The CC chemokine ligand 3 regulates CD11c+CD11b+CD8α− dendritic cell maturation and activation following viral infection of the central nervous system: implications for a role in T cell activation

The role of CC chemokine ligand 3 (CCL3) in activation of dendritic cells (DCs) following mouse hepatitis virus (MHV) infection of the central nervous system (CNS) was examined. The results indicate that CCL3 participates in an effective host response to MHV infection by contributing to CD11c+CD11b+CD8α− DC maturation, activation, and migration to cervical lymph nodes (CLN). Diminished CD8α− DC activation correlated with reduced IFN-γ expression by virus-specific T cells accompanied by increased IL-10 production suggesting that CCL3 contributes to an effective host response to viral infection by enhancing the T cell activation potential of DC.

• Publication year

  2004

• Venue

  Virology

• Publication date

  2004-07-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.virol.2004.06.027PMID 15327893PMCID 7111789
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• CCL3 enhances the T cell activation potential of dendritic cells in the antiviral response.

  Confidence 0.87

  박진우 (dztg5apj7m) extractionKiller Whale (322360f1c1) reviewB (s683577b42) reviewmexicorea (qjvnbu8xg3) reviewq (76h6bfydm6) reviewAK (4715169a40) review
• Reduced activation of CD8α− dendritic cells is associated with lower IFN-γ expression by virus-specific T cells and higher IL-10 production.

  Confidence 0.91

  박진우 (dztg5apj7m) extractionKiller Whale (322360f1c1) reviewB (s683577b42) reviewmexicorea (qjvnbu8xg3) reviewq (76h6bfydm6) reviewAK (4715169a40) review
• CCL3 contributes to maturation, activation, and migration of CD11c+CD11b+CD8α− dendritic cells to cervical lymph nodes during mouse hepatitis virus infection of the central nervous system.

  Confidence 0.95

  박진우 (dztg5apj7m) extractionKiller Whale (322360f1c1) reviewB (s683577b42) reviewmexicorea (qjvnbu8xg3) reviewq (76h6bfydm6) reviewAK (4715169a40) review

• ccl3

  chemokine

  CC chemokine ligand 3, a chemokine examined for its role in antiviral immune responses in the central nervous system.

  박진우 (dztg5apj7m) extractionKiller Whale (322360f1c1) reviewB (s683577b42) reviewmexicorea (qjvnbu8xg3) reviewq (76h6bfydm6) reviewAK (4715169a40) review
• cd11c+cd11b+cd8α− dendritic cell

  cell type

  A dendritic cell subset identified by CD11c, CD11b, and absence of CD8α expression.

  Aliases: CD8α− DC

  박진우 (dztg5apj7m) extractionKiller Whale (322360f1c1) reviewB (s683577b42) reviewmexicorea (qjvnbu8xg3) reviewq (76h6bfydm6) reviewAK (4715169a40) review
• central nervous system

  anatomical structure

  The brain and spinal cord compartment studied as the site of viral infection.

  Aliases: CNS

  박진우 (dztg5apj7m) extractionKiller Whale (322360f1c1) reviewB (s683577b42) reviewmexicorea (qjvnbu8xg3) reviewq (76h6bfydm6) reviewAK (4715169a40) review
• cervical lymph node

  anatomical structure

  Lymph nodes in the neck that drain immune cells from the central nervous system in this setting.

  Aliases: CLN

  박진우 (dztg5apj7m) extractionKiller Whale (322360f1c1) reviewB (s683577b42) reviewmexicorea (qjvnbu8xg3) reviewq (76h6bfydm6) reviewAK (4715169a40) review
• ifn-γ

  cytokine

  Interferon gamma, a cytokine measured as an indicator of T cell effector response.

  Aliases: interferon gamma

  박진우 (dztg5apj7m) extractionKiller Whale (322360f1c1) reviewB (s683577b42) reviewmexicorea (qjvnbu8xg3) reviewq (76h6bfydm6) reviewAK (4715169a40) review
• il-10

  cytokine

  Interleukin-10, an immunoregulatory cytokine measured in T cell responses.

  Aliases: interleukin-10

  박진우 (dztg5apj7m) extractionKiller Whale (322360f1c1) reviewB (s683577b42) reviewmexicorea (qjvnbu8xg3) reviewq (76h6bfydm6) reviewAK (4715169a40) review
• mouse hepatitis virus

  virus

  A mouse coronavirus used here as the infectious agent that targets the central nervous system.

  Aliases: MHV

  박진우 (dztg5apj7m) extractionKiller Whale (322360f1c1) reviewB (s683577b42) reviewmexicorea (qjvnbu8xg3) reviewq (76h6bfydm6) reviewAK (4715169a40) review
• virus-specific t cells

  cell population

  T cells that recognize and respond to viral antigens during infection.

  박진우 (dztg5apj7m) extractionKiller Whale (322360f1c1) reviewB (s683577b42) reviewmexicorea (qjvnbu8xg3) reviewq (76h6bfydm6) reviewAK (4715169a40) review

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