Lysyl oxidase: mechanism, regulation and relationship to liver fibrosis.

Lysyl oxidase oxidizes peptidyl lysine in collagen and elastin substrates to residues of alpha-aminoadipic-delta-semialdehyde. The peptidyl aldehydes can then undergo spontaneous condensations with unreacted epsilon-amino groups and with neighboring aldehyde functions, thus forming the covalent crosslinkages which convert elastin and collagen into insoluble fibers. The unique role of lysyl oxidase in the post-translational modification of these proteins qualifies this enzymatic reaction as a potentially pivotal site of biological and/or chemotherapeutic control of collagen fiber deposition. Recent advances in the study of the catalytic mechanism, in the development of active site inhibitors, and in the biosynthesis and regulation of this unusual catalyst are reviewed as are studies on the response of lysyl oxidase in fibrotic liver.

• Publication year

  1994

• Venue

  Pathology, Research and Practice

• Publication date

  1994-10-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0344-0338(11)80995-7PMID 7899140
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1987cited by this paper
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  1986cited by this paper
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  1984cited by this paper
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  1984cited by this paper
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  1984cited by this paper
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  1984cited by this paper
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  1983cited by this paper
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  1982cited by this paper
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  1982cited by this paper
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  1981cited by this paper
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  1981cited by this paper
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  1981cited by this paper
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  1981cited by this paper
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  1981cited by this paper
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  1979cited by this paper
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  1978cited by this paper
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  1977cited by this paper
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  1976cited by this paper
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  1974cited by this paper
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  1961cited by this paper
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  1961cited by this paper

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