐transferase inhibitors on nitroglycerin action in pig isolated coronary arteries

  2002cites this paper
• Effects of acute hypoxia on the energy status and antioxidant defense system in the blood of carp - Cyprinvs carpio L.

  2002cites this paper
• Protein denitration/modification by Escherichia coli nitrate reductase and mammalian cytochrome P-450 reductase.

  2002cites this paper
• Toxicity of Thiocyanate to Fish, Plankton, Worm, and Aquatic Ecosystem

  2000cites this paper
• Plant cell biodegradation of a xenobiotic nitrate ester, nitroglycerin

  1997cites this paper
• Isoform-specific biotransformation of glyceryl trinitrate by rat aortic glutathione S-transferases.

  1996cites this paper
• Inhibition of the pharmacological actions of glyceryl trinitrate after the electroporetic delivery of a glutathione S-transferase inhibitor.

  1996cites this paper
• Metabolism of a nitrate ester, dihydropyridine derivative in rabbit hepatic microsomes and cytosol.

  1995cites this paper
• GSH-independent denitration of organic nitrate esters in rabbit hepatic and vascular cytosol.

  1995cites this paper
• Purification and characterization of glutathione-independent denitration enzyme of organic nitrate esters in rabbit hepatic cytosol.

  1995cites this paper
• Nitric oxide donors: biochemical pharmacology and therapeutics.

  1995cites this paper
• Theoretical studies on the biocidal activity of phenylthiocyanates

  1995cites this paper
• GSH-independent denitration of the nitrate ester of a dihydropyridine derivative in rabbit hepatic cytosol.

  1995cites this paper
• A Modified Product Inhibition Model Describes the Nonlinear Pharmacokinetics of Nicorandil in Rats

  1994cites this paper
• Effect of systemic anaphylaxis on the hepatic drug-metabolizing system in rats.

  1993cites this paper
• Microbial cleavage of nitrate esters: defusing the environment.

  1993cites this paper
• Nitroglycerin metabolism in vascular tissue: role of glutathione S-transferases and relationship between NO. and NO2- formation.

  1993cites this paper
• Acute Effects of Nitroglycerin Depend on Both Plasma and Intracellular Sulfhydryl Compound Levels In Vivo Effect of Agents With Different Sulfhydryl‐ Modulating Properties

  1993cites this paper
• Modification by hydroxyl radicals of functional reactivity in rabbit lingual artery.

  1993cites this paper
• Glutathione S-transferases: biomedical applications.

  1993cites this paper
• Do nitrates differ?

  1992cites this paper
• Possible mechanisms of activation of soluble guanylate cyclase by organic nitrates.

  1992cites this paper
• Metabolism of nitroglycerin by smooth muscle cells. Involvement of glutathione and glutathione S-transferase.

  1992cites this paper
• The unique feature of dog liver cytosolic glutathione S-transferases. An isozyme not retained on the affinity column has the highest activity toward 1,2-dichloro-4-nitrobenzene.

  1991cites this paper
• CUTANEOUS METABOLISM OF NITROGLYCERIN IN VIABLE RAT SKIN IN VITRO

  1990cites this paper
• Purification and characterization of glutathione transferases with an activity toward nitroglycerin from human aorta and heart. Multiplicity of the human class Mu forms.

  1990cites this paper
• Nitroglycerin and isosorbide dinitrate stimulation of glutathione disulfide efflux from perfused rat liver.

  1989cites this paper
• Biotransformation of organic nitrate esters in vitro by human liver, kidney, intestine, and blood serum.

  1988cites this paper
• [Mechanism of the anti-alcohol action of fenazepam].

  1987cites this paper
• [Phosphorylation and activation of glutathione peroxidase and glutathione-S-transferase by cAMP-dependent protein kinase].

  1986cites this paper
• Metabolism of nipradilol by liver homogenates from different species. I. Comparative studies on the denitration of nipradilol and other organic nitrates.

  1986cites this paper
• Pharmacokinetics and pharmacodynamics of nitroglycerin and aspirin

  1986cites this paper
• Pharmacokinetics of the new antihypertensive agent nipradilol in rats. 1st communication: Metabolism and disposition after single oral administration of [14C]nipradilol.

  1985cites this paper
• Role of hemoglobin in the differential biotransformation of glyceryl trinitrate and isosorbide dinitrate by human erythrocytes.

  1985cites this paper
• N-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin.

  1985cites this paper
• [Studies on glutathione S-transferase in human kidney--biochemical characterization and immunohistochemical study in human embryonal tissue].

  1985cites this paper
• Evidence that DDT-dehydrochlorinase from the house fly is a glutathione S-transferase

  1984cites this paper
• CHAPTER 2 – Lipid Peroxide Actions in the Regulation of Prostaglandin Biosynthesis

  1984cites this paper
• Aging selectively alters glutathione S-transferase isozyme concentrations in liver and lung cytosol.

  1984cites this paper
• Blood vessel uptake and metabolism of organic nitrates in the rat.

  1984cites this paper
• Rapid microbial degradation of organic nitrates in rat excreta. Re-examination of the urinary and fecal metabolite profiles of pentaerythritol tetranitrate in the rat.

  1984cites this paper
• Biotransformation of nitroglycerin in blood and its bioavailability and pharmacokinetics during cardiopulmonary bypass

  1983cites this paper
• ELIMINATION OF GLYCERYL TRINITRATE: EFFECTS OF SEX, AGE, SPECIES AND ROUTE OF ADMINISTRATION

  1982cites this paper
• [Absorption of isosorbide dinitrate in guinea-pig intestine and in the colon of sheep (author's transl)].

  1982cites this paper
• Evidence that the Ya and Yc subunits of glutathione transferase B (ligandin) are the products of separate genes.

  1982cites this paper
• Regulation of epididymal glutathione S-transferases: effects of orchidectomy and androgen replacement.

  1982cites this paper
• Assays for differentiation of glutathione S-transferases.

  1981cites this paper
• [Age-related changes in the glutathione-S-transferase and glutathione peroxidase activity of rat liver cytosol].

  1981cites this paper
• Mouse liver glutathione S-transferases. Biochemical and immunological characterization.

  1981cites this paper
• NITROGLYCERIN STABILITY: EFFECTS ON BIOAVAILABILITY, ASSAY AND BIOLOGICAL DISTRIBUTION

  1981cites this paper
• The reversibility of N-oxidation in vivo. The fate of 14C-N-hydroxychlorphentermine and 14C-nitrochlorphentermine in the rat.

  1980cites this paper
• Propylthiouracil. A substrate for the glutathione S-transferases that competes with glutathione.

  1980cites this paper
• Chapter 4 – Glutathione Transferases

  1980cites this paper
• Rapid disappearance of nitroglycerin following incubation with human blood.

  1980cites this paper
• Physiological significance of glutathione S-transferases.

  1980cites this paper
• The glutathione peroxidase activity of glutathione S-transferases.

  1980cites this paper
• The binding and catalytic activities of forms of ligandin after modification of its thiol groups.

  1979cites this paper
• Cytochrome P450 product complexes and glutathione consumption produced in isolated hepatocytes by norbenzphetamine and its N-oxidized congeners.

  1979cites this paper
• The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents.

  1979cites this paper
• Molecular weight, subunits, and multiple forms of glutathione S-transferase from the house fly

  1978cites this paper
• Hepatic accumulation and intracellular binding of conjugated bilirubin.

  1978cites this paper
• Glutathione transferases. Catalysis of nucleophilic reactions of glutathione.

  1978cites this paper
• Effect of repeated oral administration of isosorbide dinitrate on hepatic glutathione S-transferase activitiy in the rat.

  1978cites this paper
• The glutathione S-transferases: a group of multifunctional detoxification proteins.

  1978cites this paper
• Glutathione transferase from human erythrocytes. Nonidentity with the enzymes from liver.

  1978cites this paper
• Plasma concentrations of isosorbide dinitrate after oral administration of a sustained-release formulation to human subjects.

  1977cites this paper